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j.urnal of Cancer Metastasis and Treatment 2019年第11期4卷 36-46页

作者： Molly E.Heft neal Catherine T.Haring j.cqueline E.Mann j.Chad Brenner Matthew E.Spector Paul L.Swiecicki Department of Otolaryngology Head and Neck Surgery University of MichiganAnn ArborMI 48103USA Department of Internal Medicine Division of Hematology/OncologyUniversity of Michigan Medical SchoolAnn ArborMI 48103USA Department of Pharmacology University of MichiganAnn ArborMI 48103USA Rogel Cancer Center University of MichiganAnn ArborMI 48103USA

Unresectable recurrent or metastatic head and neck cancer is an incurable disease with survival of approximately 12 months. Head and neck tumors exhibit numerous derangements in the tumor microenvironment that aid in immune evasion and may serve as targets for future therapies. Pembrolizumab is now approved as a first line therapy. Despite the promise of currently approved immunotherapies there continues to be low response rates and additional strategies are needed. Here, alterations in the immune microenvironment and current therapeutic strategies are reviewed with a focus on novel immunologic approaches.

关键词： Immunotherapy head and neck immune evasion immune derangement checkpoint inhibitors recurrent/metastatic

Vaccination with the Live Attenuated FrancisellanovicidaMutant FTN0109Protects against Pulmonary Tularemia

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World j.urnal of Vaccines 2015年第1期5卷 25-36页

作者： Aimee L. Cunningham M. neal Guentzel j.eh-j.en Yu Nikita Trivedi Karl E. Klose j.mes P. Chambers Bernard P. Arulanandam South Texas Center for Emerging Infectious Disease and Center for Excellence in Infection Genomics University of Texas at San Antonio San Antonio TX USA Department of Microbiology and Immunology University of Texas Health Science Center at San Antonio San Antonio TX USA

Francisella tularensis is considered a potential bioterrorism agent due to its low infectious dose, high mortality rate, and ability to be spread via the aerosol route. We characterized the F. tularensis subspecies novicida mutant strain FTN0109 as a potential vaccine candidate against tularemia. This strain, which lacks an outer membrane lipoprotein, is attenuated in vitro and in vivo, as it exhibits reduced replication within murine j.74 macrophages and has a pulmonary LD50 in BALB/c and C57BL/6 mice of >105 CFU (compared to WT parental strain U112, LD50 FTN0109 also conferred complete protection in BALB/c mice against subsequent pulmonary challenge with 10 LD50 (60,000 CFU) of the murine virulent Francisella strain LVS. We also have demonstrated partial protection (50%) against the highly human virulent subspecies tularensis strain SCHU S4 (25 LD50, 12,500 CFU) following intratracheal vaccination in the Fischer 344 rat, a second rodent model for tularemia. Overall, our results suggest that FTN0109 serves as a potential putative vaccine candidate against pulmonary tularemia.

关键词： Tularemia F. tularensis Vaccines Live Attenuated

崆岭高级变质地体单颗粒锆石SHRIMP U-Pb年代学研究──扬子克拉通>3.2Ga陆壳物质的发现

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中国科学（D辑） 2001年第1期31卷 27-35页

作者：高山 umin Qiu 凌文黎 neal j.McNaughton David I.Groves 西北大学地质学系西安710069 Key Center for Teaching and Research in Strategic Mineral Deposits The University of Western Australia 中国地质大学地球科学院武汉43374

对崆岭高级变质地体主体奥长花岗片麻岩２个样品和不具Ｅｕ异常的变碎屑沉积岩２个样品单颗粒锆石ＳＨＲＩＭＰＵ－Ｐｂ原位（ｉｎ－ｓｉｔｕ）定年结果，揭示出奥长花岗岩浆的侵入年龄为２９４７～２９０３Ｍａ在变沉积岩中发... 详细信息

对崆岭高级变质地体主体奥长花岗片麻岩２个样品和不具Ｅｕ异常的变碎屑沉积岩２个样品单颗粒锆石ＳＨＲＩＭＰＵ－Ｐｂ原位（ｉｎ－ｓｉｔｕ）定年结果，揭示出奥长花岗岩浆的侵入年龄为２９４７～２９０３Ｍａ在变沉积岩中发现了年龄为３．３Ｇａ的碎屑锆石，直接证明扬子克拉通曾存在古太古代陆壳物质．不具Ｅｕ异常变碎屑沉积岩的亏损地慢Ｎｄ模式年龄（ＴＤＭ＝３．２－３．３Ｇａ）进一步证明了这一点．

关键词：崆岭高级变质地体锆石U-PB年龄 SHRIMP 太古宙

Primary Prevention of Cardiovascular Disease

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Cardiovascular Innovations and Applications 2016年第B9期1卷 379-389页

作者： Danny j.Eapen William M.Schultz Robert E.Heinl Nima Ghasemzadeh Tina Varghese Diana E.Kurian Christina E.Mathai Pratik Sandesara Bryan R.Kindya Marc P.Allard-Ratick neal K.Bhatia Ij.oma Isiadinso Laurence Sperling Department of Medicine Emory UniversityAtlantaGAUSA Department of Pharmacy Houston Methodist HospitalHoustonTXUSA Department of Medicine University of South FloridaTampaFLUSA

Cardiovascular disease(CVD)is the leading cause of death *** article focuses on current guidelines for the primary prevention of CVD and addresses management of key risk *** modifi cation,weight loss,exercise,and tobacco use cessation are specifi c areas where focused efforts can successfully reduce CVD risk on both an individual and a societal *** c areas requiring management include dyslipidemia,hypertension,physical activity,diabetes,aspirin use,and alcohol *** preventive efforts have maj.r public health *** the global population continues to grow,health care expenditures will also rise,with the potential to eventually overwhelm the health care *** it is imperative to apply our collective efforts on CVD prevention to improve the cardiovascular health of individuals,communities,and nations.

