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减少腹部内脏脂肪对雌性大鼠生殖衰老早期表型的影响

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减少腹部内脏脂肪对雌性大鼠生殖衰老早期表型的影响

Management of chronic heart failure in the older population

2016全国中西医结合妇产科研究进展学术研讨会暨2016年第一届江浙沪中西医结合妇产科高峰论坛

作者：孙妍 Bauer Jessica 舒君 neal-perry genevieve 复旦大学附属妇产科医院艾伯特爱因斯坦医学院妇产科学系华盛顿大学医学院妇产科学系

目的:女性生殖功能的维持与营养代谢状况密切相关。白色脂肪组织尤其是内脏脂肪是一个高度活跃的内分泌器官,其所分泌的诸多信号分子对下丘脑-垂体-性腺轴及机体的生殖功能发挥着重要的调节作用。内脏脂肪随年龄的增长而增加,与多种衰... 详细信息

目的:女性生殖功能的维持与营养代谢状况密切相关。白色脂肪组织尤其是内脏脂肪是一个高度活跃的内分泌器官,其所分泌的诸多信号分子对下丘脑-垂体-性腺轴及机体的生殖功能发挥着重要的调节作用。内脏脂肪随年龄的增长而增加,与多种衰老所致疾病呈正相关,直接影响着人类患病的风险。由于75%的妇女在生殖衰老即围绝经期前后出现体重增加尤其是腰腹围增宽的现象,是否所增加的内脏脂肪介导女性生殖衰老的发生,目前仍然尚未明了。本研究旨在分析可能引起女性生殖衰老的不良因素,探讨年龄相关的腹部内脏脂肪积聚在生殖衰老早期表型发生中的作用;并解析内脏脂肪积聚影响女性生殖衰老发生的可能机制。方法:选取早期衰老即9个月月龄性周期规律的雌性Sprage-Dawley大鼠,经腹部切开手术移除所见腹部内脏脂肪,设假手术组为对照。3周后经MRI分析大鼠体脂百分数并行糖耐量测定;两组大鼠随后行去卵巢手术(Ovariectomized,OVX)并给予雌激素+孕激素皮下注射模拟雌激素正反馈作用;经颈静脉插管,在预期LH释放当日动态连续获取血样测定黄体生成素(Luiteinizing Hormone,LH)水平;采用实时荧光定量PCR的方法检测下丘脑促LH分泌相关基因的表达;运用促性腺激素释放激素(Gonadotropin-releasing hormone,GnRH)激发试验观察减少腹部内脏脂肪含量对垂体LH释放的影响。结果:结果显示,雌性Sprage-Dawley大鼠经手术减少腹部内脏脂肪含量4周后,雌激素正反馈所诱导的总LH分泌量及LH分泌峰均明显高于假手术对照组。同时,下丘脑胰岛素样生长因子(Insulin-like growth factor 1,IGF1)的mRNA表达水平显著上调。但减少腹部内脏脂肪含量对大鼠的体重、体脂百分数及糖耐量无明显影响。减少腹部内脏脂肪含量不改变垂体对GnRH的反应性。结论:以上结果提示,腹部内脏脂肪积聚与雌性大鼠出现生殖衰老的早期表型密切相关,减少腹部内脏脂肪的积聚可明显升高早期生殖衰老雌性大鼠LH的分泌水平,该作用至少部分是通过上调下丘脑IgF1基因表达的中枢机制来实现的。本研究为发掘雌性大鼠生殖衰老发生的影响因素提供了新的视点,为延缓女性生殖衰老的发生提供了干预新策略。

关键词：内脏脂肪 LH 下丘脑

来源： cnki会议评论

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Journal of Geriatric Cardiology 2014年第4期11卷 329-337页

作者： Nahid Azad genevieve Lemay Ottawa Hospital Civic Campus Geriatric Assessment Unit 1053 Carling Avenue Box 678 Ottawa ON K1Y 4E9 Canada

