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Timing of Surgery and Complications of Acute Appendicitis:A Retrospective Study

Surgical Science 2019年第5期10卷 147-153页

作者： Ricardo Purchio Galletti Vinicius Oliveira Fernandes neil Ferreira Novo Willy Marcus Franca Faculty of Medical Science and Health PUC/SP(FCMSPUC/SP)SorocabaBrazil Department of Medicine Service of Statistical Studies of PUC/SPSorocabaBrazil Laboratory of Surgery Technique and Experimental Surgery of FCMS PUC/SPFaculty of Medical Science and HealthSorocabaBrazil

Introduction: Acute appendicitis (AA) is the most frequent surgical condition of the abdomen during childhood. Its clinical presentation in children under 5 may be atypical and thus causes a delay in diagnosis, which often leads to complications such as perforation and peritonitis. Patients with unperforated AA at hospital admission may have their surgery postponed up to 24 hours while antibiotics are initiated without significant increase in complications, instead of undergoing immediate surgery. Immediate surgery to prevent complications has been questioned. Delaying surgery in patients admitted to hospital with AA has not increased the risk of perforation. Objective: To determine the impact of timing of surgery of patients with AA admitted to our Pediatric Surgery Ward of the Sorocaba Hospital Complex of the Medical Science and Health Faculty (CHS-PUC/SP) on the rate of complications (perforation, peritoneal drainage and infection of the surgical wound). Methods: We reviewed the records of 195 children aged 4 to 12 years, admitted between 2010 and 2014. They were separated in 2 groups according to timing of surgery under 7 hours (group A) and 7 to 24 hours (group b) and had their rate of complications (infection of the surgical wound, drainage and perforation (grade IV) assessed. Results: Ninety-seven children underwent surgery less than 7 hours after admission (group A) and 98 children were operated between 7 and 24 hours after admission (group b). Groups A and b had no significant difference regarding the rates of wound infection (p = 0.2277), peritoneal drain insertion (p = 0.4085) or perforation (p = 0.7125). Conclusions: In our study, timing of surgery for AA had no impact on the occurrence of complications, such as infection of the surgical wound, peritoneal drainage or perforation.

关键词： Acute Appendicitis Intrabdominal Abscess Antibiotic Therapy Appendix Perforation

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Almond Consumption Is Associated with better Nutrient Intake, Nutrient Adequacy, and Diet Quality in Adults: National Health and Nutrition Examination Survey 2001-2010

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Food and Nutrition Sciences 2016年第7期7卷 504-515页

作者： Carol E. O’neil Theresa A. Nicklas Victor L. Fulgoni III Louisiana State University Agricultural Center Baton Rouge LA USA USDA/ARS Children’s Nutrition Research Center Department of Pediatrics Baylor College of Medicine Houston TX USA Nutrition Impact LLC Battle Creek MI USA

Purpose: The purpose of this study was to examine the association between almond consumption, the most widely consumed tree nut in the US, and nutrient intake, nutrient adequacy, diet quality, and weight/adiposity in adults. Methods: Data from adults (N=24,808), 19+ years, participating in the NHANES 2001-2010 were used. The NCI method was used to estimate the usual intake of almonds and selected nutrients. Almond consumers were defined as those consuming any amount of almonds/almond butter. Percentages of the consumers/non-consumers below the Estimated Average Requirement (EAR) or above the Adequate Intake (AI) for select nutrients were determined. To assess significant differences for the percentage of almond consumers vs. non-consumers with intakes less than the EAR or above the AI, a Z-statistic for differences in population proportions was used. Covariate-controlled linear regression was used to determine differences in diet quality, measured by the Healthy Eating Index-2010 (HEI-2010), between the consumer groups. body mass indices and waist circumference were assessed. P was set at p be non-Hispanic white, older, of higher income, more physically active, and were less likely to be a current smoker than non-consumers. Usual intake of almonds among consumers was 29.5 ± 1.5 g/day. Usual intake of protein;dietary fiber;vitamins A, D, E, and C;thiamin;niacin;riboflavin;folate, calcium, copper, magnesium, iron, phosphorus, selenium, zinc, and potassium was higher in almond consumers. Almond consumers were less likely to be below the EAR for protein, vitamins A, D, E, b12, and C;riboflavin;calcium;copper;magnesium;iron;phosphorus;and zinc. They were also more likely to be above the AI for dietary fiber and potassium. Total HEI-2010 scores were approximately 15 points higher in almond consumers. body mass indices and waist circumference measures were lower in almond consumers. Conclusions: Moderate consumption of

关键词： Almond Consumption Tree Nut Consumption Diet Quality Nutrients Nutrient Adequacy Adults NHANES

