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Design of ANN Based Non-Linear Network Using Interconnection of Parallel Processor

Computer Systems Science & Engineering 2023年第9期46卷 3491-3508页

作者： Anjani Kumar Singha Swaleha Zubair Areej Malibari Nitish Pathak Shabana Urooj neelam Sharma Department of Computer Science Aligarh Muslim UniversityAligarh202002India Department of Industrial and Systems Engineering College of EngineeringPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Information Technology Bhagwan Parshuram Institute of Technology(BPIT)GGSIPUNew Delhi110078India Department of Electrical Engineering College of EngineeringPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Artificial Intelligence&Machine Learning Maharaja Agrasen Institute of Technology(MAIT)GGSIPUNew Delhi110086India

Suspicious mass traffic constantly evolves,making network behaviour tracing and structure more *** networks yield promising results by considering a sufficient number of processing elements with strong interconnections between *** offer efficient computational Hopfield neural networks models and optimization constraints used by undergoing a good amount of parallelism to yield optimal *** neural network(ANN)offers optimal solutions in classifying and clustering the various reels of data,and the results obtained purely depend on identifying a *** this research work,the design of optimized applications is presented in an organized *** addition,this research work examines theoretical approaches to achieving optimized results using *** mainly focuses on designing *** optimizing design approach of neural networks analyzes the internal process of the neural *** in developing the network are based on the interconnections among the hidden nodes and their learning *** methodology is proven best for nonlinear resource allocation problems with a suitable design and complex *** ANN proposed here considers more or less 46k nodes hidden inside 49 million connections employed on full-fledged parallel *** proposed ANN offered optimal results in real-world application problems,and the results were obtained using MATLAB.

关键词： Artificial neural network(ANN) multiprocessor hidden node nonlinear optimization parallel processing

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Calcium chloride linked camel milk derived casein nanoparticles for the delivery of sorafenib in hepatocarcinoma cells

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BIOCELL 2022年第1期46卷 127-136页

作者： AASTHA MITTAL neelam MAHALA KOWTHAVARAPU VENKATA KRISHNA UMA S.DUBEY SUNIL KUMAR DUBEY Department of Biological Sciences Birla Institute of Technology and SciencePilani CampusPilani(BITS-PILANI)333031India Department of Pharmacy Birla Institute of Technology and SciencePilani CampusPilani(BITS-PILANI)333031India R&D Healthcare Division Emami Ltd.Kolkata700056India

Sorafenib,a multikinase inhibitor used for the treatment of hepatocellular carcinoma,is limited by its low oral *** overcome this drawback,we have developed novel camel milk casein-derived nanoparticles as a drug delivery *** milk casein is not only biocompatible on oral administration but is actually a dietary protein of pharmaceutical *** is used because of its amphiphilic nature,self-assembling property,ability to show sustained release,and capability of encapsulating both hydrophilic and hydrophobic *** this study,camel milk casein nanoparticles loaded with sorafenib were developed and *** of casein nanoparticles was done by dynamic light scattering(DLS),zeta potential analysis,scanning light microscopy(SEM),and *** drug content in nanoparticle and drug-protein binding studies were conducted by UV *** cytotoxicity and cellular uptake efficiency studies were performed in HepG2 cell *** was observed that the cytotoxic effect of sorafenib loaded camel milk casein nanoparticles was more than free sorafenib in HepG2 *** work suggests camel milk casein as a suitable drug delivery molecule for *** the future,it may also be used in enhancing the efficacy and specific distribution of other water-insoluble anticancer drugs.

关键词： Camel milk derived casein nanoparticles Sorafenib UV spectroscopy FTIR HepG2 cells Apoptosis

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N-Summet-k and Its Application in the Construction of Pascal Triangle and Pascal Matrix

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Journal of Applied Mathematics and Physics 2016年第1期4卷 169-177页

作者： neelam Jeevan Kumar Department of Electrical and Electronics Engineering Jawaharlal Nehru Technological University Hyderabad College of Engineering Jagtial India

Summetor is an operator used in the mathematics to calculate the special numbers like binomial coefficients and combinations of group elements. It has many applications in algebra, matrices like calculation of pascal triangle elements and pascal matrix formation, etc. This paper explains about its functions and properties of N-Summet-k. The result of variation between N and k is shown in tabulation.

关键词： Summetor N-Summet-k Binomial Coefficients Pascal’s Triangle Pascal’s Matrix

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Text Augmentation-Based Model for Emotion Recognition Using Transformers

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Computers, Materials & Continua 2023年第9期76卷 3523-3547页

作者： Fida Mohammad Mukhtaj Khan Safdar Nawaz Khan Marwat Naveed Jan neelam Gohar Muhammad Bilal Amal Al-Rasheed Department of Computer Science The University of HaripurHaripur22620Pakistan Department of Computer Systems Engineering Faculty of Electrical and Computer EngineeringUniversity of Engineering and Technology PeshawarPeshawar25120Pakistan Department of Electronics Engineering Technology University of TechnologyNowshera24100Pakistan Department of Computer Science Shaheed Benazir BhuttoWomen UniversityPeshawar25000Pakistan Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia

