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Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study

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World Journal of Stem Cells 2024年第1期16卷 19-32页

作者： ErdinçCivelek Serdar Kabatas Eyüp Can Savrunlu Furkan Diren necati Kaplan Demet Ofluoğlu Erdal Karaöz Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalÇorlu 59860TekirdağTurkey Department of Physical Medicine and Rehabilitation Ofluoğlu KlinikGöztepe 34728IstanbulTurkey Liv Hospital Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell)Beşiktaş34340IstanbulTurkey Department of Histology and Embryology Istinye UniversityFaculty of MedicineZeytinburnu 34010IstanbulTurkey Istinye University Center for Stem Cell and Tissue Engineering Research and PracticeBeşiktaş34340IstanbulTurkey

BACKGROUND Peripheral nerve injury can result in significant clinical complications that have uncertain ***,there is a lack of effective pharmacological interventions for nerve damage,despite the existence of several small compounds,Despite the objective of achieving full functional restoration by surgical intervention,the persistent challenge of inadequate functional recovery remains a significant concern in the context of peripheral nerve *** To examine the impact of exosomes on the process of functional recovery following a complete radial nerve *** A male individual,aged 24,who is right-hand dominant and an immigrant,arrived with an injury caused by a knife *** cut is located on the left arm,specifically below the *** neurological examination and electrodiagnostic testing reveal evidence of left radial nerve *** sural autograft was utilized for repair,followed by the application of 1 mL of mesenchymal stem cell-derived exosome,comprising 5 billion *** exosome was split into four equal volumes of 0.25 mL each and delivered microsurgically to both the proximal and distal stumps using the subepineural *** patient was subjected to a period of 180 d during which they had neurological examination and electrodiagnostic *** The duration of the patient’s follow-up period was 180 *** increasing Tinel’s sign and sensory-motor recovery were detected even at the 10th wk following nerve *** the conclusion of the 6-mo post-treatment period,an evaluation was conducted to measure the extent of improvement in motor and sensory functions of the *** assessment was based on the British Medical Research Council scale and the Mackinnon-Dellon *** results indicated that the level of improvement in motor function was classified as M5,denoting an excellent ***,the level of improvement in sensory function was classified as S3+,indicating a good *** is

关键词： Mesenchymal stem cell Exosomes Radial nerve Sural nerve

Allogeneic mesenchymal stem cells may be a viable treatment modality in cerebral palsy

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World Journal of Clinical Cases 2024年第9期12卷 1585-1596页

作者： Osman Boyalı Serdar Kabatas ErdinçCivelek Omer Ozdemir Yeliz Bahar-Ozdemir necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Turkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34360Turkey Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Department of Histology and Embryology Istinye UniversityFaculty of Medicineİstanbul 34010Turkey Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Turkey

BACKGROUND Cerebral palsy(CP)describes a group of disorders affecting movement,balance,and *** in motor functions constitute the main body of CP *** symptoms surface in early childhood and patients are affected for the rest of their ***,treatment involves various pharmacotherapies for different types of CP,including antiepileptics for epilepsy and Botox A for focal ***,none of these methods can provide full symptom *** has prompted researchers to look for new treatment modalities,one of which is mesenchymal stem cell therapy(MSCT).Despite being a promising tool and offering a wide array of possibilities,mesenchymal stem cells(MSCs)still need to be investigated for their efficacy and *** To analyze the efficacy and safety of MSCT in CP *** Our sample consists of four CP patients who cannot stand or walk without external *** of these cases received allogeneic MSCT six times as 1×106/kg intrathecally,intravenously,and intramuscularly using umbilical cord-derived MSCs(UC-MSC).We monitored and assessed the patients pre-and post-treatment using the Wee Functional Independence Measure(WeeFIM),Gross Motor Function Classification System(GMFCS),and Manual Ability Classification Scale(MACS)*** utilized the Modified Ashworth Scale(MAS)to measure *** We found significant improvements in MAS scores after the intervention on both *** months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;four months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;12 months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=***,there was no significant difference in motor functions based on WeeFIM results(P>0.05).GMFCS and MACS scores differed significantly at 12 months after the intervention(P=0.046,P=0.046).Finally,there was no significant change in cognitive functions(P>0.05).CONCLUSION In light of our findings,we believe that UC-MSC therapy has a positive effect on spasticity

关键词： Cerebral palsy Mesenchymal stem cell Transplantation Wharton’s jelly Muscle spasticity

Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury:First results of a phase I study

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World Journal of Stem Cells 2024年第6期16卷 641-655页

