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Applied Mathematics 2015年第8期6卷 1208-1213页

作者： Nita H. Shah Bij.l M. Yeolekar nehal j. shukla Department of Mathematics Gujarat University Ahmedabad India Department of Mathematics Columbus State University Columbus USA

In this paper, we analyse population dynamics of liquor habit. Liquor free and Liquor endemic equilibrium are computed. The local and global stabilities of the proposed problem are established. The numerical simulatio... 详细信息

关键词： Liquor Habit Basic Reproduction Number Local Stability Global Stability State-Space Simulation

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Quality of life assessment in patients with chronic pancreatitis receiving antioxidant therapy

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World j.urnal of Gastroenterology 2010年第32期16卷 4066-4071页

作者： nehal S Shah Alistair j.Makin Aali j.Sheen Aj.th K Siriwardena Hepatobiliary Surgery Unit Manchester Royal InfirmaryManchester M13 9WLUnited Kingdom Department of Gastroenterology Manchester Royal InfirmaryManchester M13 9WLUnited Kingdom

AIM:To undertake a baseline study comparing quality of life(QoL) in patients with chronic pancreatitis(CP) on Antox to those with CP,matched for disease duration,who were not on this ***:CP was defined according to the Zurich *** eight consecutive patients with CP who were taking Antox(antioxidants) were compared with 69 consecutive control CP patients not on *** Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core questions 30 and Pancreatic Modification(28 questions) were used to assess *** of a total of 137 patients 28 in each group were matched for disease duration(within 12 mo).Median disease duration was 8(1-22) years in the Antox group and 7(1-23) years in the Non-Antox cohort(P = NS,Mann-Whitney U-test).Other parameters(age,gender,etiology,endocrine and exocrine insufficiency) were similar between ***:Median visual analogue pain score in the Antox group was 3(0-8) compared with 6(0-8) in the Non-Antox group(P < 0.01).Perceptions of cognitive,emotional,social,physical and role function were impaired in the Non-Antox group compared to Antox patients(P < 0.0001,P = 0.0007,P = 0.0032 and P < 0.005 and P < 0.001,respectively).Analgesics and opiate usage was significantly lower in the Antox group(P < 0.01).Overall physical health and global QoL was better in the Antox group(P < 0.0001,95% CI:1.5-3).CONCLUSION:Contemporary quality of life assessments show that after correction for disease duration and cigarette smoking,patients with CP taking antox had better scores than non-antox controls.

关键词： Chronic pancreatitis Antioxidants Quality of life Assessment Management

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Risk scoring model for prediction of non-home discharge after transcatheter aortic valve replacement

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j.urnal of Geriatric Cardiology 2020年第10期17卷 621-627页

作者： Alexis K Okoh Ebru Ozturk j.stin Gold Emaad Siddiqui nehal Dhaduk Bruce Haik Chun-Guang CHEN Marc Cohen Mark j.Russo Cardiovascular Outcomes Research Institute RWJ Barnabas Health-NBIMCNewarkNew JerseyUSA Department of Medicine Division of BiostatisticsHacettepe UniversityAnkaraTurkey Rutgers New j.rsey Medical School NewarkNew JerseyUSA Department of Surgery Division of Cardiothoracic SurgeryRutgers Robert Wood Johnson Medical SchoolNew BrunswickNew JerseyUSA

Background Patients undergoing transcatheter aortic valve replacement(TAVR) are likely to be discharged to a location other than home. We aimed to determine the association between preoperative risk factors and non-home discharge after TAVR. Methods Patients discharged alive after TAVR at three centers were identified from a prospectively maintained database randomly divided into 80% derivation and 20% validation cohorts. Logistic regression models were fit to identify preoperative factors associated with non-home discharge in the derivation cohort. Multivariable models were developed and a nomogram based risk-scoring system was developed for use in preoperative counseling. Results Between j.ne 2012 and December 2018, a total of 1,163 patients had TAVR at three centers. Thirty-seven patients who died before discharge were excluded. Of the remaining 1,126 patients(97%) who were discharged alive, the incidence of non-home discharge was 25.6%(n = 289). The patient population was randomly divided into the 80%(n = 900) derivation cohort and 20%(n = 226) validation cohort. Mean ± SD age of the study population was 83 ± 8 years. In multivariable analysis, factors that were significantly associated with non-home discharge were extreme age, female sex, higher STS scores, use of general anesthesia, elective procedures, chronic liver disease, non-transfemoral approach and postoperative complications. The unbiased estimate of the C-index was 0.81 and the model had excellent calibration. Conclusions One out of every four patients undergoing TAVR is discharged to a location other than home. Identification of preoperative factors associated with non-home discharge can assist patient counseling and postoperative disposition planning.

