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British Soccer Academy Personnel Perceive Psychological and Technical/Tactical Attributes as the Most Important Contributors to Development

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Journal of Science in Sport and Exercise 2022年第1期4卷 37-48页

作者： Rich J.Kite Mark R.Noon Rhys Morris Peter Mundy neil D.Clarke Faculty of Health Academy Sports Science and Medical Department Coventry City Football ClubCoventryUK

Purpose Understanding the desired attributes for talented soccer players may give insight into the process of(de)selection and player *** study aimed to explore soccer academy personnel’s perceptions of attributes associated with talent and *** Thirty English and Scottish academy personnel(managers,coaches,recruitment,sports scientists)provided per-ceptions into what attributes contribute to‘talent’,via an online *** an E-Delphi method,seven experts refined these inputs over several rounds until a consensus was reached,resulting in 82 agreed *** terminology was resubmitted via a second online survey,where 45 academy personnel rated each using a Likert *** A ranking of attributes by importance was produced,finding Psychological and Technical/Tactical attributes con-sidered of greatest *** were observed,whereby recruitment personnel consistently over-emphasised the importance of several attributes compared to other personnel(P=0.02-0.04).When analyzed within each age phase,11 variations in the perceived importance of attributes were demonstrated in the youth phase(11-16 years,P=0.01)compared with 5 in the professional phases(17-23 years,P=0.01-0.05)Conclusion The present study demonstrates that‘talent’requires multifaceted developments,with academy personnel per-ceiving psychological attributes the most important contributor to development.

关键词： Talent development Characteristics Elite player performance plan Youth

Cilia in cell signaling and human disorders

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Protein & Cell 2010年第8期1卷 726-736页

作者： neil A.Duldulao Jade Li Zhaoxia Sun Department of Genetics Yale University School of Medicine333 Cedar St.SHM I-329ANew HavenCT 06520USA

One of the most widespread cellular organelles in nature is cilium,which is found in many unicellular and multicellular *** thought to be a mostly vestigial organelle,the cilium has been discovered in the past several decades to play critical motile and sensory roles involved in normal organogenesis during *** role of cilia has also been implicated in an ever increasing array of seemingly unrelated human diseases,including blindness,kidney cysts,neural tube defects and *** this article we review some of the recent developments in research on cilia,and how defects in ciliogenesis and function can give rise to developmental disorders and disease.

关键词： cilia ciliogenesis ciliopathy model organisms

Campaigning by Human Branding:Associating with American Presidents

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Fudan Journal of the Humanities and Social Sciences 2020年第4期13卷 495-515页

作者： neil Collins Political Science and International Relations Nazarbayev UniversityNur-SultanKazakhstan Department of Government and Politics University College Cork(UCC)Cork T12 K8AFIreland

Human branding has become an essential issue in political *** is exempli fied in the election of American *** paper examines the American experience to suggest a typology of human branding that may apply in both presidential and other political *** examines examples of presidential human brands from George Washington on but,given significant changes to electoral procedures,concentrates on first-time successful presidential candidates since *** fourfold typology offers an interrelated set of ideal types that will augment the analysis of human *** is applied to presidents when they take up office rather than after *** typology draws on the source of primary brand association and relation to the core political system of each politician.

关键词： Human branding Branding by association US presidential elections Typology Political marketing

Binding of bacterial secondary messenger molecule c di-GMP is a STING operation

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Protein & Cell 2013年第2期4卷 117-129页

作者： neil Shaw Songying Ouyang Zhi-Jie Liu Tianjin Key Laboratory of Protein Science School of Life SciencesNankai UniversityTianjin 300071China National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Initial skirmishes between the host and pathogen result in spillage of the contents of the bacterial *** the spillage,the secondary messenger molecule,cyclic dimeric guanosine monophosphate(c di-GMP),was recently shown to be bound by stimulator of interferon genes(STING).Binding of c di-GMP by STING activates the Tank Binding Kinase(TBK1)mediated signaling cascades that galvanize the body’s defenses for elimi-nation of the *** addition to c di-GMP,STING has also been shown to function in innate immune re-sponses against pathogen associated molecular pat-terns(PAMPs)originating from the DNA or RNA of *** pivotal role of STING in host defense is exemplified by the fact that STING-/-mice die upon infection by ***,STING plays an essential role in innate immune responses against *** opens up an exciting possibility of targeting STING for development of adjuvant therapies to boost the im-mune defenses against invading ***,STING could be targeted for mitigating the inflamma-tory responses augmented by the innate immune *** review summarizes and updates our current understanding of the role of STING in innate immune responses and discusses the future challenges in de-lineating the mechanism of STING-mediated responses.

