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Allogeneic and autologous stem cell transplantation with busulfan, cyclophosphamide, and etoposide conditioning therapy for relapsed/refractory non-Hodgkin lymphoma

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Modern Chemotherapy 2013年第4期2卷 57-65页

作者： neelima vidula Andrew M. Evens Irene B. Helenowski Borko Jovanovic Jane N. Winter Jayesh Mehta Seema Singhal Stephanie F. Williams Olga Frankfurt Jessica K. Altman Joanne Monreal Leo I. Gordon Department of Preventive Medicine Northwestern University Chicago USA Division of Hematology-Oncology Northwestern University Chicago USA Division of Hematology-Oncology Northwestern University Chicago USA Division of Hematology-Oncology The University of Massachusetts Medical School Worcester USA Division of Hematology-Oncology University of California San Francisco USA

The optimal stem cell transplantation (SCT) conditioning therapy for relapsed/refractory non-Hodgkin lymphoma (NHL) is not clearly defined. In a retrospective analysis, we examined 25 patients with “high risk” relapsed/refractory NHL who received busulfan, cyclophosphamide, and etoposide (Bu/Cy/VP16) conditioning with autologous or allogeneic SCT. The majority of patients had aggressive histology and 52% had primary refractory NHL. Furthermore, 48% of patients had chemotherapy-resistant disease at the time of SCT. Fifty-six percent of patients underwent allogeneic SCT, while 44% had autologous SCT. The median engraftment time for neutrophils and platelets was 13.5 and 14 days, respectively. The 100-day treatment-related mortality (TRM) was 16%, while the 2-year non-relapse mortality (NRM) rate was also 16%. At a median follow-up of 15 months, the estimated 2-year disease-free survival (DFS) rate was 64% (95% confidence interval (CI): 36%-82%) and the estimated 2-year overall survival (OS) was 69% (95% CI: 40%-86%). Furthermore, the 2-year disease-specific survival (DSS) rate was 73% (95% CI: 40%-90%). Using Cox proportional hazard modeling, the International Prognostic Index at time of relapse predicted DFS and OS. Altogether, Bu/Cy/VP16 was associated with early TRM;however, late toxicities (including NRM) were uncommon resulting in relatively good survival rates in a high-risk relapsed/refractory NHL population.

关键词： Stem Cell Transplantation Busulfan Cyclophosphamide Etoposide Non-Hodgkin Lymphoma

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Impact of Pollutant Concentration and Particle Deposition on the Radiative Flow of Casson-Micropolar Fluid between Parallel Plates

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 665-690页

作者： Ghaliah Alhamzi Badr Saad T.Alkahtani Ravi Shanker Dubey Vinutha Kalleshachar neelima Nizampatnam Department of Mathematics and Statistics College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11564Saudi Arabia Department of Mathematics College of ScienceKing Saud UniversityRiyadh11989Saudi Arabia Department of Mathematics Amity School of Applied SciencesAmity University RajasthanJaipur302002RajasthanIndia Department of Studies in Mathematics Davangere UniversityDavangere577002India Department of Electronics and Communication Engineering Amrita School of EngineeringAmrita Vishwa VidyapeethamBengaluru560035India

Assessing the behaviour and concentration of waste pollutants deposited between two parallel plates is essential for effective environmental *** the effectiveness of treatment methods in reducing pollution scales is made easier by analysing waste discharge *** waste discharge concentration analysis is useful for assessing how effectively wastewater treatment techniques reduce pollution *** study aims to explore the Casson micropolar fluid flow through two parallel plates with the influence of pollutant concentration and thermophoretic particle *** explore the mass and heat transport features,thermophoretic particle deposition and thermal radiation are *** governing equations are transformed into ordinary differential equations with the help of suitable similarity *** Runge-Kutta-Fehlberg’s fourthfifth order technique and shooting procedure are used to solve the reduced set of equations and boundary *** integration of a neural network model based on the Levenberg-Marquardt algorithm serves to improve the accuracy of predictions and optimize the analysis of *** outcomes are displayed to analyze the characteristics of the relevant dimensionless parameters in the current *** reveal that concentration upsurges as the micropolar parameter *** concentration reduces with an upsurge in the thermophoretic *** upsurge in the external pollutant source variation and the local pollutant external source parameters enhances mass *** surface drag force declines for improved values of porosity and micropolar parameters.