Chronic heart failure （CHF） is the leading cause of hospitalization for those over the age of 65 and represents a significant clinical and economic burden. About half of hospital re-admissions are related to co-morbidities, polypharmacy and disabilities associated with CHF. Moreover, CHF also has an enormous cost in terms of poor prognosis with an average one year mortality of 33%–35%. While more than half of patients with CHF are over 75 years, most clinical trials have included younger patients with a mean age of 61 years. Inadequate data makes treatment decisions challenging for the providers. Older CHF patients are more often female, have less cardiovascular diseases and associated risk factors, but higher rates of non-cardiovascular conditions and diastolic dysfunction. The prevalence of CHF with reduced ejection fraction, ischemic heart disease, and its risk factors declines with age, whereas the prevalence of non-cardiac co-morbidities, such as chronic renal failure, dementia, anemia and malignancy increases with age. Diabetes and hypertension are among the strongest risk factors as predictors of CHF particularly among women with coronary heart disease. This review paper will focus on the specific consideration for CHF assessment in the older population. Management strategies will be reviewed, including non-pharmacologic, pharmacologic, quality care indicators, quality improvement in care transition and lastly, end-of-life issues. Palliative care should be an integral part of an interdiscipli-nary team approach for a comprehensive care plan over the whole disease trajectory. In addition, frailty contributes valuable prognostic in-sight incremental to existing risk models and assists clinicians in defining optimal care pathways for their patients.

关键词： Heart failure Elderly patient Management Hypertension Coronary artery disease diabetes

Treatment, residual chlorine and season as factors affecting variability of trihalomethanes in small drinking water systems

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Frontiers of Environmental Science & Engineering 2015年第1期9卷 171-179页

作者： Roberta DYCK genevieve COOL Manuel RODRIGUEZ Rehan SADIQ School of Engineering University of British Columbia Okanagan Kelowna V1V 1V7 Canada Ecole superieure d'amenagement du territoire Universite Laval Quebec G1V 0A6 Canada

Seasonal variability in source water can lead to challenges for drinking water providers related to operational optimization and process control in treatment facilities. The objective of this study is to investigate seasonal variability of water quality in municipal small water systems （〈 3000 residents） supplied by surface waters. Residual chlorine and trihalomethanes （THM） were measured over seven years （2003-2009）. Comparisons are made within each system over time, as well as between systems according to the type of their treatment technologies. THM concentrations are generally higher in the summer and autumn. The seasonal variability was generally more pronounced in systems using chlorination plus additional treatment. Chloroform, total THM （TTHM） and residual chlorine concentrations were generally lower in systems using chlorination plus additional treatment. Conversely, brominated THM concentrations were higher in systems using additional treatment. Residual chlorine was highest in the winter and lowest in the spring and summer. Seasonal variations were most pronounced for residual chlorine in systems with additional treatment. There was generally poor correlation between THM concentrations and concentrations of residual chlorine. Further study with these data will be beneficial in finding determinants and indicators for both quantity and variability of disinfection byproducts and other water quality parameters.

关键词： drinking water residual chlorine seasonal variability small municipal systems treatment technologies trihalomethanes

Evolutionary consequences of deception： Complexity and informational content of colony signature are favored by social parasitism

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Current Zoology 2014年第1期60卷 137-148页

作者： Maria Cristina LORENZI Laura AZZANI Anne-genevieve BAGNRRES Department of Life Sciences and Systems Biology University of Turin via Accademia Albertina 13 10123 Torino Italy I.R.B.I. - UMR CNRS 7261 - Universit6 de Tours Facult6 des Sciences Parc Grandmont 37200 Tours France

