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A new angiotensin-converting enzyme inhibitor from Peperomia pellucida(L.) Kunth

Asian Pacific Journal of Tropical Biomedicine 2019年第6期9卷 257-262页

作者： Islamudin Ahmad neneng siti silfi ambarwati Berna Elya Hanita Omar Kamarza Mulia Arry Yanuar Osamu Negishi Abdul Mun'im Department of Pharmaceutical Sciences Faculty of PharmacyMulawarman UniversitySamarindaEast KalimantanIndonesia Department of Cosmetology Engineering FacultyUniversitas Negeri JakartaEast JakartaIndonesia Department of Pharmaceutical Sciences Faculty of PharmacyUniversitas IndonesiaDepokWest JavaIndonesia Chemistry Division Centre for Foundation Studies in ScienceUniversity of MalayaKuala LumpurMalaysia Department of Chemical Engineering Faculty of EngineeringUniversitas IndonesiaDepokWest JavaIndonesia Department of Applied Biochemistry Faculty of Life and Environmental SciencesUniversity of TsukubaTsukubaIbarakiJapan

Objective:To isolate,identify,and evaluate a new angiotensin-converting enzyme inhibitor from Peperomia pellucida(L.)Kunth ***:A dried sample of Peperomia pellucida herb was successively macerated with n-hexane and ethyl *** ethyl acetate extract solution was evaporated to obtain the crude *** liquid column chromatography and thin layer chromatography were performed to obtain two pure ***,both compounds were elucidated and identified using the spectroscopic ***-converting enzyme inhibitory activity studies of both compounds were determined using angiotensin-converting enzyme kit WST-1 with spectrophotometer microplate reader 96-well at 450 nm ***:Two bioactive compounds were successfully isolated from Peperomia pellucida herb,including a new compound of 2,3,5-trimethoxy-9-(12,14,15-trimethoxybenzyl)-1 H-indene and pellucidin *** compounds demonstrated angiotensin-converting enzyme inhibitory activity,with IC50 values of 72 μM(27.95 μg/mL)and 1 1μM(4.4 μg/mL),***:In the present study,two active angiotensin-converting enzyme inhibitors were successfully isolated and purified from Peperomia pellucida which is used as an antihypertensive in traditional medicine,and support its use as an angiotensin-converting enzyme-inhibiting drug.

关键词： 2,3,5-trimethoxy-9-(12,14,15-trimethoxybenzyl)-1H-indene Angiotensin-converting enzyme inhibitor Pellucidin A Peperomia pellucida(L) Kunth

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