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Possible Cortical Spreading depression Recorded Intraoperatively Following a Generalized Seizure: Illustrative Case

Neuroscience & Medicine 2024年第3期15卷 119-128页

作者： Greg Schaublin Romina Shirka Nabil Azar Callan Broderick Jayson neil George R. Lee Kiara Ebinger Real Time Neuromonitoring Associates Nashville USA Real Time Tele-Epilepsy Consultants Nashville USA Seastnan Medical LLC Kansas City USA Midwest Neurosurgery Associates Kansas City USA Research Medical Center Kansas City USA

Background: We present a compelling case fitting the phenomenon of cortical spreading depression detected by intraoperative neurophysiological monitoring (IONM) following an intraoperative seizure during a craniotomy for revascularization. Cortical spreading depression (CSd, also called cortical spreading depolarization) is a pathophysiological phenomenon whereby a wave of depolarization is thought to propagate across the cerebral cortex, creating a brief period of relative neuronal inactivity. The relationship between CSd and seizures is unclear, although some literature has made a correlation between seizures and a cortical environment conducive to CSd. Methods: Intraoperative somatosensory evoked potentials (SSEPs) and electroencephalography (EEG) were monitored continuously during the craniotomy procedure utilizing standard montages. Electrophysiological data from pre-ictal, ictal, and post-ictal periods were recorded. Results: during the procedure, intraoperative EEG captured a generalized seizure followed by a stepwise decrease in somatosensory evoked potential cortical amplitudes, compelling for the phenomenon of CSd. The subsequent partial recovery of neuronal function was also captured electrophysiologically. discussion: While CSd is considered controversial in some aspects, intraoperative neurophysiological monitoring allowed for the unique analysis of a case demonstrating a CSd-like phenomenon. To our knowledge, this is the first published example of this phenomenon in which intraoperative neurophysiological monitoring captured a seizure, along with a stepwise subsequent reduction in SSEP cortical amplitudes not explained by other variables.

关键词： Cortical Spreading depression Electroencephalography Intraoperative Neurophysiological Monitoring Seizure

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Thermo-analytical study on stainless steelmaking dust

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Journal of Central South University of Technology 2003年第4期10卷 301-306页

作者：彭及彭兵余笛唐谟堂 neil souza Janusz A.Kozinski Jonathan Lobel School of Metallurgical Science and Engineering School of Information Science and Engineering department of Metallurgical Engineering

Thermo-gravimetric analyzer (TGA) was used to determine the thermal behavior of stainless steelmaking dust and FTIR was used to detect the components of off-gas. The TGA results indicate that three mass loss/gain stages exist in the thermal process. The mass loss of the dust in the first stage results from the evaporation of moisture and the reaction between dissociated carbon and metal oxides in the dust. The evaporation of moisture within the dust happens at 90-350 ℃ and the formation of carbon dioxide happens at 250-470 ℃. The mass gain of the dust in the second stage results from the oxidation of metals in the dust by the oxygen at 470-950 ℃. The third stage is a slow mass loss process, and some metals in the dust are evaporated into the atmosphere in this stage. The evaporation of metals is carried out mainly at 900-1 200 ℃ and the dust is sintered at high temperature over 1 200 ℃.

关键词： thermal analysis stainless steelmaking dust environmental protection

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The diagnostic conundrum in necrotizing otitis externa

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 59-65页

作者： Abiya A.Ahmed Shaan Rashid Vinay K.Gupta neil C.Molony Keshav K.Gupta Bradford Royal Infirmary Bradford Teaching Hospitals NHS Foundation TrustWest BromwichWest YorkshireUK Sandwell and West Birmingham Hospitals NHS Trust West BromwichUK Russells Hall Hospital DudleyUK

Necrotizing otitis externa(NOE)is an aggressive and fast‐evolving infection of the external auditory *** diagnoses and untreated cases can lead to severe,even fatal consequences and so early diagnosis and treatment are *** is a notoriously challenging diagnosis to *** is therefore important to understand what diagnostic modalities are available and how otolaryngologists can use them to accurately treat such an aggressive *** review aims to evaluate the different diagnostic options available in NOE and discuss their advantages and limitations,thus,providing an up‐to‐date picture of the multimodal approach required in the diagnosis of this disease.

