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Verrucous carcinoma of the esophagus: A case report and literature review

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World Journal of Clinical Cases 2014年第7期2卷 284-288页

作者： Chintan Ramani neil shah Ramasamy Swami Nathan Department of internal medicine Hackensack UMC mountainsideMontclairNJ 07042United States

Verrucous carcinoma of the esophagus is a variant of a squamous cell cancer. Our case is a 78-year-old male patient comes in with the dysphagia and weight loss, and on endoscopy(EGD) he is found to have an irregular intraluminal mass at the distal esophagus. With the deep EGD assisted biopsy, diagnosis of the verrucous carcinoma is made. Due to multiple co morbidities and possible infiltration to the pericardium, patient is taken for the esophageal stent placement and is being referred for the chemo-radiation treatment. The diagnosis can be very difficult to make with the superficial biopsies due to very non specific histological changes and requires very high clinical suspicion and deep mucosal biopsies are required for accurate diagnosis of the tumor. Chronic and local disease process is the main risk factor for the development of the verrucous carcinoma of the esophagus. Surgery is the treatment of the choice for the early stage tumor and advanced cases are treated with the palliation and possibly chemoradiation. The prognosis is usually guarded and needs long term follow up.

关键词： Verrucous carcinoma Hyperkeratosis Esophageal stent placement Esophageal carcinoma Endoscopic Ultrasound

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伊马替尼失效的机制和对策

伊马替尼失效的机制和对策

第九次全国血液学学术会议

作者： neil P．shah 加州大学洛杉矶分校

小分子的选择性BCR-ABL激酶抑制剂——伊马替尼的出现,使慢性髓细胞白血病(CML)的治疗发生了革命性的变化。尽管伊马替尼初始治疗疗效高,总体耐受性良好,但其临床复发的情况开始逐渐增多。目前,对于多数伊马替尼失效和不能耐受的CML患者... 详细信息

小分子的选择性BCR-ABL激酶抑制剂——伊马替尼的出现,使慢性髓细胞白血病(CML)的治疗发生了革命性的变化。尽管伊马替尼初始治疗疗效高,总体耐受性良好,但其临床复发的情况开始逐渐增多。目前,对于多数伊马替尼失效和不能耐受的CML患者,有效的治疗选择很少。通过对伊马替尼主要耐药机制的了解,现已开发了两个新型的BCR-ABL抑制剂:dasatinib (BMS-354825)和AMN107,早期的临床试验结果已显示两者具有广阔的治疗前景。与伊马替尼相比,dasatinib(BMS-354825)和AMN107对BCR-ABL的抑制更强,而且,体外实验结果显示,两者几乎对所有的伊马替尼耐药的BCR-ABL激酶结构域突变均有效。但值得注意的是,它们都不能

关键词：伊马替尼慢性髓细胞白血病耐药性异基因干细胞移植

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全球股市低迷亚洲首当其冲

海外经济评论 2008年第28期 25-28页

作者： Jonathan Cheng Tariq Engineer Alison Tudor neil shah

一年前，当信贷危机在美国和欧洲刚刚崭露头角时，许多投资者都将亚洲股票视为了天堂。时至今日，全球股市经历了6个多月的下跌，而亚洲市场的跌幅位居前列。

关键词：亚洲市场股市低迷信贷危机全球股市投资者股票跌幅

The synthesis of polymers of intrinsic microporosity (PIMs)

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Science China Chemistry 2017年第8期60卷 1023-1032页

作者： neil B.McKeown School of Chemistry University of Edinburgh David Brewster Road Edinburgh EH9 3F J U

Polymers of intrinsic microporosity （PIMs） are a class of porous organic polymer （POP） that form microporous solids due to the inefficient packing of their rigid and contorted macromolecular chains. In contrast to other types of POP, PIMs are not comprised of a network of cross-linked covalent bonds so that they can be dissolved in organic solvents and processed into robust films, coatings or fibres. Here, over twelve years＇ accumulated research on the synthesis of PIMs is reviewed. To date, three types of polymerisation reaction have been used successfully to prepare PIMs of sufficient molecular mass to form robust self-standing films. These involve the formation of dibenzodioxin, Tr6ger＇s base and imide linkages between monomeric units. This rapid development of synthetic methods for preparing PIMs has been driven by their rich potential for numerous diverse applications and this synergistic relationship between synthesis and functionality is set to continue.

