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Neural Regeneration Research 2023年第1期18卷 119-120页

作者： Sara Kelley nelson perez-urrutia Rodrigo Morales Department of Neurology University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Potential causes for the clinical and pathological variability observed in Alzheimer’s disease(AD):AD is an age-related neurodegenerative disorder characterized by the impairment of cognitive functions such as memory,learning,and *** commonly described clinical symptoms are due to particular pathological changes in the brain,including inflammation,synaptic loss,and neuronal *** changes are a consequence of the accumulation of abnormally folded amyloid-β(Aβ)and tau proteins in specific areas of the central nervous *** the progressive aging of the world’s population,the number of people affected by AD is expected to substantially and consistently increase in the coming *** positions AD as one of the main public health challenges in the near future.

关键词： clinical Alzheimer amyloid

Decoding complexity: the need to enhance precision and streamline spatial understanding in neuroscience

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Neural Regeneration Research 2025年第3期20卷 801-802页

作者： Sameehan Mahajani Armita Salahi Brenda Gonzalez Charlotte nelson Frank Hsiung Biology&Applications Division NodexusSan JoseCAUSA

Neuroscience is the ultimate frontier in our quest for a comprehensive understanding of human behavior. Since its launch in 2009, the Human Connectome Project has emerged as a pioneering force, making heroic strides i... 详细信息

关键词： behavior frontier dating

Characterization of spatial relationships between three remotely sensed indirect indicators of biodiversity and climate:a 21years’data series review across the Canadian boreal forest

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International Journal of Digital Earth 2016年第7期9卷 676-696页

作者： Liliana perez Trisalyn nelson Nicholas C.Coops Fabio Fontana C.Ronnie Drever Laboratory of Environmental Geosimulation(LEDGE) Department of GeographyUniversity of MontrealMontrealQCCanada Spatial Pattern Analysis&Research(SPAR)Lab Department of GeographyUniversity of VictoriaVictoriaBCCanada Department of Forest Resources Management University of British ColumbiaVancouverBCCanada The Nature Conservancy OttawaONCanada

Climate drives ecosystem processes and impacts *** patterns over large areas,such as Canada’s boreal,can be monitored using indirect indicators derived from remotely sensed *** this paper,we characterized the historical space–time relationships between climate and a suite of indirect indicators of biodiversity,known as the Dynamic Habitat Index(DHI)to identify where climate variability is co-occurring with changes in biodiversity *** represented biodiversity using three indirect indicators generated from 1987 to 2007 National Oceanic and Atmospheric Administration Advanced Very High Resolution Radiometer *** quantifying and clustering temporal variability in climate data,we defined eight homogeneous climate variability zones,where we then analyzed the *** identified unique areas of change in climate,such as the Hudson Plains,that explain significant variations in *** variability in temperatures and growing season index had a strong influence on observed vegetation productivity and seasonality changes throughout Canada’s *** in precipitation,for most of the area,was not associated with DHI *** methodology presented here enables assessment of spatial–temporal relationships between biodiversity and climate variability and characterizes distinctive zones of variation that may be used for prioritization and planning to ensure long-term biodiversity conservation in Canada.

关键词： Climate change biodiversity boreal forest spatial–temporal analysis fPAR DHI

Biosphere 2’s Lessons about Living on Earth and in Space

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Space(Science & Technology) 2021年第1期2021卷 274-284页

作者： Mark nelson Institute of Ecotechnics(US/UK) USA

Biosphere 2,the largest and most biodiverse closed ecological system facility yet created,has contributed vital lessons for living with our planetary biosphere and for long-term habitation in *** the space life support perspective,Biosphere 2 contrasted with previous BLSS work by including areas based on Earth wilderness biomes in addition to its provision for human life support and by using a soil-based intensive agricultural system producing a complete human *** previous BLSS system had included domestic farm *** human and domestic animal wastes were also recycled and returned to the crop *** 2 was important as a first step towards learning how to miniaturize natural ecosystems and develop technological support systems compatible with *** 2’s mostly successful operation for three years(1991-1994)changed thinking among space life support scientists and the public at large about the need for minibiospheres for long-term habitation in *** an Earth systems laboratory,Biosphere 2 was one of the first attempts to make ecology an experimental science at a scale relevant to planetary issues such as climate change,regenerative agriculture,nutrient and water recycling,loss of biodiversity,and understanding of the roles wilderness biomes play in the Earth’s *** 2 aroused controversy because of narrow definitions and expectations of how science is to be *** cooperation between engineers and ecologists and the requirement to design a technosphere that supported the life inside without harming it have enormous relevance to what is required in our global *** of bioregenerative life support systems for near-term space applications such as initial Moon and/or Mars bases,will be severely limited by high costs of transport to space and so will rely on lighter weight,hydroponic systems of growing plants which will focus first on water and air regeneration and gradually increase its production of fo

