检索结果-南通市图书馆

水稻抗稻瘟病菌防卫反应的细胞学分析与防卫基因表达研究

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

水稻抗稻瘟病菌防卫反应的细胞学分析与防卫基因表达研究

Synthesis of Substituted benzothiazepine Compounds with Medicinal Potential

第六届中国科学家论坛

作者：王忠华贾育林林卉 barbara Valent J．neil Rutger

本实验对水稻类病变坏死突变体1mml（LmmKaty）与原亲本及双单倍体 YT14和 YT16接种稻瘟病菌 24h 内的抗病反应、细胞学和分子作用机理进行了研究。人工接种实验表明,与原亲本相比,该突变体对稻瘟病菌具有更强的抗性。细胞自动荧光分析... 详细信息

本实验对水稻类病变坏死突变体1mml（LmmKaty）与原亲本及双单倍体 YT14和 YT16接种稻瘟病菌 24h 内的抗病反应、细胞学和分子作用机理进行了研究。人工接种实验表明,与原亲本相比,该突变体对稻瘟病菌具有更强的抗性。细胞自动荧光分析发现,突变体接种20-24h 后会出现自动荧光检测,而对照则不会发生。表明该突变体通过细胞程序性死亡阻止稻瘟病菌的蔓延,从而提高了抗病性。Northern blotting 结果发现,抗病品系 YT14中的防卫相关基因、苯丙氨酸解氨酶基因和 b-葡聚糖酶基因在人工接种稻瘟病菌6h 后开始表达,16-24h 后上述基因表达量快速增加;而病程相关蛋白基因 PR-1和几丁质酶基因在人工接种稻瘟病菌24h 后才开始表达。与 YT14相比,感病品系中上述基因的表达明显延迟。由此表明,在人工接种稻瘟病菌24h 内水稻可启动抗病防卫反应,从而对稻瘟病菌产生抗性。

关键词：水稻类病变突变体抗病性细胞学防卫反应

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

International Journal of Organic Chemistry 2020年第3期10卷 123-134页

作者： Clare E. Gutteridge brett W. Sadowski Stephen M. Hughes J. Alan Friedlander Leighton G. Rodrigo Michael C. baxter Nathan C. Lorei Jonathan E. Harrell Michael T. O’neil Department of Chemistry United States Naval Academy Annapolis MD USA Division of Experimental Therapeutics Walter Reed Army Institute of Research Silver Spring MD USA

A versatile synthetic approach toward a series of benzothiazepines with medicinal potential (for example, compound 1) that allows incorporation of structural variation at the three aromatic regions of the structure, and at the sulfur atom, was developed. Knoevenagel condensation of indan-1,3-diones with benzaldehydes, yielded 2-benzylidineindan-1,3-diones, which undewent thio-Michael addition and intramolecular imine formation upon reaction with 2-aminothiophenols, to produce the target benzothiazepines. Use of indan-1,3-diones, benzaldehydes or 2-aminothiophenols bearing further substitution enabled production of novel 5,11-dihydro-12H-benzo[b]indeno [1,2-e][1,4]thiazepin-12-one analogs 1 - 14, including compounds bearing substitution at novel positions within the scaffold.

关键词： benzothiazepine Knoevenagel Condensation Thio-Michael Addition benzylidene Indandione 2-Aminothiophenol

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

惯性导航传感器

战术导弹控制技术 2010年第1期17卷 40-42页

作者： neil M. barbour 尚克军（译）刘峰（译）林思刚（译）杜祖良（校译）曲蕴杰（审译） Charles Stark Draper Laboratory Cambridge MA 02139 USA 不详

在诸多导航应用领域．最重要的需求并非是提高导航系统的精度／性能，而是在满足性能需求的前提下降低成本、减小体积。特别是小型导航传感器使得制导、导航、控制产品应用到以前认为不可能的应用场合的时候（如炮弹、制导弹药）。环形... 详细信息

在诸多导航应用领域．最重要的需求并非是提高导航系统的精度／性能，而是在满足性能需求的前提下降低成本、减小体积。特别是小型导航传感器使得制导、导航、控制产品应用到以前认为不可能的应用场合的时候（如炮弹、制导弹药）。环形激光陀螺（RLG）、光纤陀螺（FOG）和微机电系统（MEMS）陀螺及加速度计这三大技术推动了导航技术在军事和商业领域的发展。环形激光陀螺和光纤陀螺已经成熟，但后者仍在持续发展，MEMS技术则是一个非常活跃的研发领域。本文对于这几方面的进展情况都将进行描述，重点放在MEMS传感器的设计和性能方面，与特定传感器性能相关的一些的推动因素将被提及。文章的最后对各种传感器技术的未来发展及应用进行了预测。

关键词：导航传感器环形激光陀螺 MEMS传感器性能需求产品应用惯性 MEMS技术制导弹药

Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Medicine 2021年第2期15卷 275-291页

