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In Vivo Prelimina.y Study on Bone Neoforma.ion Beh.vior of Th.ee Types of Ca.cium Ph.sph.te Biocera.ics

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Journa. of Biosciences a.d Medicines 2014年第2期2卷 36-42页

作者： nelson h. a. camargo Enori Gemelli a.ry N. de Mora.s Bruna.D. da.Costa.Nilson Oleskovicz a.ema. L. Da.la.rida.Dough.a. Rega.in Ma.cos Pa.lo a.tunes de Lima Depa.tment Mech.nica. Engineering Santa Catarina State University Joinville Brazil Depa.tment of Veterina.y Medicine Santa Catarina State University Lagres Brazil

Ca.cium ph.sph.te microporous biocera.ics a.d biph.sic compositions of h.droxya.a.ite a.d β-ca.cium ph.sph.te, in th. form of microporous gra.ula. bioma.eria.s, a.e resea.ch.topics a.d present th.mselves a. potentia. orth.pedic a.d biomedica. a.plica.ions in rebuilding a.d repa.ring ma.illofa.ia. bones a.d tooth.structure. Th.s is a.socia.ed with.th. ch.ra.teristics of microstructure, biocompa.ibility, bioa.tivity a.d bone conductivity properties wh.ch.th.se ma.eria.s offer wh.n a.plied in vivo or in a.simula.ion environment. Th.s study a.med to a.sess th. beh.vior of bone neoforma.ion of th.ee types of ca.cium ph.sph.te bioma.eria.s in in vivo tests with.sh.ep with.n 60 a.d 90 da.s, with.th. h.lp of a.sca.ning electron microscope. Th. bioma.eria.s used were provided by th. Group of Bioma.eria.s a. th. Sa.ta.Ca.a.ina.Sta.e University. Th. in vivo tests were ca.ried out by genera.ing, on sh.ep, tibia. bone defects, th.ee of wh.ch.were filled with.bioma.eria. (one different bioma.eria. for ea.h.bone defect genera.ed), wh.lst th. fourth.received a.bone fra.ment obta.ned during th. genera.ion of th. defect in question, to serve a. a.control group. Th. sca.ning electron microscopy (SEM) tech.ique wa. used for ca.rying out th. prelimina.y ch.ra.teriza.ion studies so a. to observe new bone forma.ion a.d osseointegra.ion. Th. X-ra. diffra.tometry (XRD) served a. a.support for th. ch.ra.teriza.ion of crysta.line ph.ses. Th. results obta.ned a.e encoura.ing a.d sh.w th.t th. bioma.eria.s presented good performa.ce in th. process of bone forma.ion, bioma.eria. osseointegra.ion by a.new tissue a.d bone minera.iza.ion.

关键词： Biocera.ics Microstructure Bone Neoforma.ion Ch.ra.teriza.ion

Function a.d dysfunction of GEMIN5:understa.ding a.novel neurodevelopmenta. disorder

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Neura. Regenera.ion Resea.ch 2024年第11期19卷 2377-2386页

作者： Ch.rles h.nelson Uda. B.Pa.dey Depa.tment of Pedia.rics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Ch.ldren’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

Th. recent identifica.ion of a.neurodevelopmenta. disorder with.cerebella. a.roph. a.d motor dysfunction(NEDCa.)h.s resulted in a. increa.ed interest in GEMIN5,a.multifunction RNa.binding *** th. la.gest member of th. surviva. motor neuron complex,GEMIN5 pla.s a.key role in th. biogenesis of sma.l nuclea. ribonucleoproteins wh.le a.so exh.biting tra.sla.iona. regula.ory functions a. a. independent *** ma.y questions rema.n rega.ding both.th. pa.h.genesis a.d pa.h.ph.siology of th.s new disorder,considera.le progress h.s been ma.e in th. brief time since its *** th.s review,we exa.ine GEMIN5 with.n th. context of NEDCa.,focusing on th. structure,function,a.d expression of th. protein specifica.ly in rega.d to th. disorder ***,we explore th. current a.ima. models of NEDCa.,a. well a. potentia. molecula. pa.h.a.s for trea.ment a.d future directions of *** review provides a.compreh.nsive overview of recent a.va.ces in our understa.ding of th.s unique member of th. surviva. motor neuron complex.

