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Colon mucosal neoplasia referred for endoscopic mucosal resection:Recurrence of adenomas and prediction of submucosal invasion

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World Journal of Gastrointestinal Endoscopy 2020年第7期12卷 198-211页

作者： Mamoon Ur Rashid neelam khetpal Hammad Zafar Saeed Ali Evgeny Idrisov Yuan Du Assaf Stein Deepanshu Jain Muhammad Khalid Hasan Department of Internal Medicine Advent Health Graduate Medical EducationOrlandoFL 32804United States Department of Internal Medicine Univerity of Iowa hospitalIowa CityIA 52242United States Department of Gastroenterology University of Oklahoma Health SciencesOklahomaOK 73104United States Center for Interventional Endoscopy AdventHealthOrlandoFL 32803United States

BACKGROUND Endoscopic mucosal resection(EMR)is an effective and minimally invasive alternative to surgery for large polyps and laterally spreading *** morphology and surface characteristics may help predict submucosal invasion of the lesion(SMIL)during endoscopic *** is one of the largest singlecenter studies reporting endoscopic mucosal resection for larger(≥20 mm)colorectal lesions in the United *** To determine the recurrence rate of adenomas and endoscopic features that may predict submucosal invasion of colonic mucosal *** This is a retrospective cohort study of all the patients referred for endoscopic mucosal resection for lesions≥20 mm,spanning a period from January 2013 to February *** main outcome measure was identifying features that may predict submucosal invasion of mucosal lesions and predict recurrence of adenomas on follow-up surveillance colonoscopy performed at 4-6 *** A total of 480 patients with 500 lesions were included in the *** median age was 68(Inter quantile range:14)with 52%*** most common lesion location was ascending colon(161;32%).Paris classification 0-IIa(Flat elevation of mucosa-316;63.2%);Kudo Pit Pattern IIIs(192;38%)and Granular surface morphology(260;52%)were most *** invasion was present in 23(4.6%)out of 500 *** independent risk factors for SMIL were Kudo Pit Pattern IIIL+IV and V(Odds ratio:4.5;P value40 mm).Almost all recurrences(98.8%)were treated endoscopically.

关键词： Endoscopy Polyp Endoscopic mucosal resection Recurrence Submucosal invasion

Is the speed of adjusting to environmental change condition dependent?An experiment with house mice(Mus musculus)

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Current Zoology 2024年第3期70卷 350-360页

作者： Karem Lopez-Hervas neelam Porwal Mathilde Delacoux Alexandros Vezyrakis Anja Guenther RG Behavioural Ecology of Individual Differences Max Planck Institute for Evolutionary Biology24306 PlönGermany Department of Evolutionary Biology Faculty of BiologyAdam Mickiewicz UniversityWieniawskiego 161-712 PoznańPoland Department for Collective Behaviour Max Planck Institute of Animal Behaviour78464 ConstanceGermany Centre for the Advanced Study of Collective Behaviour University of Konstanz78464 ConstanceGermany Animal Ecology Institute for Biochemistry and BiologyUniversity of Potsdam14469 PotsdamGermany

Environmental conditions change constantly either by anthropogenic perturbation or naturally across space and ***,a change in behavior is the frst response to changing *** fexibility can potentially improve an organism’s chances to survive and ***,we lack an understanding on the time-scale such behavioral adjustments need,how they actually affect reproduction and survival and whether behavioral adjustments are suffcient in keeping up with changing *** used house mice(Mus musculus)to test whether personality and life-history traits can adjust to an experimentally induced food-switch fexibly in adulthood or by intergenerational plasticity,that is,adjustments only becoming visible in the offspring *** lived in 6 experimental populations of semi-natural environments either on high or standard quality food for 4 *** showed previously that high-quality food induced better conditions and a less risk-prone ***,we tested whether the speed and/or magnitude of adjustment shows condition-dependency and whether adjustments incur ftness ***-history but not personality traits reacted fexibly to a food-switch,primarily by a direct reduction of reproduction and sloweddown *** whose parents received a food-switch developed a more active stress-coping personality and gained weight at a slower rate compared with their respective ***,the modulation of most traits was condition-dependent,with animals previously fed with high-quality food showing stronger *** study highlights that life-history and personality traits adjust at different speed toward environmental change,thus,highlighting the importance of the environment and the mode of response for evolutionary models.

