检索结果-南通市图书馆

物流管理对肯尼亚肯尼亚医疗用品管理局（KEMSA）的影响

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

物流管理对肯尼亚肯尼亚医疗用品管理局（KEMSA）的影响

作者： nelly WANGUI NJOROGE 北京交通大学

学位级别：硕士

本研究的旨在分析物流管理对肯尼亚肯尼亚医疗用品管理局（KEMSA）绩效的影响。该研究旨在实现以下具体目标:回顾和研究运输管理和订单管理如何影响肯尼亚肯尼亚医疗用品管理局的绩效,回顾和分析肯尼亚医疗用品管理局的仓储管理,调查库... 详细信息

本研究的旨在分析物流管理对肯尼亚肯尼亚医疗用品管理局（KEMSA）绩效的影响。该研究旨在实现以下具体目标:回顾和研究运输管理和订单管理如何影响肯尼亚肯尼亚医疗用品管理局的绩效,回顾和分析肯尼亚医疗用品管理局的仓储管理,调查库存管理如何影响肯尼亚医疗用品管理局的业绩第二章文献将从工作论文,期刊,书籍,报告,期刊和互联网资源等角度,回顾和批判性讨论以往的研究理论,同时指出研究差距。第三章将解释采用是研究方法。本研究旨在确定物流管理对肯尼亚肯尼亚医疗用品管理局（KEMSA）业绩的影响,涉及数据收集、测量和分析,本章讨论用于数据收集,处理和分析的程序和技术。第四章将呈现研究结果。研究运输管理、订单管理、仓储管理和库存管理四个方面如何影响肯尼亚肯尼亚医疗用品管理局（KEMSA）的绩效。本章重点关注数据分析,回答提出的研究问题。第五章的目标是分析讨论第四章提出的定性分析结果,同时得出结论和提出建议。

关键词：物流管理肯尼亚医疗用品管理局组织绩效运输管理订单管理仓库管理库存管

Problems of Technogenic Society in the Process of Noospheric Transformation

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Problems of Technogenic Society in the Process of Noospheric...

Prognostic Significance of Absolute Lymphocytic Count Recovery in Pediatric Patients with Acute Lymphoblastic Leukemia at South Egypt Cancer Institute

作者： Vladimir Inozemtsev nelly Lepskaya National Research University Bauman Moscow State Technical University (BMSTU) Belarusian State University International Sakharov Environmental Institute (ISEI BSU)

The main factors affecting the increase of the contradictory influence of scientific and technological progress on the life of society and nature, as well as the appearance of inconsistency of unbalanced human needs to the natural cycles of the biosphere are identified. It is shown that the sustainable development of mankind will be possible only in the equilibrium(non-degrading) biosphere, so the future of the biosphere should be the subject of close attention of representatives of many branches of scientific knowledge, on the basis of which it is possible to solve the problems of environmental forecasting. The purpose of the article is to substantiate the new principles of human action, consistent with the laws of the natural Universe for the entry of mankind into the noosphere society, to ensure co-evolution of man and the biosphere. It is revealed that the eradication of consumer standards, the correlation of human behavior in relation to themselves and nature, with morality in accordance with humanistic principles will implement the basic provisions of the strategy of sustainable development.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2019年第12期10卷 958-970页

作者： Azza Shibl Noha Gaber nelly Alieldin Heba Sayed Department of Pediatric Oncology South Egypt Cancer Institute (SECI) Assiut University Assiut Egypt Department of Clinical Pathology South Egypt Cancer Institute (SECI) Assiut University Assiut Egypt Department of Cancer Epidemiology National Cancer Institute Cairo Egypt

