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Breeding and biotechnological efforts in Jatropha curcas *** sustainable yields

Oil Crop Science 2021年第4期6卷 180-191页

作者： S.Arockiasamy Jyothirmayi Kumpatla Sainath Hadole Vijay Yepuri Manoj Patil Vineeta Shrivastava Chandrasekhara Rao Nagesh Kancharla Saakshi Jalali Alok Varshney neeta madan Sai Pothakani Vinod Nair Sridhar Peyyala Vishwnadharaju Mudunuri Ananthan Gopal Niranjan S.Kumar Jawahar Pachiyannan Satyanarayana Seelamanthula J.V.Narasimham Makarand Phadke Anindya B Ajit Sapre Santanu Dasgupta Agronomy Division Reliance Technology GroupReliance Industries LtdGhansoliNavi Mumbai400701India Jatropha Breeding Station Reliance Industries LtdIDA-PeddapuramADB Road SamalkotaAndhra Pradesh533440India

Jatropha is a non-edible,important bioenergy plant,which can grow in marginalized *** seeds possess about 36%oil and this would be converted into biodiesel or *** provides an option for sustainable feed and fuel production due to its inherent qualities including hardy nature,drought tolerance and surviving with limited amount of water,tolerance to unfavorable conditions and excessive ***,heterozygosity,low productivity and poor understanding of its genome are the major impediments to elite line ***,classical breeding and advanced technological investments remain limited owing to long juvenile phase and breeding *** technologies that lead to identification of elite genotypes and development of high yielding elite Jatropha lines and effective methods of detoxification of seeds needs immediate *** tissue culture system,doubled haploids(DH)and genomic tools are increasingly made available to improve the seed yield and its oil quantity through the development of geminivirus disease resistant *** application of advanced,sequencing technologies has presented a repertoire of genomic information for this important yet orphan *** the present investigation,we highlight the achievements made in Jatropha towards development of high yielding,virus resistant elite lines and hybrids with yield potential ranging from 3 to 5 tons per hectare in a year,which is a first ever report in the *** also developed potential biotechnological tools such as genetic transformation,genome editing and next generation genomics tools including linkage maps and QTLs for accelerating breeding efforts through marker assisted *** of our concerted and continuous efforts during the past 15 years,we have overcome all the obstacles and developed high yielding,disease resistant hybrids/lines,advanced cultivation technologies with thorough knowledge on Agronomy of the Jatropha *** Jatropha cultivat

关键词： Breeding Hybrids Micropropagation Transformation Sequencing Mapping QTLs CRISPR

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BACE1 inhibitors:A promising therapeutic approach for the management of Alzheimer’s disease

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Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 369-381页

作者： Richa Arya Smita Jain Sarvesh Paliwal Kirtika madan Swapnil Sharma Achal Mishra Prashant Tiwari Sunil Kumar Kadiri Banasthali University Banasthali-304022(Raj.)India Department of Pharmacy Guru Ghasidas VishwavidyalayaBilaspurChhattisgarh-495009India Department of Pharmacology College of Pharmaceutical SciencesDayananda Sagar UniversityBengaluru-560111India

Alzheimer’s disease is a neurological disorder marked by the accumulation of amyloid beta(Aβ)aggregates,resulting from mutations in the amyloid precursor *** enzymeβ-secretase,also known asβ-site amyloid precursor protein cleaving enzyme 1(BACE1),plays a crucial role in generating Aβ*** no targeted therapy available for Alzheimer’s disease,inhibiting BACE1 aspartic protease has emerged as a primary treatment *** 1999,compounds demonstrating potential binding to the BACE1 receptor have advanced to human *** optimization of synthetically derived compounds,coupled with computational approaches,has offered valuable insights for developing highly selective leads with drug-like *** review highlights pivotal studies on the design and development of BACE1 inhibitors as anti-Alzheimer’s disease *** summarizes computational methods employed in facilitating drug discovery for potential BACE1 inhibitors and provides an update on their clinical status,indicating future directions for novel BACE1 *** promising clinical results of Elenbecestat(E-2609)catalyze the development of effective,selective BACE1 inhibitors in the future.

