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Is triglyceride to high-density lipoprotein cholesterol ratio a surrogates for insulin resistance in youth?

Health 2013年第3期5卷 481-485页

作者： Antonio C.oliveira Ana M.oliveira nelson oliveira Atila oliveira Marcele Almeida Lorena M.Veneza Ana Luisa oliveira Luis Adan Ana M.Ladeia Bahian School of Medicine and Public Health Science Development Foundation of BahiaSalvadorBrazil Department of Health State University of Feira de SantanaFeira de SantanaBrazil Science and Technology Faculty SalvadorBrazil Pontifical Catholic University CampinasBrazil Department of Pediatrics Federal University of Bahia School of MedicineSalvadorBrazil

As elevated triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio has been described as predictor for cardio metabolic disease with insulin resistance (IR) in the background, the aim was to assess the relationship between this ratio and IR in youth. Oral glucose tolerance test was performed in 318 Brazilian students (175 girls, 11.2 ± 3.2 years, BMI_z-score 1.2 ± 1.4 SD). Measurements: BMI, waist circumference (WC), blood pressure (BP), lipids, insulin and high sensitivity Creactive protein (hsCRP). Excessive weight and abdominal obesity were defined using BMI_z-score and WC and IR by Homeostasis model assessment-insulin resistance (HOMA-IR). TG/HDL-C median was 2.37. There was an association between TG/ HDL-C and WC, systolic and diastolic BP, insulin, HOMA-IR, hsCRP, (p < 0.001). Stratified TG/HDL-C into two groups, based on a cut off point of 2.73 (Group 1: <2.73 and Group 2: ≥2.73). Ad- justing for age, gender, ethnicity TG/HDL-C was an independent variable predicting IR (PR = 1.44;CI: 1.07 - 1.96;p = 0.018). For every 1 (cm) in WC increased there was an addition of 0.04 of the value of TG/HDL-C and in those with TG/HDL-C ≥ 2.73 for every 10 (cm) increase in WC there was an improve of 4% in the ratio. In conclusion: In youth, the TG/HDL-C ratio could be a useful index for identifying groups with IR.

关键词： Insulin Resistance TG/HDL-C Ratio Childhood Obesity Metabolic Disease

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Decoding complexity: the need to enhance precision and streamline spatial understanding in neuroscience

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Neural Regeneration Research 2025年第3期20卷 801-802页

作者： Sameehan Mahajani Armita Salahi Brenda Gonzalez Charlotte nelson Frank Hsiung Biology&Applications Division NodexusSan JoseCAUSA

Neuroscience is the ultimate frontier in our quest for a comprehensive understanding of human behavior. Since its launch in 2009, the Human Connectome Project has emerged as a pioneering force, making heroic strides i... 详细信息

关键词： behavior frontier dating

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Geographic information technology usage in developing countries – A case study in Mozambique

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Geo-Spatial Information Science 2018年第4期21卷 331-345页

作者： nelson Amade Marco Painho Tiago oliveira Universidade Catolica de Mocambique BeiraMozambique Nova Information Management School Universidade Nova de LisboaLisboaPortugal

Geographic information technologies(GIT)have matured,have become pervasive throughout many types of organizations over recent decades and gained a wide range of attention in diverse sectors of *** goal of this paper is to identify the main drivers and uses of GIT in organizations and to give an overview of GIT uses in developing countries with a focus on a case study developed for Mozambique by analyzing the results of a survey of 123 Mozambican organizations that are current GIT *** results show that the main drivers behind are compatibility,complexity,competitive pressure,donor pressure,government policy,intention to adopt,innovation,relative advantage,security,and technology *** of the public and private sectors use GIT for customer/resource/risk management,decision support,education,research,monitoring,prediction,simulation,suitability analysis,sustainability,use and access.

关键词： Geographic information technologies organizations remote sensing GPS geographic information systems Mozambique

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AtDREB2A-CA Influences Root Architecture and Increases Drought Tolerance in Transgenic Cotton

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Agricultural Sciences 2017年第10期8卷 1195-1225页

作者： Maria Eugenia Lisei-de-Sa Fabricio B.M.Arraes Giovani G.Brito Magda A.Beneventi Isabela T.Lourenco-Tessutti Angelina M.M.Basso Regina M.S.Amorim Maria C.M.Silva Muhammad Faheem nelson G.oliveira Junya Mizoi Kazuko Yamaguchi-Shinozaki Maria Fatima Grossi-de-Sa Embrapa Recursos Genéticos e Biotecnologia BrasíliaBrazil Empresa de Pesquisa Agropecuária de Minas Gerais UberabaBrazil Universidade Federal do Rio Grande do Sul Porto AlegreBrazil Embrapa Clima Temperado PelotasBrazil Universidade de Brasília BrasíliaBrazil Embrapa Agroenergia BrasíliaBrazil Japan International Research Center for Agricultural Sciences(JIRCAS) TsukubaJapan Universidade Catolica de Brasilia BrasiliaBrazil

