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“A stitch in time”: Intraoperative diaphragmatic injury during laparoscopic nephrectomy - A case of immediate recognition and expert management

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第1期7卷 44-47页

作者： Prakash Gyandev Gondode Sridhar Panaiyadiyan neha.garg Sakshi Duggal Department of Anaesthesiology Pain Medicine and Critical Care All India Institute of Medical SciencesNew DelhiIndia Department of Urology All India Institute of Medical SciencesNew DelhiIndia

Laparoscopy within the urology field has undergone a noteworthy surge in popularity over the past decade,with particular importance given to renal surgeries such as simple nephrectomy,radical nephrectomy,donor nephrectomy,nephroureterectomy,and partial nephrectomy.1 This shift toward laparoscopic procedures among urologists can be attributed to the many benefits of these procedures,including reduced postoperative pain,shorter hospital stays,and faster recovery times.2 However,as with any evolving surgical technique,laparoscopic procedures in renal surgery bring forth their own set of distinctive challenges and complications.

关键词： nephrectomy faster attributed

Iron supplementation during malaria infection in pregnancy and childhood:A review

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Asian Pacific Journal of Tropical Medicine 2024年第1期17卷 12-20页

作者： neha Surela Amrendra Chaudhary Poonam Kataria Jyoti Das National Institute of Malaria Research Sector-8DwarkaNew Delhi-110077India

Malaria presents a significant global public health challenge,with severe malarial anaemia being a primary manifestation of the *** understanding of anaemia caused by malaria remains incomplete,making the treatment more *** is a crucial micronutrient essential for haemoglobin synthesis,oxygen delivery,and other vital metabolic functions in the *** is indispensable for the growth of human beings,as well as bacteria,protozoa,and viruses in vitro and in *** deficiency is among the most common nutritional deficiencies and can have detrimental effects during developmental stages of ***-induced iron deficiency occurs due to the hemolysis of erythrocytes and the suppression of erythropoiesis,leading to *** iron requirements is particularly critical during pivotal life stages such as pregnancy,infancy,and *** intake alone may not suffice to meet adequate iron requirements,thus highlighting the vital role of iron *** iron supplementation can alleviate iron deficiency,it can exacerbate malaria infection by providing additional iron for the ***,in the context of pregnancy and childhood,iron supplementation combined with malaria prevention and treatment has been shown to be beneficial in improving birth outcomes and ensuring proper growth and development,*** review aims to identify the role and impact of iron supplementation in malaria infection during the life stages of pregnancy and childhood.

关键词： Iron supplementation Malaria Pregnancy Childhood

Covalent Bond Based Android Malware Detection Using Permission and System Call Pairs

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Computers, Materials & Continua 2024年第3期78卷 4283-4301页

作者： Rahul Gupta Kapil Sharma R.K.garg Department of Information Technology Delhi Technological UniversityNew Delhi110042India Department of Mechanical Engineering Deenbandhu Chhotu Ram University of Science and TechnologyMurthal131039India

The prevalence of smartphones is deeply embedded in modern society,impacting various aspects of our *** versatility and functionalities have fundamentally changed how we communicate,work,seek entertainment,and access *** the many smartphones available,those operating on the Android platform dominate,being the most widely used *** widespread adoption of the Android OS has significantly contributed to increased malware attacks targeting the Android ecosystem in recent ***,there is an urgent need to develop new methods for detecting Android *** literature contains numerous works related to Android malware *** far as our understanding extends,we are the first ones to identify dangerous combinations of permissions and system calls to uncover malicious behavior in Android *** introduce a novel methodology that pairs permissions and system calls to distinguish between benign and malicious *** approach combines the advantages of static and dynamic analysis,offering a more comprehensive understanding of an application’s *** establish covalent bonds between permissions and system calls to assess their combined *** introduce a novel technique to determine these pairs’Covalent Bond Strength *** pair is assigned two scores,one for malicious behavior and another for benign *** scores serve as the basis for classifying applications as benign or *** correlating permissions with system calls,the study enables a detailed examination of how an app utilizes its requested permissions,aiding in differentiating legitimate and potentially harmful *** comprehensive analysis provides a robust framework for Android malware detection,marking a significant contribution to the *** results of our experiments demonstrate a remarkable overall accuracy of 97.5%,surpassing various state-of-the-art detection techniques proposed in the current literature.