作者： Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig Ebojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike bickeboller Gadi Rennert Susanne Arnold Paul brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson neil Caporaso Penella Woll Philip Lazarus Matthew bSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China State Key Laboratory of Reproductive Medicine Center for Global HealthNanjing Medical UniversityNanjing 211166China Department of bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing 211166China Jiangsu Key Lab of Cancer biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer MedicineNanjing Medical UniversityNanjing 211166China China International Cooperation Center for Environment and Human Health School of Public HealthNanjing Medical UniversityNanjing 211166China Division of Cancer Epidemiology and Genetics National Cancer InstituteBethesdaMD 20892-9304USA Department of Integrative Oncology British Columbia Cancer AgencyVancouverBC V5Z 1L3Canada Faculty of Medicine University of Oviedo and CIBERESPOviedo 33006Spain Program in Epidemiology Public Health Sciences DivisionFred Hutchinson Cancer Research CenterSeattleWA 98109-1024USA Public Health Sciences Division Swedish Cancer InstituteSeattleWA 98026USA Department of Clinical biochemistry Copenhagen University HospitalCopenhagen DK-1017Denmark National Cancer Institute BethesdaMD 20892-9304USA Genetic Epidemiology Group International Agency for Research on CancerLyon 69372France Cancer Center Cluster Salzburg at PLUS Department of Molecular BiologyUniversity of SalzburgHeidelberg 5020Austria Institute of Medical Informatics Biometry and EpidemiologyChair of EpidemiologyLudwig Maximilians UniversityMunichBavaria 80539Germany Department of Genetic Epidemiology University Medical Center GoettingenGoettingen 37075Germany Technion Faculty of Medicine Carmel Medical CenterHaifa 3448516Israel Markey Cancer Center University of KentuckyLexingtonKY 40506-0054USA Department of Molecular and Clinical Cancer Medicine Roy Castle Lung Cancer Research ProgrammeThe University of Liverpool Institute of Translational MedicineLiverpool L697Z

Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely *** integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility *** identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive *** factor enrichment analysis revealed that USF1 was AD-specific while CREb1 was *** annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency *** results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments.

关键词： lung cancer genome-wide association study function annotation immune homologous recombination repair deficiency genetic heterogeneity

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

荧光碳点的快速宏量制备及多功能应用

Engineering 2017年第3期 263-277页

作者：王丹王志勇詹求强蒲源王洁欣 neil R. Foster 戴黎明 beijing Advanced Innovation Center for Soft Matter Science and Engineering & State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Center of Advanced Science and Engineering for Carbon (Case4Carbon) Department of Macromolecular Science and Engineering Case School of EngineeringCase Western Reserve University SCNU-ZJU Joint Research Center of Photonics South China Academy of Advanced Optoelectronics South China Normal University Department of Chemical Engineering Curtin University

荧光纳米材料在化学传感、生物成像及光电器件等领域具有重要应用前景,其合成方法的研究得到广泛关注。我们采用柠檬酸和乙二胺作为原料,在150℃、常压的相对温和条件下,通过"一锅法"反应制备了氮掺杂荧光碳点。所得荧光碳点光学带隙为3... 详细信息

荧光纳米材料在化学传感、生物成像及光电器件等领域具有重要应用前景,其合成方法的研究得到广泛关注。我们采用柠檬酸和乙二胺作为原料,在150℃、常压的相对温和条件下,通过"一锅法"反应制备了氮掺杂荧光碳点。所得荧光碳点光学带隙为3.4 e V,在单光子或双光子激发下呈现出明亮的荧光,且荧光发射波长稳定(λ=450 nm)。基于荧光碳点低细胞毒性和长荧光寿命的优势,实现了荧光碳点作为离体肿瘤细胞(He La细胞)标记和荧光寿命成像探针的应用,获得了高对比度的荧光寿命成像结果。通过将所得荧光碳点与普通油墨混合制备均匀分散的荧光墨水,可用于普通纸张及其他基材(如柔性塑料薄膜、纺织品、衣服)的荧光图案化,为固态荧光传感、荧光防伪标记和可穿戴光电子设备应用研究提供了基础。

关键词：宏量碳点双光子荧光寿命成像图案化

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

现代语言学乔姆斯基革命的结果 1

现代语言学乔姆斯基革命的结果

1983年

作者：（英）尼尔·史密斯（neil Smith）（英）达埃德尔·威尔逊（Deirdre Wilson）李谷城等译

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

让内容创作为你的品牌服务

新营销 2013年第9期15卷 86-86页

作者： neil Mody 陈晓芝

内容为王，这是大家都在热烈讨论的话题。然而2013年b2b内容营销基准报告却发现，只有36％的企业认为它们的内容营销是有效的。为什么呢？简单地说，有这么多竞争对手，营销人要竞争的不仅是制造的内容是否充实，而且是那些内容是否真... 详细信息

内容为王，这是大家都在热烈讨论的话题。然而2013年b2b内容营销基准报告却发现，只有36％的企业认为它们的内容营销是有效的。为什么呢？简单地说，有这么多竞争对手，营销人要竞争的不仅是制造的内容是否充实，而且是那些内容是否真正有用户参与，可以证明他们的投入是有效的。

关键词：内容品牌服务创作竞争对手营销人用户参与 b2b 企业

MEDICATION USE AND THE RISK OF STEVENS-JOHNSON SYNDROME OR TOXIC EPIDERMAL NECROLYSIS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MEDICATION USE AND THE RISK OF STEVENS-JOHNSON SYNDROME OR T...

