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Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma

中国药理学与毒理学杂志 2018年第4期32卷 342-343页

作者： Feng Zhi Rong WANG Dan-hi DENG Nai-yuan SHAO Yuan XU Lian XUE Ya PENG Ya-tian LIU Department of Neurosurgery The First People's Hospital of Changzhou Changzhou China Modern Medical Research Center The Third Affiliated Hospital of Soochow UniversityChangzhou 213003 China Department of Radiation Oncology Jiangsu Cancer Ho

OBJECTIVE Glioblastoma multiforme(GBM) is the most malignant primary tumor of the central nervous system and is associated with a very poor *** further improvements in outcomes have been reported since radiotherapy-temozolomide therapy was ***,*** new agents to treat GBM is *** study aimed to evaluate the anti-tumor effect of evodiamine(Evo) on GBM cells,and to determine the underlying mechanisms *** U251,LN229,HEB and PC12 cells were treated with various concentrations of evodiamine for 24 and48 hours,cell viability was measured by MTT *** U251 and LN229 cells were treated with ***(0-10 μmol·L^(-1)) for 24 h,and then stained with Hoechst *** Annexin V-FITC Apoptosis Detection Kit was used to detect apoptosis in the *** oxygen species(ROS) production was detected using dichlorofluorescein diacetate(DCFH-DA) *** changes in mitochondrial *** potential(MMP) were assessed by JC-1 after cells were treated with *** *** levels of p-PI3K,PI3K,p-Akt,Akt,Bax,Bcl-2,p-p38,p38,p-JNK,JNK,p-ERK,ERK,Cytochrome c,Caspase-3,cleaved Caspase-3,PRAP,and cleaved PARP were measured by Western blot *** According to MTT assay results,Evo significantly inhibited the cell proliferation in a time-and dose-dependent *** microscopy and flow cytometry analyses revealed that Evo induced cell apoptosis in a concentration-dependent ***,Evo induced reactive oxygen species(ROS) production and mitochondrial membrane potential(MMP) ***,Evo induced apoptosis in cancer cells by suppressing PI3K/AKT signaling and inducing MAPK ***(p38 and JNK,but not ERK) to regulate apoptotic proteins(Bax,Bcl-2,Cytochrome c,***-3,and PARP).CONCLUSION In summary,Evo inhibits cell proliferation by inducing cellular apoptosis via suppressing PI3K/AKT and activating MAPK in GBM;these results indicate that Evo may be regarded as a ne

关键词：胶质母细胞瘤治疗方法肿瘤临床分析

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物质性与虚空性——理解汉人民间宗教的两个向度

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思想战线 2020年第1期46卷 49-58页

作者：石峰贵州师范大学历史与政治学院

中国台湾学者林玮嫔宗教物质性研究的物质性视角,以及日本学者大贯惠美子"零"能指理论的虚空性视角,是反思物质性研究的依据。利用这两种视角,能更好地探究汉人社会民间宗教的全貌。同样,只有将物质性和虚空性同时作为观察的视角,才能... 详细信息

中国台湾学者林玮嫔宗教物质性研究的物质性视角,以及日本学者大贯惠美子"零"能指理论的虚空性视角,是反思物质性研究的依据。利用这两种视角,能更好地探究汉人社会民间宗教的全貌。同样,只有将物质性和虚空性同时作为观察的视角,才能对社会形成全面深入的认识。在人类社会研究中,虚空性的研究更应强化。

关键词：汉人社会民间宗教物质性 “零”能指虚空性

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SYNTHESIS AND APPLICATIONS OF NANOMATERIALS IN MICROELECTRONICS

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化工学报 2000年第S1期51卷 173-177页

作者： Kuang Xiumeng and Virissimo David C. (hi-Q Materials, Inc. 2516 Katherine Street.El Cajon, CA 92020)

The technology boom in microelectronics and telecommunication industry has presented a unique opportunity for nanomaterials. Nanomaterials enable the creation of unique devices, components and systems through the control of matter on a near molecular level. These new devices, components and systems will exhibit novel physical, chemical, mechanical, electrical, optical and biological properties. The synthesis processes of nanomaterials are reviewed and the applications of nanomatorials in microelectronics are discussed in this paper.

关键词： Nanomaterials Nanotechnology Chemical Engineering Microelectronics

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On-Chip Characterization of Interconnect Line-Induced Delay Time in 0.15μm CMOS Technology with 7-Level Metallization

On-Chip Characterization of Interconnect Line-Induced Delay ...

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2001 6～(th) International Conference on Solid-State and Integrated Circuit Technology

作者： hi-DeokLee DaeM.Kim Dept.of Electronics Engineering Chungnain National UniversityTaejon305-764Korea Computational Sciences Korea Institute for Advanced StudySeoul130-012Korea

＜正＞A novel method is presented by which to perform on-chip characterization of interconnect line-induced delaytime for ULSI circuit *** chips werefabricated using 0.15μm CMOS technology using stateof the art process *** contribution of eachinterconnect parameters,such as coupling capacitanceand line resistance,etc.,on the delay time are extractedelectrically in real time,free of ambiguity causedbygeometric variation of metal *** delay time ismodeled simply as a function of interconnect *** delay time equation enables easy and accurateprediction of chip *** is shown that the delaytime induced by 3 mm and 5 mm interconnect lines islarger than pure gate delay by about 25 and 80 times,respectively.