关键词： polymers of intrinsic microporosity synthesis porous organic polymers

Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury

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World Journal of Gastroenterology 2004年第12期10卷 1699-1708页

作者： neil Kaplowitz Gastroenterology/Liver Division Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA

Deficiencies in vitamins or other factors(B6,B12,folic acid, betaine)and genetic disorders for the metabolism of the non-protein amino acid-homocysteine(Hcy)lead to hyperhomocysteinemia(HHcy).HHcy is an integral component of several disorders including cardiovascular disease,neurodegeneration,diabetes and alcoholic liver *** unleashes mediators of inflammation such as NFκB,IL-1β,IL-6,and IL-8,increases production of intracellular superoxide anion causing oxidative stress and reducing intracellular level of nitric oxide(NO),and induces endoplasrnic reticulum(ER)stress which can explain many processes of Hcy-promoted cell injury such as apoptosis, fat accumulation,and *** models have played an important role in determining the biological effects of *** stress may also be involved in other liver diseases such as α_1-antitrypsin(α_1-AT)deficiency and hepatitis C and/or B virus *** research should evaluate the possible potentiative effects of alcohol and hepatic virus infection on ER stress-induced liver injury,study potentially beneficial effects of lowering Hcy and preventing ER stress in alcoholic humans,and examine polymorphisrn of Hcy metabolizing enzymes as potential risk-factors for the development of HHcy and liver disease.

关键词： Animals Endoplasmic Reticulum Humans Hyperhomocysteinemia Liver Diseases, Alcoholic Oxidative Stress

No evidence of Permacol rejection presented by Wotton and Akoh

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World Journal of Gastroenterology 2010年第5期16卷 657-658页

作者： neil James Smart Department of General Surgery Royal Devon&Exeter HospitalBarrack RoadExeterEX2 5DW United Kingdom

Wotton and Akoh in their previously reported case in this journal postulate that Permacol *** letter provides a detailed critique of that claim and provides an alternative explanation for the histological data provided by the *** is also argued that Wotton and Akoh have misrepresented one of the papers in the discussion in their article and a clarification of that referenced paper is given.

关键词： Porcine dermal collagen implant(Permacol) Renal Transplant Rejection

Gamma-ray bursts in the swift-Fermi era

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Frontiers of physics 2013年第6期8卷 661-678页

作者： neil Gehrels Soebur Razzaque Astrophysics Science Division NASA Goddard Space Flight Center Greenbelt MD 20771 USA George Mason University Fairfax VA 22030 USA Resident at Space Science Division Naval Research Laboratory Washington DC 20375 USA

Gamma-ray bursts （GRBs） are among the most violent occurrences in the universe. They are pow- erful explosions, visible to high redshift, and thought to be the signature of black hole birth. They are highly luminous events and provide excellent probes of the distant universe. GRB research has greatly advanced over the past 10 years with the results from Swift, Fermi and an active followup community. In this review we survey the interplay between these recent observations and the theoretical models of the prompt GRB emission and the subsequent afterglows.

关键词： gamma-ray bursts (GRBs) Swift Fermi

Relative abundance of American badger (Taxidea taxus) and red fox (Vulpes vulpes) in landscapes with high and low rodenticide poisoning levels

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Integrative Zoology 2012年第1期7卷 41-47页

作者： Gilbert PROULX neil MacKENZIE Alpha Wildlife Research&Management Sherwood ParkAlbertaCanada

Over the past decade,extensive poisoning campaigns have been conducted in southern Saskatchewan to control Richardson’s ground squirrel Spermophilus richardsonii(Sabine,1822)*** campaigns might impact on predator abundance by decreasing prey levels,and also through secondary *** spotlighting,we investigated the relative abundance of American badgers Taxidea taxus(Schreber,1777)and red fox Vulpes vulpes(Linnaeus,1758)in 2 study areas with road access and crops,but with different levels of *** the study area with relatively low poisoning(19.6%of the area traversed by roads),there were 2.2 times more American badgers per km of road and 6.4 times more red foxes per km than in the study area with high poisoning(89.7%of the area).It is recommended that an Integrated Pest Management program be developed to conserve natural predators across landscapes.

关键词： ground squirrels poisoning populations predators

Herb-Induced Liver Injury: A Global Concern

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Chinese Journal of Integrative Medicine 2018年第9期24卷 643-644页

作者： neil Kaplowitz USC Research Center for Liver Disease USC Keck School of Medicine

Chinese medicine and herb medicine though used to treat liver diseases are an important cause of liver injury. Many phytochemicals have the potential to injure the liver, some in a dose-related fashion and more often in an idiosyncratic fashion, meaning occurrence is uncommon to rare in the population using these treatments. As is the case with pharmaceuticals, the phytochemicals are usually tolerated despite either no or mild transient subclinical injury but rarely in some susceptible patients cause moderate to severe liver injury which is likely mediated by the adaptive immune system.

关键词： herb-induced liver injury diagnosis and management guideline Chinese medicine