关键词： innate immune response adaptor protein dimeric assembly crystal structure c di-GMP

Protective effects of trilinolein extracted from Panax notoginseng against cardiovascular disease

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Acta Pharmacologica Sinica 2002年第12期23卷 104-109页

作者： Paul CHAN,G neil THOMAS,Brian TOMLINSON Division of Cardiovascular Medicine Taipei Medical College Affiliated Taipei Wan Fang Hospital Taipei China Department of Medicine and Therapeutics The Chinese University of Hong Kong Prince of Wales Hospital Shatin NT Hong Kong SAR China Department of Medicine and Therapeutics The Chinese University of Hong Kong Prince of Wales Hospital Shatin NT Hong Kong SAR China

Trilinolein is a triacylglycerol purified from a commonly used traditional Chinese medicine Panax notoginseng. Trilinolein has been reported to provide a number of beneficial effects including reducing thrombogenicity and arrhythmias and increasing erythrocyte deformability. Additionally, trilinolein has been reported to be an antioxidant, which can counteract free radical damage associated with atherogenesis, and myocardial damage seen with is-chaemia and reperfusion. These pharmacologic effects may explain the perceived benefits derived from treating circulatory disorders with the herb over the centuries.

关键词： antioxidants cardiovascular system Chinese traditional medicine trilinolein Panax notoginseng

Localized orbital scaling correction for systematic elimination of delocalization error in density functional approximations

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National Science Review 2018年第2期5卷 203-215页

作者： Chen Li Xiao Zheng neil Qiang Su Weitao Yang Department of Chemistry Duke University Synergetic Innovation Center of Quantum Information and Quantum Physics Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China CAS Center for Excellence in Nanoscience University of Science and Technology of China Department of Physics Duke University Key Laboratory of Theoretical Chemistry of Environment School of Chemistry and EnvironmentSouth China Normal University

The delocalization error of popular density functional approximations(DFAs) leads to diversified problems in present-day density functional theory calculations. For achieving a universal elimination of delocalization error, we develop a localized orbital scaling correction(LOSC) framework, which unifies our previously proposed global and local scaling approaches. The LOSC framework accurately characterizes the distributions of global and local fractional electrons, and is thus capable of correcting system energy, energy derivative and electron density in a self-consistent and size-consistent manner. The LOSC–DFAs lead to systematically improved results, including the dissociation of cationic species, the band gaps of molecules and polymer chains, the energy and density changes upon electron addition and removal, and photoemission spectra.

关键词： localized orbital scaling correction delocalization error density functional approximation localized frontier orbital local fraction orbitalet

Gut microbiome and pancreatic cancer cachexia:An evolving relationship

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World Journal of Gastrointestinal Oncology 2022年第7期14卷 1218-1226页

作者： Andrew Hendifar Rasaq Akinsola Hayato Muranaka Arsen Osipov Shant Thomassian Natalie Moshayedi Julianne Yang Jonathan Jacobs Suzanne Devkota neil Bhowmick Jun Gong Department of Medicine Division of Hematology and OncologyCedars-Sinai Medical CenterLos AngelesCA 90048United States The Vatche and Tamar Manoukian Division of Digestive Diseases Department of MedicineUniversity of CaliforniaLos AngelesCA 90095United States Department of Medicine David Geffen School of Medicine at UCLAUniversity of CaliforniaLos AngelesLos AngelesCA 90095United States Cedars-Sinai Medical Center Department of MedicineInflammatory Bowel and Immunobiology Research InstituteUniversity of CaliforniaLos AngelesCA 90048United States