关键词： Earth Biosphere bases

Impact of gender and race on expectations and outcomes in total knee arthroplasty

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World Journal of Orthopedics 2020年第5期11卷 265-277页

作者： Brian A perez James Slover Emmanuel Edusei Annamarie Horan Afshin Anoushiravani Atul F Kamath Charles L nelson Department of Orthopedics University of PennsylvaniaPhiladelphiaPA 19104United States Department of Orthopedic Surgery New York University Langone HealthNew YorkNY 10016United States Department of Orthopaedic Surgery Cleveland ClinicClevelandOH 44195United States

BACKGROUND Total joint arthroplasty is one of the most common surgeries performed in the United States with total knee arthroplasty(TKA)being one of the most successful surgeries for restoring function and diminishing *** with the demonstrated success of TKA and a higher prevalence of arthritis and arthritis related disability among minorities,racial and gender disparity remains a constant issue in providing care for the adult reconstruction *** To assess the role of demographics and expectations on differences in perioperative patient reported outcomes(PRO)following *** One hundred and thirty-three patients scheduled for primary unilateral TKA secondary to moderate to severe osteoarthritis were enrolled in this twoinstitution prospective *** PRO questionnaires were collected at four time *** analysis was conducted to determine the impact of gender,ethnic background and expectation surveys responses to assess PRO at these time *** Females were associated with worse preoperative Knee Injury and Osteoarthritis Outcome Scores(KOOS)for symptoms,pain,and activities of daily *** Americans were associated with worse KOOS for pain,activities of daily living,and quality of *** worse preoperative scores,no difference was noted in these categories between the groups ***,all pre-operative psychometric scales were equivalent across groups except Geriatric Depression scale,which was significantly different between groups within the Race and Age Group(P<0.05).Conversely,Pain Catastrophizing Scale,was significantly different for all subscales and total score within Age Group(P<0.05),and the Magnification,Helplessness subscales as well as the Total score were significantly different between groups for Race and Relationship Status(P<0.01).CONCLUSION We conclude that female and African American patients have lower preoperative KOOS scores compared to white male *** postoper

关键词： Knee Joints Arthroplasty Osteoarthritis Race Gender Postoperative Outcomes

Evolutionary implications of deception in mimicry and masquerade

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Current Zoology 2014年第1期60卷 6-15页

作者： Ximena J. nelson School of Biological Sciences University of Canterbury Private Bag 4800 Christchurch New Zealand

Aggressive mimicry occurs when an organism resembles some aspect of another organism （the model） in order to obtain prey through its deceptive resemblance. This may function either through the overt response of the receiver or through the lack of response of the receiver. Reviewing selected examples, I discuss some of the difficulties in ascribing a model for the mimic. I also discuss how a single animal can have multiple ploys in its armoury of deceptive signals, thus belonging within two or more categories of deceptive signalling. In addition to aggressive mimicry, these may include crypsis or camouflage, mas- querade （mimicry of inanimate objects）, and Batesian or protective mimicry. Each of these examples of deception has multiple evolutionary pathways, and some deceptive signals may be more costly to receivers than others, but no single organism is subject to a single selection pressure, leading to the reality that many evolutionary pathways contribute to the diversity we see around us. New technologies are opening new channels of investigation into deceptive signaling in many different sensory modalities, and this is reflected in the recent increase in studies investigating the structure and function of deceptive signals. In turn, these studies are beginning to expose the fascinating complexity of deceptive signaling systems, allowing us to discover the myriad, non-mutually exclusive, solutions that can be selected for to obtain prey

关键词： Mimicry Masquerade Crypsis Deceptive communication Cleaner fish Pre-existing biases

Geographic information technology usage in developing countries – A case study in Mozambique

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Geo-Spatial Information Science 2018年第4期21卷 331-345页

作者： nelson Amade Marco Painho Tiago Oliveira Universidade Catolica de Mocambique BeiraMozambique Nova Information Management School Universidade Nova de LisboaLisboaPortugal