作者： Serdar Kabatas ErdinçCivelek Osman Boyalı Gülseli Berivan Sezen Omer Ozdemir Yeliz Bahar-Ozdemir necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Traumatic brain injury(TBI)is characterized by a disruption in the normal function of the brain due to an injury following a trauma,which can potentially cause severe physical,cognitive,and emotional *** cell transplantation has evolved as a novel treatment modality in the management of TBI,as it has the potential to arrest the degeneration and promote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-MSCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of MSC therapy in *** We present 6 patients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 patients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transplantation of WJ-MSCs at a target dose of 1×106/kg for each application *** was assessed using the Modified Ashworth scale(MAS),motor function according to the Medical Research Council Muscle Strength Scale,quality of life was assessed by the Functional Independence Measure(FIM)scale and Karnofsky Performance Status *** Our patients showed only early,transient complications,such as subfebrile fever,mild headache,and muscle pain due to ***,which resolved within 24 *** the one year follow-up,no other safety issues or adverse events were *** 6 patients showed improvements in their cognitive abilities,muscle spasticity,muscle strength,performance scores and fine motor skills when compared before and after the *** values,which we used to assess spasticity,were observed to statistically significantly decrease for both left and right sides(P<0.001).The FIM scale includes both motor scores(P<0.05)and cognitive scores(P<0.001)and showed a significant increase in pretest posttest *** difference observed in the participants’Karnofsky Performance Scale values pre and post the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly Stem cell therapy Transplantation Mesenchymal stem cell

Poles of L-Functions on Quaternion Groups

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Chinese Annals of Mathematics,Series B 2014年第4期35卷 519-526页

作者： ?etin üRTS Department of Mathematics TOBB University of Economics and Technology Ankara Turkey

The author shows that the(partial) standard Langlands L-functions on quarternion groups have at most simple poles at certain positive integers.

关键词： Siegel Eisenstein series L-Functions Quaternion groups RegularizedSiegel-Weil formula

Compressive failure of spruce wood rings reinforced with glass epoxy composite

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Journal of Forestry Research 2015年第2期26卷 517-522页

作者： Nurdan ?etin Yerlikaya Alaattin Aktas Department of Industrial Design Faculty of Art and DesignYalova University Department of Mechanical Engineering Faculty of EngineeringIstanbul University

We experimentally tested under radial compressive loads and statistically analyzed rings constructed from spruce wood and reinforced with glass *** used the Weibull distribution in statistical analysis,and tested five types of rings including unreinforced and composite reinforced（CR） as wound around the ring,oriented as two layers at angles of 45°,60°,75° and 90° to the column *** calculated 95 % reliability of load carrying capacity of the rings by Weibull *** highest load carrying capacity was obtained with CR rings at 60° to the axial axis of the *** carrying capacities of rings at CR90,CR75,CR60 and CR45 were 137,192,215 and 126 %greater,respectively,than unreinforced *** unreinforced rings,failures resulted from catastrophic breaking of wood *** of the reinforced rings failed catastrophically because the outer surface of the rings was reinforced with glass–epoxy composite *** began at the core of the materials under the composite layer for all specimens and resulted in failure of the rings.

关键词： Reinforced ring Composite material Composite reinforced Spruce wood

The genesis of the slab window-related Arzular low-sulfidation epithermal gold mineralization(eastern Pontides,NE Turkey)

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Geoscience Frontiers 2013年第4期4卷 409-421页

作者： Enver Akaryali necati Tysz Gumushane University Department of Geology Karadeniz Technical University.Department of Geology

The Arzular mineralization is one of the best examples of epithermal gold deposits in the eastern Pontides orogenic belt. The mineralization is hosted by the subduction-related basaltic andesites and is mainly controlled by E W and NE SW trending fracture zones. The main ore minerals are galena. sphalerite, pyrite, chalcopyrite, tetrahedrite and gold. Homogenization temperatures of fluid inclu- sions are between 130 and 295 C for quartz and between 90 and 133 C for sphalerite. Sulphur isotope values obtained fiom pyrite, galena and sphalerite vary between 1.2‰ and 3‰ indicating that sulphur belongs to magmatic origin and was derived from the Lutetian non-adakitic granitic intrusions in the region. Oxygen isotope values are between 15.0‰, and 16.7‰ and hydrogen isotope values are between -87‰ and 91‰ The sulphur isotope thermometer yielded temperatures in the range of 244-291 C for the ore formation. Our results support the hypothesis that the Arzular mineralization is a low-sulfidation epithermal gold deposit associated with non-adakitic subduction- related granitic magmas that were generated by slab window-related processes in a south-dipping subduction zone during the Lutetian.