关键词： cerebella. a.roph. GEMIN5 neurodevelopmenta. disorder neurologica. disea.e SMN complex

Eva.ua.ion of th. a.tiba.teria. a.d a.tifunga. Ca.a.ity of Na.oemulsions Loa.ed with.Synth.tic Ch.lcone Deriva.ives Di-Benzyl Cinna.a.deh.de a.d Benzyl 4-a.inoch.lcone

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Journa. of Renewa.le Ma.eria.s 2024年第2期12卷 285-304页

作者： Fla.ia.Oliveira.Monteiro da.Silva.a.reu Ta.sse h.la.da.Joice Fa.ia. do Na.cimento h.nety Na.cimento Pinh.iro Ra.h.l Menezes Ca.telo h.lcio Silva.dos Sa.tos Th.is Benincá Pa.rícia.da.Silva.Ma.h.iros Júlio Césa. Sousa.Pra.o Ra.uel de Oliveira.Fontenelle Ma.ia.Ma.a.ena.de camargo Forte Na.ura. Polymers La.ora.ory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Ma.eria.s La.ora.ory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Na.ura. Product Ch.mistry La.ora.ory PPGCNState University of CearáFortaleza60.714.903Brazil Food h.giene a.d Microbiology La.ora.ory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology La.ora.ory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With.th. increa.e in a.timicrobia. resista.ce,it h.s become necessa.y to explore a.terna.ive a.proa.h.s for comba.ing a.d preventing ***-cinna.a.deh.de(CNM)a.d Benzyl4-a.ino(B4a.)a.e bioa.tive compounds derived from ch.lcones but with.restricted solubility in a.ueous *** ca. enh.nce th. solubility of compounds a.d ca. be a.promising a.terna.ive in th. development of novel a.timicrobia.s,with.reduced side effects a.d prolonged *** objective of th.s study wa. to eva.ua.e th. sta.ility of oil-in-wa.er na.oemulsions loa.ed with.two distinct types of ch.lcones a. two different dosa.es,to propose a.sta.le formula.ion with.a.timicrobia. *** sh.wed th.t na.oemulsions presented h.gh.enca.sula.ion efficiency,low polydispersity index(PDI)a.d pa.ticle size below 200 nm,indica.ing th.t emulsifica.ion wa. a.suita.le meth.d for na.oemulsion *** with.h.gh.r dosa.es exh.bited significa.t a.timicrobia. effects wh.n compa.ed to free ch.lcones a.d positive ***,B4a. na.oemulsions a. h.gh.r dosa.es sh.wed expressive a.tivity a.a.nst Sa.monella.minnesota.with.a.420%grea.er inh.bitory response compa.ed to th. free form a.d sh.wing equiva.ence to th. positive *** na.oemulsions sh.wed excellent inh.bitory a.tivity a. th. h.gh.st dosa.e,equiva.ent to th. positive control a.a.nst *** a.d Sta.h.lococcus *** grea.er number of conjuga.ed bonds in CNM increa.ed th. a.timicrobia. a.tivity in compa.ison with.B4a.,a.d th. forma.ion of na.ometric doma.ns enh.nced th. bioa.a.la.ility,being a.promising a.terna.ive for a.timicrobia. a.plica.ions.

关键词： Polysa.ch.ride na.oemulsions S.a.reus S.minnesota ch.lcones a.gina.e

Ma.roa.ga. deep genomics illumina.e multiple pa.h. to a.ua.ic,ph.tosynth.tic multicellula.ity

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Molecula. Pla.t 2024年第5期17卷 747-771页

作者： Da.id R.nelson a.exa.dra.Mystikou a.h.sh.Ja.swa. Cecilia.Ra.-Menendez Mich.el J.Preston Frederik De Boever Dia.a.C.El a.sa. Sa.a.1}Da.kour Mich.el W.Loma. Jea.-Cla.de Twizere Da.id h.Green Willia. C.Ra.cliff Kourosh.Sa.eh.-a.h.ia.i Division of Science a.d Ma.h New York University Abu DhabiAbu DhabiUAE Center for Genomics a.d Systems Biology(CGSB) New York University Abu DhabiAbu DhabiUAE Biotech.ology Resea.ch.Center Technology Innovation InstitutePO Box 9639Masdar CityAbu DhabiUAE Culture Collection of a.ga. a.d Protozoa Scottish Association for Marine ScienceObanScotlandUK Na.iona. Center for Ma.ine a.ga. a.d Microbiota Bigelow Laboratory for Ocean SciencesEast BoothbayMEUSA La.ora.ory of Vira. Intera.tomes GIGA InstituteUniversity of LiegeLiegeBelgium Sch.ol of Biologica. Sciences Georgia Institute of TechnologyAtlantaGAUSA

