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Impact of 0.1% sodium hyaluronate and 0.2% sodium hyaluronate artificial tears on postoperative discomfort following cataract extraction surgery: a comparative study

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Eye and Vision 2019年第1期6卷 41-49页

作者： Panagiota Ntonti Eirini-Kanella Panagiotopoulou Georgios Karastatiras nektarios breyannis Sevasti Tsironi Georgios Labiris Department of Ophthalmology University Hospital of Alexandroupolis68100 DraganaAlexandroupolisGreece Department of Ophthalmology Papanikolaou General HospitalThessalonikiGreece Department of Ophthalmology Naval Hospital of AthensAthensGreece Department of Ophthalmology Athinaiki KlinikiAthensGreece

Background:Recent artificial tear preparations have provided 0.2%concentration of sodium ***,no published data exist on their potential superiority against 0.1%in alleviating dry-eye-disease symptoms in cataract extraction ***:A total of 180 patients that underwent cataract extraction surgery were randomly divided into 2 groups according to their postoperative regime:Study group(SG)received fixed combination of tobramycin and dexamethasone(FCTD)quid for 3 weeks,and additionally 0.2%sodium hyaluronate provided in the COMOD®device quid for 6 *** group(CG)received fixed combination of tobramycin and dexamethasone(FCTD)quid for 3 weeks,and additionally 0.1%sodium hyaluronate provided in the COMOD®device quid for 6 *** following indexes were evaluated at 3 postoperative checkpoints:(1)Surface discomfort index(SDI)which was derived by four direct 10-scale Likert-type questions that were addressed to the patient and pertained to:(a)foreign body sensation(FBS),(b)blinking discomfort(BD),(c)stinging sensation(SS),(d)tearing sensation(TS),(2)Tear breakup time(TBUT),(3)Schirmer’s test,(4)Central corneal thickness(CCT),and (4)Central Corneal Sensitivity(CCS).Results:Both groups showed reduced CCS values at all postoperative examination points;however,SG participants had significantly better CCS(all p<0.05).SG had better TBUT than CG at the 3rd(p=0.03)and 6th examination points(p=0.04).Moreover,SG had better SDI scores at the 3rd(SDI=9.26±0.55)and 6th weeks(SDI=9.47±0.48)*** participants(p=0.03 and p<0.01,respectively).Conclusion:The increased 0.2%sodium hyaluronate concentration in the artificial tears provided in the COMOD®device seems to address dry-eye-disease symptoms better in patients who underwent phacoemulsification surgery than the 0.1%*** registration:*** Identifier:NCT03705949 Oct 15,2018,retrospectively registered.

关键词： Cataract Postoperative regime Artificial tears Surface discomfort index Hylocomod Hylogel Sodium hyaluronate

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