Geographic information technologies(GIT)have matured,have become pervasive throughout many types of organizations over recent decades and gained a wide range of attention in diverse sectors of *** goal of this paper is to identify the main drivers and uses of GIT in organizations and to give an overview of GIT uses in developing countries with a focus on a case study developed for Mozambique by analyzing the results of a survey of 123 Mozambican organizations that are current GIT *** results show that the main drivers behind are compatibility,complexity,competitive pressure,donor pressure,government policy,intention to adopt,innovation,relative advantage,security,and technology *** of the public and private sectors use GIT for customer/resource/risk management,decision support,education,research,monitoring,prediction,simulation,suitability analysis,sustainability,use and access.

关键词： Geographic information technologies organizations remote sensing GPS geographic information systems Mozambique

Perspectives on the clinical management ocalized prostate cancer

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Asian Journal of Andrology 2014年第4期16卷 511-514页

作者： Joel B nelson Department of Urology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA.

Defined broadly, prostate cancer has two states： An indolent histologicalmanifestation of a locally proliferative and invasive process or a clinically relevant, potentially lethal disease. Likewise, the management of clinically localized prostate cancer must address two questions： what sort of disease is this and what needs to be done.

关键词： @@

Refining spatial neighbourhoods to capture terrain effects

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Ecological Processes 2012年第1期1卷 98-108页

作者： Trisalyn A nelson Colin Robertson Spatial Pattern Analysis and Research Lab Department of GeographyUniversity of VictoriaPO Box 3060VictoriaBritish ColumbiaV8W 3R4SCanada Department of Geography and Environmental Studies Wilfrid Laurier UniversityWaterlooOntarioN2L 3C5Canada

Introduction:Spatially explicit ecological research has increased substantially in the past 20 *** spatial approaches require the definition of a spatial neighbourhood or the region over which spatial relationships are modelled or *** neighbourhood definitions impact analysis results,and there are benefits in considering neighbourhood definitions that better capture ecological *** goal of this research is to present a simple and flexible approach in constraining ecological spatial neighbourhoods using terrain ***:Using watershed boundaries,we can restrict spatial neighbourhoods from combining populations or processes that should be separated by terrain *** demonstrate the need for ecological constraints by way of a simulation study and highlight our approach with a case study examining mountain pine beetle(Dendroctonus ponderosae,Coleoptera;Hopkins)infestation hot ***:Our results demonstrate how failure to constrain neighbourhoods can lead to errors when the spatial signals from unrelated populations are ***,unconstrained spatial neighbourhoods can unintentionally detect spatial relationships across many ***:There will be benefits to studies that develop new,ecology-based approaches in defining spatial neighbourhoods that better illuminate ecological function of phenomena under study.

关键词： spatial weights spatial analysis spatial ecology hot spots topography

Experimental and numerical evaluation of multidirectional compressive and flexure behavior of three-dimensional printed concrete

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Frontiers of Structural and Civil Engineering 2023年第11期17卷 1643-1661页

作者： Lalit KUMAR Dhrutiman DEY Biranchi PANDA nelson MUTHU Department of Mechanical Engineering Indian Institute of Technology GuwahatiAssam 781039India

Three-dimensional concrete printing(3DCP)can proliferate the industrialization of the construction sector,which is notoriously conservative and indolent toward ***,the mechanical behavior of 3DCP should be characterized and modeled considering the interfaces when its performance is thoroughly compared to that of the existing concrete construction *** study presents an experimental and numerical investigation of uniaxial compression and three-point bending(TPB)tests on extruded 3DCP beams in different loading *** orientation of translational and depositional interfaces with respect to the direction of loading influenced the *** the elastic and post-damage behavior of the 3DCP specimens were compared with those of the conventionally cast specimen under quasi-static loading *** the higher compressive strength of the casted specimen,the flexural strength of the 3DCP specimens was *** study employed the finite element and cohesive zone models of the appropriate calibrated traction-separation law to model fracture in the notched TPB ***,the real-time acoustic emission test revealed the nature of failure phenomenon of three-dimensional-printed specimens under flexion,and accordingly,the cohesive law was *** predicted load-displacement responses are in good agreement with the experimental ***,the effects of cohesive thickness and notch shape on the performance under bending were explored through parametric studies.

关键词： three-dimensional printing anisotropy flexure compression cohesive zone model finite element model