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An exponential expanding meshes sequence and finite difference method adopted for two-dimensional elliptic equations

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International Journal of Modeling, Simulation, and Scientific Computing 2016年第2期7卷 109-125页

作者： Navnit Jha neelesh Kumar Faculty of Mathematics and Computer Science Department of Mathematics South Asian University ChanakyapuriNew Delhi 110021India

We demonstrate a new nonuniform mesh finite difference method to obtain accurate solutions for the elliptic partial differential equations in two dimensions with nonlinear first-order partial derivative *** method will be based on a geometric grid network area and included among the most stable differencing scheme in which the nine-point spatial finite differences are implemented,thus arriving at a compact *** general,a third order of accuracy has been achieved and a fourth-order truncation error in the solution values will follow as a particular *** efficiency of using geometric mesh ratio parameter has been shown with the help of *** convergence of the scheme has been established using the matrix analysis,and irreducibility is proved with the help of strongly connected characteristics of the iteration *** difference scheme has been applied to test convection diffusion equation,steady state Burger’s equation,ocean model and a semi-linear elliptic *** computational results confirm the theoretical order and accuracy of the method.

关键词： Geometric mesh finite difference compact method elliptic partial differential equations convection diffusion equation Stommel ocean model

Design of a 2-DOF-PID controller using an improved sine-cosine algorithm for load frequency control of a three-area system with nonlinearities

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Protection and Control of Modern Power Systems 2022年第1期7卷 490-507页

作者： neelesh Kumar Gupta Manoj Kumar Kar Arun Kumar Singh Department of Electrical Engineering NIT JamshedpurJamshedpurJharkhand 831014India

This paper proposes an improved sine-cosine algorithm(ISCA)based 2-DOF-PID controller for load frequency control.A three-area test system is built for study,while some physical constraints(nonlinearities)are considered for the investigation of a realistic power *** proposed method is used as the parameter optimizer of the LFC control-ler in different *** 2-DOF-PID controllers are used because of their capability of fast disturbance rejection without significant increase of overshoot in set-point *** 2-DOF-PID controllers’efficacy is observed by examining the responses with the outcomes obtained with PID and FOPID *** simulation results with the suggested scheme are correlated with some of the existing algorithms,such as SCA,SSA,ALO,and PSO in three dif-ferent scenarios,i.e.,a disturbance in two areas,in three areas,and in the presence of physical *** addition,the study is extended to a four-area power *** analysis is performed using the Wilcoxon Sign Rank Test(WSRT)on 20 independent *** confirms the supremacy of the proposed method.

关键词： 2-DOF-PID FOPID Load frequency control WSRT Statistical analysis Improved sine-cosine algorithm

Gastroprotective effect of Achyranthes aspera Linn,leaf on rats

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Asian Pacific Journal of Tropical Medicine 2012年第3期5卷 197-201页

作者： Ashish K Das Papiya Bigoniya neelesh K Verma AC Rana Department of Pharmacology Radharaman College of PharmacyBhopal-02M.P.India Rayat College of Pharmacy Rail Majranear Ropar NawanshahrPunjabIndia

Objective:The study was aimed al evaluating the antiulcer activity of ethanolic extract of Achyranthes aspera(EEAA) ***:The anti-ulcer assays were performed on pylorus ligation and chronic ethanol induced ulcer *** effects of the EEAA on gastric content volume,*** acidity,total acidity and ulcer index were ***:The percentage of ulcer protection(59.55%and 35.58%) was significantly(P < 0.001) higher in the groups treated with the high dose of EEAA(600 mg/kg),it also reduced the volume of gastric juice and total acidity whereas,gastric pH was increased ***:The results of this study show significant gastroprotective activity of EEAA may be due to presence of phyto-constituents like flavanoids,saponins and tannins.

关键词： Antiulcer Achyranthes aspera Gastroprotective Omeprazole Ethanol

Wound healing activity of aqueous extract of Crotalaria verrucosa in Wistar albino rats

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Asian Pacific Journal of Tropical Medicine 2010年第10期3卷 783-787页

作者： Meena Kumari Eesha BR Mohanbabu Amberkar Sarath babu Rajshekar neelesh Kumar Department of Pharmacology Kasturba Medical CollegeManipal University

Objective:To evaluate the wound healing effect of aqueous extract of Crotalaria verrucosa(C. verrucosa) in ***:Three wound models including incision,excision and dead space wounds were used in this *** parameters studied were breaking strength in incision models,granulation tissue dry weight,breaking strength and hydroxyproline content in dead space wounds,percentage of wound contraction and period of epithelialization in excision wound ***:Two doses of the extract with and without dexamethasone showed significant increases in mean hydroxyproline,total protein content and dry weight of granulation tissue but it was higher with dose 800 mg/kg comparing with the *** dexamethasone treated group showed a significant(P<0.001) reduction in the wound breaking strength when compared to control group in incision type of wound *** of *** with dexamethasone significantly(P<0.001) increased the breaking strength compared to the dexamethasone treated only *** excision wound model,the percentage of the wound contraction was significantly(P<0.01) increased by two doses of test extract on all the days except the lower dose which exhibited only on 12th,16th days of drug treatment and it also reversed the dexamethasone suppressed wound *** significantly(P<0.001) reduced the time required for epithelialization and reversed the epithelialization delaying effect of dexamethasone (P<0.001).Conclusions:*** was found to possess significant wound healing property. This was evident by decrease in the period of epithelialization,increase in the rate of wound contraction,skin breaking strength,and granulation tissue dry weight *** C. verrucosa could be a good wound healing agent.