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速发性接触反应：接触性荨麻疹综合征

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临床皮肤科杂志 1989年第1期18卷 31-36页

作者： Laht.,A. Maib.,hi

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MISSION OBJECTIVES OF SJ-5 SATELLITE COMPLETELY AChiEVED

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Bulletin of the Chinese Academy of Sciences 2000年第1期14卷 33-34页

作者： Gui Wenzhuang(Bureau of hi-tech Research & Development, CAS)

The SJ-5 (Shijian-5) spacecraft is the first China-made satellite for scientific research with theCAS as the user. Blasting off from the TaiyuanSatellite Launch Center on May 10, l999, the SJ-5completed its main experimental tasks on scheduleafter a 90-day-long earth-orbit flight. The normaloperation of the satellite’s platform provided aguarantee for the smooth fulfillment of its *** payloads aboard the satellite were independent-

关键词： MISSION OBJECTIVES OF SJ-5 SATELLITE COMPLETELY AChiEVED

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Bacteriological Quality and Risk Factors for Contamination of Raw Mixed Vegetable Salads Served in Collective Catering in Abidjan (Ivory Coast)

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Advances in Microbiology 2017年第6期7卷 405-419页

作者： Evelyne Toe Adjéhi Dadié Etienne Dako Guillaume Loukou Laboratory of Nutrition and Food Safety Department of Food Science and Technology University of Nanguy Abrogoua Abidjan Ivory Coast Laboratory of Biotechnology and Molecular Biology School of Food Science Nutrition and Family Studies Faculty of Health Science and Community Services University of Moncton New-Brunswick Canada Laboratoire Nationale de la Santé Publique (LNSP) Abidjan Ivory Coast

The aim of this study was to determine the bacteriological quality of raw mixed vegetable salads served in collective catering in Abidjan and to assess the factors likely to favor contamination. An investigation was conducted to determine the practical risk of contamination. A total of 306 samples were collected and analyzed for the detection and enumeration of Enterobacteriaceae, E. coli and Salmonella according to standard microbiology methods. The most important risk factors were lack of training (96.7%), decontamination (84.0%), cross-contamination of vegetables in contact with fresh chicken or fish (76.7%) and salads that were uncovered and unprotected, thus exposed to the air and at ambient temperature for sale (97.7%). Theprevalence was 100%, 77.8% and 2.6% respectively for Enterobacteriaceae, E. coli and Salmonella. The average load of Enterobacteriaceae and E. coli was 4.93 log10 (CFU/g) and 1.89 log10 (CFU/g), respectively. Unsatisfactory microbiological quality samples were 52.3%. The results showed a failure of the sanitary quality in more than half of the products. Raising awareness in all of the workers in the food chain for vegetable salads is thus necessary to protect the health of the consumers.

关键词： Vegetable Salads E. coli Salmonella Risk Factors Collective Catering

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Mercury Concentration Profile in Sediment Cores of a Tropical Lagoon under high Anthropogenic Activities around an Urban City—Abidjan, Côte d’Ivoire

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Journal of Geoscience and Environment Protection 2021年第5期9卷 83-94页

作者： Achille Gueu Sébastien Koffi Ouffoué Bruno Zeli Digbéhi Laboratoire de géologie marine Université Félix Houphou&#235 t BOIGNY Abidjan C&#244 te d’Ivoire Centre Ivoirien Antipollution Abidjan C&#244 te d’Ivoire Laboratoire de chimie organique et de substances naturelles Université Félix Houphou&#235 t BOIGNY Abidjan C&#244 te d’Ivoire

The present study focuses on the quantification of mercury in sediment cores from Cocody, Banco, Koumassi and Milliardaires bays in Abidjan, Côte d’Ivoire. It aims at assessing the state of mercury contamination of the lagoon bottom using DMA-80 (Direct Mercury Analyser). The automatic analyzer DMA-80 mercury is an innovative instrument for the analysis of mercury at very low content in solid and liquid samples in five minutes, without requiring any prior steps of pretreatment wet. The results showed, according to the lithological description of different bays, that the cored sediments consist of mud, sand, sandy mud or muddy sand with occasional shells. In addition, our results showed the presence of mercury in the sediments of the lagoon bottom at a degree of contamination that varies from moderate to very high according to the calculated contamination factor (CF) values. The highest contamination was observed in Cocody Bay at the surface with a contamination factor of 7.5, while the lowest contamination was observed in Milliardaires Bay at the water-sediment interface with a contamination factor of 1.67. In addition, mercury concentrations compared to sediment guide values (SQGs) reveal that these sediments mostly show occasional biological effects but no toxicity except Koumassi core (sediments at 20 cm depth). Also, dredging, hydrodynamics have probably impacted the mercury content. The depositional environment of mercury metal is therefore a limiting factor for its fate in the aquatic environment.

关键词： DMA-80 Mercury Pollution Sediments

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The characteristic periodicity of droughts in Korea

The characteristic periodicity of droughts in Korea

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第三届中日韩气象学术会议

作者： Sun-Ju Lee hi-Ryong Byun Dept.of Environmental Atmospheric Sciences Pukyong national UniversityRep.of Korea Dept.of Environmental Atmospheric Sciences Pukyong national UniversityRep.of Korea

＜正＞The characteristic periodicities of droughts have been investigated in *** use more data available,3 durations were applied;1 station with 228 years data（Y228, 1778～2005）,5 stations with 92 years（Y92,1914～2... 详细信息

关键词： Drought EDI Periodicity Wavelet and Spectrum analysis

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碳材料上难熔稀有金属涂层

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新型炭材料 1991年第2期7卷 47-48页

作者： hi seak yoon 刘银全

一、引言Strife和Shcehan简述了高温下炭材料的抗氧化性.影响其性能的主要因素有涂层的粘着力,涂层的裂纹/裂片,涂层的浸蚀性和氧的渗透性以及与碳的热-化学的相容性。

关键词：碳材料涂层难熔稀有金属

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