关键词： Android malware android security hybrid analysis permission and system call pairs

Immune consequences of exercise in hypoxia:A narrative review

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Journal of Sport and Health Science 2024年第3期13卷 297-310,I0002页

作者： Johannes Burtscher Qadar Pasha neha Chanana Gregoire P.Millet Martin Burtscher Barbara Strasser Institute of Sport Sciences University of LausanneLausanne 1015Switzerland Institute of Hypoxia Research New Delhi 110067India Department of Biochemistry Jamia HamdardNew Delhi 110062India Department of Sport Science University of InnsbruckInnsbruck 6020Austria Faculty of Medicine Sigmund Freud Private UniversityVienna 1020Austria Ludwig Boltzmann Institute for Rehabilitation Research Vienna 1100Austria

Immune outcomes are key mediators of many health benefits of exercise and are determined by exercise type,dose(frequency/duration,intensity),and individual ***,reduced availability of ambient oxygen(hypoxia)modulates immune functions depending on the hypoxic dose and the individual capacity to respond to *** combined exercise and hypoxia(e.g.,high-altitude training)sculpts immune responses is not well understood,although such combinations are becoming increasingly ***,in this paper,we summarize the impact on immune responses of exercise and of hypoxia,both independently and together,with a focus on specialized cells in the innate and adaptive immune *** review the regulation of the immune system by tissue oxygen levels and the overlapping and distinct immune responses related to exercise and hypoxia,then we discuss how they may be modulated by nutritional ***,antioxidant,and anti-inflammatory mechanisms underlie many of the adaptations that can lead to improved cellular metabolism,resilience,and overall immune functions by regulating the survival,differentiation,activation,and migration of immune *** review shows that exercise and hypoxia can impair or complement/synergize with each other while regulating immune system *** acclimatization,training,and nutritional strategies can be used to avoid risks and tap into the synergistic potentials of the poorly studied immune consequences of exercising in a hypoxic state.

关键词： Altitude Exercise Hypoxia Immune response Training

Repeated pregnancy losses with multiple aneuploidies and major genomic imbalance:A case report

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Asian pacific Journal of Reproduction 2024年第3期13卷 143-146页

作者： Shailesh Pande Shiny Babu Harshavardhan Gawde neha Minde Genetic Research Center ICMR-National Institute for Research in Reproductive and Child HealthJehangir Merwanji StreetParelMumbai-400012India

Rationale:If one of the partners is having balanced autosomal translocation,it is usually observed that the offspring inherit either normal chromosomes,balanced translocation identical to one of the parent or unbalanced chromosomal rearrangements of the same parental chromosome having ***:A unique case presented with history of 8 miscarriages for genetic *** last abortus material evaluation showed monosomy of chromosome X(Turner syndrome)in all the analyzed *** was a history of infertility and also repeated second trimester abortions on the paternal *** the maternal side,there was a history of intellectual ***:History of repeated abnormal pregnancy ***’s karyotype is normal;however,husband shows translocation between chromosome 4 and ***:Peripheral blood sample around 3 mL was collected for *** biopsy was done and DNA was extracted and processed for whole exome ***:Wife’s karyotype is normal and husband has translocation between chromosome 4 and ***,the entire pregnancy outcome including embryo screening has different,complete or partial aneuploidies of chromosomes other than chromosome 4 and *** lesson:Though the translocation in one of the parent is balanced,we have to think beyond traditional ways for evaluating a couple with repeated pregnancy loss as we cannot predict the errors at cell *** of in vitro fertilization and preimplantation genetic diagnosis in couples having balanced translocations should be discussed so that early intervention can prevent the agony of pregnancy loss.

关键词： In vitro fertilization Karyotype Products of conception Preimplantation genetic testing PGT Recurrent pregnancy loss

garg incontinence scores: New scoring system on the horizon to evaluate fecal incontinence. Will it make a difference?