关键词： Crotalaria verrucosa Incision wound Excision wound Deadspace wound Wound breaking strength

雾化治疗中气溶胶在深层肺泡输运特性的数值模拟

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医用生物力学 2022年第4期37卷 644-649页

作者：唐浦 Aranyak CHAKRAVARTY neelesh A.PATANKAR 匡波上海交大通大学机械与动力工程学院上海200240 美国西北大学机械工程学院伊利诺伊州60208

目的基于计算流体动力学的方法,模拟计算单个肺泡中的气体与气溶胶颗粒输运情况,研究深层肺泡内气体流动和气溶胶颗粒输运特性。方法采用一端有周期性扩张/收缩半球形壁的长直导管作为单一肺泡及肺泡管的简化近似,建立二维数学模拟模型... 详细信息

目的基于计算流体动力学的方法,模拟计算单个肺泡中的气体与气溶胶颗粒输运情况,研究深层肺泡内气体流动和气溶胶颗粒输运特性。方法采用一端有周期性扩张/收缩半球形壁的长直导管作为单一肺泡及肺泡管的简化近似,建立二维数学模拟模型。考虑呼吸气体在半球边界上的扩散,采用欧拉-欧拉方法对肺泡管中气体以及气溶胶颗粒的输运方程进行求解。结果整个呼吸过程中,管道中空气的成分比率以稳定的周期方式随时间变化。气溶胶在管道输运主要依赖于颗粒的扩散系数,平流输运只有微小的影响。气溶胶颗粒尺寸减小时,气溶胶的扩散速度与深度均有提高,粒径小于4μm时该现象尤为明显,且呼吸频率和幅度的增大可以显著提升颗粒的输运能力。结论雾化治疗中,粒径较小的气溶胶颗粒可以增强药物扩散速度。深呼吸有助于提升颗粒的输运效果,治疗中应鼓励患者深呼吸。

关键词：雾化疗法深层肺泡模型气溶胶输运欧拉-欧拉方法数值模拟动网格

Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways

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Chinese Journal of Natural Medicines 2017年第1期15卷 15-40页

作者： Do Luong Huynh neelesh Sharma Amit Kumar Singh Simrinder Singh Sodhi ZHANG Jiao-Jiao Raj Kumar Mongre Mrinmoy Ghosh Nameun Kim Yang Ho Park Dong Kee Jeong Laboratory of Animal Genetic Engineering and Stem Cell Biology Department of Animal Biotechnology Faculty of Biotechnology Jeju National University Jeju 63243 Republic of Korea Division of Veterinary Medicine Faculty of Veterinary Science & Animal Husbandry Sher-e-Kashmir University of Agricultural Sciences & Technology R.S. Pura Jammu 181102 India BRM Institute Seoul 06111 Republic of Korea

Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis(Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anticancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase Akt(also known as protein kinase B) and AMP-activated protein kinase(AMPK) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity. Furthermore, wogonin also decreases DNA adduct formation with a carcinogenic compound 2-Aminofluorene and inhibits growth of drug resistant malignant cells and their migration and metastasis, without any side effects. Recently, newly synthesized wogonin derivatives have been developed with impressive anti-tumor activity. This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin. We also summarize the potential of wogonin and its derivatives used alone or as an adjunct therapy for cancer treatment. Furthermore, pharmacokinetics and side effects of wogonin and its analogues have also been discussed.

关键词： Anti-cancer Apoptosis Wogonin Signaling pathways Pharmacokinetics

A bi-level optimization for a make-to-order manufacturing supply chain planning:a case in the steel industry Lanndon

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Journal of Management Analytics 2021年第4期8卷 598-621页

作者： Lanndon A.Ocampo neelesh N.Vasnani Felixter Leone S.Chua Lance Brandon M.Pacio Brian J.Galli Department of Industrial Engineering Cebu Technological UniversityCebu CityPhilippines Graduate School Cebu Technological UniversityCebu CityPhilippines Department of Industrial Engineering University of San CarlosCebu CityPhilippines School of Computer Science Innovation&Management EngineeringHofstra UniversityHempsteadNew YorkUSA

This paper presents an actual case application of a newly developed gametheoretic model in analyzing a single manufacturer-many supplier,multi-period,make-to-order supply chain with fuzzy *** supply chain under consideration comprises an exclusive supplier for every component required by the manufacturer in producing its *** certain instances,some supply chains enable the manufacturer to opt for a third-party subcontractor to produce a portion of its *** assume that the supply chain faces a price and lead-time-sensitive demand,which is relevant in a make-to-order *** vertical interaction within the supply chain is played as a Stackelberg game,where the manufacturer is considered the leader and the suppliers as the *** show some important managerial insights in supply chain planning under a make-to-order condition.