Emotion Recognition in Conversations(ERC)is fundamental in creating emotionally ***-BasedNetwork(GBN)models have gained popularity in detecting conversational contexts for ERC ***,their limited ability to collect and acquire contextual information hinders their *** propose a Text Augmentation-based computational model for recognizing emotions using transformers(TA-MERT)to address *** proposed model uses the Multimodal Emotion Lines Dataset(MELD),which ensures a balanced representation for recognizing human *** used text augmentation techniques to producemore training data,improving the proposed model’s *** encoders train the deep neural network(DNN)model,especially Bidirectional Encoder(BE)representations that capture both forward and backward contextual *** integration improves the accuracy and robustness of the proposed ***,we present a method for balancing the training dataset by creating enhanced samples from the original *** balancing the dataset across all emotion categories,we can lessen the adverse effects of data imbalance on the accuracy of the proposed *** results on the MELD dataset show that TA-MERT outperforms earlier methods,achieving a weighted F1 score of 62.60%and an accuracy of 64.36%.Overall,the proposed TA-MERT model solves the GBN models’weaknesses in obtaining contextual data for ***-MERT model recognizes human emotions more accurately by employing text augmentation and transformer-based *** balanced dataset and the additional training samples also enhance its *** findings highlight the significance of transformer-based approaches for special emotion recognition in conversations.

关键词： Emotion recognition in conversation graph-based network text augmentation-basedmodel multimodal emotion lines dataset bidirectional encoder representation for transformer

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Alternative models of cancer stem cells: The stemness phenotype model, 10 years later

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World Journal of Stem Cells 2021年第7期13卷 934-943页

作者： Vivek Kaushik Yogesh Kulkarni Kumar Felix neelam Azad Anand Krishnan V Iyer Juan Sebastian Yakisich School of Pharmacy Department of Pharmaceutical SciencesHampton UniversityHamptonVA 23668United States

The classical cancer stem cell(CSCs)theory proposed the existence of a rare but constant subpopulation of *** this model cancer cells are organized hierarchically and are responsible for tumor resistance and tumor ***,eliminating CSCs will eventually lead to cure of *** simplistic model has been challenged by experimental *** 2010 we proposed a novel and controversial alternative model of CSC biology(the Stemness Phenotype Model,SPM).The SPM proposed a non-hierarchical model of cancer biology in which there is no specific subpopulation of CSCs in ***,cancer cells are highly plastic in term of stemness and CSCs and non-CSCs can interconvert into each other depending on the *** model predicts the existence of cancer cells ranging from a pure CSC phenotype to pure non-CSC phenotype and that survival of a single cell can originate a new *** the past 10 years,a plethora of experimental evidence in a variety of cancer types has shown that cancer cells are indeed extremely plastic and able to interconvert into cells with different stemness *** this review we will(1)briefly describe the cumulative evidence from our laboratory and others supporting the SPM;(2)the implications of the SPM in translational oncology;and(3)discuss potential strategies to develop more effective therapeutic regimens for cancer treatment.

关键词： Cancer Stem cells Stemness Plasticity Chemotherapy Interconversion

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Geospatial Analysis of Urban Heat Island Effects and Tree Equity

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Open Journal of Forestry（林学期刊） 2024年第1期

作者： Jillian Gorrell Sharon R.Jean-Philippe Paul D.Ries Jennifer K.Richards neelam C.Poudyal Rochelle Butler

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Exploiting DNA repair pathways for tumor sensitization,mitigation of resistance,and normal tissue protection in radiotherapy

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Cancer Drug Resistance 2021年第2期4卷 244-263页

作者： Jac A.Nickoloff Lynn Taylor neelam Sharma Takamitsu A.Kato Department of Environmental and Radiological Health Sciences Colorado State UniversityFt.CollinsCO 80523USA.

More than half of cancer patients are treated with radiotherapy,which kills tumor cells by directly and indirectly inducing DNA damage,including cytotoxic DNA double-strand breaks(DSBs).Tumor cells respond to these threats by activating a complex signaling network termed the DNA damage response(DDR).The DDR arrests the cell cycle,upregulates DNA repair,and triggers apoptosis when damage is *** DDR signaling and DNA repair pathways are fertile terrain for therapeutic *** review highlights strategies to improve therapeutic gain by targeting DDR and DNA repair pathways to radiosensitize tumor cells,overcome intrinsic and acquired tumor radioresistance,and protect normal *** biological and environmental factors determine tumor and normal cell responses to ionizing radiation and genotoxic *** include cell type and cell cycle phase distribution;tissue/tumor microenvironment and oxygen levels;DNA damage load and quality;DNA repair capacity;and susceptibility to apoptosis or other active or passive cell death *** provide an overview of radiobiological parameters associated with X-ray,proton,and carbon ion radiotherapy;DNA repair and DNA damage signaling pathways;and other factors that regulate tumor and normal cell responses to *** then focus on recent studies exploiting DSB repair pathways to enhance radiotherapy therapeutic gain.

