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家庭血压监测:澳大利亚专家共识说明

中华高血压杂志 2015年第8期23卷 708-708页

作者：罗雪琚叶鹏 Sharman JE Howes FS Head GA McGrath XY Stowasser M Schlaich M Glasziou P nelson mr

医生所测诊室血压可能获取到并无代表性的血压测量结果,从而影响对高血压的准确评估和治疗。家庭血压监测（home blood pressure monitoring,HBPM）是在医疗保健工作者指导下,在一定的时间内（比如7d）患者在家里自行测量血压（通常在... 详细信息

医生所测诊室血压可能获取到并无代表性的血压测量结果,从而影响对高血压的准确评估和治疗。家庭血压监测（home blood pressure monitoring,HBPM）是在医疗保健工作者指导下,在一定的时间内（比如7d）患者在家里自行测量血压（通常在早晨和晚间）。当患者不能进行24 h动态血压监测（ambulatory blood pressure monitoring，ABPM）时，HBPM则为诊治高血压提供了另一种方法。HBPM有良好的重复性，良好的耐受性，比较便宜，且对心血管病发病和死亡的预测均优于诊室血压。HBPM可结合诊室血压测量用来识别“白大衣性高血压”和“隐蔽性高血压”。HBPM平均血压≥135／85mmHg（1mmHg=0．133kPa）是高血压诊断的适合阈值。HBPM还有利于患者管理血压，增强药物治疗依从性，达到目标血压水平。该文建议，在合适情况下，应考虑将HBPM常规应用于高血压的临床管理中。

关键词：动态血压监测澳大利亚白大衣性高血压家庭药物治疗依从性专家血压测量患者管理

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超低剂量四联疗法治疗高血压的成本效益

中华高血压杂志 2023年第11期31卷 1085-1085页

作者： Atkins ER Chye A Lung T Nolde JM Billot L Burke M Chalmers J Figtree GA Hay P Hillis GS Jansen S Marschner S Neal B nelson mr Reid CM Usherwood T Schlaich M Chow CK Rodgers A 刘青 (译) 练桂丽(审校) 不详

确定含有厄贝沙坦37.5 mg、氨氯地平1.25 mg、吲达帕胺0.625 mg和比索洛尔2.5 mg的四药联用与厄贝沙坦150 mg相比,对于未经治疗或接受单药治疗的高血压患者的成本效益和成本效用。方法:研究者对四联超低剂量治疗高血压试验进行内部试验... 详细信息

确定含有厄贝沙坦37.5 mg、氨氯地平1.25 mg、吲达帕胺0.625 mg和比索洛尔2.5 mg的四药联用与厄贝沙坦150 mg相比,对于未经治疗或接受单药治疗的高血压患者的成本效益和成本效用。方法:研究者对四联超低剂量治疗高血压试验进行内部试验和建模经济评估。分析是预先计划的,并在试验期间获取药物和卫生服务的使用情况。

关键词：卫生服务成本效用成本效益超低剂量单药治疗厄贝沙坦四联疗法吲达帕胺

无心血管病老年人群的高血压治疗和控制相关影响因素:一项横断面研究

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中华高血压杂志(中英文) 2021年第4期29卷 398-398页

作者：周卫叶鹏 Chowdhury EK nelson mr Ernst ME Margolis KL Beilin LJ Johnston CI Woods RL Murray AM Wolfe R Storey E Shah RC Lockery JE Tonkin AM Newman AB Williamson JD Abhayaratna WP Stocks NP Fitzgerald SM Orchard SG Trevaks RE Donnan GA Grimm R McNeil JJ Reid CM

虽已有各种降压疗法,但在老龄化人口中,血压控制仍不够理想。另外,人们对老年人群高血压管理的认识也有差距。研究者探讨无明显心血管病的老年高血压患者的降压治疗和控制情况,试图确定"未治疗"和"治疗但未控制"高血压的相关因素。方法...