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World Journal of Gastroenterology 2024年第3期30卷 204-210页

作者： Petr Tsarkov Inna Tulina Parvez Sheikh Darya D Shlyk Pankaj garg Department of Colorectal Surgery Sechenov First Moscow State Medical UniversityMoscow 119991Russia Department of Oncologic Colorectal Surgery Sechenov First Moscow State Medical UniversityMoscow 119991Russia Department of Colorectal Surgery Saifee HospitalMumbai 400004MaharashtraIndia Department of Colorectal Surgery Garg Fistula Research InstitutePanchkula 134113HaryanaIndia

The main aim of this opinion review is to comment on the recent article published by garg et al in the World Journal of Gastroenterology 2023;29:4593–*** authors in the published article developed a new scoring system,garg incon-tinence scores(GIS),for fecal incontinence(FI).FI is a chronic debilitating disease that has a severe negative impact on the quality of life of the *** IV criteria define FI as multiple episodes of solid or liquid stool passed into the clothes at least twice a *** associated social stigmatization often leads to significant under-reporting of the condition,which further impairs *** important point is that the complexity and vagueness of the disease make it difficult for the patients to properly define and report the magnitude of the problem to their *** to this,the management becomes even more *** issue is resolved up to a considerable extent by a scoring *** were several scoring systems in use for the last three *** prominent of them were the Cleveland Clinic scoring system or the Wexner scoring system,*** Hospital or Vaizey’s scores,and the FI severity ***,there were several shortcomings in these scoring *** the opinion review,we tried to analyze the strength of GIS and compare it to the existing scoring *** main pitfalls in the existing scoring systems were that most of them gave equal weightage to different types of FI(solid,liquid,flatus,etc.),were not comprehensive,and took only the surgeon’s perception of FI into *** GIS,almost all shortcomings of previous scoring systems had been addressed:different weights were assigned to different types of FI by a robust statistical methodology;the scoring system was made comprehensive by including all types of FI that were previously omitted(urge,stress and mucus FI)and gave priority to patients’rather than the physicians’perceptions while developing the scoring *** to this,GIS in

关键词： Fecal incontinence Scoring system Urge Stress Flatus

Exploring the combination of biochar‐amended soil and automated irrigation technology for water regulation and preservation in green infrastructure

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Deep Underground Science and Engineering 2024年第1期3卷 39-52页

作者： Honghu Zhu Yuanxu Huang Haihong Song Jian Chen Songlei Han Tanwee Mazumder Ankit garg School of Earth Sciences and Engineering Nanjing UniversityNanjingChina Department of Civil and Smart Engineering Construction Guangdong Engineering Center for Structure Safety and Health MonitoringShantou UniversityShantouChina Shanghai Municipal Engineering Design Co. LtdShanghaiChina Indian Institute of Technology Madras ChennaiIndia

Biochar is a carbon sink material with the potential to improve water retention in various ***,for the long‐term maintenance of green infrastructure,there is an additional need to regulate the water contents in the covers to maintain vegetation growth in semiarid *** this study,biochar‐amended soil was combined with subsurface drip irrigation,and the water preservation characteristics of this treatment were investigated through a series of one‐dimensional soil column *** ascertain the best treatment method specific to semiarid climatic conditions,the test soil was amended with 0%,1%,3%,and 5%*** irrigation devices equipped with soil moisture sensors were used to control the subsurface water content with the aim of enhancing vegetation *** soil column test lasted 150 h,during which the volumetric water contents and soil suction data were *** experimental results reveal that the soil specimen amended with 3%biochar is the most water‐saving regardless of the time *** with a higher biochar content(e.g.,5%)consumes a more significant amount of water due to the enhancement of the water‐holding *** on the experimental results,it can be concluded that the appropriate ratio can be determined within 1%–3%,which can reduce not only the amount of irrigated/used water but also the time *** technology can be explored for water content regulation in green infrastructure and the development of barriers for protecting the environment around deep underground waste containment.