关键词： BACE1 inhibitors Amyloid precursor protein β-secretase Structure-based drug design 3D-QSAR β-amyloid precursor protein

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Gd^(3+) ion induced UV upconversion emission and temperature sensing in Tm^(3+)/Yb^(3+):Y_(2)O_(3) phosphor

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稀土学报:英文版 2023年第9期41卷 1295-1301,I0001页

作者： madan M.Upadhyay Kaushal Kumar Optical Materials&Bio-imaging Research Laboratory Department of PhysicsIndian Institute of Technology(Indian School of Mines)Dhanbad-826004India

Cubic phase Tm^(3+)/Yb^(3+):Y_(2)O_(3) and Tm^(3+)/Yb^(3+)/Gd^(3+):Y_(2)O_(3) phosphors were prepared by low temperature combustion technique for upconversion emission in UV-visible *** 980 nm excitation has generated UV emission at 314 nm in tridoped phosphor due to the energy transfer from Tm^(3+) to Gd^(3+)*** emission bands from Tm^(3+) are also observed in both the *** coupled Stark sublevels ^(1)G_(4(a))(476 nm) and ^(1)G_(4(b))(488 nm) of Tm^(3+) ion were utilised for optical thermometry using fluorescent intensity ratio(FIR) *** result shows that maximum absolute sensitivity in tridoped phosphor is observed to be 1.33 × 10^(-3) K^(-1) at 298 ***,temperature rise of phosphor at various pump power densities was also measured and it is estimated to achieve 407 K at the pump power density of 38.46 W/cm^(2).

关键词： Upconversion UV emission Combustion synthesis Temperature sensing Optical heating Gd^(3+)emission

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Evolution of heart transplant donor characteristics in the 21st century: A United States single center’s experience

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World Journal of Transplantation 2024年第3期14卷 22-29页

作者： Alexander M Spring Christiana Gjelaj Shivank madan Snehal R Patel Omar Saeed Sandhya Murthy Yogita Rochlani Daniel B Sims Sasha Vukelic Stephen J Forest Jamil F Borgi Daniel J Goldstein Ulrich P Jorde Montefiore-Einstein Center for Heart and Vascular Care Montefiore Medical CenterAlbert Einstein College of MedicineBronxNY 10467United States Division of Cardiothoracic Surgery Tulane UniversityNew OrleansLA 70112United States

Despite a record setting number of heart transplants performed annually,the national donor shortage continues to plague transplant teams across the United *** we describe the barriers to adaptation of numerous“non-traditional”orthotopic heart transplant donor characteristics including donors with hepatitis C virus,those meeting criteria for donation after cardiac death,donors with coronavirus disease 19 infection,donors with the human immunodeficiency virus,and grafts with left ventricular systolic *** center’s objective was to increase our transplant volume by expanding our donor pool from“traditional”donors to these“non-traditional”*** detail how medical advances such as certain laboratory studies,pharmacologic interventions,and organ care systems have allowed our center to expand the donor pool thereby increasing transplantation volume without adverse effects on outcomes.

关键词： Orthotopic heart transplantation Hepatitis C virus COVID-19 Left ventricular systolic dysfunction Human immunodeficiency virus Donation after cardiac death

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Estimation and feedback control of air-fuel ratio for gasoline engines

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Control Theory and Technology 2015年第2期13卷 151-159页

作者： madan KUMAR Tielong SHEN Department of Engineering and Applied Science Sophia University