虽已有各种降压疗法,但在老龄化人口中,血压控制仍不够理想。另外,人们对老年人群高血压管理的认识也有差距。研究者探讨无明显心血管病的老年高血压患者的降压治疗和控制情况,试图确定"未治疗"和"治疗但未控制"高血压的相关因素。方法:研究者分析了参加老年人阿司匹林减少心血管事件研究的年龄≥65岁,来自澳大利亚和美国的参与者19 114例的基线数据。

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mrI对外踝不稳患者的外踝韧带和腓骨肌腱的诊断价值

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第三军医大学学报 2015年第3期37卷 193-197页

作者： nelson F.SooHoo 加利福尼亚大学洛杉矶分校罗纳德-里根医学中心骨科美国加利福尼亚州90095-17311

目的分析mrI对自感无症状的外踝不稳患者的诊断价值。方法采用3.0T核磁共振仪扫描评估11例无症状但有踝关节损伤史的患者的14侧踝关节。成像平面包括轴向PD和T2加权序列、冠状快速自旋回波脂肪饱序列、矢状T1加权序列和矢状面STIR序列。... 详细信息

目的分析mrI对自感无症状的外踝不稳患者的诊断价值。方法采用3.0T核磁共振仪扫描评估11例无症状但有踝关节损伤史的患者的14侧踝关节。成像平面包括轴向PD和T2加权序列、冠状快速自旋回波脂肪饱序列、矢状T1加权序列和矢状面STIR序列。2位肌肉骨骼领域的放射学专家审阅所有图像,对于异常显现达成一致的认识。结果 14侧踝关节中7例(50%)呈现距腓前韧带异常,8例踝关节(占57%)呈现跟腓韧带异常,2例踝关节(占14%)呈现距腓后韧带的异常。除此之外,9例踝关节(占64%)发现有腓骨肌腱的病理表现。结论在外踝不稳患者中,mrI可以显示外侧韧带结构以及腓骨肌腱的异常,但这些异常可以无症状。

关键词：踝关节不稳肌腱炎韧带损伤核磁共振成像足踝扭伤

Impact of Mitral Valve Repair in Patients with End-Stage Congestive Heart Failure

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World Journal of Cardiovascular Surgery 2012年第4期2卷 86-90页

作者： John D. nelson Pierre Mikhael Michael A. Wait Bonnie J. Kuykendall Kendall A. Nettle Michael E. Jessen Dan M. Meyer Department of Cardiovascular and Thoracic Surgery University of Texas Southwestern Medical Center Dallas USA

Objective: The utility of mitral valve repair in patients with Mitral Regurgitation (mr) and advanced CHF remains controversial. Methods: 37 patients with mr and Left Ventricular Ejection Fraction (LVEF) 25% as well as patients with LVIDd Results: Operative mortality was 0% for the group. There were significant reductions in NYHA Class (p = 0.0004), mitral regurgitation (p 25%. There were no significant differences in cardiac outcome changes between patients with LVIDd 25%, and between patients with LVIDd Conclusions: MV repair in patients with low LVEF and mr can be performed safely, with significant improvement in LVEF and symptom profile. No survival difference were noted between those patients with severely depressed LVEF or those with elevated ventricular dimensions (LVIDd) when compared to those with less severe but still significant cardiac impairment. Consideration should be given to these patients as an option prior to transplantation.

关键词： Mitral Valve Repair Mitral Regurgitation Heart Failure

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders Joseph nelson Siewe Fodjo Olivia Kamoen Luis-Jorge Amaral Amber Hadermann Chiara Trevisan Mark J.Taylor Julia Gauglitz Achim Hoerauf Yasuaki Sato Katja Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag Sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan mrC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for Sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

Prevalence of epilepsy in the onchocerciasis endemic middle belt of Ghana after 27 years of mass drug administration with ivermectin

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Infectious Diseases of Poverty 2023年第4期12卷 106-106页