关键词： cardiovascular disease primary prevention tobacco diabetes dyslipidemia aspirin alcohol exercise

Erdheim-Chester disease mimicking a primary brain *** report

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中国神经肿瘤杂志 2004年第2期2卷 137-137页

作者： Rushing E j.Bouffard j. neal C j.Koeller K Martin j.Ozdemirli M Mena H Ecklund j.M Department of Neuropathology Armed Forces Institute of PathologyWashingtonDC 20306-6000 USA.

Erdheim-Chester disease (ECD) is a rare systemic histiocytic disease. The authors present a case report detailing the presentation and treatment of a 26-year-old man diagnosed with seizures and a well - circumscribed temporoparietal mass that had been demonstrated on imaging studies. Both preoperative and intraoperative diagnoses were consistent with a low - grade astrocytic neoplasm. Subsequent pathological examination indicated a histiocytic proliferation positive for CD68 and factor Ⅷ, and negative for CDla and S100, with Touton giant cells characteristic of ECD. This case represents the first isolated occurrence of intracranial ECD and its potential to mimic glial neoplasms.

关键词： Erdheim-Chester疾病原发性脑肿瘤 ECD 病例

Comments on Two Issues in the Third Amendment of the Patent Law

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中国专利与商标 2009年第1期 25-29页

作者： S.Sam Li is a senior partner of the j.ncheng Tongda & neal(j.&N)Law Firm Guest Research Fellow of the Institute for International Intellectual Property of the Peking University Chairman of the Patent Committee of the CAEFI Quality Brands Protection Committee(QBPC)

If the last amendment to the Patent Law was to bring it into compliance with the WTO requirement, the upcoming a- mendment to the Patent Law is motivated by China’s desire to build an innovation-oriented nation. The ... 详细信息

关键词： Comments on Two Issues in the Third Amendment of the Patent Law

Smith-Lemli-Opitz综合征的啮齿动物模型中的视网膜退行性病变电生理、生物化学和形态学方面的特性

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美国医学会眼科杂志（中文版） 2005年第2期17卷 124-124页

作者： Steven j. Flicsler neal S. Peachey Michael j. Richards Barbara A. Nagel Dana K. Vaughan 韩亮（译）

目的：评估Smith-Lemli—Opitz综合征（SLOS）动物模型的电生理、组织学和生物化学方面的特性。

关键词： Smith-Lemli-Opitz综合征视网膜退行性病变动物模型生物化学电生理形态学啮齿组织学

难治性高血压患者的降压药物使用、血压控制及临床特征

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中华高血压杂志 2019年第12期27卷 1136-1136页

作者：刘青(译) 叶鹏(摘/审校) Carcel C neal B Oparil S Rogers K Narkiewicz K Wang j. Schiffrin EL Poulter N Azizi M Chalmers j 不详

研究者评估了难治性高血压(treatment resistant hypertension,TRH)患者的特征以及在一个多国三级专科医疗中心样本中TRH的患病率情况。方法:TRH患者调查研究对西欧、东欧、北美、南美、澳大利亚和亚洲的三级中心医疗记录进行了回顾性... 详细信息

研究者评估了难治性高血压(treatment resistant hypertension,TRH)患者的特征以及在一个多国三级专科医疗中心样本中TRH的患病率情况。方法:TRH患者调查研究对西欧、东欧、北美、南美、澳大利亚和亚洲的三级中心医疗记录进行了回顾性分析。从病历中提取人口统计学、病史和用药数据。基于估计代表人口计算TRH的患病率和发病率。

关键词：难治性高血压降压药物患病率临床特征

健康受试者和青光眼患者的白天眼内压与夜间最高眼内压之间的相关性

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世界核心医学期刊文摘（眼科学分册） 2005年第7期1卷 13-13页

作者： Mosaed S. Liu j.H.K. weinreb R.N. 司冰心 Hamilton Glaucoma Center University of California San Diego Department of Ophthalmology 9500 Gilman Drive San Diego CA 92093- 0946 United States

Purpose: To evaluate the correlations between office- hour intraocular pressures (IOP) and peak nocturnal IOP in healthy and glaucomatous eyes. Design: Retrospective review of laboratory records. Methods: We reviewed 24- hour data of IOP collected from 33 younger healthy subj.cts (aged 18 to 25 years), 35 older healthy subj.cts (aged40 to 74 years), and 35 untreated older glaucoma patients (aged40 to 79 years) housed in a sleep laboratory. Measurements of IOP were taken every 2 hours using a pneumatonometer in the sitting and supine positions during the diurnal/wake period (7 am to 11 pm) and in the supine position during the nocturnal/sleep period. Correlations between average sitting or supine IOP in the right eye between 9:30 am and 3:30 pm (office hours) and peak right eye IOP during the nocturnal hours were analyzed. Results: The average values of supine IOP during office hours were found to have the strongest correlation with peak nocturnal IOP in older glaucoma subj.cts (r=.713, P j.cts (r =.523, Pj.cts (r=.224, P=.21). The correlation between average sitting IOP values during office hours and peak nocturnal IOP was also strong in older glaucoma subj.cts (r=.601, Pj.cts (r=.412, Pj.cts (r=- .077, P=.672). Conclusion: Using a modification of the diurnal IOP curve, the magnitude of peak nocturnal IOP in untreated glaucoma patients can be estimated during routine office visits. Supine IOP measurements estimate peak nocturnal IOP better than sitting measurements. This estimation may provide the clinician with valuable information regarding the nocturnal IOP peak in glaucoma patients.

关键词：眼内压健康受试者气动眼压计仰卧位调查记录临床医生