Nearly 80% of patients with pancreatic ductal adenocarcinoma(PDAC)develop cachexia along their disease *** is characterized by progressive weight loss,muscle wasting,and systemic inflammation and has been linked to poorer outcomes and impairments in quality of *** of PDAC cachexia has historically involved a multidisciplinary effort comprised of nutritional support,pancreatic enzyme replacement therapy,and/or pharmacologic *** current interventions to mitigate PDAC cachexia,a significant proportion of patients continue to die from complications associated with cachexia underscoring the need for novel insights and treatments for this *** highlight the feasibility and effectiveness of a recent enteral feeding prospective trial at our institution to improve cachexia outcomes in patients with advanced ***,we were among the first to characterize the stool microbiome composition in patients with advanced PDAC receiving enteral feeding for the treatment of *** insights into the relationship between enteral nutritional support,cachexia,and the gut microbiome are *** promising results are discussed in the context of a potential ability to modulate the stool microbiome as a new interventional strategy to mitigate PDAC cachexia.

关键词： Gut microbiome Pancreatic cancer Stool Cachexia Inflammation Weight

Rediscovering Don Swanson:The Past,Present and Future of Literature-based Discovery

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Journal of Data and Information Science 2017年第4期2卷 43-64页

作者： neil R.Smalheiser Department of Psychiatry University of Illinois at ChicagoChicagoIL 60612USA

Purpose： The late Don R. Swanson was well appreciated during his lifetime as Dean of the Graduate Library School at University of Chicago, as winner of the American Society for Information Science Award of Merit for 2000, and as author of many seminal articles. In this informal essay, I will give my personal perspective on Don＇s contributions to science, and outline some current and future directions in literature-based discovery that are rooted in concepts that he ***/methodology/approach： Personal recollections and literature review. Findings： The Swanson A-B-C model of literature-based discovery has been successfully used by laboratory investigators analyzing their findings and hypotheses. It continues to be a fertile area of research in a wide range of application areas including text mining, drug repurposing, studies of scientific innovation, knowledge discovery in databases, and bioinformatics. Recently, additional modes of discovery that do not follow the A-B-C model have also been proposed and explored （e.g. so-called storytelling, gaps, analogies, link prediction, negative consensus, outliers, and revival of neglected or discarded research questions）. Research limitations： This paper reflects the opinions of the author and is not a comprehensive nor technically based review of literature-based discovery. Practical implications： The general scientific public is still not aware of the availability of tools for literature-based discovery. Our Arrowsmith project site maintains a suite of discovery tools that are free and open to the public （http：//***）, as does BITOLA which is maintained by Dmitar Hristovski （http：// http：//***/bitola）, and Epiphanet which is maintained by Trevor Cohen （http：//***/）. Bringing user-friendly tools to the public should be a high priority, since even more than advancing basic research in informatics, it is vital that we ensure that scientists actually use discovery t

关键词： Literature-based discovery Biography Text mining Knowledge discovery indatabases Implicit information Information science

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Crime forecasting:a machine learning and computer vision approach to crime prediction and prevention

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Visual Computing for Industry,Biomedicine,and Art 2021年第1期4卷 76-89页

作者： neil Shah Nandish Bhagat Manan Shah Department of Computer Engineering Sal Institute of Technology and Engineering ResearchAhmedabadGujarat 380060India Department of Chemical Engineering School of TechnologyPandit Deendayal Energy UniversityGandhinagarGujarat 382426India

A crime is a deliberate act that can cause physical or psychological harm,as well as property damage or loss,and can lead to punishment by a state or other authority according to the severity of the *** number and forms of criminal activities are increasing at an alarming rate,forcing agencies to develop efficient methods to take preventive *** the current scenario of rapidly increasing crime,traditional crime-solving techniques are unable to deliver results,being slow paced and less ***,if we can come up with ways to predict crime,in detail,before it occurs,or come up with a“machine”that can assist police officers,it would lift the burden of police and help in preventing *** achieve this,we suggest including machine learning(ML)and computer vision algorithms and *** this paper,we describe the results of certain cases where such approaches were used,and which motivated us to pursue further research in this *** main reason for the change in crime detection and prevention lies in the before and after statistical observations of the authorities using such *** sole purpose of this study is to determine how a combination of ML and computer vision can be used by law agencies or authorities to detect,prevent,and solve crimes at a much more accurate and faster *** summary,ML and computer vision techniques can bring about an evolution in law agencies.

关键词： Machine learning Computer vision Crime forecasting