Background: Leukemia is the most common cause of disease-related death in childhood despite significant improvement in survival and modern risk stratification. Prognostic significance of absolute lymphocytic count (ALC) recovery was studied in pediatric patients with acute lymphoblastic leukemia?(ALL). Methods: One hundred twenty one patients newly diagnosed asALL ≤ 18 yearstreated at pediatric oncology department, South Egypt Cancer Institute from 2011 to 2015 were enrolled. Age, sex, initial total leucocytic count, immunophenotyping, central nervous system (CNS) involvement, mediastinal mass, bone marrow (BM) response on day fifteen and after finishing induction remission were compared to ALC recovery on day 15 (ALC-15) and day 29 (ALC-29) of induction response. Also, prognostic impact of ALC recovery on event free survival (EFS) and overall survival (OS) was evaluated. Results: ALC didn’t show any significant relation to known patients’ prognostic factors. Patients with low ALC didn’t show significant lower response on day 15 and post induction evaluation from those with high ALC (p = 0.74, 0.6 respectively). ALC-15 ≥ 500 cells/uL showed a prognostic significance as patients with ALC-15 500 cells/uL had a poorer outcome (4- EFS 47.8% ± 0.12%) than patients with ALC-15 ≥ 500 cells/uL who carried a better outcome (4-EFS 66.3% ± 0.05%). Neither ALC-500 (day 29) nor ALC-350 (day 15 & day 29) had impact on OS or EFS. In multivariate analysis, ALC-15 500 cells/uL still had a poor impact on outcome (OR 2.56, 95% CI 1.27 - 5.14) with d15-BM response (OR 2.99, 95% CI 1.35 - 6.61) and age 10 (OR 1.96, 95% CI 1.01 - 3.69). Conclusions: ALC-15 has an independent prognostic impact on outcome as well as simple, inexpensive, and easy to interpret. Although, it’s utility in risk stratification of ALL still need a confirmation through a multicenter study with uniform variables, large cohort and long duration of follow up.

关键词： ALC Pediatric ALL Outcome

What can we learn from β-cell failure biomarker application in diabetes in childhood?A systematic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2021年第8期12卷 1325-1362页

作者： María F Calderón-Hernández nelly F Altamirano-Bustamante Cristina Revilla-Monsalve María Belen Mosquera-Andrade Myriam M Altamirano-Bustamante Unidad de Investigación en Enfermedades Metabólicas Centro Médico Nacional Siglo XXIIMSSMexico 06720Mexico Department of Endocrinology Instituto Nacional de PediatríaMexico 04530Mexico

BACKGROUND The prevalence of diabetes as a catastrophic disease in childhood is growing in the *** search for novel biomarkers ofβ-cell failure has been an elusive task because it requires several clinical and biochemical measurements in order to integrate the risk of metabolic *** To determine which biomarkers are currently used to identifyβ-cell failure among children and adolescents with high risk factors for diabetes *** This systematic review was carried out using a modified version of the PICO protocol(Participants/Intervention/Comparison/Outcome).Once our research question was established,terms were individually researched on three different databases(PubMed,BIREME and Web of Science).The total articles obtained underwent a selection process from which the 78 most relevant articles were retrieved to undergo further *** were assessed individually according to quality *** First,we made the classification of theβ-cell-failure biomarkers by the target tissue and the evolution of the disease,separating the biomarkers in relation to the types of ***,we demonstrated that most biomarkers currently used as early signs ofβ-cell failure are those that concern local or systemic inflammation processes and oxidative stress as well as those related to endothelial dysfunction ***,we explored the novelties of diabetes as a protein conformational disease and the novel biomarker called real human islet amyloid polypeptide amyloid ***,we ended with a discussion about the best practice of validation and individual control of using different types of biomarkers in type 1 and type 2 diabetes in order to assess the role they play in the progress of diabetes in *** This review makes widely evident that most biomarkers currently used as early signs ofβ-cell failure are those that concern local or systemic inflammation processes and oxidative stress as well as those related to endo

关键词： Biomarker β-cell failure Children Adolescents Diabetes mellitus Metabolic syndrome

玉米（Zea MaysL.）穗行数主效QTL定位及近等基因系构建

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

玉米（Zea MaysL.）穗行数主效QTL定位及近等基因系构建

作者： ADA MENIE nelly SANDRINE 华中农业大学

学位级别：硕士

玉米(Zea mays L.)籽粒是我国粮食、食品、饲料及能源产品的重要原料。单穗籽粒产量由穗粒数(Kernel Number per Ear, KNE)和百粒重决定;KNE是一个重要的产量组成因子,可分解为穗行数(Kernel Row Number, KRN)和行粒数(Kernel Number pe... 详细信息