关键词： Micropolar fluid thermal radiation porous medium thermophoretic particle deposition waste discharge concentration

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Coupling effect of pond ash and polypropylene fiber on strength and durability of expansive soil subgrades:An integrated experimental and machine learning approach

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第5期13卷 1101-1112页

作者： Nitin Tiwari neelima Satyam Department of Civil Engineering Indian Institute of Technology IndoreIndoreIndia

This study explores the coupling effect of pond ash(PA)and polypropylene(PP)fiber to control the strength and durability of expansive *** PA is used to chemically treat the expansive soil and PP fiber is adopted as reinforcement against tensile *** sustainable use of PA and PP fiber are demonstrated by performing mechanical(*** compressive strength,split tensile strength and ultrasonic pulse velocity),chemical(pH value,electrical conductivity and calcite content),and microstructural analyses before and after 2nd,4th,6th,8th and 10th freezing-thawing(F-T)*** curing methods with 7 d,14 d and 28 d curing periods are considered to reinforce the 5%,10%,15%and 20%PA-stabilized expansive soil with 0.25%,0.5%and 1%PP *** order to develop predictive models for mechanical and durability parameters,the experimental data are processed utilizing artificial neural network(ANN),in association with the leave-one-out cross-validation(LOOCV)as a resampling method and three different activation *** mechanical and durability properties of the PA-stabilized expansive soil subgrades are increased with PP fiber *** results of ANN modeling predict the mechanical properties perfectly,and the correlation coefficient(R)approaches up to 0.96.

关键词： Expansive soil subgrades Waste utilization Freezing-thawing(F-T) Microstructural assessment Pond ash(PA) Polypropylene(PP)fiber

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Probabilistic rainfall thresholds in Chibo, India: estimation and validation using monitoring system

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Journal of Mountain Science 2019年第4期16卷 870-883页

作者： Abhirup DIKSHIT neelima SATYAM Discipline of Civil Engineering Indian Institute of Technology Indore Simrol

The Himalayan region has been severely affected by landslides especially during the monsoons. In particular, Kalimpong region in Darjeeling Himalayas has recorded several landslides and has caused significant loss of life, property and agricultural land. The study region, Chibo has experienced several landslides in the past which were mainly debris and earth slide. Globally, several types of rainfall thresholds have been used to determine rainfall-induced landslide incidents. In this paper, probabilistic thresholds have been defined as it would provide a better understanding compared to deterministic thresholds which provide binary results, i.e., either landslide or no landslide for a particular rainfall event. Not much research has been carried out towards validation of rainfall thresholds using an effective and robust monitoring system. The thresholds are then validated using a reliable system utilizing Microelectromechanical Systems(MEMS) tilt sensor and volumetric water content sensor installed in the region. The system measures the tilt of the instrument which is installed at shallow depths and is ideal for an early warning system for shallow landslides. The change in observed tilt angles due to rainfall would give an understanding of the applicability of the probabilistic model. The probabilities determined using Bayes' theorem have been calculated using the rainfall parameters and landslide data in 2010-2016. The rainfall values were collected from an automatic rain gauge setup near the Chibo region. The probabilities were validated using the MEMS based monitoring system setup in Chibo for the monsoon season of 2017. This is the first attempt to determine probabilities and validate it with a robust and effective monitoring system in Darjeeling Himalayas. This study would help in developing an early warning system for regions where the installation of monitoring systems may not be feasible.

关键词： Early warning Probabilistic thresholds Kalimpong Monitoring

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Myrmechis bakhimensis ***,*** & ***,a new species of Orchidaceae from Sikkim Himalaya

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植物分类学报 2007年第3期45卷 321-323页

作者： Debabrata MAITY neelima PRADHAN Gaurgopal MAITI Botanical Survey of India Sikkim Himalayan CircleGangtok-737 103SikkimIndia Department of Botany University of KalyaniKalyani-741 235NadiaWest BengalIndia

Myrmechis bakhimensis D. Maity,N. Pradhan & G. G. Maiti (Orchidaceae),a new species from Sikkim Himalaya,is described and illustrated. The new species most closely resembles M. japonica (Reichb.) Rolfe and M. chinensis Rolfe with similar shape and size of lamina and the “T”-shaped epichile,but differs by the perfectly glabrous and eciliate floral bract,5-nerved dorsal sepal,and emarginate,mucronate epichile.

