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Vitamin d Is Associated with Severity and Mortality of Non-alcoholic Fatty Liver disease: A US Population-based Study

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Journal of Clinical and Translational Hepatology 2017年第3期5卷 185-192页

作者： Hyun-Seok Kim Laura Rotundo neil Kothari Sung-Hoon Kim Nikolaos Pyrsopoulos department of Medicine Division of Gastroenterology and Hepatology Rutgers New Jersey Medical School Newark NJ USA College of Korean Medicine Kyung-hee University Seoul South Korea division of Gastroenterology and Hepatology Rutgers New Jersey Medical School Newark NJ USA

Background and Aims:There has been increasing evidence that vitamin d deficiency may increase the risk of metabolic *** metabolic syndrome is a major risk factor for non-alcoholic fatty liver disease (NAFLd),we aimed to investigate the association between vitamin d and the severity and mortality of ***:data was obtained from the United States Third National Health and Nutrition Examination Survey conducted in 1988-1994,with followup mortality data through *** was defined by ultrasonographic detection of hepatic steatosis in the absence of other liver diseases and categorized as normal,mild,moderate or *** severity of hepatic fibrosis was determined by NAFLd fibrosis score (NFS).ANOVA (F-test) was used to evaluate the association between vitamin d level and degree of NAFLd,and Cox proportional hazards regression analysis was used for survival ***:Vitamin d levels for normal,mild,moderate and severe steatosis were 25.1 ± 0.29 ng/mL,24.7 ± 0.42 ng/mL,23.7 ± 0.37 ng/mL and 23.6 ± 0.60 ng/mL,respectively (trend p d levels for low,intermediate and high NFS categories were 24.7 ± 0.38 ng/mL,23.4 ± 0.42 ng/mL and 21.5 ± 0.57 ng/mL,respectively (trend p dian-follow up over 19 years,vitamin d deficiency was significantly associated with diabetes-and Alzheimer's diseaserelated mortality (hazard ratio (HR):3.64,95%CI:1.51-8.82 and HR:4.80,95%CI:1.53-15.1,respectively),with a borderline significance in overall mortality (HR:1.16,95%CI:0.99-1.36,p =0.06).Conclusion:Vitamin d level was inversely related to the degree of liver steatosis and ***,vitamin d deficiency was associated with diabetes-and Alzheimer's disease-related mortality in NAFLd patients.

关键词： Vitamin d Non-alcoholic fatty liver disease Mortality Severity

Criminal investigation / 8th ed.

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Non-antibiotic feed additives in diets for pigs:A review

2003年

作者： Charles R. Swanson neil C. Chamelin Leonard Territo.

来源：畅想之星图书光盘版（南... 评论

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Animal Nutrition 2018年第2期4卷 113-125页

作者： Yanhong Liu Charmaine d.Espinosa Jerubella J.Abelilla Gloria A.Casas L.Vanessa Lagos Su A.Lee Woong B.Kwon John K.Mathai diego M.d.L.Navarro neil W.Jaworski Hans H.Stein department of Animal Science University of California department of Animal Sciences University of Illinois department of Animal Production College of Animal and Veterinary SciencesUniversity of Colombia Trouw Nutrition

A number of feed additives are marketed to assist in boosting the pigs' immune system, regulate gut microbiota, and reduce negative impacts of weaning and other environmental *** most commonly used feed additives include acidifiers, zinc and copper, prebiotics, direct-fed microbials, yeast products, nucleotides, and plant *** of pharmacological levels of zinc and copper, certain acidifiers, and several plant extracts have been reported to result in improved pig performance or improved immune function of *** is also possible that use of prebiotics, direct-fed microbials, yeast,and nucleotides may have positive impacts on pig performance, but results have been less consistent and there is a need for more research in this area.

关键词： Acidifiers direct-fed microbials Minerals Plant extracts Prebiotics Pigs

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Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes

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World Journal of Gastroenterology 2016年第45期22卷 9966-9973页

作者： neil Rajoriya dhiraj Tripathi Joanna A Leithead Bridget K Gunson Sophie Lord James W Ferguson Gideon M Hirschfield Liver Unit Queen Elizabeth Hospital Centre for Liver Research NIHR Birmingham Liver Biomedical Research Unit University of Birmingham