Nestmate recognition codes show remarkable chemical complexity, involving multiple biochemical pathways. This complexity provides the opportunity to evaluate the ecological and social conditions that favor the evolution of complex signaling. We investigated how the chemical signatures of three populations of the social paper wasp Polistes biglumis differed in terms of concentration of hydrocarbons, proportions of branched hydrocarbons and overall variation. We tested whether the variation in chemical signatures among populations could be explained by the prevalence of social parasites or whether this was just an effect of local abiotic conditions which influenced the composition of the hydrocarbon cuticular layer. We studied the chemical signa- ture in three populations in which obligate social parasites differed in the selection pressures they imposed on host populations. Within each population, we restricted our analyses to non-parasitized hosts, to avoid potential short-term effects of parasite pres- ence on the host chemical signatures. We found that host colonies in parasitized populations had more diverse profiles than the parasite-free population. Moreover, the overall concentration of hydrocarbons and the relative proportion of branched hydrocar- bons were larger in the parasitized populations, relative to the non-parasitized one. This is to our knowledge the first evidence in favour of the hypothesis that different traits in the host chemical signatures as a whole undergo evolutionary changes resulting from directional or balancing selection imposed by social parasites. We conclude that obligate social parasites act as ＇engines of diversity＇ on host chemical signatures and operate in favor of a geographic mosaic of diverging communication codes

关键词： Polistes Brood parasitism Cipher Nestmate recognition Hydrocarbons Geographic mosaic Crozier's paradox

In vivo and in vitro use of plasma membrane DNA in the detection and follow-up of systemic lupus erythematosus

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分子细胞生物学报:英文版 2011年第3期3卷 200-201页

作者： Jacqueline Keyhani Ezzatollah Keyhani genevieve Servais Jean Duchateau Laboratory for Life Sciences 19979 TehranIran Immunology Department University Hospital BrugmannU.L.B.BrusselsBelgium

Dear Editor,Systemic lupus erythematosus(SLE)is a chronic inflammatory autoimmune disease in which the immune system attacks the patient’s tissues,resulting in inflammation and damage(Tan et al.,1982).SLE is associated with the presence of abnormally elevated titers of a variety of antibodies,including antibodies to doublestranded(ds)DNA,in the serum(Egner,2000).

关键词： lupus erythematosus damage vivo

New Findings Validate an Ancient Technique:How Massage Affects the Biochemistry of Inflammation

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Chinese Journal of Integrative Medicine 2012年第7期18卷 483-484页

作者： genevieve HSIA 陈可冀 Acupuncture and Integrative Medicine College Cardiovascular Disease Center of Xiyuan Hospital China Academy of Chinese Medical Sciences

Massage is a manual soft tissue manipulation, and includes holding, causing movement, and/or applying pressure to the body defined by American Massage Therapy Association （AMTA）. References to massage can be found in many ancient civilizations. The ancient Chinese medical book called Huangdi＇s Internal Classic （Huang Di Nei Jing, 2760 BC） recommended ＂use massage therapy for treatment of numbness caused by channels blockage.＂

关键词： In New Findings Validate an Ancient Technique AMTA

Chemical Analysis of Tire Traces in Traffic Accidents Investigation

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Journal of Forensic Science and Medicine 2015年第2期1卷 99-108页

作者： Line Gueissaz genevieve Massonnet Faculty of Law Criminal Justice and Public AdministrationSchool of Criminal JusticeUniversity of LausanneBatochimeCH-1015 Lausanne-DorignySwitzerland

The aim of the forensic investigation of traffic accidents is to help establish the nature and/or the circumstances of the *** might be done with the purpose of determining the legal responsibilities of each person involved or to provide families,with a reconstruction of the events,to help understand why their relatives were injured or killed.A methodology for the comparison of chemical profiles of tire traces and tire tread samples obtained by pyrolysis-gas chromatography/mass spectrometry has been *** profiles are represented by relative abundances of 86 *** variability of the tread within and between 12 tires was *** the level of the source as"brand and model"the intra-variability was found to be smaller than the inter-variability leading to the complete discrimination of the 12 tires of the sample *** tests were carried out on a racetrack in order to produce tire traces which origin was *** results obtained with a supervised classification method showed that more than 94%of the replicates of the traces were correctly assigned to the class membership(i.e.,brand and model)of the tire at their *** results support that the chemical profile of one trace does not differ from the chemical profile of the tire at its origin but differs generally from the other chemical profiles of the sample set.