关键词：新种喜玛拉雅锡金兰科植物 Myrmechis bakhimensis D. Maity N. Pradhan & G. G. Maiti

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Optimization of growth medium for microbially induced calcium carbonate precipitation(MICP) treatment of desert sand

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Journal of Arid Land 2023年第7期15卷 797-811页

作者： Monika DAGLIYA neelima SATYAM Ankit GARG Department of Civil Engineering Indian Institute of TechnologyIndore 453552India Guangdong Engineering Center for Structure Safety and Health Monitoring Shantou UniversityShantou 515063China

Wind-induced sand erosion is a natural process, and can have several negative impacts on human health, environment, and economy. To mitigate the wind-induced sand erosion, an environmental friendly technique that helps to bind soil particles is desirable. The microbially induced calcium carbonate precipitation(MICP) treatment has lately become renowned and a viable alternative to enhance the binding of sand particles(especially against wind erosion). The efficiency of Sporosarcina pasteurii bacteria in inducing calcite formation can be influenced by various factors, including the type of growth media used for bacterial culture. Most of the studies have mainly validated the efficiency of S. pasteurii bacteria usually under single growth media for the MICP treatment. However, the efficiency of S. pasteurii under different growth media on calcite formation is rarely explored. The current study explores the effect of *** bacteria on calcite formation under the presence of three different growth media, namely,molasses(MS), tryptic soy broth(TB), and nutrient broth(NB). The three growth media have been applied in the laboratory with and without bacterial solution(control samples). Altered cementation media concentrations(0.5 and 1.0 M) with different pore volumes(PVs), namely, 0.25, 0.50, and 1.00 PV were used in sand-filled tubes for 7 and 14 treatment cycles(1 cycle=24 h). The pH and EC were measured for 12-h period in every 2 h interval, to monitor values at the time of treatment at room temperature. The calcite precipitation was confirmed using SEM(scanning electron microscope), PXRD(powder X-ray diffraction), and calcimeter tests. It was observed that MS generates lower calcite precipitation as compared with NB and TB. However, MS has the advantage of being more economical and abundant(waste product from sugar mills and refineries) as compared with other growth media(NB and TB). It was observed that the minimum and the maximum calcite precipitation using MS i

关键词： growth media molasses tryptic soy broth nutrient broth S.pasteurii calcium carbonate

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Rock-like behavior of biocemented sand treated under non-sterile environment and various treatment conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第3期13卷 705-716页

作者： Meghna Sharma neelima Satyam Krishna RReddy Discipline of Civil Engineering Indian Institute of Technology IndoreIndore453552India Department of Civil Materialsand Environmental EngineeringUniversity of Illinois at ChicagoChicagoILUSA

Microbially induced calcite precipitation(MICP)is a recently developed technique for microbiological ground improvement that has been applied for mitigating various geotechnical ***,the major challenges,such as calcite precipitation uniformity,presence of different bacteria,cementation solution optimization for cost reduction,and implementation under non-sterile and uncontrolled field environment are still not fully explored and require detailed investigation before field *** study aims to address these challenges of MICP to improve the geotechnical properties of sandy *** series of experiments were conducted using poorly graded Narmada River(India)sand,which were subjected to various biotreatment schemes and tested for unconfined compressive strength(UCS),split tensile strength(STS),ultrasonic pulse velocity(UPV),hydraulic conductivity(after 6 d,12 d,and 18 d of treatment),and calcite *** microstructure of sand was examined through a scanning electron microscope(SEM).Initially,the sand was individually augmented with two non-pathogenic bacterial strains,***(S.)pasteurii and Bacillus(B.)*** stopped-flow injection method was adopted to provide cementation solutions at three different durations(treatment cycle)of 12 h,24 h,and 48 h and three different pore volumes(PVs)of 1,0.75,and *** pore volume here refers to the porosity which is expressed as a ratio,i.e.a porosity of 50%was used as *** results showed rock-like behaviors of biocemented sand with the UCS,STS,and UPV enhancement up to 2333 kPa,437 kPa,and 2670 m/s,*** hydraulic conductivity reduction of 96.6%was achieved by 12%of calcite formation after 18 d of treatment using Sporosarcina pasteurii,12-h treatment cycle,and one pore volume of cementation media in each ***,a 24-h treatment cycle and 0.5-pore volume cementation solution were found to be the optimal treatment which was effective and economical to achiev

关键词： Bacteria Microbially induced calcite precipitation (MICP) Soil stabilization Microstructure Calcite content

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A paradigm shift:emerging roles of microglia,a non-neuronal cell,in learning and memory

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Neural Regeneration Research 2021年第10期16卷 1992-1993页

作者： neelima Gupta S.Thameem Dheen Department of Anatomy Yong Loo Lin School of MedicineNational University of SingaporeSingapore

Microglial cells are non-neuronal cells which serve as the first line of defence against various injuries and insults in the central nervous system(CNS).They act as sentinels that constantly patrol the surrounding parenchyma through their ramified processes in the *** response to any pathological insult,microglia become activated,undergo proliferation,migrate to the site of injury or infection,and release chemokines and cytokines followed by the phagocytosis of dead cells and debris.