关键词： diagnostic malignant otitis externa necrotizing osteomyelitis skull base osteomyelitis temporal bone osteomyelitis

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Intracranial pressure is elevated at 24h post-stroke inmice

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Neuroprotection 2024年第1期2卷 60-64页

作者： Kirby E.Warren Rebecca J.Hood Fredrick R.Walker neil J.Spratt School of Biomedical Sciences and Pharmacy University of NewcastleCallaghanAustralia Hunter Medical Research Institute NewLambton HeightsAustralia School of Biomedicine Discipline of Anatomy and PathologyFaculty of Health and Medical SciencesThe University of AdelaideAdelaideAustralia department of Neurology John Hunter HospitalNewLambton HeightsAustralia

Background:It has long been assumed that post-stroke intracranial pressure(ICP)elevation occurs because of large infarct and edema ***,we have repeatedly shown IcP elevation at 24 h post-stroke in the presence of little to no edema in *** processes are often conserved across species and types of ***,we aimed to determine if an ICP rise occurs at 24 h post-stroke in the presence of small infarct and edema volumes in ***:Mice were randomized by random number table to either photothrombotic stroke or sham surgery(n=15).Epidural ICP was recorded using a fiber optic catheter at 1 h post-stroke(baseline)and between 23 and ***:ICP was significantly higher at 24 h compared to baseline in stroke animals(n=6;10.71±6.45mmHg vs.3.74±2.20mmHg,respec-tively;p=0.03).ICP at 24 h was also significantly higher in stroke mice compared to sham(n=6;3.45±1.43mmHg;p=0.02).There was no change in ICP in sham mice(p=0.9).Edema volumes in stroke animals were small(0.04±0.04 mm3)and unlikely to have caused significant ICP ***:This study provides evidence of an edema-independent ICP elevation following small ischemic stroke in *** occurrence of this rise supports our findings in other species and suggests it is caused by a previously undescribed mechanism.

关键词： cerebraledema intracranial pressure ischemic stroke

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香港米埔湿地都市里的“绿野仙踪”

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森林与人类 2024年第8期 68-71页

作者：褚萌萌 neil Fifer(摄影) 新华社不详

香港米埔及内后海湾湿地被誉为“鸟类天堂”,这片湿地早在20世纪初就是传统的基围养殖区,基围虾塘还是香港的非物质文化遗产。负责管理这片湿地的世界自然基金会香港分会借鉴人类合理利用自然的传统经验,保留并经营着湿地的农渔业生产,... 详细信息

香港米埔及内后海湾湿地被誉为“鸟类天堂”,这片湿地早在20世纪初就是传统的基围养殖区,基围虾塘还是香港的非物质文化遗产。负责管理这片湿地的世界自然基金会香港分会借鉴人类合理利用自然的传统经验,保留并经营着湿地的农渔业生产,使米埔成为人与自然和谐共存的样板。

关键词：养殖区香港米埔世界自然基金会基围虾非物质文化遗产合理利用

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Brécey的美味评ATOLL IN400 SE合并式放大器

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视听前线 2024年第7期 15-18页

作者： neil Gader 剑萍(译) 不详

只要一想到法国,我的脑海马上就涌现出很多东西来。我开始回忆起米其林星级餐厅的美食,开车穿过普罗旺斯时的美景,新鲜的烘焙巧克力面包的味道,还有沿着塞纳河的漫步——好吧,你懂的。你也许奇怪为什么我完全忘记了这个国家蓬勃发展的... 详细信息

只要一想到法国,我的脑海马上就涌现出很多东西来。我开始回忆起米其林星级餐厅的美食,开车穿过普罗旺斯时的美景,新鲜的烘焙巧克力面包的味道,还有沿着塞纳河的漫步——好吧,你懂的。你也许奇怪为什么我完全忘记了这个国家蓬勃发展的音响产业?

关键词：合并式放大器普罗旺斯塞纳河巧克力

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Multimodality treatment of potentially curative gastric cancer: Geographical variations and future prospects

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World Journal of Gastroenterology 2014年第36期20卷 12892-12899页

作者： neil d Merrett discipline of Surgery School of Medicine University Of Western Sydney Penrith NSW 2751 Australia department of Upper Gastrointestinal Surgery Sydney South West Local Health District Liverpool NSW 2170 Australia