关键词： animal personality context dependence environmental change Match-mismatch non-genetic inheritance phenotypic flexibility phenotypic plasticity

Management of proximal tibial stress fracture associated with advanced knee osteoarthritis:A systematic review

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Chinese Journal of Traumatology 2024年第3期27卷 147-152页

作者： Mukesh Kumar Saini Mahendra Singh Devendra Singh Prem Manohar Seervi Pera Jayavardhan Reddy neelam Ramana Reddy Department of Orthopaedics Dr SN Medical CollegeJodhpur342011India Department of Orthopaedics Star HospitalsB Block Banjara HillsHyderabad500034India

Purpose:Tibial stress fracture associated with knee osteoarthritis is an unusual and difficult clinical *** is no clear existing treatment guideline for this uncommon clinical *** aim of this study is to review the impact of various treatment options for patients with advanced knee osteoarthritis associated with proximal tibial stress ***:The study was performed using the databases of PubMed and *** index for non-randomized studies score was used to evaluate the included studies’*** concluded data included the treatment approach,reported outcome measure,and time to fracture *** literature search was started in December 2021 and accomplished in January 2022.A narrative description of the different methods and comparison of their results were ***:Out of total assessed 69 studies,9 studies were included in our *** commonest treatment approach used was total knee arthroplasty by long tibial stem *** mean preoperative knee society score and knee functional score were 30.62 and 23.17,*** mean postoperative knee society knee score was 86.87,while the functional score was *** average reported time to achieve fracture union was 4 months(a range of 2.07-5.50 months).Conclusion:The optimal clinical outcome for treating either acute or mobile tibial stress fracture in patients with advanced knee osteoarthritis can be achieved with long stem total knee ***,due to heterogeneity of data,comparison of different treatment options for chronic proximal tibial stress fracture mal-union/non-union coexisting with knee osteoarthritic and such inferences need to be judged cautiously.

关键词： Tibial stress fracture Knee osteoarthritis Total knee arthroplasty

Geospatial Analysis of Urban Heat Island Effects and Tree Equity

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Open Journal of Forestry 2024年第1期14卷 1-18页

作者： Jillian Gorrell Sharon R. Jean-Philippe Paul D. Ries Jennifer K. Richards neelam C. Poudyal Rochelle Butler School of Natural Resources University of Tennessee 203 Third Creek Building Knoxville Tennessee USA

In recent decades, Urban Heat Island Effects have become more pronounced and more widely examined. Despite great technological advances, our current societies still experience great spatial disparity in urban forest access. Urban Heat Island Effects are measurable phenomenon that are being experienced by the world’s most urbanized areas, including increased summer high temperatures and lower evapotranspiration from having impervious surfaces instead of vegetation and trees. Tree canopy cover is our natural mitigation tool that absorbs sunlight for photosynthesis, protects humans from incoming radiation, and releases cooling moisture into the air. Unfortunately, urban areas typically have low levels of vegetation. Vulnerable urban communities are lower-income areas of inner cities with less access to heat protection like air conditioners. This study uses mean evapotranspiration levels to assess the variability of urban heat island effects across the state of Tennessee. Results show that increased developed land surface cover in Tennessee creates measurable changes in atmospheric evapotranspiration. As a result, the mean evapotranspiration levels in areas with less tree vegetation are significantly lower than the surrounding forested areas. Central areas of urban cities in Tennessee had lower mean evapotranspiration recordings than surrounding areas with less development. This work demonstrates the need for increased tree canopy coverage.