关键词： biochar drip irrigation underground water preservation water regulation

Overlap in oncogenic and pro-inflammatory pathways associated with areca nut and nicotine exposure

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Cancer Pathogenesis and Therapy 2024年第3期2卷 187-194页

作者： Krati garg Anuj Kumar Vidisha Kizhakkethil Pramod Kumar Shalini Singh Department of Biochemical Engineering and Biotechnology Indian Institute of Technology(IIT)DelhiDelhi 110016India Division of Molecular Biology ICMR-National Institute of Cancer Prevention and Research(ICMR-NICPR)Indian Council of Medical ResearchNoidaUttar Pradesh 201301India Department of Biotechnology Vellore Institute of Technology(VIT)VelloreTamil Nadu 632024India ICMR-National Institute of Cancer Prevention&Research(ICMR-NICPR) Indian Council of Medical ResearchNoidaUttar Pradesh 201301India

Background:Betel nut/areca nut/Areca catechu is one of the most commonly used psychoactive substance,and is also a major preventable cause of *** other psychoactive substances,such as nicotine,the mechanisms underlying addiction to areca nuts and related oncogenesis remain *** reports suggest a possible overlap in the mechanisms of action of nicotine and areca nuts in the human ***,this study aimed to investigate the interactome of human proteins associated with areca nut exposure and the intricate similarities and differences in the effects of the two psychoactive substances on ***:A list of proteins associated with areca nut use was obtained from the available literature using terms from Medical Subject Headings(MeSH).Protein-protein interaction(PPI)networks and functional enrichment were *** results obtained for both psychoactive substances were ***:Given the limited number of common proteins(36/226,16%)in the two sets,a substantial overlap(612/1176 nodes,52%)was observed in the PPI networks,as well as in Gene *** nuts mainly affect signaling pathways through three hub proteins(alpha serine/threonine-protein kinase,tumor protein 53,and interleukin-6),which are common to both psychoactive substances,as well as two unique hub proteins(epidermal growth factor receptor and master regulator of cell cycle entry and proliferative metabolism).Areca nut-related proteins are associated with unique pathways,such as extracellular matrix organization,lipid storage,and metabolism,which are not found in nicotine-associated ***:Areca nuts affect regulatory mechanisms,leading to systemic toxicity and *** nuts also affect unique pathways that can be studied as potential markers of exposure,as well as targets for anticancer therapeutic agents.

关键词： Cancer Areca nut Nicotine Interactome Cell signaling

Readmission rate and early complications in patients undergoing total knee arthroplasty:A retrospective study

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World Journal of Orthopedics 2024年第8期15卷 713-721页

作者： Tushar Jethi Deepak Jain Rajnish garg Harpal Singh Selhi Department of Orthopedics Fortis Hospital LudhianaLudhiana 141123PunjabIndia Department of Orthopedics Dayanand Medical College&HospitalLudhiana 141001PunjabIndia Department of Orthopedic Surgery Dayanand Medical College&HospitalLudhiana 141001PunjabIndia

BACKGROUND Total knee arthroplasty(TKA)can improve pain,quality of life,and functional *** uncommon,postoperative complications are extremely consequential and thus must be carefully tracked and communicated to patients to assist their decision-making before *** of the risk factors for complications and readmissions after TKA,taking into account common causes,temporal trends,and risk variables that can be changed or left unmodified,will benefit this *** To assess readmission rates,early complications and their causes after TKA at 30 days and 90 days *** This was a prospective and retrospective study of 633 patients who underwent TKA at our hospital between January 1,2017,and February 28,*** the 633 patients,28 were not contactable,leaving 609 who met the inclusion *** inpatient and outpatient hospital records were retrieved,and observations were noted in the data collection *** Following TKA,the 30-day and 90-day readmission rates were determined to be 1.1%(n=7)and 1.8%(n=11),*** unplanned visit rate at 30 days following TKA was 2.6%(n=16)and at 90 days was 4.6%(n=28).At 90 days,the unplanned readmission rate was 1.4%(n=9).Reasons for readmissions included medical(27.2%,n=3)and surgical(72.7%,n=8).Unplanned readmissions and visits within 90 days of follow-up did not substantially differ by age group(P=0.922),body mass index(BMI)(P=0.633),unilateral vs bilateral TKA(P=0.696),or patient comorbidity status(30-day P=0.171 and 90-day P=0.813).Reoperation rates after TKA were 0.66%(n=4)at 30 days and 1.15%(n=8)at 90 *** average length of stay was 6.53 *** In this study,there was a low readmission rate following *** was no significant correlation between readmission rate and patient factors such as age,BMI,and co-morbidity status.

关键词： Total knee arthroplasty Length of stay Readmission Rates Causes Risk factors Prospective Retrospective Follow-up Reoperation