玉米(Zea mays L.)籽粒是我国粮食、食品、饲料及能源产品的重要原料。单穗籽粒产量由穗粒数(Kernel Number per Ear, KNE)和百粒重决定;KNE是一个重要的产量组成因子,可分解为穗行数(Kernel Row Number, KRN)和行粒数(Kernel Number per Row, KNPR),因此,KRN是决定玉米产量最为重要性状之一,通过鉴定和克隆控制穗行数(KRN)的QTL/基因,有助于玉米产量性状遗传改良。在课题组前期研究中,利用来源于V54(8-10行,供体)和L87(14-16行,受体)的F2群体将一个穗行数主效QTL(qKRN8)定位在bin8.03-bin8.04之间,可解释15.13%的表型变异。在此工作基础上,本研究利用分子标记辅助选择方法构建QTL qKRN8的近等基因系;同时通过高代回交群体重定位qKRN8。主要试验结果如下：1、qKRN8-NIL构建。本研究以玉米自交系V54为供体亲本,L87为轮回亲本,通过连续两代回交,结合对目标QTL qKRN8和背景的分子标记辅助选择,构建了以L87为背景的qKRN8近等基因系。用均匀分布于全基因组的在双亲间有多态性的82对SSR标记,对96株含有目标QTL的BC2F1单株进行遗传背景分析,其中编号为S905和S604单株具有较高的背景回复率,分别为95%和94%。这两个单株用于构建BC3F1群体。2、qKRN8重定位和标记开发。通过对构建的BC3F1群体进行表型和基因型分析,将qKRN8重定位于第八染色体的umc1904和umc1202之间,重定位结果和F2初定位结果相吻合。并在目标区段内(umc1904-umc1202)开发了7对SSR和Indel标记,标记间平均距离为1-2Mb。3、构建目标区段内跨叠系和精细定位。用qKRN8目标区段两侧的标记(umc1904和umc1202)检测含有4106单株的BC4F1群体,筛选交换单株并自交,种子质量好且量大的交换单株自交果穗共5穗,于2014年冬播种海南,用于子代测验,并将qKRN8精细定位全umc1904和SD32区间内。

关键词：玉米穗行数 QTL近等基因系高代回交群体重定位跨叠系精细定位

Function, kinetic properties, crystallization, and regulation of microbial malate dehydrogenase

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第4期17卷 247-261页

作者： Toshiko TAKAHASHI-INIGUEZ nelly ABURTO-RODRIGUEZ Ana Laura VILCHIS-GONZALEZ Maria Elena FLORES Departamento de Biologla Molecular y Biotecnologia lnstituto de Investigaciones BiomddicasUniversidad Nacional Autonoma de MexicoMexicoD.F.04510Mexico

Malate dehydrogenase （MDH） is an enzyme widely distributed among living organisms and is a key protein in the central oxidative pathway. It catalyzes the interconversion between malate and oxaloacetate using NAD＋ or NADP＊ as a cofactor. Surprisingly, this enzyme has been extensively studied in eukaryotes but there are few reports about this enzyme in prokaryotes. It is necessary to review the relevant information to gain a better understanding of the function of this enzyme. Our review of the data generated from studies in bacteria shows much diversity in their molecular properties, including weight, oligomeric states, cofactor and substrate binding affinities, as well as differences in the direction of the enzymatic reaction. Furthermore, due to the importance of its function, the transcription and activity of this enzyme are rigorously regulated. Crystal structures of MDH from different bacterial sources led to the identification of the regions involved in substrate and cofactor binding and the residues important for the dimer-dimer interface. This structural information allows one to make direct modifications to improve the enzyme catalysis by increasing its activity, cofactor binding capacity, substrate specificity, and thermostability. A comparative analysis of the phylogenetic reconstruction of MDH reveals interesting facts about its evolutionary history, dividing this superfamily of proteins into two principle clades and establishing relationships between MDHs from different cellular compartments from archaea, bacteria, and eukaryotes.

关键词： Malate dehydrogenase Carbon metabolism Tricarboxylic acid cycle

Influence of the changing environment on food composition and condition factor in Labeo victorianus(Boulenger,1901)in rivers of Lake Victoria Basin,Kenya

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aquaculture and Fisheries 2023年第2期8卷 227-238页

作者： nelly F.Nakangu Frank O.Masese James E.Barasa Geraldine K.Matoll Jacques W.Riziki Mulongaibalu Mbalassa Department of Fisheries&Aquatic Sciences University of EldoretEldoretPO Box 1125-30100Kenya Unit´e d’Enseignement et de Recherche en Hydrobiologie Appliqu´ee(UERHA) D´epartement de Biologie-ChimieInstitut Sup´erieur P´edagogique de Bukavu(ISP)RDB.P.854 BukavuCongo School of Life Sciences College of AgricultureEngineering and ScienceUniversity of KwaZulu-NatalScottsvillePietermaritzburg320012South Africa

