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Prevalence of Antimicrobial Resistance of ESKAPE Pathogens before and during Pandemic COVID-19 Pandemic in a University Affiliated Hospital in Tangerang, Indonesia

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Open Journal of Medical Microbiology 2023年第2期13卷 146-158页

作者： Nata Pratama Hardjo Lugito Cucunawangsih Cucunawangsih Veronica Wiwing neneng suryadinata Department of Internal Medicine Faculty of Medicine Pelita Harapan University Tangerang Indonesia Department of Clinical Microbiology Faculty of Medicine Pelita Harapan University Tangerang Indonesia Department of Medicine Faculty of Medicine Pelita Harapan University Tangerang Indonesia

Introduction: Antimicrobial resistance is the most important health problems currently. Antibiotic prophylaxis to prevent bacterial co-infections in hospitalized COVID-19 patients, and lack of surveillance were associated with antimicrobial resistance. ESKAPE pathogens consisting of E. faecium, S. aureus, K. pneumoniae, A. baumanii, P. aeruginosa and Enterobacter spp. are associated with healthcare-associated infections. Patients and Methods: This descriptive, retrospective, longitudinal study aims to describe the resistance rates of bloodstream infection due to ESKAPE pathogens from patients admitted in Siloam Hospital Karawaci, before and during COVID-19 pandemic (January 1st, 2019 until December 31st, 2022). Out of 296 ESKAPE pathogens collected from blood samples, S. aureus was the most frequent species, followed by K. pneumoniae, A. baumannii, P. aeruginosa, Enterobacter spp., and E. faecium. Results: Resistance rates of E. faecium were alarmingly high from 2019 until 2021, but in 2022 no sample was found. Resistance rates of S. aureus and MRSA decreased from 2019 until 2021 and then increased again in 2022 while for K. pneumoniae it peaked in 2020 and reached the lowest in 2022. Resistance pattern of A. baumanii was not favorable from 2019 until 2021, but decreased dramatically in 2022. Resistance pattern of P. aeruginosa was quite variable in 2021 and 2022 while for Enterobacter spp. it was variable in 2020 to 2022. Conclusion: The COVID-19 pandemic affected the antimicrobial resistance pattern of ESKAPE pathogens in Banten province, Indonesia. Resistance rates increased as the pandemic peaked in 2020 to 2021, and decreased as the pandemic resolves in 2022.

关键词： Antimicrobial Resistance COVID-19 Pandemic ESKAPE Pathogens Multidrug Resistance

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A new angiotensin-converting enzyme inhibitor from Peperomia pellucida(L.) Kunth

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Asian Pacific Journal of Tropical Biomedicine 2019年第6期9卷 257-262页

作者： Islamudin Ahmad neneng Siti Silfi Ambarwati Berna Elya Hanita Omar Kamarza Mulia Arry Yanuar Osamu Negishi Abdul Mun'im Department of Pharmaceutical Sciences Faculty of PharmacyMulawarman UniversitySamarindaEast KalimantanIndonesia Department of Cosmetology Engineering FacultyUniversitas Negeri JakartaEast JakartaIndonesia Department of Pharmaceutical Sciences Faculty of PharmacyUniversitas IndonesiaDepokWest JavaIndonesia Chemistry Division Centre for Foundation Studies in ScienceUniversity of MalayaKuala LumpurMalaysia Department of Chemical Engineering Faculty of EngineeringUniversitas IndonesiaDepokWest JavaIndonesia Department of Applied Biochemistry Faculty of Life and Environmental SciencesUniversity of TsukubaTsukubaIbarakiJapan

Objective:To isolate,identify,and evaluate a new angiotensin-converting enzyme inhibitor from Peperomia pellucida(L.)Kunth ***:A dried sample of Peperomia pellucida herb was successively macerated with n-hexane and ethyl *** ethyl acetate extract solution was evaporated to obtain the crude *** liquid column chromatography and thin layer chromatography were performed to obtain two pure ***,both compounds were elucidated and identified using the spectroscopic ***-converting enzyme inhibitory activity studies of both compounds were determined using angiotensin-converting enzyme kit WST-1 with spectrophotometer microplate reader 96-well at 450 nm ***:Two bioactive compounds were successfully isolated from Peperomia pellucida herb,including a new compound of 2,3,5-trimethoxy-9-(12,14,15-trimethoxybenzyl)-1 H-indene and pellucidin *** compounds demonstrated angiotensin-converting enzyme inhibitory activity,with IC50 values of 72 μM(27.95 μg/mL)and 1 1μM(4.4 μg/mL),***:In the present study,two active angiotensin-converting enzyme inhibitors were successfully isolated and purified from Peperomia pellucida which is used as an antihypertensive in traditional medicine,and support its use as an angiotensin-converting enzyme-inhibiting drug.

关键词： 2,3,5-trimethoxy-9-(12,14,15-trimethoxybenzyl)-1H-indene Angiotensin-converting enzyme inhibitor Pellucidin A Peperomia pellucida(L) Kunth

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