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在新计算机的bIOS中可以找到什么

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电子与电脑 2001年第7期1卷 94-95页

作者： neil Randall

尽管b1OS经常被大家所忽视,不过它可以决定你新买的计算机的潜力.作为有经验的计算机用户,当你购买计算机时免不了要问诸如什么类型的CPU、硬盘的大小和速度、内存和显存的大小以及插槽和驱动器架的数量之类的问题.然而,经常被遗漏就是b... 详细信息

尽管b1OS经常被大家所忽视,不过它可以决定你新买的计算机的潜力.作为有经验的计算机用户,当你购买计算机时免不了要问诸如什么类型的CPU、硬盘的大小和速度、内存和显存的大小以及插槽和驱动器架的数量之类的问题.然而,经常被遗漏就是b1OS.

关键词：计算机 bIOS 性能操作系统硬盘启动选项

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药物的不良反应

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英国医学杂志中文版 1998年第2期1卷 77-81页

作者： Munir Pirmohamed Alasdair M breckenridge neil R Kitteringham b Kevin Park 冷希圣 Department of Pharmacology and Therapeutics University of Liverpool Box 147Liverpool 169 3BX senior lecturer in clinical pharmacology Department of Pharmacology and Therapeutics University of Liverpool Box 147Liverpool L69 3BX professor of clinical pharmacology Department of Pharmacology and Therapeutics University of Liverpool Box 147Liverpool L69 3BX senior lecturer in pharmacology Department of Pharmacology and Therapeutics University of Liverpool Box 147Liverpool L69 3BX professor of pharmacology

所谓药物的不良反应是指在药物的临床应用过程中,伴随预期治疗效果而出现的副作用。与此有区别的是,药物的严重意外反应则是指病人应用某种药物时出现没有预料到的严重问题,但这种严重意外却与该药的药理学特性无关,也就是说有的病人可... 详细信息

所谓药物的不良反应是指在药物的临床应用过程中,伴随预期治疗效果而出现的副作用。与此有区别的是,药物的严重意外反应则是指病人应用某种药物时出现没有预料到的严重问题,但这种严重意外却与该药的药理学特性无关,也就是说有的病人可能发生,有的不一定发生。

关键词：不良反应药物治疗药理学特性预期治疗效果毒性机制临床应用过程药理学方面代谢产物特异体质临床试验

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Inconel 601合金在高温硼硅酸盐核废物玻璃熔体中的腐蚀行为

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材料热处理学报 2017年第11期38卷 92-100页

作者：毛仙鹤袁晓宁 Clive T brigden 陶钧 neil C Hyatt Michal Miekina Russell JHand 西北核技术研究所陕西西安710024 谢菲尔德大学材料科学与工程系固化科学实验室

研究了Inconel 601合金在普通硼硅酸盐核废物玻璃(MW)和添加ZnO、Mn_2O_3改性的硼硅酸盐玻璃(MZMF)的1060℃高温熔体中浸泡168 h和336 h的腐蚀行为,利用扫描电子显微镜和能谱仪、X射线衍射分析仪,研究了合金与玻璃的腐蚀界面的表面形貌... 详细信息

研究了Inconel 601合金在普通硼硅酸盐核废物玻璃(MW)和添加ZnO、Mn_2O_3改性的硼硅酸盐玻璃(MZMF)的1060℃高温熔体中浸泡168 h和336 h的腐蚀行为,利用扫描电子显微镜和能谱仪、X射线衍射分析仪,研究了合金与玻璃的腐蚀界面的表面形貌、元素组成以及相结构变化。结果表明:合金表面生成了Cr_2O_3层,其中合金在MW中的腐蚀深度比在MZMF中大10μm;在MW熔体中,MgO、Fe_2O_3和Cr_2O_3反应生成MgCr_2O_4和FeCr_2O_4,破坏了合金和玻璃之间的Cr_2O_3层,使该层呈碎片状。在MZMF高温熔体中长期浸泡后,合金表面形成的Cr_2O_3层呈连续均匀的状态,并且Cr_2O_3层外附着一层含b、O、Fe、Mn、Zn的锯齿状化合物,阻碍了Cr_2O_3层与MgO或其他化学物质反应,减缓了合金的腐蚀速率。

关键词： Inconel 601合金高温腐蚀硅酸盐玻璃核废物

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耕作对东北黑土团聚体粒级分布及其稳定性的短期影响

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土壤学报 2009年第1期46卷 154-158页

作者：梁爱珍张晓平杨学明 neil McLaughlin 申艳李文凤中国科学院东北地理与农业生态研究所长春130012 加拿大农业与农业食品部Harrow研究中心加拿大农业与农业食品部东部谷物与油种研究中心中国科学院研究生院北京100049

土壤团聚体粒级分布是作物发芽和出苗以及根系发展的重要影响因子,其团聚作用在土壤固碳过程中具有不可或缺的贡献,团聚体的结构性破坏将导致土壤有机质的流失,而团聚体稳定性直接影响着土壤侵蚀程度.

