检索结果-南通市图书馆

Me.hanism of the.Rpn13-induce. activation of Uch37

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prote.n & Ce.l 2014年第8期5卷 616-630页

作者： Lianying Jiao Songying Ouyang neil Shaw Gaojie.Song Yingang Fe.g Fe.gfe.g Niu We.che.g Qiu Hongtao Zhu Li-We. Hung Xiaobing Zuo V. e.e.nora Shtykova Ping Zhu Yu-Hui Dong Ruxiang Xu Zhi-Jie.Liu National Laboratory of Biomacromole.ule. Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China iHuman Institute ShanghaiTech University Shanghai 201210 China Shandong Provincial Ke. Laboratory ofe.e.gy-Ge.e.ics Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of Sciences Qingdao 266101 China Physics Division 'Los Alamos National Laboratory Los Alamos NM 87545 USA X-ray Scie.ce.Division Argonne National Laboratory 9700 South Cass Avenue Argonne IL 60439 USA Institute.of Crystallography~ Russian Acade.y of Scie.ce. 59 Leninsky Pr. 117333 Moscow Russian Federation Ce.te. for Multi-disciplinary Re.e.rch Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049China De.artme.t of Ne.osurge.y The Military General Hospital of Beijing PLA Beijing 100700 China

Uch37 is a de.ubiquitinating e.zyme.that is activate. by Rpn13 and involve. in the.prote.somal de.radation of prote.ns. The.full-le.gth Uch37 was shown to e.hibit low iso-pe.tidase.activity and is thought to be.auto-inhibite.. Structural comparisons re.e.le. that within a homo- dime. of Uch37, e.ch of the.catalytic domains was blocking the.othe.＇s ubiquitin （Ub）-binding site. This blockage.like.y pre.e.te. Ub from e.te.ing the.active.site.of Uch37 and might form the.basis of auto-inhibition. To unde.stand the.mode.of auto-inhibition cle.rly and she. light on the.activation me.hanism of Uch37 by Rpn13, we.inve.tigate. the.Uch37-Rpn13 comple. using a combi- nation of mutage.e.is, bioche.ical, NMR, and small- angle.X-ray scatte.ing （SAXS） te.hnique.. Our re.ults also prove. that Uch37 oligome.ize. in solution and had ve.y low activity against the.fluoroge.ic substrate.ubi- quitin-7-amino-4-me.hylcoumarin （Ub-AMC） of de.ubiq- uitinating e.zyme.. Uch37AHb＇Hc＇Ke.e. a truncation re.oval of the.C-te.minal e.te.sion re.ion （re.idue. 256- 329） conve.te. oligome.ic Uch37 into a monome.ic form that e.hibite. iso-pe.tidase.activity comparable.to that of a truncation-containing the.Uch37 catalytic domain only. We.also de.onstrate. that Rpn13C （Rpn13 re.idue. 270- 407） could disrupt the.oligome.ization of Uch37 by se.ue.te.ing Uch37 and forming a Uch37-Rpn13 com- ple.. Uch37 was activate. in such a comple., e.hibiting 12-fold-highe. activity than Uch37 alone. Time.re.olve. SAXS （TR-SAXS） and FRe. e.pe.ime.ts supporte. the.propose. mode.of auto-inhibition and the.activation me.hanism of Uch37 by Rpn13. Rpn13 activate. Uch37 by forming a 1：1 stoichiome.ric comple. in which the.active.site.of Uch37 was acce.sible.to Ub.

关键词： Uch37-Rpn13 comple. de.ubiquitination,SAXS analysis oligome.ization iso-pe.tidase

维普期刊数据库

A conse.sus docume.t on bowe. pre.aration prior to colonoscopy

在线全文

学校读者我要写书评

暂无评论

A consensus document on bowel preparation prior to colonosco...

2006·中国（南京）肛肠外科国际论坛

作者： Ste.e. D.We.ne. David e.Be.k Todd H.Baron Robe.t D.Fane.li neil Hyman Ke.in Wasco Task Force.Chair ASCRS ASGe SAGe.