关键词： Slab windowEpithermal goldIsotopeFluid inclusionMineralizationTectonics

A Modified Gravity Theory: Null Aether

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Communications in Theoretical Physics 2019年第3期71卷 312-326页

作者： Metin Gürses ?etin ?entürk Department of Mathematics Faculty of Sciences Bilkent University Department of Physics Faculty of Sciences Bilkent University Department of Aeronautical Engineering University of Turkish Aeronautical Association

General quantum gravity arguments predict that Lorentz symmetry might not hold exactly in nature. This has motivated much interest in Lorentz breaking gravity theories recently. Among such models are vector-tensor theories with preferred direction established at every point of spacetime by a fixed-norm vector field. The dynamical vector field defined in this way is referred to as the "aether". In this paper, we put forward the idea of a null aether field and introduce, for the first time, the Null Aether Theory(NAT) — a vector-tensor theory. We first study the Newtonian limit of this theory and then construct exact spherically symmetric black hole solutions in the theory in four dimensions, which contain Vaidya-type non-static solutions and static Schwarzschild-(A)dS type solutions, Reissner-Nordstr?m-(A)dS type solutions and solutions of conformal gravity as special cases. Afterwards, we study the cosmological solutions in NAT:We find some exact solutions with perfect fluid distribution for spatially flat FLRW metric and null aether propagating along the x direction. We observe that there are solutions in which the universe has big-bang singularity and null field diminishes asymptotically. We also study exact gravitational wave solutions — AdS-plane waves and pp-waves — in this theory in any dimension D ≥ 3. Assuming the Kerr-Schild-Kundt class of metrics for such solutions, we show that the full field equations of the theory are reduced to two, in general coupled, differential equations when the background metric assumes the maximally symmetric form. The main conclusion of these computations is that the spin-0 aether field acquires a "mass" determined by the cosmological constant of the background spacetime and the Lagrange multiplier given in the theory.

关键词： Aether theory Newtonian limit black holes cosmological solutions Kerr-Schild-Kundt class of metrics Ads-plane waves pp-waves

A Parallel Boundary Element Formulation for Tracking Multiple Particle Trajectories in Stoke’s Flow for Microfluidic Applications

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Computer Modeling in Engineering & Sciences 2015年第3期104卷 227-249页

作者： Z.Karakaya B.Baranoglu B.Çetin A.Yazici Computer Engng.Dept. Atilim UniversityTurkey Manufacturing Engng.Dept. Atilim UniversityTurkey Microfluidics & Lab-on-a-chip Research Group Mech.Engng.Dept.Bilkent UniversityTurkey Software Engng.Dept. Atilim UniversityTurkey

A new formulation for tracking multiple particles in slow viscous flow for microfluidic applications is *** method employs the manipulation of the boundary element matrices so that finally a system of equations is obtained relating the rigid body velocities of the particle to the forces applied on the *** formulation is specially designed for particle trajectory tracking and involves successive matrix multiplications for which SMP(Symmetric multiprocessing)parallelisation is *** is observed that present formulation offers an efficient numerical model to be used for particle tracking and can easily be extended for multiphysics simulations in which several physics involved.

关键词： Boundary Element Method particle tracking Stoke's flow parallel computing

Measurement of choroidal thickness and macular thickness during and after pregnancy

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 321-325页

作者： DondüMelek Ulusoy necati Duru Mustafa Atas Hasan Altinkaynak Zeynep Duru Gokhan Acmaz Department of Ophthalmology Kayseri Education and Research Hospital Department of Ophthalmology Ankara Atatürk Education and Research Hospital Department of Ophthalmology Ankara Numune Education and Research Hospital Department of Obstetrics and Gynecology Kayseri Education and Research Hospital

AIM: To investigate the effect of pregnancy on subfoveal choroidal thickness(SFCT) and macular thickness in both pregnant and not pregnant healthy ***: Twenty-nine healthy pregnant women in their third trimester and 36 age-matched healthy women were enrolled in a prospective, cross-sectional *** and parafoveal thickness in the four quadrants and SFCT were measured by optical coherence tomography(OCT) in the healthy pregnant women(*** group) and healthy women(i.e. control group).OCT measurements were again measured 3mo after delivery in the study ***: Mean SFCT measurements in the control group, pregnant women of the study group, and after delivery of the study group were 320.86 ±59.18 μm,387.97 ±59.91 μm, and 332.40 ±26.03 μm, *** was a statistically significant difference in the mean SFCT values between pregnant women of the study group and the control group(P =0.000). Foveal and parafoveal thickness values were not statistically significant in either the study or control ***: SFCT increases during pregnancy and returns to normal range in the three months after delivery. Macular thickness does not show any change during pregnancy.

关键词： choroidal thickness enhanced depth imaging optical coherence tomography foveal thickness pregnancy