Drought is a major environmental factor limiting cotton (Gossypium hirsutum L.) productivity worldwide and projected climate changes could increase their negative effects in the future. Thus, targeting the molecular mechanisms correlated with drought tolerance without reducing productivity is a challenge for plant breeding. In this way, we evaluated the effects of water deficit progress on AtDREB2A-CA transgenic cotton plant responses, driven by the stress-inducible rd29 promoter. Besides shoot and root morphometric traits, gas exchange and osmotic adjustment analyses were also included. Here, we present how altered root traits shown by transgenic plants impacted on physiological acclimation responses when submitted to severe water stress. The integration of AtDREB2A-CA into the cotton genome increased total root volume, surface area and total root length, without negatively affecting shoot morphometric growth parameters and nor phenotypic evaluated traits. Additionally, when compared to wild-type plants, transgenic plants (17-T0 plants and its progeny) highlighted a gradual pattern of phenotypic plasticity tosome photosynthetic parameters such as photosynthetic rate and stomatal conductance with water deficit progress. Transgene also promoted greater shoot development and root robustness (greater and deeper root mass) allowing roots to grow into deeper soil layers. The same morpho-physiological trend was observed in the subsequent generation (17.6-T2). Our results suggest that the altered root traits shown by transgenic plants are the major contributors to higher tolerance response, allowing the AtDRE2A-CA-cotton plants to maintain elevated stomatal conductance and assimilate rates and, consequently, reducing their metabolic costs involved in the antioxidant responses activation. These results also suggest that these morpho-physiological changes increased the number of reproductive structures retained per plant (26% higher) when compared with its non-transgenic cou

关键词： Dehydration Responsive Element Binding Factors Water Deficit Tolerance Gossypium hirsutum Physiological Phenotyping Transcription Factor Stress-Inducible Promoter

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Biosphere 2’s Lessons about Living on Earth and in Space

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Space(Science & Technology) 2021年第1期2021卷 274-284页

作者： Mark nelson Institute of Ecotechnics(US/UK) USA

Biosphere 2,the largest and most biodiverse closed ecological system facility yet created,has contributed vital lessons for living with our planetary biosphere and for long-term habitation in *** the space life support perspective,Biosphere 2 contrasted with previous BLSS work by including areas based on Earth wilderness biomes in addition to its provision for human life support and by using a soil-based intensive agricultural system producing a complete human *** previous BLSS system had included domestic farm *** human and domestic animal wastes were also recycled and returned to the crop *** 2 was important as a first step towards learning how to miniaturize natural ecosystems and develop technological support systems compatible with *** 2’s mostly successful operation for three years(1991-1994)changed thinking among space life support scientists and the public at large about the need for minibiospheres for long-term habitation in *** an Earth systems laboratory,Biosphere 2 was one of the first attempts to make ecology an experimental science at a scale relevant to planetary issues such as climate change,regenerative agriculture,nutrient and water recycling,loss of biodiversity,and understanding of the roles wilderness biomes play in the Earth’s *** 2 aroused controversy because of narrow definitions and expectations of how science is to be *** cooperation between engineers and ecologists and the requirement to design a technosphere that supported the life inside without harming it have enormous relevance to what is required in our global *** of bioregenerative life support systems for near-term space applications such as initial Moon and/or Mars bases,will be severely limited by high costs of transport to space and so will rely on lighter weight,hydroponic systems of growing plants which will focus first on water and air regeneration and gradually increase its production of fo

关键词： Earth Biosphere bases

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Perspectives on the clinical management ocalized prostate cancer

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Asian Journal of Andrology 2014年第4期16卷 511-514页

作者： Joel B nelson Department of Urology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA.

Defined broadly, prostate cancer has two states： An indolent histologicalmanifestation of a locally proliferative and invasive process or a clinically relevant, potentially lethal disease. Likewise, the management of clinically localized prostate cancer must address two questions： what sort of disease is this and what needs to be done.