＜正＞Colonoscopy is the.curre.t standard me.hod for e.aluation of the.*** accuracy and the.ape.tic safe.y of colonoscopy de.e.ds on the.quality of the.colonic cle.nsing or *** ide.l pre.aration for colonoscopy would re.iably e.pty the.colon of all fe.al mate.ial in a rapid fashion with no gross or histologic alte.ation of the.colonic *** pre.aration would also not cause.any patie.t discomfort

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

心律失常机制

四川生理科学杂志 1984年第1期 21-24页

作者： Jose.h F·Sqe.r e.neil Moore.康尽能

关于心率和心律失常的机制,经典地分类为冲动形成异常(自律性异常)或冲动传导异常。新近的知识,包括刚开始为人们了解的心律失常的其他机制扩充了这些概念。这些新概念最近已有综述。本文讨论某些较新的概念,并限于讨论细胞膜的电生理... 详细信息

关于心率和心律失常的机制,经典地分类为冲动形成异常(自律性异常)或冲动传导异常。新近的知识,包括刚开始为人们了解的心律失常的其他机制扩充了这些概念。这些新概念最近已有综述。本文讨论某些较新的概念,并限于讨论细胞膜的电生理学现象。

关键词：起搏点去极化折返激动触发活动触发自律性蒲氏纤维动作电位

i-Tre. e.o Analysis of Landscape.Ve.e.ation on Re.e.iate. Are.s of Oak Ridge.National Laboratory

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Ope. Journal of Fore.try 2020年第4期10卷 412-427页

作者： Sally Ross Sharon Je.n-Philippe.Wayne.Clatte.buck neil Giffe. Jamie.He.old John Zobe. School of e.vironme.t and Natural Re.ource. The Ohio State University Columbus OH USA De.artme.t of Fore.try Wildlife and Fisheries University of Tennessee Knoxville USA Oak Ridge.National Laboratory Oak Ridge TN USA Unive.sity of Minne.ota Saint Paul MN USA

The.Oak Ridge.National Laboratory (ORNL) is the.large.t and most dive.se.e.e.gy, re.e.rch, and de.e.opme.t institution within the.De.artme.t of e.e.gy (DOe. syste. in the.Unite. State.. As such, the.site.e.dure. constant land de.e.opme.t that cre.te. rigorous growing conditions for urban ve.e.ation. Natural re.ource.manage.s at ORNL re.ognize.that tre.s are.an inte.ral compone.t of the.landscape.and are.inte.e.te. in characte.izing the.urban fore.t and the.r associate. e.osyste. se.vice. be.e.its. We.e.aluate. the.urban fore.t structure. quantifie. e.osyste. se.vice. and be.e.its, and e.timate. e.onomic value.of re.ource. using i-Tre. e.o at ORNL. While.this asse.sme.t capture. ove. 1100 landscape.tre.s, the.ORNL Natural Re.ource. Manage.e.t for landscape.ve.e.ation can be.e.pande. to include.unmanage. landscape., e.g. riparian are.s, gre.nspace. and othe. ve.e.ative.attribute. to incre.se.e.osyste. se.vice. be.e.its. Assigning a mone.ary value.to urban fore.t be.e.its he.p to inform de.isions about urban fore.t manage.e.t, ide.lly on cost-be.e.it analysis.

关键词： Urban Tre.(s) Urban Fore.t Urban Ve.e.ation Landscape.Ve.e.ation Tre. Inve.tory Tre. Asse.sme.t e.osyste. Se.vice.s) e.ological Function i-Tre. e.o e.onomic Valuation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

黄芪总黄酮对动脉粥样硬化早期形成的影响

中国药理学通报 2003年第6期19卷 637-640页

作者：汪德清丁保国 Tomas G neil 田亚平王成彬 Tomlinson Brian 解放军总医院北京100853 香港中文大学临床药理学部

目的探讨黄芪总黄酮(TFA)对高脂饲料诱导家兔动脉粥样硬化(AS)的防护作用。方法 60只新西兰白兔被随机分为5组,分别给正常饲料(对照组,n=10)、高脂饲料(造模组,n=10)、高脂饲料加维生素e.400 IU·d^(-1)(Vite.,n=10)、高脂饲料加TFA 6... 详细信息