关键词：耕作水稳性团聚体质量分形维数

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热情或冷淡对教学能力的影响

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心理学探新 1989年第2期14卷 49-52页

作者：陈纪方荆建华 W.neil Wildmeyer Tohn W.Loy 河南教育学院教育系

我们检验了凯利的热情或冷淡控制对于人的第一印象和教学能力影响的研究。一位主持人以宝座教授的身分给240名大学生上了一堂课。在他到来之前,半数受试了解到他是一个相当热情的人,另一半受试则得知他是冷淡的,照此办理,告诉上述每一... 详细信息

我们检验了凯利的热情或冷淡控制对于人的第一印象和教学能力影响的研究。一位主持人以宝座教授的身分给240名大学生上了一堂课。在他到来之前,半数受试了解到他是一个相当热情的人,另一半受试则得知他是冷淡的,照此办理,告诉上述每一组中的一半受试他是一位体育教授,另一半受试则被告知他是社会心理学教授。对2(热情或冷淡条件)×2(主持人的专业)×2(受试的性别)的多元方差分析表明:(a)预先得知主持人是热情的受试比被告知他是冷淡的受试更倾向于认为他是一个有能力的教师,一个令人愉快,和蔼可亲,温文尔雅,幽默活泼的人。(b)主持人的专业和受试的性别都不影响受试对教师的认知。结果讨论涉及到晕轮、前后关系和身分影响的问题。

关键词：教师教学能力主持人社会心理学冷淡凯利第一印象人格品质体育评价学生

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Risk factors of extraneural spreading in astrocytomas and oligodendrogliomas in donors with gliomas: A systematic review

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World Journal of Transplantation 2022年第6期12卷 131-141页

作者： Serena Ammendola Valeria barresi Elena bariani Ilaria Girolami Antonia D’Errico Matteo brunelli Massimo Cardillo Letizia Lombardini Amedeo Carraro Ugo boggi Owen Cain Desley neil Albino Eccher Section of Pathology Department of Diagnostics and Public HealthUniversity of VeronaVerona 37134Italy Division of Pathology Central HospitalBolzano 39100Italy Department of Experimental Diagnostic and Specialty Medicine(DIMES)University of BolognaBologna 40138Italy National Transplant Center Istituto Superiore di SanitàRome 00161Italy General Surgery and Liver Transplant Unit Verona University HospitalVerona 37126Italy Division of General and Transplant Surgery Pisa University HospitalPisa 56126Italy Department of Cellular Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Department of Pathology and Diagnostics Verona University HospitalVerona 37126Italy

bACKGROUND Patients with a history of primary brain tumors can be eligible for organ donation under extended *** risk assessment of tumor transmission via organ transplant in primary brain tumors is primarily based on the assessment of tumor histotype and *** surgeries,chemo-/radiotherapy,and ventriculoperitoneal shunt placement can lead to a disruption of the blood-brain barrier,concurring to an increase in the transmission *** To investigate the role of tumor transmission risk factors in donors with oligodendrogliomas and *** We searched PubMed and EMbASE databases for studies reporting extraneural spreading of oligoden-drogliomas and astrocytomas and extracted clinical-pathological data on the primary tumor histotype and grade,the elapsed time from the diagnosis to the onset of metastases,sites and number of metastases,prior surgeries,prior radiotherapy and/or chemotherapy,ventriculoatrial or ventriculo-peritoneal shunt placement,and the presence of isocitrate dehydrogenase 1/2 mutation and 1p/19q *** analysis was performed using R *** correlation between chemotherapy or radiotherapy and the presence of multiple extra-central nervous system metastases was analyzed usingχ2 and Fischer exact *** Kaplan-Meier method was used to evaluate the presence of a correlation between the metastasis-free time and:(1)Localization of metastases;(2)The occurrence of intracranial recurrences;and(3)The occurrence of multiple *** Data on a total of 157 patients were *** time from the initial diagnosis to metastatic spread ranged from 0 to 325 mo in patients with oligodendrogliomas and 0 to 267 mo in those with ***,19%and 39%of patients with oligodendroglioma and astrocytoma did not receive any adjuvant *** most frequent metastatic sites were bone,bone marrow,and lymph *** lungs and the liver were the most commonly involved visceral ***