关键词： Aortic valve replacement Non-home discharge Postoperative risk Transcatheter Transfemoral

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A Pilot Trial Testing the Feasibility of Using Molecular-Guided Therapy in Patients with Recurrent Neuroblastoma

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j.urnal of Cancer Therapy 2012年第5期3卷 602-612页

作者： Giselle L. Saulnier Sholler William Ferguson Genevieve Bergendahl Erika Currier Shannon R. Lenox j.ffrey Bond Marni Slavik William Roberts Deanna Mitchell Don Eslin j.cqueline Kraveka j.el Kaplan nehal Parikh Suman Malempati Gina Hanna Emily Eugster David Cherba j.remy Miller Craig Webb Cardinal Glennon Children’s Hospital Saint Louis University School of Medicine St. Louis University St. Louis USA Center for Cancer Genomics and Computational Biology Pediatric Oncology Translational Research Program at the Van Andel Research Institute in Grand Rapids Grand Rapids USA Center for Children’s Cancer and Blood Disorders Arnold Palmer Hospital for Children MD Anderson Cancer Center Orlando Orlando USA Department of Pediatric Oncology Helen DeVos Children’s Hospital Michigan State University Grand Rapids USA Department of Pediatric Oncology Oregon Health Science University Portland USA Division of Hematology/Oncology 2j Connecticut Children’s Medical Center Hartford USA Pediatric Hematology/Oncology Medical University of South Carolina Charleston USA Pediatric Oncology Levine Children’s Hospital Charlotte USA Rady Children’s Hospital San Diego University of California San Diego School of Medicine at the University of California San Diego San Diego USA Vermont Cancer Center Department of Medicine University of Vermont Burlington USA

Background: Neuroblastoma is the most common extracranial solid tumor in children, and treatment options for recurrent neuroblastoma are limited. Using molecular profiling to target the molecular vulnerabilities of neuroblastoma with existing therapeutic agents may result in a rational, data-driven approach with potential to improve clinical outcomes. Methods: The primary obj.ctive of this pilot study was to evaluate the feasibility of supporting real-time treatment decisions through predictive modeling of genome-wide mRNA gene expression data from neuroblastoma tumor biopsies. Feasibility was defined as completion of tumor biopsy, histopathological evaluation, RNA extraction and quality control, gene expression profiling within a CLIA-certified laboratory, bioinformatic analysis, generation of a drug predicttion report, molecular tumor board review yielding a formulated treatment plan, and independent medical monitor review within a 2-week period. Results: Five patients with multiply relapsed or refractory neuroblastoma were enrolled between April and j.ne 2010. All biopsies passed histopathology and RNA quality control. Generation of gene expression data and its analysis (3-7 days), reports which linked this data into medically actionable drug candidates (1-5 days), molecular tumor board (1-3 days) and independent medical monitor review (1 day) were all completed in real-time. The average time was 10.5 days for all patients. Conclusion: This study shows that it is feasible to create therapeutic treatment plans based on genomic profiling in less than 12 days. This warrants further testing in a Phase I study to determine safety of predicted treatments and evaluate whether the information obtained in these analyses would result in patient benefit.

关键词： Neuroblastoma Molecular Guided Therapy Predictive Therapies Molecular Profiling Genomic Profiling Pediatric Cancer

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美国放射学院适宜性标准:肩关节置换术后影像学检查(续)

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中华肩肘外科电子杂志 2017年第4期5卷 299-304页

作者：张晓萌陈建海 Soterios Gyftopoulos Zehava S.Rosenberg Catherine C.Roberts j.nny T.Bencardino Marc Appel Steven j.Baccei R.Carter Cassidy Eric Y.Chang Michael G.Fox Bennett S.Greenspan Mary G.Hochman j.n A.j.cobson Douglas N.Mintz j.el S.Newman nehal A.Shah Kirstin M.Small Barbara N.Weissman 北京大学人民医院创伤骨科 100044 纽约大学医疗中心纽约市纽约关节病医院纽约市梅奥诊所亚利桑那州凤凰城纽约大学医学院纽约市 j.mes j.Peters VA医疗中心纽约市马萨诸塞大学医疗中心伍斯特英国医疗脊柱和全关节服务列克星敦 VA圣地亚哥医疗系统圣地亚哥弗吉尼亚卫生系统夏洛茨维尔奥古斯塔大学佐治亚州医学院奥古斯塔贝斯以色列女执事医疗中心波士顿密歇根大学医疗中心安娜堡纽约特种外科医院纽约市新英格兰浸信会医院波士顿布列根和妇女医院波士顿

过去的20年里,在美国实施的肩关节置换术的数量迅速增长,其中包括部分或全肱骨头表面置换术、半肩置换术、全肩关节置换术和反式全肩关节置换术。影像学检查在诊断这些肩关节置换术引起的并发症方面起到了重要作用。本综述分为两个部分... 详细信息

过去的20年里,在美国实施的肩关节置换术的数量迅速增长,其中包括部分或全肱骨头表面置换术、半肩置换术、全肩关节置换术和反式全肩关节置换术。影像学检查在诊断这些肩关节置换术引起的并发症方面起到了重要作用。本综述分为两个部分。第一部分阐述了对各种影像学检查模式的总体探讨,包括X线片、计算机断层扫描、核磁共振成像、超声、核医学以及它们提供有益的以治疗为导向的信息时所发挥的作用。第二部分重点研究最佳影像学方法的选择,用于肩关节置换术的并发症,包括无菌性松动、感染、骨折、肩袖肌腱撕裂和神经损伤。在本报告中所提供的美国放射学院适宜性标准循证指南,是通过广泛分析来自同行评审期刊的现有医学文献,并应用行之有效的方法学而完成的(兰德/加州大学洛杉矶分校的适宜性方法以及推荐评价、发展和评估分级),它们用于特殊临床情况下的影像学检查和治疗措施的适宜性评价。多学科专家小组对指南进行了进一步的分析和审查。由于用于推荐合适成像算法的数据会出现不足或模棱两可,在这种情况下,专家意见可能对现有证据进行补充。为此,将美国《放射学院适宜性标准:肩关节置换术后影像学检查》翻译成中文,供同道参考。

关键词：全肩关节置换术美国放射学院影像学检查适宜性标准核磁共振成像计算机断层扫描循证指南

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