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Vasodilator response to <i>Psidium guajave</i>leaves of mesenteric bed vessels from diabetic and non-diabetic rats

Journal of Diabetes Mellitus 2014年第1期4卷 6-11页

作者： Habeib Zaheri Golam Reza Farshidfar nepton soltani Fatemah Kharazmi Mohammad Kamalinajad Department of Biochemistery Faculty of Medicine Hormozgan University of Medical Sciences Bandar Abbas Iran Department of Biology Faculty of Science Shahid Bahonar University Kermam Iran Department of Pharmacognosy Faculty of Pharmacy Shahid Bahashti University of Medical Sciences Tehran Iran Department of Physiology Faculty of Medicine and Research Center for Molecular Medicine Hormozgan University of Medical Sciences Bandar Abbas Iran

Mortality from cardiovascular abnormalities is almost three times more prevalent in the diabetic population than that in the general population. Psidium guajave has been used traditionally for a long time as a medicinal herb to cure diabetes. Endothelial dependent vasorelaxation effect of Psidium guajave extract on normal aortic rings was observed. This study was designed to investigate the endothelium and nitric oxide roles inPGE-induced vasorelaxation in diabetic rat vessel. Diabetes was induced by a single intraperitoneal injection of streptozotocin. Eight weeks later, superior mesenteric arteries of non-diabetic and diabetic groups were isolated and perfused according to the McGregor method. Prepared vascular beds were constricted with phenylephrine to induce 70% - 75% of maximal constriction. Psidium guajave extract at concentrations of 0.1 to 4 mg/100ml added to the medium and perfusion pressure was recorded. Baseline perfusion pressure of diabetic group was significantly higher than non-diabetic rats in both intact and denuded endothelium. Psidium guajave extract caused a significantly dose depended decrease in perfusion pressure in non-diabetic and diabetic groups in both intact and denuded endothelium. In the presence of N (ω)-nitro-L-arginine methyl ester, Psidium guajave ex-tractinduced relaxation in intact mesenteric beds of non-diabetic and diabetic animals was not suppressed. From the results of this study, it may be concluded that vasorelaxatory effect of Psidium guajave extract is not mediated by endothelium and nitric oxide in both diabetic and non-diabetic vessel and supports the use of the plant’s leaves as a natural, adjunct phytomedicine in the management of diabetes vessel complications.

关键词： Psidium guajave Linn Extract Diabetes Mellitus Mesenteric Bed Vasorelaxation Nitric Oxide

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Effect of the administration of Psidium guava leaves on blood glucose, lipid profiles and sensitivity of the vascular mesenteric bed to Phenylephrine in streptozotocin-induced diabetic rats

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Journal of Diabetes Mellitus 2012年第1期2卷 138-145页

作者： Abdol Hassan Mansoori Bahrani Habib Zaheri nepton soltani Fatemeh Kharazmi Mansoor Keshavarz Mohammad Kamalinajad Department of Physiology School of Medicine and Cardiovascular Research Center Hormozgan University of Medical Sciences Bandar Abbas Iran

The leaf of Psidium guava is traditionally used in Asia to manage, control and treat diabetes. We designed this study to elucidate the effect of the administration of oral doses of aqueous and ethanol extract from Psidium guava leaves on plasma glucose, lipid profiles and the sensitivity of the vascular mesenteric bed to Phenylephrine in diabetic and non diabetic rats. Animals were divided into 5 groups (n = 10): two groups served as non-diabetic controls (NDC), while the other groups had diabetes induced with a single injection of streptozotocin (STZ). Psidium guava-treated chronic diabetic (PSG-CD) and Psidium guava-treated controls (PSG-C) received 1g/l of Psidium guavaadded to the drinking water for 8 weeks. The mesenteric vascular beds were prepared using the McGregor method. Administration of Psidium guava caused Ca/Mg ratio, plasma glucose, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), total cholesterol and triglyceride concentrations to return to normal levels, and was shown to decrease alteration in vascular reactivity to vasoconstrictor agents. Our results support the hypothesis that Psidium guava could play a role in the management of diabetes and the prevention of vascular complications in STZ-induced diabetic rats.

关键词： Diabetes Lipid Profile Psidium Guava Blood Glucose Mesenteric Bed Ca/Mg Ratio

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Effect of the administration of Psidium guava leaves on blood glucose, lipid profiles and sensitivity of the vascular mesenteric bed to Phenylephrine in streptozotocin-induced diabetic rats

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Journal of Diabetes Mellitus（糖尿病） 2012年第1期

作者： Abdol Hassan Mansoori Bahrani Habib Zaheri nepton soltani Fatemeh Kharazmi Mansoor Keshavarz Mohammad Kamalinajad

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