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An Analytic Method for Designing Countermeasures against Computer Intrusions

通讯和计算机（中英文版） 2014年第1期11卷 10-21页

作者： Joshua Ojo Nehinbe Solanke Olakunle O. nehibe johnson ige UK College of Business and Computing llford Essex London IG2 6NW United Kingdom Department of Computer Science Olabisi Onabanjo University Ago lwoye Nigeria Internal Control Nebson Limited Lagos Nigeria

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SRS27,a semisynthetic diterpenoid lactone,inhibits airway inflammation and hyper-responsiveness via NF-κB pathway in an allergic mouse asthma model

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中国药理学与毒理学杂志 2015年第S1期29卷 53-53页

作者： Jonathan Chee Woei LIM Fera Yiqian GOH Sreenivasa Rao SAGINEEDU Audrey Chee Hui YONG Shiran Mohd SIDIK Nordin Haji LAJIS Wai-Shiu Fred WONG johnson STANSLAS Pharmacotherapeutics Unit Department of MedicineFaculty of Medicine and Health SciencesUniversiti Putra Malaysia Department of Pharmacology Yong Loo Lin School of MedicineNational University Health System Laboratory of Natural Products Institute of BioscienceUniversiti Putra Malaysia Faculty of Pharmacy Segi University College 9Jalan Teknologi Histopathology Unit Department of PathologyFaculty of Medicine and Health SciencesUniversiti Putra Malaysia Immunology Program Life Science InstituteNational University of Singapore

Andrographis paniculata contains two main diterpenoid constituents,andrographolide(AGP)and 14-deoxy-11,12-didehydroandrographolide(DDAG),which were found to exhibit antiasthma effects in a mouse asthma ***,due to inadequacies of both compounds in terms of drug-likeness,DDAG analogues were semisynthesised to tackle these *** objective of the study was to investigate the potential of DDAG analogues as new antiasthma *** the analogues,(SRS27)was proven to inhibit cysteinyl leukotrienes(CysLT)and nitric oxide(NO)synthesis in mouse macrophages,like ***,on the other hand,failed to exhibit such ***27 is less cytotoxic than AGP,suggests that a simple chemical modification of DDAG produces a compound with CysLT and NO inhibitory activites similar to AGP while maintaining toxicity profile similar to *** is interesting to note that other analogues such as SRS28,SRS49,SRS76 and SRS83 with chemical modifications on the same carbon numbers 3 and 19 of DDAG were unable to show inhibition of CysLT and NO ***,the potential anti-inflammatory effect of SRS27 was investigated in ovalbumin(OVA)-induced mouse asthma *** compound was administered in a prophylactic manner and showed a substantial decrease in mouse asthma model ***27 at 3mg·kg-1 significantly reduced OVA-induced total cell such as macrophages,eosinophils,lymphocytes and neutrophils,as well as inflammatory cytokines such as IL-4,IL-5,IL-13 and eotaxin in bronchoalveolar lavage BAL *** compound also suppressed serum ige *** addition,SRS27 suppressed mucus hyper-secretion and expression of inflammatory mediators such as TNF-α,MCP-1,Muc5 ac,RANTES,IL-33 and ***27 is the first known DDAG derivative tested positive in mouse asthma model and as such SRS27 could serve as a prototype prophylactic agent.

关键词： NF-κB A549cell line andrographolide analogues nitr

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