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Navigating the Third Frontier of Antimicrobial Therapy to Support Women’s Health

Open Journal of Obstetrics and Gynecology 2020年第8期10卷 1011-1035页

作者： Emma Wittman neela yar Bryan Larsen College of Osteopathic Medicine Marian University Indianapolis Indianapolis IN USA

This paper explores one of the underappreciated reasons for lack of efficacy in certain cases of antimicrobial therapy, namely the occurrence of a non-genetic resistance to antimicrobial drugs due to a metabolic quiescence of microorganisms. This review has centered on those microorganisms of particular importance in obstetrics and gynecology and accordingly has reviewed the nature and extent of the persister phenotype in relation to infectious agents affecting women’s health. We show how the quiescent persister microbial phenotype represents the next significant issue that could compromise successful antibiotic therapy. A brief history of antimicrobial therapy is provided as context for the problem posed by the persister phenotype. This review has been focused on the current literature having relevance for physicians concerned with women’s health. The study of this phenotype has led to increasing understanding of the molecular mechanisms for this state which also provides ideas for rational development of drug candidates to interdict these organisms in human disease and explores the possibility of developing specifically targeted molecules to address persisters, research on screening botanicals, existing drugs and chemicals to discover novel approaches to the clinical consequence of microbial persisters. Of interest in this review, is the return to naturally occurring botanical substances, first to be used as anti-infectives, now being considered as possible agents to address persister microorganisms. Overall this paper aims to provide information tailored especially to the obstetrics and gynecology specialists.

关键词： Gynecologic Infection Obstetric Infection Antibiotic Therapy Antimicrobial Resistance Quiescent Microorganisms Mechanisms

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Effects of Farnesol on Drug-Resistant and Non-Resistant <i>Candida albicans</i>: Implications for Cosmetic and Pharmaceutical Applications

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Advances in Microbiology 2020年第8期10卷 383-396页

作者： neela yar Emma Wittman Dominic Schaut Francesco De Seta Bryan Larsen College of Osteopathic Medicine Marian University Indianapolis Indianapolis IN USA Department of Medical Sciences University of Trieste Institute for Maternal and Child Health-IRCCS BurloGarofolo Trieste Italy

Background: Farnesol is added to numerous consumer products that intentionally, or inadvertently come in contact with tissues that may harbor the opportunistic yeast, Candida albicans. Objective: This study explores biological consequences of the exposure of Candida albicans from community infections or from a panel of antifungal drug resistant organisms on growth and survival of these organisms when exposed to farnesol. Methods: ATCC supplied Candida albicans from the MP8 drug resistance panel and an additional 12 strains of community-acquired Candida albicans were cultured in the presence of farnesol. With standard micobiologic techniques and flow cytometry evaluation, a series of experiments considered growth, morphology, viability and entrance into the quiescent persister phenotype of Candida with

关键词： Farnesol Candida albicans Antifungal Resistance Persister Phenotype Quorum Sensing

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Navigating the Third Frontier of Antimicrobial Therapy to Support Women’s Health

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Open Journal of Obstetrics and Gynecology（妇产科期刊） 2020年第8期

作者： Emma Wittman neela yar Bryan Larsen

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