In 4-stroke internal combustion engines, air-fuel ratio control is a challenging task due to the rapid changes of engine throttle,especially during transient operation. To improve the transient performance, managing the cycle-to-cycle transient behavior of the mass of the air, the fuel and the burnt gas is a key issue due to the imbalance of cyclic combustion process. This paper address the model-based estimation and control problem for cyclic air-fuel ratio of spark-ignition engines. A discrete-time model of air-fuel ratio is proposed, which represents the cycle-to-cycle transient behavior of in-cylinder state variables under the assumptions of cyclic measurability of the total in-cylinder charge mass, combustion efficiency and the residual gas fraction. With the model,a Kalman filter-based air-fuel ratio estimation algorithm is proposed that enable us to perform a feedback control of air-fuel ratio without using lambda sensor. Finally, experimental validation result is demonstrated to show the effectiveness of proposed estimation and control scheme that is conducted on a full-scaled gasoline engine test bench.

关键词： Discrete-time model AFR estimation using Kalman filter in-cylinder charge combustion efficiency PI controller

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The path forward in prostate cancer therapeutics

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Asian Journal of Andrology 2018年第3期20卷 213-214页

作者： Jeanny B Aragon-Ching Ravi A madan Department of Genitourinary Medical Oncology Inova Schar Cancer Institute Fairfax VA 22031USA Genitourinary Malignancies Branch Center for Cancer Research National CancerInstitute National Institutes of Health BethesdaMD. USA

The last decade has seen remarkable advances in the treatment of prostatecancer. Until 2010, only docetaxel had demonstrated the ability to improve the survival in metastatic castration-resistant prostate cancer （mC... 详细信息

关键词： INCREASED SURVIVAL DOUBLE-BLIND ENZALUTAMIDE MITOXANTRONE ABIRATERONE IPILIMUMAB PREDNISONE PLACEBO

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Effect of process and formulation variables on the preparation of parenteral paclitaxel-loaded biodegradable polymeric nanoparticles:A co-surfactant study

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Asian Journal of Pharmaceutical Sciences 2016年第3期11卷 404-416页

作者： Navneet Sharma Parshotam madan Senshang Lin College of Pharmacy and Health Sciences St. John's University

The purpose of this study was to evaluate the effect of process(homogenization speed and evaporation time) and formulation(aqueous/organic phase ratio, surfactant concentration, polymer type and concentration, and drug amount) variables on the preparation of paclitaxel-loaded biodegradable polymeric nanoparticles using modified solvent evaporation technique. Thereafter, a formulation was selected and subjected to evaluation of inclusion of a co-surfactant for further reduction of particle size. Particle size, encapsulation efficiency and in-vitro drug release kinetics were evaluated. It was observed that the inclusion of vitamin E TPGS(0.01%), Poloxamer 188(0.5%) or Tween 80(0.25%) reduced the particle size of nanoparticles to 230, 244 or 301 nm from 438 nm, respectively. Encapsulation efficiency increased for both vitamin E TPGS and Poloxamer 188 up to concentration at 0.010%and 0.25%, respectively, while this was not the case for Tween 80. Comparison of drug release kinetics demonstrated that drug release accelerated from paclitaxel-loaded biodegradable nanoparticles prepared with the inclusion of Tween 80 but was delayed for Poloxamer 188 and vitamin E TPGS. Thus, it was concluded that the particle size of the nanoparticles could be reduced further and the paclitaxel release kinetics could easily be adjusted by taking advantage by the inclusion of a co-surfactant.