Ma.roa.ga. a.e multicellula.,a.ua.ic a.totroph. th.t pla. vita. roles in globa. clima.e ma.ntena.ce a.d h.ve diverse a.plica.ions in biotech.ology a.d eco-engineering,wh.ch.a.e directly linked to th.ir multicellula.ity ***,th.ir genomic diversity a.d th. evolutiona.y mech.nisms underlying multicellula.ity in th.se orga.isms rema.n *** th.s study,we sequenced 110 ma.roa.ga. genomes from diverse clima.es a.d ph.la.a.d identified key genomic fea.ures th.t distinguish.th.m from th.ir microa.ga. *** for cell a.h.sion,extra.ellula. ma.rix forma.ion,cell pola.ity,tra.sport,a.d cell differentia.ion distinguish.ma.roa.ga. from microa.ga. a.ross a.l th.ee ma.or ph.la.constituting conserved a.d unique gene sets supporting multicellula. *** genes sh.w ph.lum-a.d clima.e-specific expa.sions th.t ma. fa.ilita.e nich. ***,our study revea.s genetic determina.ts of convergent a.d divergent evolutiona.y tra.ectories th.t h.ve sh.ped morph.logica. diversity in ma.roa.ga. a.d provides genome-wide fra.eworks to understa.d ph.tosynth.tic multicellula. evolution in a.ua.ic environments.

关键词： ma.roa.ga. multicellula.ity compa.a.ive genomics evolution a.h.some endogenous vira. elements

Nuclea.ion a.d Growth.Mech.nisms for Pd-Pt Bimeta.lic Na.odendrites a.d Th.ir Electroca.a.ytic Properties

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Na.o Resea.ch 2010年第2期3卷 69-80页

作者： Byungkwon Lim Ma.iong Jia.g Ta.kyung Yu Pedro h.C.camargo Youna. Xia Depa.tment of Biomedica. Engineering Washington UniversitySt.LouisMissouri 63130USA Depa.tment of Ch.mistry Washington UniversitySt.LouisMissouri 63130USA

In a.seed-media.ed synth.sis, na.ocrysta. growth.is often described by a.suming th. a.sence of h.mogeneous nuclea.ion in th. solution. h.re we provide new insigh.s into th. nuclea.ion a.d growth.mech.nisms underlying th. forma.ion of bimeta.lic na.odendrites th.t a.e ch.ra.terized by a.dense a.ra. of Pt bra.ch.s a.ch.red to a.Pd na.ocrysta. core. Th.se na.ostructures ca. be ea.ily prepa.ed by a.one-step, seeded growth.meth.d th.t involves th. reduction of K2PtCl4 by L-a.corbic a.id in th. presence of 9-nm trunca.ed octa.0}dra. Pd seeds in a. a.ueous solution. Tra.smission electron microscopy (TEM) a.d h.gh.resolution TEM a.a.yses revea.ed th.t both.h.mogeneous a.d h.terogeneous nuclea.ion of Pt occurred a. th. very ea.ly sta.es of th. synth.sis a.d th. Pt bra.ch.s grew th.ough.oriented a.ta.h.ent of sma.l Pt pa.ticles th.t h.d been formed via.h.mogeneous nuclea.ion. Th.se new findings contra.ict th. genera.ly a.cepted mech.nism for seeded growth.th.t only involves h.terogeneous nuclea.ion a.d simple growth.via.a.omic a.dition. We h.ve a.so investiga.ed th. electroca.a.ytic properties of th. Pd-Pt na.odendrites for th. oxygen reduction a.d formic a.id oxida.ion rea.tions by conducting a.compa.a.ive study with.foa.-like Pt na.ostructures prepa.ed in th. a.sence of Pd seeds under oth.rwise identica. conditions.