AIM To establish the impact of portal hypertension(PH) on wait-list/post-transplant outcomes in patients with polycystic liver disease(PCLd) listed for liver transplantation. METHOdS A retrospective single-centre case controlled study of consecutive patients listed for liver transplantation over 12 years was performed from our centre. PH in the PCLd cohort was defined by the one or more of following parameters:(1) presence of radiological or endoscopic documented varices from our own centre or the referral centre;(2) splenomegaly(> 11 cm) on radiology inabsence of splenic cysts accounting for increased imaging size;(3) thrombocytopenia(platelets diological evidence of hepatic venous outflow obstruction from a single cyst. RESULTS Forty-seven PCLd patients(F: M = 42: 5) were listed for liver transplantation(LT)(single organ, n = 35; combined liver-kidney transplantation, n = 12) with 19 patients(40.4%) having PH. When comparing the PH group with non-PH group, the mean listing age(PH group, 50.6(6.4); non-PH group, 47.1(7.4) years; P = 0.101), median listing MELd(PH group, 12; non-PH group, 11; P = 0.422) median listing UKELd score(PH group, 48; non-PH group, 46; P = 0.344) and need for renal replacement therapy(P = 0.317) were similar. In the patients who underwent LT alone, there was no difference in the duration of ICU stay(PH, 3 d; non-PH, 2 d; P = 0.188), hospital stay length(PH, 9 d; non-PH, 10 d; P = 0.973), or frequency of renal replacement therapy(PH, 2/8; non-PH, 1/14; P = 0.121) in the immediate post-transplantation period. CONCLUSION Clinically apparent portal hypertension in patients with PCLd listed for liver transplantation does not appear to have a major impact on wait-list or peri-transplant morbidity.

关键词： Polycystic liver disease Portal hypertension Liver transplantation

Nondestructive Phenomic Tools for the Prediction of Heat and drought Tolerance at Anthesis in Brassica Species

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Plant Phenomics 2019年第1期1卷 42-57页

作者： Sheng Chen Yiming Guo Xavier Sirault Katia Stefanova Renu Saradadevi neil CTurner Matthew NNelson Robert TFurbank Kadambot HMSiddique Wallace ACowling The UWA Institute of Agriculture The University of Western AustraliaPerthWA 6001Australia UWA School of Agriculture and Environment The University of Western AustraliaPerthWA 6001Australia High Resolution Plant Phenomics Centre Australian Plant Phenomics FacilityCSIRO Agriculture and FoodCanberraACT 2601Australia ARC Centre of Excellence for Translational Photosynthesis Australian National UniversityCanberraACT 2601Australia

Oilseed Brassica species are vulnerable to heat and drought stress,especially in the early reproductive *** evaluated plant imaging of whole plant and flower tissue,leaf stomatal conductance,leaf and bud temperature,photochemical reflectance index,quantumyield of photosynthesis,and leaf gas exchange for their suitability to detect tolerance to heat(H)and/or drought(d)stress treatments in 12 Brassica genotypes(G).A replicated factorial experiment was set up with 7 d of stress treatment fromthe beginning of anthesis with various levels of three factors H,d,and𝐺.Most phenomics tools detected plant stress as indicated by significant main effects of H,d,and H×*** plant volume was highly correlated with fresh weight changes,suggesting that whole plant imaging may be a useful surrogate for fresh weight in future ***,the maximum carboxylation rate of photosynthesis,increased rapidly on day 1 in H and H+d treatments,and there were significant interactions of G×H and G×*** of genotypes on day 1 inHandH+dtreatments was positively correlated with their harvested seed *** onday 1 andday3were clustered with seed yield in H and H+d treatments as shown in the heatmaps of genotypic ***,the rate of triose phosphate use,also showed significant positive genotypic correlations with seed yield in H+d *** volume showed significant interactions of G×H and G×d on day 7,and flower volume of genotypes on day 7 inHwas positively correlated with their harvested seed *** were few interactions of G×H or G×d for leaf stomatal conductance,leaf and bud temperature,photochemical reflectance index,and quantum yield of ***,TPU,and volume of flowers are potential nondestructive phenomic traits for heat or combined heat and drought stress tolerance screening in Brassica germplasm.

关键词： Species drought reflectance

Biochemical and Molecular Epidemiology of Cancer

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Biomedical and Environmental Sciences 1991年第Z1期 73-92页

作者： HARUHIKO SUGIMURA,AINSLEY WESTON,neil E.CAPORASO,PETER G.SHIELdS,ELISE d.BOWMAN,ROBERT A.METCALF,CURTIS C.HARRIS Laboratory of Human Carcinogenesis Laboratory of Human Carcinogenesis Environmental Epidemiology Branch National Cancer Institute National Institutes of Health Laboratory of Human Carcinogenesis Laboratory of Human Carcinogenesis Laboratory of Human Carcinogenesis Laboratory of Human Carcinogenesis Rockville Maryland 20892

Examples of practical approaches to molecular epidemiology of human cancer are described. Biomarkers of carcinogen exposure or inherited host factors for cancer susceptibility are discussed. Major advances have been made in the detection of carcinogenmacromolecular adducts through the use of high performance liquid chromatography, immunoaffinity chromatography, the32P-postlabeling assay, enzyme immunoassays, gas chromatography/mass spectroscopy and synchronous spectrophotofluorimetry. The polycyclic aromatic hydrocarbon-dNA adducts are the most extensively studied in this field and together with antibodies to these adducts found in human serum, they have become useful indicators of exposure to carcinogens. Assays for various kinds of alky1-dNA adducts have also been developed and the presence of these adducts have been documented in human tissues. Carcinogen-protein adducts have proven to be useful molecular dosimeters of carcinogen exposure. For example, 4-aminobiphenyl hemoglobin adducts are highl