关键词： Car chemometrics pyrolysis road rubber tire marks tread

Gregarious pupation act as a defensive mechanism against cannibalism and intraguild predation

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Insect Science 2016年第4期23卷 612-620页

作者： Claudia Roberge Bruno Frechette genevieve Labrie Francois Dumont Eric Lucas Universite du Quebec a Montreal Departement des Sciences Biologiques CP 8888 Succ. Centre Ville Montreal Centre de recherche sur les grains Inc (CEROM) 740 chemin Trudeau St-Mathieu-de-Beloeil Quebec J3G OE2 Canada

Coccinellid pupae use an array of defensive strategies against their natural enemies. This study aims to assess the efficiency of gregarious pupation as a defensive mechanism against intraguild predators and cannibals in coccinellid. The study was designed specifically （i） to determine the natural occurrence of gregarious pupation in the field for different coccinellid species, and （ii） to evaluate the adaptive value of gregarious pupation as a defensive mechanism against 2 types of predators （i.e., cannibals and intraguild predators）. In the field, gregarious pupation consisted of a group of 2-5 pupae. The proportion of gregarious pupation observed varied according to species, the highest rate being observed with Harmonia axyridis Pallas （Coccinellidae; 14.17%）. Gregarious pupation had no impact on the probability that intraguild predators and cannibals locate pupae. Intraguild predation occurred more often in site with gregarious pupation, while cannibalism occurred as often in site with gregarious pupation as in site with isolated pupa. However, for a specific pupa, the mortality rate was higher for isolated pupae than for pupae located in a gregarious pupation site both in the presence of intraguild predators and in the presence of cannibals. The spatial location of pupae within the group had no impact on mortality rate. Since it reduces the risk of predation, it is proposed that gregarious pupation act as a defensive mechanism for 11. axyridis pupae.

关键词： attack abatement Coccinellidae dilution effect encounter effect grouping behavior Pentatomidae Selfish herd

Effectiveness of royal jelly supplementation in glycemic regulation:A systematic review

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World Journal of Diabetes 2019年第2期10卷 96-113页

作者： Kamel Omer Maxwell J Gelkopf genevieve Newton Department of Human Health and Nutritional Sciences University of Guelph

BACKGROUND Royal jelly(RJ)has been observed to have therapeutic properties in diabetic individuals,including the reduction of high blood *** systematic review synthesized existing evidence to investigate the effectiveness of RJ supplementation in managing measures of blood *** To determine the effectiveness of RJ supplementation on glycemic responses in healthy and non-insulin dependent diabetic adults,as well as animal models of *** This was a systematic review employing the PRISMA ***-reviewed,published articles were extracted from several databases using key words related to target population,intervention and outcome and hand-selected for *** articles proceeded to data extraction phase,where information on target parameters and effectiveness of treatment was *** this,the risk of bias for each included study was ***,the long-term and immediate effectiveness of RJ supplementation in glycemic control were assessed using the Grading of Recommendations,Assessment,Development and Evaluations(GRADE)tool,which rates the quality of *** Of 168 articles extracted from database searching,eighteen were included for analysis in this systematic *** the studies,studied populations,intervention styles and outcome measures were largely *** this,the results in studies indicate a general trend of positive effect of RJ in glycemic regulation in vitro and in ***,some dose-dependent glycemic effects were observed,along with some large effect *** risk of bias for human and animal studies is generally low-unclear risk,although lack of blinding is a serious concern in both ***,as per the GRADE tool,the quality of evidence is low,and very low for long-term and immediate effectiveness of RJ,respectively.A major limitation affecting evidence quality is the heterogeneity among included *** blood glucose and glucose clearance a

关键词： Royal jelly Type 2 diabetes Dietary supplement Glycemic control 10-hydroxy-trans-2-decenoic acid Hyperglycemia Adults Animals