关键词： Pa.la.ium pla.inum seeded growth oxygen reduction formic a.id oxida.ion

Incorpora.ion of Ca.bopla.in in Microporous Gra.ula. Ca.cium Ph.sph.te Biph.sic Ma.rix

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Journa. of Biosciences a.d Medicines 2014年第2期2卷 30-35页

作者： Cleoma. Copa.ti N. h. a. camargo E. Gemelli Ch.mistry Depa.tment Santa Catarina University Joinville Brazil Mech.nica. Engineering Depa.tment Santa Catarina University Joinville Brazil

Th. h./β-TCP biph.sic biocera.ics sta.d out on resea.ch.s in different a.ea. of biomedica. a.plica.ions. Th.se biocera.ics with.microporous microstructures a.so sta.d out in biomedica. a.plica.ions on controlled drug relea.e. Th.s study a.med a. th. synth.sis of th. biph.sic h./β-TCP powder, a.d a. th. ela.ora.ion a.d ch.ra.teriza.ion of th. microporous biph.sic h./β-TCP gra.ula. bioma.eria.. Th. microporous gra.ula. ma.eria. wa. ela.ora.ed th.ough.th. process of cera.ic powder sieving (200 μm h.sizes). Th. gra.ula. ma.eria. wa. sintered a. 1100°C/2 h. providing th. microporous biph.sic gra.ula. bioma.eria.. Th. drug loa.ing in th. bioma.eria. wa. performed th.ough.th. h.gh.va.uum meth.d. Th. results h.re presented a.e rela.ed to th. synth.sis meth.d a.d ela.ora.ion of th. biph.sic bioma.eria.. Th. results obta.ned from th. drug loa.ing th.ough.th. h.gh.va.uum meth.d conducted th. incorpora.ion of th. drug onto th. surfa.e a.d into th. microporous gra.ula. bioma.eria..

关键词： Ela.ora.ion Biph.sic Bioma.eria. Microporosity Drug

Effect of Wa.elength.on Metrologica. Ch.ra.teristics of Non-h.logra.h.c Fiber Specklegra. Sensor

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Ph.tonic Sensors 2015年第1期5卷 1-5页

作者： Victor h. a.ISTIZa.a. a.eja.dro h.YOS Edga. RUEDa.nelson D. GOMEZ Jorge a. GOMEZ Grupo de Sistema. en Opera.iones y Desa.rollo a.lica.o -SODa. Universidad Cooperativa de Colombia Cll 50A#41-40 Medellin Colombia Grupo de Fisica.Ba.ica.y a.lica.a Politecnico Colombiano Jaime Isaza Cadavid Cra 48 #7-151 Medellin Colombia Grupo de Optica.y Fotonica Instituto de Fisica Universidad de Antioquia Cll 70No. 52-21 Medellin Colombia Grupo de lnvestiga.ion en a.toma.ica Electronica y Ciencias Computacionales-AE&CC- Instituto Tecnologico Metropolitano - lnstitucion Universitaria Cll 54A #30-01 Medellin Colombia

In th.s pa.er, we report some results a.out th. effects of va.ying th. wa.elength.in a.structure of a.non-h.logra.h.c fiber specklegra. sensor. In th.se a.ra.gements, th. speckle pa.tern produced by a.multi-mode optica. fiber is coupled to th. a.ingle-mode optica. fiber with.lower numerica. a.erture, wh.ch.produces a.filtering effect th.t ca. be used a. a. optica. tra.sduction mech.nism. Th. influence of th. wa.elength.on th. sensor performa.ce is eva.ua.ed by ch.nging th. la.er wa.elength. a.d a.strong effect on th. linea.ity a.d reproducibility of its response is found. La.ers emitting a. 1310nm, 1550nm, a.d 1625nm a.e used.

关键词： Optica. sensing speckle sensor optica. fiber sensor mech.nica. perturba.ion sensor

New Insigh.s into th. Growth.Mech.nism a.d Surfa.e Structure of Pa.la.ium Na.ocrysta.s

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Na.o Resea.ch 2010年第3期3卷 180-188页

作者： Byungkwon Lim h.roka.u Koba.a.h. Pedro h.G.camargo La.rence F.a.la.d Jingyue Liu Youna. Xia Depa.tment of Biomedica. Engineering Washington UniversitySt.LouisMissouri 63130USA Ma.eria.s Science a.d Tech.ology Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA Center for Na.oscience a.d Depa.tment of Ch.mistry a.d Bioch.mistry University of Missouri-St.LouisSt.LouisMissouri 63121USA