大豆-小麦-玉米轮作体系下长期施肥对大豆田土壤线虫种群结构的影响

中成药上市后药物流行病学评价培训会议

作者： JEAN-CLAUDE ROUJEAU JUDITH P.KELLY LUIGI NALDI bERTHOLD RZANY RObERT S.STERN THERESA ANDERSON ARIANE AUQUIER SYLVIE bASTUJI-GARIN OSVALDO CORREIA FRANCESCO LOCATI MAJA MOCKENHAUPT CATHERINE PAOLETTI SAMUEL SHAPIRO neil SHEAR ERWIN SCHPF DAVID W.KAUFMAN Department of Dermatology Universite Paris Ⅻ CreteilFrance M.D. the Slone Epidemiology Unit Boston University School of MedicineBostonM.S. Gruppo Italiano Studi Epidemiologici in Dermatologia Department of DermatologyUniversita degli Studi di MilanoBergamoItalyM.D. the Department of Dermatology Beth Israel HospitalHarvard Medical SchoolBostonM.D. the Slone Epidemiology Unit Boston University School of MedicineBostonR.N. the Department of biostatistics and Epidemiology INSERM Unite 351Institut Gustave-RoussyVillejuifFranceM.S. the Department of Public Health Universite Paris Ⅻ CreteilFranceM.D. Grupo Portugues EIYS Department of Dermatology and ImmunologyHospital S.JoaoFaculdade de MedicinaPortoPortugalM.D. the Department of biostatistics and Epidemiology INSERM Unite 351Institut Gustave-RoussyVillejuifFrance the Slone Epidemiology Unit Boston University School of MedicineBostonM.B.F.R.C.P.(E.) the Department of Pharmacology Sunnybrook Health Science CentreTorontoM.D. the Slone Epidemiology Unit Boston University School of MedicineBostonSC.D.

*** epidermal necrolysis and Stevens-Johnson syndrome are rare,life-threatening, drug-induced cutaneous *** conducted a case-control study to quantify the risks associated with the use of specific drugs. *** were obtained through surveillance networks in France,Germany,Italy,and *** use before the onset of disease was compared in 245 people who were hospitalized because of toxic epidermal necrolysis or Stevens-Johnson syndrome and 1147 patients hospitalized for other reasons(controls).Crude relative risks were calculated and adjusted for confounding by multivariate methods when numbers were large enough. *** drugs usually used for short periods, the risks were increased for trimethoprim-sulfamethoxazole and other sulfonamide antibiotics(crude relative risk,172;95 percent confidence interval,75 to 396), chlormezanone(crude relative risk,62;21 to 188),aminopenicillins (multivariate relative risk,6.7;2.5 to 18), quinolones(multivariate relative risk,10;2.6 to 38),and cephalosporins(multivariate relative risk,14;3.2 to 59). For acetaminophen,the multivariate relative risk was 0.6 (95 percent confidence interval,0.2 to 1.3) in France but 9.3(3.9 to 22) in the other *** drugs usually used for months or years,the increased risk was confined largely to the first two months of treatment, when crude relative risks were as follows:carbamazepine, 90(95 percent confidence interval,19 to∞);phenobarbital, 45(19 to 108);phenytoin,53(11 to∞);valproic acid,25(4.3 to∞);oxicam nonsteroidal antiinflammatory drugs(NSAIDs),72(25 to 209);allopurinol,52(16 to 167);and corticosteroids,54(23 to 124).For many drugs,including thiazide diuretics and oral hypoglycemic agents,there was no significant increase in risk. *** use of antibacterial sulfonamides, anticonvulsant agents,oxicam NSAIDs,allopurinol,chlormezanone, and corticosteroids is associated with large increases in the risk of Stevens-Johnson syndrome or toxic epi

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

大豆科技 2011年第1期 37-37页

作者： FengjuanPan neil b．McLaughlin QingYu Allen G．Xue YanliXu XiaozengHan ChunjieLi DanZhao 战丽莉（摘译）

本文对长期施肥大豆-小麦-玉米轮作体系下，大豆田土壤线虫种群结构做以研究。试验小区施肥长达13年，包括三种施肥处理：不施肥（NF）、化肥（尿素和磷酸氢二铵，CF）和化肥配施有机肥（MCF）。在5～10月大豆的5个生长期取样，用于计... 详细信息

本文对长期施肥大豆-小麦-玉米轮作体系下，大豆田土壤线虫种群结构做以研究。试验小区施肥长达13年，包括三种施肥处理：不施肥（NF）、化肥（尿素和磷酸氢二铵，CF）和化肥配施有机肥（MCF）。在5～10月大豆的5个生长期取样，用于计算土壤线虫的种群结构和生态指数。施肥对植物寄生线虫、食细菌和食真菌线虫丰富度具有显著影响（P〈0．05），但对总土壤线虫和杂食一捕食线虫影响不显著。

关键词：种群结构肥料土壤线虫大豆土壤性质