关键词： Metastatic gliomas Extra-central nervous system metastases Tumor transmission Expanded donor Risk factors Transplantation

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Free electron lasers driven by plasma accelerators:status and near-term prospects

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High Power Laser Science and Engineering 2021年第4期9卷 112-126页

作者： C.Emma J.Van Tilborg R.Assmann S.barber A.Cianchi S.Corde M.E.Couprie R.D'Arcy M.Ferrario A.F.Habib b.Hidding M.J.Hogan C.b.Schroeder A.Marinelli M.Labat R.Li J.Liu A.Loulergue J.Osterhoff A.R.Maier b.W.J.Mc neil W.Wang SLAC National Accelerator Laboratory Menlo ParkCA 94025USA bELLA Center Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Deutsches Elektronen-Synchrotron DESY 22607 HamburgGermany INFN-LNF 00044 FrascatiItaly LOA ENSTA ParisCNRSEcole PolytechniqueInstitut Polytechnique de Paris91762 PalaiseauFrance Synchrotron SOLEIL L'Orme des MerisiersSaint-Aubin91192 Gif-sur-YvetteFrance Scottish Centre for the Application of Plasma-based Accelerators SCAPA Department of PhysicsUniversity of StrathclydeScottish Universities Physics Alliance SUPAGlasgow G11XQUK Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China Department of Physics University of StrathclydeScottish Universities Physics Alliance SUPAGlasgow G1IXQUK Cockcroft Institute Warrington WA44ADUK

Owing to their ultra-high accelerating gradients,combined with injection inside micrometer-scale accelerating wakefield buckets,plasma-based accelerators hold great potential to drive a new generation of free-electron lasers(FELs).Indeed,the first demonstration of plasma-driven FEL gain was reported recently,representing a major milestone for the *** groups around the world are pursuing these novel light sources,with methodology varying in the use of wakefield driver(laser-driven or beam-driven),plasma structure,phase-space manipulation,beamline design,and undulator technology,among *** paper presents our best attempt to provide a comprehensive overview of the global community efforts towards plasma-based FEL research and development.

关键词： plasma accelerators free electron lasers novel light sources

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Synthesis, SAR, and in Silico ADME Screening Studies of Some 9-Amino-3-Phenylacridone Derivatives as Topoisomerase II Inhibitors

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Open Journal of Medicinal Chemistry 2023年第2期13卷 15-34页

作者： Abiodun S. Oyedele Toluwase H. Fatoki Esha Dalvie neil Osheroff Cosmas O. Okoro Department of Chemistry Tennessee State University Nashville Tennessee USA Applied bioinformatics Laboratory Department of Biochemistry Federal University Oye-Ekiti Oye-Ekiti Nigeria Departments of biochemistry Vanderbilt University School of Medicine Nashville Tennessee USA Medicine (Hematology/Oncology) Vanderbilt University School of Medicine Nashville Tennessee USA Vanderbilt Institute of Chemical biology Vanderbilt University School of Medicine Nashville Tennessee USA

Cancer is a leading cause of death globally, claiming about 9.6 million lives and approximately 420 million new cases of cancer will be diagnosed in the world by the year 2025. The aim of this study was to synthesize and computationally evaluate pharmacological potential of some derivatives of 9-amino-3-phenylacridone, as topoisomerase II (Topo II) inhibitors. In this study, 10 derivatives of 3-phenyl-9-aminoacridone were chemically synthesized and characterized, and the potential pharmacological indications of these compounds were computationally predicted by methods such as ADMET prediction, molecular target prediction and molecular docking. The results showed that two derivatives (58e and 58j) were non-permeant of blood-brain barrier, and this property was found similar to that of amsacrine and etoposide. The results of molecular docking of the ten derivatives of 3-phenyl-9-aminoacridone that were synthesized in this work showed that the synthetic compounds (58a-j) and the standard drugs have overall best binding affinities for human acetylcholine esterase than butyrylcholinesterase, and overall best binding affinities for human topo IIα than human topo IIβ. Overall, the results of this study suggest that the synthetic compounds 58a, 58c, 58f, 58g, and 58i could probably inhibit topo IIα by catalytic inhibition as seen with amsacrine, but only 58b and 58e possessed DNA non-intercalation properties as seen with etoposide, serving as topo II poison. In conclusion, this study showed that 3-phenyl-9-aminoacridone derivatives are potential inhibitor of topo IIα/β both by catalytic inhibition and poison as non-intercalator of DNA.

关键词： Cancers 9-Aminoacridone Anticancer Topoisomerase II Pharmacokinetics Molecular Docking Etoposide

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