Th.s pa.er presents a.systema.ic study of th. growth.mech.nism for Pd na.oba.s synth.sized by reducing Na.(2)PdCl_(4) with.L-a.corbic a.id in a. a.ueous solution in th. presence of bromide ions a. a.ca.ping *** electron microscopy(TEM)a.d h.gh.resolution TEM a.a.yses revea.ed th.t th. growth.a. ea.ly sta.es of th. synth.sis wa. domina.ed by pa.ticle coa.escence,followed by sh.pe focusing via.recrysta.liza.ion a.d furth.r growth.via.a.omic *** a.so investiga.ed th. deta.led surfa.e structure of th. na.oba.s using a.erra.ion-corrected sca.ning TEM a.d found th.t th. exposed{100}surfa.es conta.ned severa. types of defects such.a. a. a.a.om isla.d,a.va.a.cy pit,a.d a.omic *** th.rma. a.nea.ing,th. na.oba.s evolved into a.more th.rmodyna.ica.ly fa.ored sh.pe with.enh.nced trunca.ion a. th. corners.

关键词： Pa.la.ium na.ocrysta.s growth coa.escence surfa.e evolution

Stra.egy for relia.le identifica.ion of isch.emic stroke, th.ombolytics a.d th.ombectomy in la.ge a.ministra.ive da.a.a.es

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Stroke & Va.cula. Neurology 2021年第2期6卷 194-200页

作者： Kori S Za.h.ison Sijia.Li Ma.h.w J Reeves Opeolu a.eoye Ca.los a.camargo Lee h.Sch.a.m Renee Y h.ia Depa.tment of Emergency Medicine Massachusetts General HospitalBostonMassachusettsUSA Depa.tment of Emergency Medicine Harvard Medical SchoolBostonMassachusettsUSA Depa.tment of Epidemiology a.d Biosta.istics Michigan State UniversityEast LansingMichiganUSA University of Cincinna.i CincinnatiOhioUSA Ma.sa.h.setts Genera. h.spita. BostonMassachusettsUSA Depa.tment of Emergency Medicine University of California San FranciscoSan FranciscoCaliforniaUSA

Ba.kground a.ministra.ive da.a.a.e frequently used in stroke *** a.cura.e identifica.ion of pa.ients wh. h.d a. isch.emic stroke,a.d th.se receiving th.ombolysis a.d endova.cula. th.ombectomy(EVT)is critica. to ensure representa.iveness a.d *** exa.ined differences in pa.ient sa.ples ba.ed on mode of identifica.ion,a.d propose a.stra.egy for future pa.ient a.d procedure identifica.ion in la.ge a.ministra.ive *** We used non-public a.ministra.ive da.a.from th. sta.e of Ca.ifornia.to identify a.l pa.ients wh. h.d a. isch.emic stroke disch.rged from a. emergency depa.tment(ED)or inpa.ient h.spita.isa.ion from 2010 to 2017 ba.ed on Interna.iona. Cla.sifica.ion of Disea.e(ICD-9)(2010-2015),ICD-10(2015-2017)a.d Medica.e Severity-Dia.nosis-rela.ed Group(MS-DRG)disch.rge *** identified pa.ients with.interh.spita. tra.sfers,pa.ients receiving th.ombolytics a.d pa.ients trea.ed with.EVT ba.ed on ICD,Current Procedura. Terminology(CPT)a.d MS-DRG *** determined wh.t proportion of th.se tra.sfers a.d procedures would h.ve been identified with.ICD versus MS-DRG disch.rge *** Of 365099 isch.emic stroke encounters,most(87.70%)h.d both.a.stroke-rela.ed ICD-9 or ICD-10 code a.d stroke-rela.ed MS-DRG code;12.28% h.d only a. ICD-9 or ICD-10 code a.d 0.02% h.d only a. MS-DRG *** a.l tra.sfers(99.99%)were identified using ICD *** identified 32433 th.ombolytic-trea.ed pa.ients(8.9% of tota.)using ICD,CPT a.d MS-DRG codes;th. combina.ion of ICD a.d CPT codes identified nea.ly a.l(98%).We identified 7691 pa.ients trea.ed with.EVT(2.1%of tota.)using ICD a.d MS-DRG codes;both.MS-DRG a.d ICD-9/ICD-10 codes were necessa.y beca.se ICD codes a.one missed 13.2%of *** codes only perta.n to outpa.ient/ED pa.ients a.d a.e not useful for EVT *** ICD-9/ICD-10 dia.nosis codes ca.ture nea.ly a.l isch.emic stroke encounters a.d tra.sfers,wh.le th. combina.ion of ICD-9/ICD-10 a.d CPT codes a.e a.equa.e

关键词： th.ombolytic dia.nosis a.ministra.ive