关键词： injuries debris migrate

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Experimental study on mitigating wind erosion of calcareous desert sand using spray method for microbially induced calcium carbonate precipitation

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第5期14卷 1556-1567页

作者： Monika Dagliya neelima Satyam Meghna Sharma Ankit Garg Department of Civil Engineering Indian Institute of Technology IndoreIndoreIndia Department of Civil and Environmental Engineering Shantou UniversityShantouChina L.N.Gumilyov Eurasian National University Nur-SultanKazakhstan

Wind erosion is one of the significant natural calamities worldwide, which degrades around one-third of global land. The eroded and suspended soil particles in the environment may cause health hazards, *** and respiratory diseases, due to the presence of harmful contaminants, bacteria, and *** present study evaluates the feasibility of microbially induced calcium carbonate precipitation(MICP)technique to mitigate wind-induced erosion of calcareous desert sand(Thar desert of Rajasthan province in India). The temperature during biotreatment was kept at 36℃ to stimulate the average temperature of the Thar desert. The spray method was used for bioaugmentation of Sporosarcina(S.) pasteurii and further treatment using chemical solutions. The chemical solution of 0.25 pore volume was sprayed continuously up to 5 d, 10 d, 15 d, and 20 d, using two different concentration ratios of urea and calcium chloride dihydrate viz 2:1 and 1:1. The biotreated samples were subjected to erosion testing(in the wind tunnel) at different wind speeds of 10 m/s, 20 m/s, and 30 m/s. The unconfined compressive strength of the biocemented crust was measured using a pocket penetrometer. The variation in calcite precipitation and microstructure(including the presence of crystalline minerals) of untreated as well as biotreated sand samples were determined through calcimeter, scanning electron microscope(SEM), and energydispersive X-ray spectroscope(EDX). The results demonstrated that the erosion of untreated sand increases with an increase in wind speeds. When compared to untreated sand, a lower erosion was observed in all biocemented sand samples, irrespective of treatment condition and wind speed. It was observed that the sample treated with 1:1 cementation solution for up to 5 d, was found to effectively resist erosion at a wind speed of 10 m/s. Moreover, a significant erosion resistance was ascertained in15 d and 20 d treated samples at higher wind speeds. The calcite content

关键词： Control wind erosion Microbially induced calcium carbonate precipitation(MICP) Surface strength Wind tunnel Calcite precipitation

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Immunomodulatory and anticancer activity of Bombax ceiba Linn leaf extract

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Asian Pacific Journal of Tropical Biomedicine 2020年第9期10卷 426-432页

作者： neelima Sharma Sneha Kispotta Papiya Mitra Mazumder Department of Pharmaceutical Sciences&Technology Birla Institute of TechnologyMesraRanchiIndia

Objective:To evaluate the immunomodulatory and anticancer activity of the methanolic extract of Bombax ceiba leaves in vitro and in ***:The antioxidant property of methanolic extract of Bombax ceiba leaves was determined by measuring hydrogen peroxide scavenging and DPPH scavenging *** effect on cellular immunity in vivo was determined by measuring neutrophil adhesion,carbon clearance,sheep red blood cell induced DTH response and cyclophosphamide-induced *** vitro anticancer activity was evaluated on human leukaemia cell line(HL-60)by MTT assay,caspase-3 activity,and cell cycle ***:The methanolic extract of Bombax ceiba leaves showed antioxidant activity and significantly increased neutrophil adhesion,carbon clearance from blood,DTH response and cyclophosphamideinduced *** MTT assay showed a significant increase in the death of HL-60 cell line.A rise in caspase-3 activity and sub-G1 population in the presence of methanolic extract of Bombax ceiba leaves was ***:The methanolic extract of leaves of Bombax ceiba L possesses anticancer activity,immunomodulatory activity,and antioxidant properties,proving its therapeutic usefulness in the treatment of immuno-compromised diseases and cancers.

关键词： Anticancer Antioxidative Bombax ceiba Immunomodulatory

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