关键词： Spatial Analysis Land Cover Urban Heat Island Effect (UHIE) Evapotranspiration Tree Canopy Impervious Surface GIS Prediction Model GIS Machine Learning

Microwave gel combustion synthesis and sinterability of Nd:GGG nanopowders

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Journal of Rare Earths 2014年第6期32卷 521-525页

作者： Kiranmala Laishram Rekha Mann neelam Malhan Laser Materials Division Laser Science and Technology Centre DRDO

Neodymium doped gadolinium gallium oxide （Nd：GGG） nanopowders synthesized by microwave gel combustion using alanine as a fuel was reported. Metal nitrates solution with alanine fuel was combusted in microwave to give precursor. The micro-wave precursor powder was calcined at different temperatures from 800 to 1100 ℃. Phase pure Nd：GGG formation took place at 800 to 1100 ℃ as observed by X-ray diffraction （XRD） and Fourier transform infra-red （FTIR） spectroscopy. However particle size in-creased with calcinations temperature from 25 nm at 800 ℃ to 200 nm at 1100 ℃.Nd：GGG nanopowder obtained at different calci-nation temperatures were compacted and sintered at 1550 ℃ for 3 h in air. Most densified ceramic was obtained from Nd：GGG nanopowder calcined at 1100 ℃. Microstructure as observed from scanning electron microscopy （SEM） showed that the most densi-fied ceramic, obtained from nanopowder calcined at a higher calcination temperature, had a more uniform grain-size distribution, fewer pores and greater densification. XRD of sintered sample showed retention of phase purity.

关键词： Nd:GGG microwave gel combustion calcinations densification rare earths

Current testing strategies for hepatitis C virus infection in blood donors and the way forward

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World Journal of Gastroenterology 2014年第11期20卷 2948-2954页

作者： neelam Marwaha Suchet Sachdev Department of Transfusion Medicine Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

Screening tests for blood donations are based upon sensitivity, cost-effectiveness and their suitability for high-throughput testing. Enzyme immunoassay (EIAs) for hepatitis C virus (HCV) antibodies were the initial screening tests introduced. The ”first generation“ antibody EIAs detected seroconversion after unduly long infectious window period. Improved HCV antibody assays still had an infectious window period around 66 d. HCV core antigen EIAs shortened the window period considerably, but high costs did not lead to widespread acceptance. A fourth-generation HCV antigen and antibody assay (combination EIA) is more convenient as two infectious markers of HCV are detected in the same assay. Molecular testing for HCV-RNA utilizing nucleic acid amplification technology (NAT) is the most sensitive assay and shortens the window period to only 4 d. Implementation of NAT in many developed countries around the world has resulted in dramatic reductions in transfusion transmissible HCV and relative risk is now < 1 per million donations. However, HCV serology still continues to be retained as some donations are serology positive but NAT negative. In resource constrained countries HCV screening is highly variable, depending upon infrastructure, trained manpower and financial resource. Rapid tests which do not require instrumentation and are simple to perform are used in many small and remotely located blood centres. The sensitivity as compared to EIAs is less and wherever feasible HCV antibody EIAs are most frequently used screening assays. Efforts have been made to implement combined antigen-antibody assays and even NAT in some of these countries.

关键词： Hepatitis C virus Screening tests Blood donors Immunoassays Nucleic acid testing

Single step low temperature synthesis of gadolinium gallium garnet nanopowders

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Journal of Rare Earths 2012年第6期30卷 545-547页

作者： Rekha Mann Kiranmala Laishram neelam Malhan Laser Materials Division Laser Science and Technology CentreDRDOMetcalfe House Delhi-110054India

Solution combustion synthesis of single-phase gadolinium gallium oxide （Gd3GasO12, GGG） nanopowders, by a fuel mixture approach using urea and glycine at a low temperature of 500 ℃, was being reported for the first time. Based on the fact that urea and glycine are good fuels for gallium oxide and gadolinium oxide synthesis, the fuel mixture composition was obtained, which could lead to direct phase pure cubic Gd3Ga5O12 formation without any subsequent calcination step. Combustion was carried out in furnace pre-heated at 500 ℃. Thermogravimetric analysis （TGA） of combustion product showed negligible mass loss indicating direct formation of GGG powder. Fourier transform infrared （FTIR） spectrum of combusted product showed peak characteristic of GGG in case of mixed fuel. X-ray diffraction （XRD） confirmed formation of phase pure GGG at 500 ℃ in preheated furnace. Very fine, well dispersed nanometric particles of size range of 50-100 nm were obtained, being uniform and close to spherical morphology as observed by transmission electron microscope （TEM）.

