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美国医学会眼科杂志（中文版） 2004年第4期16卷 252-252页

作者： SusanB.bressler DanteJ.Pieramici JohnM.Koester neilm.bressler 李扬

目的：对于那些均有轻度的典型中心凹下脉络膜新生血管病变在初诊未曾接受过治疗的患者中探讨是否存在一种监测年龄相关性黄斑病变患者的基本原理。方法：参与者指定为安慰剂，他们有轻度的在基线上的典型病变的组合，是从TAP研究中识... 详细信息

目的：对于那些均有轻度的典型中心凹下脉络膜新生血管病变在初诊未曾接受过治疗的患者中探讨是否存在一种监测年龄相关性黄斑病变患者的基本原理。方法：参与者指定为安慰剂，他们有轻度的在基线上的典型病变的组合，是从TAP研究中识别出来的。这些参与者的基线水平的荧光造影和随访检查结果通过图象分析中心分级，以决定是否存在某些随访造影已经从最轻度典型病变成分转变为显著典型病变成分。

关键词：轻度中心凹年龄相关性黄斑病变脉络膜新生血管 TAP 自然病程光动力学治疗随访安慰剂检查结果

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Impact of medical therapy on patients with Crohn's disease requiring surgical resection

今日中国（法文版） 2024年第2期

作者： SONIA bressler

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World Journal of Gastroenterology 2014年第33期20卷 11808-11814页

作者： YT Nancy Fu Thomas Hong Andrew Round Brian bressler Division of Gastroenterology Department of Medicine University of British Columbia St. Paul’s Hospital Vancouver BC V6Z 1Y6 Canada Faculty of Medicine University of British Columbia Vancouver BC V6T 1Z3 Canada GI Clinic and Gastrointestinal Research Institute Vancouver BC V6Z 2K5 Canada

AIM: To evaluate the impact of medical therapy on Crohn’s disease patients undergoing their first surgical resection.

关键词： Crohn's disease Surgery Medication Phe-notype Biologics Anti-tumor necrosis factor Immuno-modulators Inflammatory bowel disease

Time of infliximab therapy initiation and dose escalation in Crohn's disease

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World Journal of Gastroenterology 2014年第1期20卷 214-218页

作者： Mindy CW Lam Terry Lee Kenneth Atkinson Brian bressler Division of Gastroenterology Department of MedicineUniversity of British ColumbiaVancouverBC V6Z 2K5Canada Centre for Health Evaluation and Outcome Sciences VancouverBC V6Z 2K5Canada

AIM: To determine if early initiation of anti-tumor necrosis factor therapy affects the need for dose escalation.

关键词： Crohn’ s disease, Infliximab, Dose escalation

Transition clinic attendance is associated with improved beliefs and attitudes toward medicine in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2017年第29期23卷 5405-5411页

作者： Nancy Fu Kevan Jacobson Andrew Round Kathi Evans Hong Qian Brian bressler Division of Gastroenterology Department of Medicine University of British Columbia Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics University of British Columbia Faculty of Medicine University of British Columbia Centre of Health Evaluation and Outcome Sciences

To evaluated the differences in knowledge, adherence, attitudes, and beliefs about medicine in adolescents with inflammatory bowel disease (IBD) attending transition clinics. METHODSWe prospectively enrolled patients from July 2012 to June 2013. All adolescents who attended a tertiary-centre-based dedicated IBD transition clinic were invited to participate. Adolescent controls were recruited from university-affiliated gastroenterology offices. Participants completed questionnaires about their disease and reported adherence to prescribed therapy. Beliefs in Medicine Questionnaire was used to evaluate patients’ attitudes and beliefs. Beliefs of medication overuse, harm, necessity and concerns were rated on a Likert scale. Based on necessity and concern ratings, attitudes were then characterized as accepting, ambivalent, skeptical and indifferent. RESULTSOne hundred and twelve adolescents were included and 59 attended transition clinics. Self-reported adherence rates were poor, with only 67.4% and 56.8% of patients on any IBD medication were adherent in the transition and control groups, respectively. Adolescents in the transition cohort held significantly stronger beliefs that medications were necessary (P = 0.0035). Approximately 20% of adolescents in both cohorts had accepting attitudes toward their prescribed medicine. However, compared to the control group, adolescents in the transition cohort were less skeptical of (6.8% vs 20.8%) and more ambivalent (61% vs 34%) (OR = 0.15; 95%CI: 0.03-0.75; P = 0.02) to treatment. CONCLUSIONAttendance at dedicated transition clinics was associated with differences in attitudes in adolescents with IBD.

关键词： Inflammatory bowel disease Adolescents Transition Beliefs Knowledge Attitudes

Precision medicine in hearing loss

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Journal of Genetics and Genomics 2018年第2期45卷 99-109页

作者： Jason R.Rudman Christine Mei Sara E.bressler Susan H.Blanton Xue-Zhong Liu Department of Otoloryngology University of Miami Miller School of Medicine Miami FL 33136 USA Dr. John T. Macdonald Foundation Department of Human Cenetics University of Miami Miller School of Medicine Miami FL 33136 USA John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine Miami FL 33136 USA

Precision medicine（PM） proposes customized medical care based on a patient＇s unique genome, biomarkers, environment and behaviors. Hearing loss（HL） is the most common sensorineural disorder worldwide and is frequently caused by a single genetic mutation. With recent advances in PM tools such as genetic sequencing and data analysis, the field of HL is ideally positioned to adopt the strategies of ***, we review current and future applications of PM in HL as they relate to the four core qualities of PM（P4）： predictive, personalized, patient-centered, and participatory. We then introduce a strategy for effective incorporation of HL PM into the design of future research studies, electronic medical records,and clinical practice to improve diagnostics, prognostics, and, ultimately, individualized patient treatment. Finally, specific anticipated ethical and economic concerns in this growing era of genomics-based HL treatment are discussed. By integrating PM principles into translational HL research and clinical practice, hearing specialists are uniquely positioned to effectively treat the heterogeneous causes and manifestations of HL on an individualized basis.

关键词： Precision medicine Personalized medicine Hearing loss Genetics

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今日中国（法文版） 2022年第4期60卷 26-27页

作者： SONIA bressler 不详