Labeo victorianus(Boulenger,1901)is one of the endemic fishes in Lake Victoria Basin(LVB)but is now threatened by multiple stressors caused by human *** investigated spatial and temporal variability in food composition and condition of *** in influent rivers of Lake Victoria,*** was done during the dry and wet seasons by *** composition analysis showed that *** is a benthophagus and omnivorous species whose diet is dominated by detritus,periphyton and *** were differences in food composition among rivers,with significant river X season interactions(PERMANOVA F=11.6,df=4,p=0.001),suggesting that the diet depended on prevailing environmental *** turbid rivers,the diet was dominated by detritus while in less turbid rivers it was dominated by insects and *** and mud also formed a significant part of the diet,which was an indication of a limited occurrence of preferable food *** were ontogenetic shifts in food composition(PERMANOVA F=4.6,df=3,p=0.001),but also with a spatial interaction(PERMANOVA F=5.6,df=7,p=0.001),further indicating the role of environmental conditions in determining the diet for different size ***,the fish condition did not differ among *** study shows that turbidity and organic matter and nutrient loading determine the diet of *** in LVB rivers,and provides further justification for the maintenance of water quality as a conservation measure for threatened species.

关键词： Condition factor Feeding Labeo victorianus Ontogenetic shifts Seasonality Tropics

Inherited Thrombophilia and Early Recurrent Pregnancy Loss among Egyptian Women

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2015年第5期5卷 251-258页

作者： Omneya M. Osman nelly N. Abulata Department of Obstetrics and Gynecology Kasr Al-Ainy Faculty of Medicine Cairo University Cairo Egypt Department of Clinical and Chemical Pathology Kasr Al-Ainy Faculty of Medicine Cairo University Cairo Egypt

Inherited thrombophilia has been implicated as a possible cause of recurrent pregnancy loss. Although numerous studies are available in literature, thrombophilia rate seems to vary fromstudy to another. The aim of our study was to determine the frequency of FII Prothrombin(G20210A), Factor V Leiden (G1691A), as well as methyl tetrahydrofolate reductase (MTHFR?C677T) polymorphisms, protein C, protein S and antithrombin III deficiency in a series of patients with unexplained RPL compared to control. Patients and Methods: 100 patients of unexplained RPL and 43 age-matched healthy controls were investigated for inherited thrombophilia. Results: MTHFR and Factor V Leiden were the commonest gene defects among cases studied (63%, 60% respectively) and control groups (41.9%, 41.9% respectively) (p = 0.019, p = 0.046 respectively). The least common deficiencies were protein S and protein C deficiency in cases (3%, 2% respectively) as well as in controls (1%, 0% respectively). 4 cases were homozygous for MTHFR and 2 cases homozygous for Factor V Leiden mutation. Odds ratio for MTHFR and Factor V mutation was 2.36 and 2.08 respectively (CI 95%). Combined defects were seen in cases and controls (p < 0.05). Conclusion: Our study found an association between MTHFR and Factor V Leiden mutations in patients with unexplained RPL among Egyptian women. Further studies are needed to define the management of genetic thrombophilia in cases of recurrent pregnancy loss.

关键词： Thrombophilia Recurrent Pregnancy Loss Genetic Mutations MTHFR

Characterisation of Micrometeorological Parameters in Ecuadorian Highland

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Atmospheric and Climate Sciences 2017年第4期7卷 455-462页

作者： nelly Perugachi Cecilia Limaico Susana Cocha Arquímides Haro Escuela Superior Politécnica de Chimborazo Riobamba Ecuador Universidad Nacional de Chimborazo Riobamba Ecuador

The interaction among air and soil affects the dynamic in the atmospheric boundary layer, this research seeks to describe this variation in small scale, in the Ecuadorian Highlands Regions and the variations produced due to its elevation and geographical position, using as base the Van Ulden and Hostlang (1985) models. From this research, there was a conclusion that the zone has strong fluids of sensitive heat and superficial heat with small variations in the latent fluid heat. Besides, there were significant variations of the Obukov length between 17:00 and 19:00, when the sunset occurs, producing a thermal inversion that modifies the atmospheric dynamic state, these results average vary during the day hours and are regulars in the daily and monthly average, in the research year, given the zone geographical position. The meteorological data utilized were taken from the meteorological station from Universidad Nacional de Chimborazo located in the Ecuadorian Highlands.

关键词： Micrometeorology Atmospheric Parameters Ecuadorian Highlands Air-Soil Interaction