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Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

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Oncology Research 2024年第1期32卷 19-47页

作者： ABHISHEK WAHI MAMTA BISHNOI neha RAINA MEGHNA AMRITA SINGH PIYUSH VERMA PIYUSH KUMAR GUPTA GINPREET kaur HARDEEP SINGH TULI MADHU GUPTA Department of Pharmaceutics School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)Pushp ViharNew Delhi110017India Department of Pharmaceutical Sciences Gurugram UniversityHaryana122003India Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh201310India Department of Biotechnology Graphic Era(Deemed to be University)DehradunUttarakhand248002India Department of Pharmacology Shobhaben Pratapbhai Patel School of Pharmacy&Technology ManagementSVKM’s NMIMSVile Parle(West)Mumbai400056India Department of Bio-Sciences and Technology Maharishi Markandeshwar Engineering CollegeMaharishi Markandeshwar(Deemed to be University)MullanaAmbala133207India

Cancer is a leading cause of death globally,with limited treatment options and several *** agents often result in toxicity which long-term conventional *** are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the *** phytoconstituents act in several ways and deliver optimum effectiveness against ***,the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility,bioavailability,and *** presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems,which possess a range of advantageous characteristics such as biocompatibility,targeted and sustained release capabilities,and enhanced protective *** holds significant potential for future advancements in cancer ***,this review aims to provide intensive literature on diverse nanocarriers,highlighting their applications as cargos for phytocompounds in ***,it offers an overview of the current advancements in the respective field,emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo ***,clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future.

关键词： Phyto-formulations Cancer Nanocarriers Nanotechnology Clinical development

Influence of pyrolysis temperature on rice straw biochar properties and corresponding effects on dynamic changes in bispyribac-sodium adsorption and leaching behavior in soil

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Pedosphere 2023年第3期33卷 463-478页

作者： Pervinder kaur neha SHARMA Khushwinder kaur Department of Agronomy Punjab Agricultural UniversityLudhianaPunjab 141004(India) Department of Chemistry Punjab Agricultural UniversityLudhianaPunjab 141004(India) Department of Chemistry Panjab UniversityChandigarh 160014(India)

Bispyribac-sodium is a weakly acidic herbicide with high water solubility and is thus a potential source of groundwater *** the risk inherent to the use of this herbicide,this study assessed the impacts of rice straw(RS)and biochar amendments on the adsorption and leaching behavior of bispyribac-sodium in *** were produced from RS at different pyrolysis temperatures and characterized using various spectral *** straw had a surface area of 3.996×10^(4)m^(2)kg^(-1),which increased under pyrolysis;biochars prepared at 350 and 550℃(RS350 and RS550)in a closed furnace with limited oxygen supply had a surface area of 5.763×10^(4)and 6.890×10^(4)m^(2)kg^(-1),respectively,and biochar prepared by purging the pyroformer with N2(RSC)had the highest surface area of 12.173×10^(4)m^(2)kg^(-1).After amendment with RS and biochar,soil Freundlich adsorption capacity(KF ads)increased to varying extents in the order RSC>RS350>RS550,from 2.89×10^(3)to 29.57×10^(3)mg^(1-1)/nkg^(-1)L1/n,compared to1.55×10^(3)mg^(1-1)/nkg^(-1)L1/nin unamended *** variability in KF ads of bispyribac-sodium amongst the RS-and biochar-amended soils was dependent on the surface area of the *** desorption of bispyribac-sodium decreased in the RS-and biochar-amended soils and varied from90.45%to 95.20%in unamended soils and from 60.95%to 89.50%in amended *** adsorption and desorption of bispyribac-sodium varied significantly depending on its concentration and the type and application rate of soil *** leaching risk evaluation indices,viz.,modified leach index(***),leach index(LEACH),groundwater ubiquity score(GUS),Hornsby index(HI),leaching index(LIN),and pesticide leaching potential(PLP)index,were used to assess the susceptibility of groundwater to herbicide *** reduce the repetitive effects of common parameters in each index,a new index was developed by employing principal component analysis(PCA)to condense their infor

关键词： desorption Freundlich model groundwater contamination leaching potential leaching risk evaluation index pesticide soil amendment Temkin isotherm

Evaluation of retinal nerve fiber layer thickness profile in thyroid ophthalmopathy without optic nerve dysfunction

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1634-1637页

作者： Kumari Mugdha Apjit kaur neha Sinha Sandeep Saxena Department of Ophthalmology King George's Medical University Lucknow 226003 India Sankara Eye Hospital Kanpur 208001 India

AIM： To evaluate retinal nerve fiber layer（RNFL）thickness profile in patients of thyroid ophthalmopathy with no clinical signs of optic nerve ***： A prospective, case-control, observational study conducted at a tertiary care centre. Inclusion criteria consisted of patients with eyelid retraction in association with any one of： biochemical thyroid dysfunction, exophthalmos, or extraocular muscle involvement; or thyroid dysfunction in association with either exophthalmos or extra-ocular muscle involvement;or a clinical activity score（CAS）〉3/7. Two measurements of RNFL thickness were done for each eye, by Cirrus HD-optical coherence tomography 6mo ***： Mean age of the sample was 38.75y（range13-70y） with 18 males and 22 females. Average RNFL thickness at first visit was 92.06 ±12.44 μm, significantly lower than control group（101.28±6.64 μm）（P =0.0001）.Thickness of inferior quadrant decreased from 118.2 ±21.27 μm to 115.0 ±22.27 μm after 6mo（P =0.02）. There was no correlation between the change in CAS and RNFL thickness. CONCLUSION： Decreased RNFL thickness is an important feature of thyroid orbitopathy, which is an inherent outcome of compressive optic neuropathy of any etiology. Subclinical RNFL damage continues in the absence of clinical activity of the disease. RNFL evaluation is essential in Grave＇s disease and active intervention may be warranted in the presence of significant damage.

关键词： thyroid ophthalmopathy retinal nerve fibrelayer optical coherence tomography

Review of Artificial Intelligence with Retailing Sector

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Journal of Computer Science Research 2020年第1期2卷 1-7页

作者： Venus kaur Vasvi Khullar neha Verma School of Information Technology Vivekananda Institute of Professional StudiesDelhiIndia

This research service provides an original perspective on how artificial intelligence(AI)is making its way into the retail *** has entered a new era where ECommerce and technology bellwethers like Alibaba,Amazon,Apple,Baidu,Facebook,Google,Microsoft,and Tencent have raised consumers’*** is enabling automated decision-making with accuracy and speed,based on data analytics,coupled with selflearning *** retail sector has witnessed the dramatic evolution with the rapid digitalization of communication(***)and;smart phones and *** is no longer the same as they became more empowered by smart devices which has entirely prevailed their expectation,habits,style of shopping and investigating the *** article outlines the Significant innovation done in retails which helped them to evolve such as Artificial Intelligence(AI),Big data and Internet of Things(IoT),Chatbots,*** article further also discusses the ideology of various author on how AI become more profitable and a close asset to customers and retailers.

关键词： Artificial Intelligence(AI) Big data Retail Internet of Things(IoT)