After much controversy, multimodality therapy is now accepted worldwide as the gold standard for treatment of resectable bulky localized gastric cancer. There is significant regional variation in the style of multimodality treatment with adjuvant chemoradiation the North American standard, neoadjuvant chemotherapy preferred in Europe and Australasia, whilst adjuvant chemotherapy is preferred in Asia. With further standardization of surgery and d1+/d2 resections increasingly accepted world wide, and in particular in the West, as the surgical standard of care for potentially curable disease, it is timely to reassess the multimodality regimes being used. The challenge in the use of multimodality therapy is how current outcomes can be standardized and improved further. Recent studies indicate that mere intensification of the regime in time, dosage or addition of further agents does not improve localized gastric cancer outcomes. More novel strategies including early commencement of adjuvant therapies, intra-peritoneal chemotherapy or assessing neoadjuvant response with positron emission tomography scanning may give improvements in outcomes. The introduction of targeted therapies means that the adjuvant use of biological agents needs to be explored. By proper assessment of the patient’s co-morbidities, full tumour staging, and a better understanding of the tumour’s molecular pathology, multimodality therapy for gastric adenocarcinoma may be individualized to optimize the likelihood of cure.

关键词： Gastric cancer Gastrectomy Multimodality Adjuvant treatment Neoadjuvant Targeted therapy Human epidermal growth factor receptor

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Psychiatric comorbidities in epilepsy:population co-occurrence,genetic correlations and causal effects

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General Psychiatry 2024年第1期37卷 103-111页

作者： Viktor H Ahlqvist Christina dardani Paul Madley-dowd Harriet Forbes Jessica Rast Caichen Zhong Renee M Gardner Christina dalman Kristen Lyal cRAIG Newschaffer Torbjorn Tomson Michael Lundberg daniel Berglind neil M davies Brian K Lee Cecilia Magnusson dheeraj Rai department of Global Public Health Karolinska InstitutetStockholmSweden Medical Research Council Integrative Epidemiology Unit Bristol Medical SchoolUniversity of BristolBristolUK Centre for Academic Mental Health Population Health SciencesBristol Medical SchoolUniversity of BristolBristolUK Faculty of Epidemiology and Population Health London School of Hygiene and Tropical MedicineLondonUK A.J.drexel Autism Institute Drexel UniversityPhiladelphiaPAUSA department of Epidemiology and Biostatistics School of Public HealthDrexel UniversityPhiladelphiaPAUSA College of Health and Human development Pennsylvania State UniversityState CollegePAUSA department of Clinical Neuroscience Karolinska InstitutetStockholmSweden Centre for Epidemiology and Community Medicine Region StockholmStockholmSweden K.G Jebsen Center for Genetic Epidemiology Department of Public Health and NursingNorwegian University of Science and TechnologyTrondheimNorway division of Psychiatry University Collge LondonLondonUK department of Statistical Sciences University Cllge LondonLondonK NIHR Biomedical Research Centre University of BristoBristolUK Avon and Wiltshire Partnership NHS Mental Health TrustBristolUK

Background Psychiatric comorbidities are common in patients with *** for the co-occurrence of psychiatric conditions and epilepsy remain poorly *** We aimed to triangulate the relationship between epilepsy and psychiatric conditions to determine the extent and possible origins of these *** Using nationwide Swedish health registries,we quantified the lifetime prevalence of psychiatric disorders in patients with *** then used summarydata from genome-wide association studies to investigate whether the identified observational associations could be attributed to a shared underlying genetic aetiology using cross-trait linkage disequilibrium score ***,we assessed the potential bidirectional relationships using two-sample Mendelian *** In a cohort of 7628495 individuals,we found that almost half of the 94435 individuals diagnosed with epilepsy were also diagnosed with a psychiatric condition in their lifetime(adjusted lifetime prevalence,44.09%;95%confidence interval(Cl)43.78%to 44.39%).We found evidence for a genetic correlation between epilepsy and some neurodevelopmental and psychiatric *** example,we observed a genetic correlation between epilepsy and attention-deficit/hyperactivity disorder(r,=0.18,95%Cl 0.09 to 0.27,pd in focal epilepsy(r=0.23,95%CI 0.09 to 0.36,pdings from Mendelian randomisation using common genetic variants did not support bidirectional effects between epilepsy and neurodevelopmental or psychiatric *** Psychiatric comorbidities are common in patients with *** correlations may partially explain some comorbidities;however,there is little evidence of a bidirectional relationship between the genetic liability of epilepsy and psychiatric *** findings highlight the need to understand the role of environmental factors or rare genetic variations in the origins of psy