作者： Kenneth Bentum Otabil Blessing Ankrah Emmanuel John Bart-Plange Emmanuel Sam Donkoh Fiona Amoabil Avarikame Fredrick Obeng Ofori-Appiah Theophilus Nti Babae Prince-Charles Kudzordzi Vera Achiaa Darko Joseph Ameyaw Joseph Gyekye Bamfo Raji Abdul Sakibu Daniel Antwi-Berko Joseph nelson Siewe Fodjo María-Gloria Basáñez Henk D.F.H.Schallig Robert Colebunders NeTroDis Research Group Centre for Research in Applied Biology School of Sciences University of Energy and Natural Resources Sunyani Ghana Department of Biological Science School of Sciences University of Energy and Natural Resources Sunyani Ghana Global Health Institute University of Antwerp Antwerp Belgium Department of Medical Laboratory Science School of Sciences University of Energy and Natural Resources Sunyani Ghana STU Clinic Sunyani Technical University Sunyani Ghana Happy Family Hospital Nkoranza Ghana Tain District Hospital Nsawkaw Ghana Department of Infectious Disease Epidemiology MRC Centre for Global Infectious Disease Analysis (MRC GIDA) and London Centre for Neglected Tropical Disease Research School of Public Health Imperial College London London UK Department of Medical Microbiology Experimental Parasitology Unit Amsterdam University Medical Centres Academic Medical Centre at the University of Amsterdam Amsterdam The Netherlands

BackgroundIn onchocerciasis-endemic areas with high ongoing Onchocerca volvulus transmission,a high prevalence of epilepsy has been *** study aimed to determine the prevalence and clinical characteristics of epilepsy in the Bono Region of Ghana following 27 years of implementation of ivermectin mass drug administration(MDA).MethodsBetween October 2020 and August 2021,cross-sectional surveys were conducted in nine communities in the Tain District and Wenchi Municipality of the Bono Region of *** the first stage,a random door-to-door approach was used to screen the population for epilepsy using a pre-tested *** suspected of having epilepsy were invited for a second-stage neurological examination for case *** *** microfilarial infection status and Ov16 seropositivity were also ***-five confidence intervals(95%CI)for prevalence values were calculated using the Wilson Score *** the 971 participants,500(51.5%)were females,and the median age(interquartile range)was 26(15‒43)*** participants(1.4%,95%CI:1.0‒2.0)were diagnosed as having epilepsy with generalized seizures being the most frequent seizure type(85.7%,12/14).The overall microfilarial prevalence of *** was 10.3%(November 2020)and 9.9%(August 2021);the Ov16 seroprevalence was 22.2%(June 2021).Only 63.2%took ivermectin in the last round of MDA distribution in March *** 1.4%prevalence of epilepsy in the Bono region is similar to the median epilepsy prevalence in sub-Saharan ***,the persistent microfilarial prevalence and low ivermectin study coverage call for the Ghana Onchocerciasis Elimination Programme to step up its efforts to ensure that the gains achieved are consolidated and improved to achieve the elimination of onchocerciasis by 2030.

关键词： Onchocerca volvulus Microflaria Onchocerciasis-associated epilepsy Seizure Ivermectin Mass drug administration Coverage

采用改良的临床mrI序列研究青少年剥脱性骨软骨炎骺软骨起源和随后骨的表现:初步研究

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国际医学放射学杂志 2017年第3期 339-339页

作者： J.Ellermann C.P.Johnson L.Wang J.A.Macalena B.J.nelson R.F.La Prade 卫淑芳 Department of Radiology and Center for Magnetic Resonance Research University of Minnesota Medical Center

摘要目的回顾性评估是否改良临床mr成像序列能够提供青少年剥脱性骨软骨炎(JOCD)病变起源的信息,并基于JOCD自然史进行分期以便更好地指导该病的临床。材料与方法该研究通过了机构伦理委员会批准,符合HIPAA。对13例病人(年龄10～22岁,平... 详细信息

摘要目的回顾性评估是否改良临床mr成像序列能够提供青少年剥脱性骨软骨炎(JOCD)病变起源的信息,并基于JOCD自然史进行分期以便更好地指导该病的临床。材料与方法该研究通过了机构伦理委员会批准,符合HIPAA。对13例病人(年龄10～22岁,平均14.9岁;男9例,女4例)和1例做比较的病人(44岁男性)进行了回顾性研究,对其中19个膝关节的20个JOCD病变进行成像,包括股骨内侧髁17个,股骨外侧髁2个,股骨内侧滑车1个。增补的3 T

关键词：剥脱性骨软骨炎 mrI 成像序列骺软骨