关键词： Make-to-order supply chain production planning Stackelberg game bi-level optimization

Evaluation of Anthropogenic Air Emissions from Marine Engines in a Coastal Urban Airshed of Texas

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Journal of Environmental Protection 2013年第7期4卷 722-731页

作者： Zuber M. Farooqui Kuruvilla John neelesh Sule Department of Mechanical and Energy Engineering University of North Texas Denton USA

Corpus Christi, Texas, is a growing urban area with a busy port and a petrochemical industrial base that is currently in compliance with the US Environmental Protection Agency’s (EPA) National Ambient Air Quality Standards (NAAQS) for ozone. However, the Texas Commission on Environmental Quality (TCEQ) has classified this urban airshed as a near non-attainment area. A comprehensive annual air emission inventory based on marine engines activity was developed for the years of 2006-2009 for the Port of Corpus Christi, Texas using recent EPA approved methodology. A regional-scale photochemical model Comprehensive Air Modeling system with extensions (CAMx) was used to evaluate the impact of these emissions on the ground level ozone concentrations by zeroing out the emissions and employing Direct Decoupled Method (DDM) for sensitivity analysis to estimate the 8-hour ozone sensitivity coefficients due to NOx and VOC emissions from marine engines. The analysis has shown a localized increase of up to 7.8 ppb in the 8-hour ozone concentration very close to the port premises and a decrease of about 1.73 ppb further downwind. Ozone sensitivity analysis using DDM on the 8-hour ozone concentrations showed a higher sensitivity to NOx emissions. Thus, any NOx related controls of marine engines will benefit local urban and regional ozone levels.

关键词： Marine Engine Emissions Ozone Photochemical Modeling Port Air Quality Management

Evaluation of remote radiologist-interpreted point-of-care ultrasound for suspected dengue patients in a primary health care facility in Colombia

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Infectious Diseases of Poverty 2023年第5期12卷 45-57页

作者： Lyda Osorio Iñigo Prieto Daniela Zuluaga Deliana Ropero neelesh Dewan Jonathan D.Kirsch Epidemiology and Population Health Research Group(GESP) School of Public HealthUniversidad del ValleCaliColombia Department of Radiology School of MedicineUniversidad del ValleCaliColombia Division of General Internal Medicine Department of Internal MedicineUniversity of Minnesota Medical SchoolMinneapolisMN 55455USA Department of Internal Medicine University of Miami Miller School of MedicineMiamiFLUSA

Background Early identification of plasma leakage may guide treatment decisions in dengue *** study evaluated the value of point-of-care ultrasound(POCUS)to detect plasma leakage and predict hospitalization or referral to a higher level of care in suspected dengue patients under routine conditions at a primary care facility in *** We conducted a cohort study between April 2019 and March 2020 in a primary care hospital in Cali,*** prospectively included and followed 178 patients who were at least 2 years old with fever of less than 10 days and clinician-suspected dengue.A trained general practitioner performed a standardized POCUS *** were quality-rated and overread by an expert radiologist,and her results and those of the general practitioner were compared using the Kappa *** regression was used to identify factors associated with plasma leakage at enrollment and explore its prognostic value regarding hospital admission or referral to a higher level of *** Half(49.6%)POCUS images were of suitable quality to be *** proportion of plasma leakage reported by the radiologist was 85.1%(95%CI:78.6-90.2%)and 47.2%by the study physician(Kappa=0.25,95%CI:0.15-0.35).The most frequent ultrasound findings were ascites(hepatorenal 87.2%,splenorenal 64%,or pelvic 21.8%)and gallbladder wall thickening(10.5%).Plasma leakage was higher in subjects with thrombocytopenia(aOR=4,95%CI:1.3-12.1)and lower in patients 30-59 years old(aOR=0.1,95%CI:0.0-0.4)than in those 18 years old or *** evidence of plasma leakage(aOR=8.2,95%CI:2.2-29.9),thrombocytopenia(aOR=6.3,95%CI:2.4-16.0)and pulse pressure(aOR=1.1,95%CI:1.07-1.2)were associated with hospital admission or referral to a higher level of *** Ultrasound is useful to detect plasma leakage in primary care and,challenges remain to guarantee high-quality images and diagnostic accuracy,for which a standardized dengue POCUS protocol and training pr

关键词： Dengue Ultrasound Plasma leakage Primary care Colombia