关键词： @@

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Refining spatial neighbourhoods to capture terrain effects

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Ecological Processes 2012年第1期1卷 98-108页

作者： Trisalyn A nelson Colin Robertson Spatial Pattern Analysis and Research Lab Department of GeographyUniversity of VictoriaPO Box 3060VictoriaBritish ColumbiaV8W 3R4SCanada Department of Geography and Environmental Studies Wilfrid Laurier UniversityWaterlooOntarioN2L 3C5Canada

Introduction:Spatially explicit ecological research has increased substantially in the past 20 *** spatial approaches require the definition of a spatial neighbourhood or the region over which spatial relationships are modelled or *** neighbourhood definitions impact analysis results,and there are benefits in considering neighbourhood definitions that better capture ecological *** goal of this research is to present a simple and flexible approach in constraining ecological spatial neighbourhoods using terrain ***:Using watershed boundaries,we can restrict spatial neighbourhoods from combining populations or processes that should be separated by terrain *** demonstrate the need for ecological constraints by way of a simulation study and highlight our approach with a case study examining mountain pine beetle(Dendroctonus ponderosae,Coleoptera;Hopkins)infestation hot ***:Our results demonstrate how failure to constrain neighbourhoods can lead to errors when the spatial signals from unrelated populations are ***,unconstrained spatial neighbourhoods can unintentionally detect spatial relationships across many ***:There will be benefits to studies that develop new,ecology-based approaches in defining spatial neighbourhoods that better illuminate ecological function of phenomena under study.

关键词： spatial weights spatial analysis spatial ecology hot spots topography

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On the Coherent States and the Squeezed States

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Chinese Physics Letters 1995年第6期12卷 321-323页

作者： YU Zurong C.A.nelson Department of Physics Nanjing UniversityNanjing 210008 Department of Physics Tongji UniversityShanghai 200092 State University of New York at Binghamton BinghamtonNY 139026000

In this paper the coherent and the squeezed state of the bose field is written as a universal form by means of a projector which transforms the old vacuum state to the new vacuum *** transformed vacuum state is the co... 详细信息

关键词： state. vacuum coherent

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Experimental and numerical evaluation of multidirectional compressive and flexure behavior of three-dimensional printed concrete

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Frontiers of Structural and Civil Engineering 2023年第11期17卷 1643-1661页

作者： Lalit KUMAR Dhrutiman DEY Biranchi PANDA nelson MUTHU Department of Mechanical Engineering Indian Institute of Technology GuwahatiAssam 781039India

Three-dimensional concrete printing(3DCP)can proliferate the industrialization of the construction sector,which is notoriously conservative and indolent toward ***,the mechanical behavior of 3DCP should be characterized and modeled considering the interfaces when its performance is thoroughly compared to that of the existing concrete construction *** study presents an experimental and numerical investigation of uniaxial compression and three-point bending(TPB)tests on extruded 3DCP beams in different loading *** orientation of translational and depositional interfaces with respect to the direction of loading influenced the *** the elastic and post-damage behavior of the 3DCP specimens were compared with those of the conventionally cast specimen under quasi-static loading *** the higher compressive strength of the casted specimen,the flexural strength of the 3DCP specimens was *** study employed the finite element and cohesive zone models of the appropriate calibrated traction-separation law to model fracture in the notched TPB ***,the real-time acoustic emission test revealed the nature of failure phenomenon of three-dimensional-printed specimens under flexion,and accordingly,the cohesive law was *** predicted load-displacement responses are in good agreement with the experimental ***,the effects of cohesive thickness and notch shape on the performance under bending were explored through parametric studies.

关键词： three-dimensional printing anisotropy flexure compression cohesive zone model finite element model

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Carboxylesterases in lipid metabolism： From mouse to human

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Protein & Cell 2018年第2期9卷 178-195页

作者： Jihong Lian Randal nelson Richard Lehner Group on Molecular and Cell Biology of Lipids University of Alberta Edmonton Alberta Canada Department of Pediatrics University of Alberta Edmonton Alberta Canada Department of Cell Biology University of Alberta Edmonton Alberta Canada

Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of car- boxylesterases in lipid metabolism and energy home- ostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro through （over）expression, knockdown of expression, and chemical inhibition in a variety of cells. Recent research advances have revealed the relevance of carboxylesterases to metabolic diseases such as obesity and fatty liver disease, suggesting these enzymes might be potential targets for treatment of metabolic disorders. In order to translate pre-clinical studies in cellular and mouse models to humans, dif- ferences and similarities of carboxylesterases between mice and human need to be elucidated. This review presents and discusses the research progress in structure and function of mouse and human car- boxylesterases, and the role of these enzymes in lipid metabolism and metabolic disorders.

关键词： carboxylesterase lipase lipid lipoprotein iver adipose intestine

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