关键词： direct synthesis solution combustion GGG mixed fuel calcinations free rare earths

Marine Bacterial Biofilms in Bioremediation of Polycyclic Aromatic Hydrocarbons(PAHs) Under Terrestrial Condition in a Soil Microcosm

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Pedosphere 2017年第3期27卷 548-558页

作者： neelam MANGWANI Supriya KUMARI Surajit DAS Laboratory of Environmental Microbiology and Ecology (LEnME) Department of Life Science National Institute of TechnologyRourkela

Polycyclic aromatic hydrocarbons （PAHs） in soil retain for a quite long period due to their hydrophobicity and aggregation properties. Biofilm-forming marine bacterial consortium （named as NCPR）, composed of Stenotrophomonas acidaminiphila NCW702, Alcaligenes faecalis NCW402, Pseudomonas mendocina NR802, Pseudornonas aeruginosa N6P6, and Pseudomonas pseudoalcaligenes NP103, was used for the bioremediation of PAHs in a soil microcosm. Phenanthrene and pyrene were used as reference PAHs. Parameters that can affect PAH degradation, such as chemotaxis, solubility of PAHs in extracellular polymeric substances （EPS）, and catechol 2,3-dioxygenase （C230） activity, were evaluated. P. aeruginosa N6P6 and P. pseudoalcaligenes NP103 showed chemotactic movement towards both the reference PAHs. The solubility of both the PAHs was increased with an increase in EPS concentration （extracted from all the 5 selected isolates）. Significantly （P 〈 0.001） high phenanthrene （70.29%） and pyrene （55.54%） degradation was observed in the bioaugmented soil microcosm. The C230 enzyme activity was significantly （P 〈 0.05） higher in the bioaugmented soil mi- crocosm with phenanthrene added at 173.26 ± 2.06 nmol rain-1 mg-1 protein than with pyrene added at 61.80 ± 2.20 nmol min-1 mg-1 protein. The C230 activity and gas chromatography-mass spectrometer analyses indicated catechol pathway of phenanthrene metabolism. However, the metabolites obtained from the soil microcosm added with pyrene revealed both the catechol and phthalate pathways for pyrene degradation.

关键词： catechol 2 3-dioxygenase activity chemotactic movement degradation extracellular polymeric substances pyrene ~he-nanthrene

Effect of Cationic Micelles on the Kinetics of Interaction of [Cr(Ⅲ)-Gly-Gly]^2＋ with Ninhydrin

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物理化学学报 2008年第12期24卷 2207-2213页

作者： AKRAM Mohd ZAIDI neelam Hazoor KABIR-UD-DIN Department of Chemistry Aligarh Muslim University Aligarh-202002 India

The effect of cationic micelles of cetyltrimethylammonium bromide (CTAB) on the interaction of chromium dipeptide complex ([Cr(Ⅲ)-Gly-Gly]2+) with ninhydrin under varying conditions has been investigated. The rates of the reaction were determined in both water and surfactant micelles in the absence and presence of various organic and inorganic salts at 70 ℃ and pH 5.0. The reaction followed first- and fractional-order kinetics with respect to [Cr(Ⅲ)- Gly-Gly2+] and [ninhydrin]. Increase in the total concentration of CTAB from 0 to 40×10-3 mol·dm-3 resulted in an increase in the pseudo-first-order rate constant (kψ) by a factor of ca 3. Quantitative kinetic analysis of kψ-[CTAB] data was performed on the basis of the pseudo-phase model of the micelles. As added salts induce structural changes in micellar systems that may modify the substrate-surfactant interactions, the effect of some inorganic (NaBr, NaCl, Na2SO4) and organic (NaBenz, NaSal, NaTos) salts on the rate was also explored. It was found that the tightly bound counterions (derived from organic salts) were the most effective.

关键词：阳离子胶束动力学相互作用甘氨酸甘氨酸茚三酮