关键词： DNA repair DNA double-strand break repair non-homologous end-joining homologous recombination radiosensitization radioprotection cancer therapy

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A new paradigm for diagnosis of neurodegenerative diseases: peripheral exosomes of brain origin

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Translational Neurodegeneration 2022年第1期11卷 532-546页

作者： neelam Younas Leticia Camila Fernandez Flores Franziska Hopfner Günter U.Höglinger Inga Zerr Prion Research Group Department of NeurologyNational Reference Center for Surveillance of TSEUniversitätsklinikum Göttingen:Universitätsmedizin GöttingenGeorg-August UniversityGöttingenGermanyRobert-Koch-Strasse 4037075 GöttingenGermany Hannover Medical School Medizinische Hochschule HannoverHannoverGermany German Center for Neurodegenerative Diseases(DZNE) MunichGermany German Center for Neurodegenerative Diseases(DZNE) GöttingenGermany.

Neurodegenerative diseases are a heterogeneous group of maladies, characterized by progressive loss of neurons. These diseases involve an intricate pattern of cross-talk between different types of cells to maintain specific signaling pathways. A component of such intercellular cross-talk is the exchange of various types of extracellular vesicles (EVs). Exosomes are a subset of EVs, which are increasingly being known for the role they play in the pathogenesis and progression of neurodegenerative diseases, e.g., synucleinopathies and tauopathies. The ability of the central nervous system exosomes to cross the blood-brain barrier into blood has generated enthusiasm in their study as potential biomarkers. However, the lack of standardized, efficient, and ultra-sensitive methods for the isolation and detection of brain-derived exosomes has hampered the development of effective biomarkers. Exosomes mirror heterogeneous biological changes that occur during the progression of these incurable illnesses, potentially offering a more comprehensive outlook of neurodegenerative disease diagnosis, progression and treatment. In this review, we aim to discuss the challenges and opportunities of peripheral biofluid-based brain-exosomes in the diagnosis and biomarker discovery of Alzheimer’s and Parkinson’s diseases. In the later part, we discuss the traditional and emerging methods used for the isolation of exosomes and compare their advantages and disadvantages in clinical settings.

关键词： Alzheimer’s disease Central nervous system Diagnosis Exosomes Blood-brain barrier Parkinson’s disease

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Extraocular retinoblastoma in Indian children:clinical,imaging and histopathological features

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 481-486页

作者： Sumita Sethi neelam Pushker Seema Kashyap Sanjay Sharma Mridula Mehta Sameer Bakhshi Saurbhi Khurana Supriyo Ghose Oculoplasty and Pediatric Ophthalmology Services Dr.Rajendra Prasad Centre for Ophthalmic SciencesAll India Institute of Medical Sciences Department of Ocular Pathology Dr.Rajendra Prasad Centre for Ophthalmic SciencesAll India Institute of Medical Sciences Department of Radiodiagnosis All India Institute of Medical Sciences Department of Medical Oncology Dr.B.R.Ambedkar Institute Rotary Cancer HospitalAll India Institute of Medical Sciences

AIMTo study eyes with extraocular dissemination (EORB), with the following aims: first to establish the mean lag period and to understand various reasons for delayed presentation, second to study their imaging profile... 详细信息

关键词： extraocular retinoblastoma imaging histopathological features

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Evaluation of Phytoremediation Potential of <i>Catharanthus roseus</i>with Respect to Chromium Contamination

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American Journal of Plant Sciences 2014年第15期5卷 2378-2388页

作者： Rumana Ahmad neelam Misra College of Natural and Applied Sciences (CONAS) Crescent University Abeokuta Nigeria Department of Life Sciences ITM University Gwalior India

A major environmental concern due to dispersal of industrial and urban wastes generated by human activities is the contamination of soil. The release of heavy metals into the terrestrial ecosystem is a major problem. Accumulation of heavy metals in environment and particularly in soil is a serious environmental concern, as the accumulated heavy metal ions can find their way into living organisms via contamination of ground water or food chain. This praxis urgently requires and demands governmental regulations in India. Two samples of sludge were collected from Banthar Industrial Pollution Control Company (BIPCC), UP State Industrial Development Corporation (UPSIDC), Leather Technology Park, Banthar, Unnao, India. In the present study, the phytoremediation potential of Catharanthus roseus, a valued medicinal plant, with respect to chromium has been analyzed. C. roseus was shown to absorb up to about 38% of the amount of Cr present in primary and secondary sludge amended soil through roots and accumulate it to about 22% in leaves. Effect of chromium concentration on the status of antioxidant enzyme peroxidase (POD) and detoxification enzyme glutathione-S-transferase (GST) from C. roseus leaves was also observed and determined. Increased expressions of POD and GST were observed on native PAGE under stress conditions as compared to control. C. roseus can well tolerate low amounts of chromium (and accumulate it to about 22% in leaves) and can, thus, prove useful in the reclamation and remediation of chromium contaminated soil and land.

关键词： Phytoremediation Bioaccumulation Catharanthus roseus Chromium Toxicity Land Reclamation

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