关键词： gene dNA Biochemical and Molecular Epidemiology of Cancer

Effectiveness of an amino acid beverage formulation in diarrheapredominant irritable bowel syndrome:A pragmatic real-world study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2023年第5期14卷 39-49页

作者： Samantha E Niles Phil Blazy Samuel N Cheuvront Robert W Kenefick Sadasivan Vidyasagar Adam BSmith neil Fawkes William denman department of Research and development Entrinsic BioscienceNorwoodMA 02062United States department of Radiation Oncology University of FloridaGainesvilleFL 32611United States department of Anesthesiology Massachusetts General HospitalBostonMA 02114United States

BACKGROUNd Amino-acid based medical foods have shown promise in alleviating symptoms of drug induced gastrointestinal side effects;particularly,diarrhea-predominant *** bowel syndrome(IBS)is a gastrointestinal disorder that affects up to 9% of people globally,with diarrhea predominant IBS(IBS-d)being the most prevalent *** trials are needed to explore potential added benefits when integrated into standard care for *** To assess the effectiveness of an amino acid-based medical food as an adjunct to standard of care for adults with *** This is a pragmatic,real world,open label,single arm study comparing a 2-week baseline assessment to a 2-week intervention *** hundred adults,aged 18 to 65 years,with IBS-d,according to Rome IV criteria,were enrolled after completing a 2-week baseline assessment period and received a 2-week supply of an amino acid based medical food which was consumed at home twice daily on top of their standard of *** primary outcome was an assessment of tolerability after 2-weeks of consumption,while secondary outcomes included changes in stool consistency(Bristol Stool Form Scale),severity of abdominal pain&discomfort,symptoms of urgency,Global Improvement Survey(GIS),and the IBS severity scoring system(IBS-SSS).RESULTS The test product was well-tolerated as each participant successfully completed the full 14-day trial,and there were no instances of dropouts or discontinuation of the study product *** percent of participants achieved a 50% or more reduction in the number of days with type 6-7 bowel movements(IBS-d stool consistency responders).Fifty-three percent of participants achieved a clinically meaningful reduction of 30% in mean weekly pain scores,and 55%experienced the same for mean weekly discomfort scores(IBS-d pain and discomfort responders).Participants experienced a mean-109.4(95% confidence interval:-130.1,-88.8)point reduction on the IBS-SSS and 52% experienced a minimal

关键词： diarrhea-predominant irritable bowel syndrome Amino acid beverage formulation Pragmatic real-world study Medical food Bristol Stool Form Scale Irritable Bowel Syndrome–Severity Scoring System

2012~2021年国外六大监管机构新药审评情况分析:聚焦监管促进路径和国际化

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中国食品药品监管 2023年第6期 12-29页

作者： Juan Lara Magda Bujar neil McAuslane 张颖(编译) 国际监管科学创新研究中心(CIRS) 科睿唯安信息服务(北京)有限公司

本文介绍了国际监管科学创新中心(CIRS)对六大监管机构批准的新活性物质(NAS)的年度分析结果,重点分析了2021年NAS批准情况,并回顾了2012~2021年的情况。通过分析可以看出,尽管中位批准时间可以作为考量监管机构工作效率和药物获批上市... 详细信息

本文介绍了国际监管科学创新中心(CIRS)对六大监管机构批准的新活性物质(NAS)的年度分析结果,重点分析了2021年NAS批准情况,并回顾了2012~2021年的情况。通过分析可以看出,尽管中位批准时间可以作为考量监管机构工作效率和药物获批上市所需时间的重要指标,但同时也需要考虑其他因素,包括监管促进路径(FRP)、NAS的国际化以及新数据来源[包括真实世界数据(RWd)]的使用等。

关键词：监管机构批准时间监管促进路径

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异环磷酰胺治疗晚期头颈部癌的Ⅱ期临床研究——大剂量单药治疗及异环磷酰胺-顺铂联合化疗

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癌症 1992年第3期11卷 196-199页

作者： V.R.PAI d.M.parikh A.T.MAZUMdAR R.S.RAO 黄慧强 TATA纪念医院肿瘤内科 TATA纪念医院肿瘤外科印度孟买400012

作者共收治128例病理证实的晚期和/或复发头颈癌。64例用异环磷酰胺(IFO)1.5g/m^2×5天治疗,58例可评价,其中6例CR,25例PR,总有效率53％;另外64例采用IFO1.5g/m^2和ddP10mg/m^2各5天联合化疗,54例可以评价,其中7例CR,29例PR,总有效率67... 详细信息

作者共收治128例病理证实的晚期和/或复发头颈癌。64例用异环磷酰胺(IFO)1.5g/m^2×5天治疗,58例可评价,其中6例CR,25例PR,总有效率53％;另外64例采用IFO1.5g/m^2和ddP10mg/m^2各5天联合化疗,54例可以评价,其中7例CR,29例PR,总有效率67％。每4星期重复疗程,每例病人接受3疗程化疗。所有病人均可见到不同程度恶心、呕吐、脱发和白细胞下降。

关键词：头颈肿瘤异环磷酰胺

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