关键词： Biodegradable Co-surfactant Nanoparticles Paclitaxel Solvent evaporation

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Perspectives on the clinical development of mmunotherapy in prostate cancer

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Asian Journal of Andrology 2018年第3期20卷 253-259页

作者： Lisa M Cordes James L Gulley Ravi A madan Clinical Center National Institutes of Health Bethesda MD 20892 USA Genitourinary Malignancies Branch Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD 20892 USA

Despite impressive survival benefits with immunotherapy in patients with various solid tumors, the full potential of these agents in prostate cancer has yet to be realized. SipuleuceI-T demonstrated a survival benefit in this population, indicating that prostate cancer is an immunoresponsive disease; however, these results have not been matched by other agents. A large trial with ipilimumab in prostate cancer failed to meet its primary objective, and small trials with PD-1/PD-L1 inhibitors did not yield a significant improvement in overall response. However, several late-stage clinical trials are underway with other vaccines in prostate cancer. Reports of clinical benefit with immunotherapies, particularly when used in combination or a select population, have provided the framework to develop sound clinical trials. Understanding immunogenic modulation, antigen spread, biomarkers, and DNA-repair defects will also help mold future strategies. Through rational patient selection and evidence-based combination approaches, patients with prostate cancer may soon derive durable survival benefits with immunotherapies.

关键词： checkpoint inhibitor immunotherapy prostate cancer therapeutic vaccine

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Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid

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Asian Journal of Pharmaceutical Sciences 2017年第1期12卷 73-82页

作者： Suhua Li Parshotam madan Senshang Lin School of Pharmacy Fairleigh Dickinson UniversityFlorham ParkNJ 07932USA College of Pharmacy and Health Sciences St.John’s UniversityQueensNYUSA

The purpose of this study was to investigate the effect of ionization of drug on drug solubilization in SMEDDS(self-microemulsifying drug delivery system) prepared using Capmul MCM and caprylic acid. Solubilization capacity of blank SMEDDS dispersions for danazol,indomethacin and haloperidol as model drugs was determined. Based on the outcomes of solubilization capacity study, drug-loaded SMEDDS formulations were prepared and subjected to dispersion/precipitation study and droplet size analysis. Blank SMEDDS dispersions exhibited the highest solubilization capacity for haloperidol followed by indomethacin and danazol. Furthermore, the solubilization of the three drugs in blank SMEDDS dispersions was explained by a modified mathematical model. Dispersion/precipitation studies indicate that drug-loaded SMEDDS formulations exhibited superiority in solubilizing the drugs in comparison to their respective drug powder. In addition, indomethacin and haloperidol were found to reduce the droplet size of the microemulsions while danazol did not affect droplet size formation for drug-loaded SMEDDS formulations. These findings suggest that ionization of drug affects drug solubilization, droplet size formation, drug loading and drug dispersion/precipitation profiles for the SMEDDS formulations.

关键词： SMEDDS Capmul MCM Caprylic acid Ionization Indomethacin Haloperidol

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Stability Analysis of an Underactuated Autonomous Underwater Vehicle Using Extended-Routh's Stability Method

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International Journal of Automation and computing 2018年第3期15卷 299-309页

作者： Basant Kumar Sahu Bidyadhar Subudhi madan Mohan Gupta Department of Electrical Engineering National Institute of Science and TechnologyBerhampur Department of Electrical Engineering National Institute of TechnologyRourkela Intelligent Systems Research Laboratory College of Engineering University of Saskatchewan

In this paper, a new approach to stability analysis of nonlinear dynamics of an underactuated autonomous underwater vehicle（AUV） is presented. AUV is a highly nonlinear robotic system whose dynamic model includes coupled terms due to the hydrodynamic damping factors. It is difficult to analyze the stability of a nonlinear dynamical system through Routh＇s stability approach because it contains nonlinear dynamic parameters owing to hydrodynamic damping coefficients. It is also difficult to analyze the stability of AUVs using Lyapunov＇s criterion and LaSalle＇s invariance principle. In this paper, we proposed the extended-Routh＇s stability approach to verify the stability of such nonlinear dynamic systems. This extended-Routh＇s stability approach is much easier as compared to the other existing methods. Numerical simulations are presented to demonstrate the efficacy of the proposed stability verification of the nonlinear dynamic systems, e.g., an AUV system dynamics.

关键词： Routh's stability extended-Routh's stability autonomous underwater vehicle (AUV) underactuated system underwaterrobots.

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