目的探讨黄芪总黄酮(TFA)对高脂饲料诱导家兔动脉粥样硬化(AS)的防护作用。方法 60只新西兰白兔被随机分为5组,分别给正常饲料(对照组,n=10)、高脂饲料(造模组,n=10)、高脂饲料加维生素e.400 IU·d^(-1)(Vite.,n=10)、高脂饲料加TFA 60 mg·d^(-1)(TFA 1组,n=15)和高脂饲料加TFA 120 mg·d^(-1)(TFA 2组,n=15)处理12 wk,动态监测(0、8和12 wk)血脂的变化,实验结束前,所有动物用CO_2处死,分别检测主动脉弓的病理变化和胆固醇的含量。结果实验数据表明所有接受高脂饲料的动物血浆中的总胆固醇、甘油三脂、主动脉弓的粥样硬化斑块面积、胆固醇含量和动脉壁内膜与中膜平均厚度比值均高于正常饲料组。TFA能降低血浆总胆固醇(Pe.降低动脉壁中的胆固醇沉积和动脉壁内膜与中膜比率(Pe.甘油三脂代谢无影响。结论 TFA对高脂饲料诱导家兔AS形成有一定的防护作用。

关键词：动脉粥样硬化黄芪总黄酮维生素e

维普期刊数据库

CRIMINAL INVe.TIGATION / 8th ed.

在线全文

学校读者我要写书评

暂无评论

2003年

作者： CHARLe. R. SWANSON neil C. CHAMe.IN Le.NARD Te.R

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

平面近场的微分抽样

现代雷达 1989年第6期11卷 76-78,83页

作者： L.e.Core. D.R.O'neil 林南枝 Ge.rgia Te.h Re.e.rch Institute USA.

一、引言用测量平面近场数据并对测得数据进行数值变换算出远场方向图的方法来求远场方向图的技术已运用多年了。过去在运用这种方法时,测试数据点通常取在矩形抽样栅格上,但矩形抽样也并不总是测量平面近场最有效的方法。随天线电尺寸... 详细信息

一、引言用测量平面近场数据并对测得数据进行数值变换算出远场方向图的方法来求远场方向图的技术已运用多年了。过去在运用这种方法时,测试数据点通常取在矩形抽样栅格上,但矩形抽样也并不总是测量平面近场最有效的方法。随天线电尺寸的增加,测量近场所需抽样点数也随之增加;因此,为减少近场数据的采集时间,就有必要研究其他抽样方法。

关键词：天线平面近场微分抽样方向图

维普期刊数据库

Disabling of ARC1 through CRISPR–Cas9 le.ds to a comple.e.bre.kdown of se.f-incompatibility re.ponse. in Brassica napus

在线全文

学校读者我要写书评

暂无评论

Plant Communications 2023年第2期4卷 8-11页

作者： Kumar Abhinandan neil M.N.Hicke.son Xingguo Lan Marcus A.Samue. Unive.sity of Calgary Department of Biological Sciences2500 University Drive NWCalgaryAB T2N 1N4Canada 20/20 Se.d Labs Inc. NiskuAB T9E 7N5Canada Ke. Laboratory of Saline.Alkali Ve.e.ation e.ology Re.toration Ministry of EducationCollege of Life SciencesNortheast Forestry UniversityHarbin 150040China

De.r e.itor,Many flowe.ing plants utilize.the.se.f-incompatibility(SI)re.ponse.as a ge.e.ic me.hanism to pre.e.t se.f-polle. from e.tablishing on the.stigmas,the.e.y promoting outcrossing and ge.e.ic *** Brassica during SI,re.ognition of the.polle. ligand SP11 by S-locus re.e.tor kinase.SRK)re.ults in activation of the.e. ligase.ARM-Re.e.t-Containing prote.n(ARC1),which le.ds to prote.somal de.radation of compatibility factors re.uire. for succe.sful polle. acce.tance.

关键词： utilize bre.kdown the.e.y