关键词： epilepsy Psychiat lifetime

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新奥尔良当代艺术中心共享办公室美国新奥尔良

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世界建筑导报 2024年第1期39卷 74-78页

作者：无 neil Alexander(摄影) Sara Essex Bradley(摄影) EdR建筑事务所不详

The Shop是一个综合的联合办公项目,位于新奥尔良市中心,坐落在新奥尔良市当代艺术中心(CAC)的三层和四层。面向科技、艺术和文化事业,The Shop成为发展中的创新工业的创业者中心。这座历史悠久的建筑之前被用做K&B的总部和一个杂货冷饮... 详细信息

The Shop是一个综合的联合办公项目,位于新奥尔良市中心,坐落在新奥尔良市当代艺术中心(CAC)的三层和四层。面向科技、艺术和文化事业,The Shop成为发展中的创新工业的创业者中心。这座历史悠久的建筑之前被用做K&B的总部和一个杂货冷饮店,70年代中期被用作当代艺术中心。顶部两层在过去40年中一直没有被充分利用,The Shop的开发标志着对这一空间的第一次大规模整修。

关键词：联合办公当代艺术中心新奥尔良市美国新奥尔良 Shop 冷饮店办公室杂货

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Multivariate Approach to Characterizing Soil Quality of Gabonese’s Ferralitic Soils

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Open Journal of Soil Science 2024年第4期14卷 237-268页

作者： neil-Yohan Musadji Rolf Gaël Mabicka Obame Michel Mbina Mounguengui Jean Aubin Ondo Lydie-Stella Koutika Eric Ravire Claude Geffroy Laboratoire de Chimie Des Milieux et Des Mat&#233riaux Inorganiques Laboratoire D&#8217Analyse Des Sols et Environnement D&#233partement Des Sciences Fondamentales De L&#8217Ing&#233nieur Institut National D&#8217Agronomie et De Biotechnologies Universit&#233 Des Sciences et Techniques De Masuku Franceville Gabon Institut de Chimie des Milieux et Maté riaux De Poitiers (IC2MP) Universit&#233 De Poitiers Poitiers France Laboratoire de Chimie Des Milieux et Des Mat&#233riaux Inorganiques Laboratoire D&#8217Analyse Des Sols et Environnement D&#233partement De Phytotechnologie Institut National D&#8217Agronomie et De Biotechnologies Universit&#233 Des Sciences et Techniques De Masuku Franceville Gabon dé partement De G&#233ologie Facult&#233 Des Sciences Universit&#233 Des Sciences et Techniques De Masuku Franceville Gabon Laboratoire Pluridisciplinaire des Sciences Ecole Normale Sup&#233rieure Libreville Gabon Centre de Recherche Sur La Productivité et La Durabilit&#233 Des Plantations Industrielles Pointe Noire Republic of Congo Sucaf Gabon Somdiaa Franceville Gabon

Assessing soil quality is essential for crop management and soil temporal changes. The present study aims to evaluate soil quality in the Ferralitic soils context countrywide. This assessment was done using multivariate soil quality indice (SQI) models, such as additive quality index (AQI), weighted quality indexes (WQIadd and WQIcom) and Nemoro quality index (NQI), applied to two approaches of indicator selection: total data set (TdS) and minimum data set (MdS). Physical and chemical soil indicators were extracted from the ORSTOM’s reports resulting from a sampling campaign in different provinces of Gabon. The TdS approach shows soil quality status according to eleven soil indicators extracted from the analysis of 1,059 samples from arable soil layer (0 - 30 cm depth). The results indicated that 87% of all provinces presented a very low soil quality (Q5) whatever the model. Among soil indicators, exchangeable K+ and Mg2+, bulk density and C/N ratio were retained in MdS, using principal component analysis (PCA). In the MdS approach, 50 to 63% of provinces had low soil quality grades with AQI, WQIadd and NQI, whereas the total was observed with WQIcom. Only 25% of provinces had medium soil quality grades with AQI and NQI models, while 12.5% (NQI) and 25% (AQI) presented high quality grades. Robust statistical analyses confirmed the accuracy and validation (0.80 r P ≤ 0.016) of AQI, WQIadd and NQI into the TdS and MdS approaches. The same sensitivity index value (1.53) was obtained with AQI and WQIadd. However, WQIadd was chosen as the best SQI model, according to its high linear regression value (R2 = 0.82) between TdS and MdS. This study has important implications in decision-making on monitoring, evaluation and sustainable management of Gabonese soils in a pedoclimatic context unfavorable to plant growth.

关键词： Gabon Ferralitic Soil Soil Indicators Standard Score Function Soil Quality Indices Sustainable Soil Soil Management

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