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An Impr.ved Method for.the Fitting and Pr.diction of the Number.of COVID-19 Confir.ed Cases Based on LSTM

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Computer., Mater.als & Continua 2020年第9期64卷 1473-1490页

作者： Bingjie Yan Jun Wang Zhen Zhang Xiangyan Tang Yize Zhou Guopeng Zheng Qi Zou Yao Lu Boyi Liu Wenxuan Tu neal Xiong School of Computer.Science and Cyber.pace Secur.ty Hainan UniversityHaikou570228China College of Humanities and Communication Hainan UniversityHaikou570228China Univer.ity of Chinese Academy of Science Beijing100049China National Univer.ity of Defense Technology Changsha410073China Depar.ment of Mathematics and Computer.Science Northeastern State UniversityTahlequahUSA

New cor.navir.s disease(COVID-19)has constituted a global pandemic and has spr.ad to most countr.es and r.gions in the *** under.tanding the development tr.nd of confir.ed cases in a r.gion,the gover.ment can contr.l the pandemic by using the cor.esponding ***,the common tr.ditional mathematical differ.ntial equations and population pr.diction models have limitations for.time ser.es population pr.diction,and even have lar.e estimation *** addr.ss this issue,we pr.pose an impr.ved method for.pr.dicting confir.ed cases based on LSTM(Long-Shor. Ter. Memor.)neur.l *** wor. compar.s the deviation between the exper.mental r.sults of the impr.ved LSTM pr.diction model and the digital pr.diction models(such as Logistic and Hill equations)with the r.al data as ***,this wor. uses the goodness of fitting to evaluate the fitting effect of the *** show that the pr.posed appr.ach has a smaller.pr.diction deviation and a better.fitting *** with the pr.vious for.casting methods,the contr.butions of our.pr.posed impr.vement methods ar. mainly in the following aspects:1)we have fully consider.d the spatiotempor.l char.cter.stics of the data,r.ther.than single standar.ized data.2)the impr.ved par.meter.settings and evaluation indicator. ar. mor. accur.te for.fitting and for.casting.3)we consider.the impact of the epidemic stage and conduct r.asonable data pr.cessing for.differ.nt stage.

关键词： COVID-19 LSTM model pr.dictive analysis

Color.ctal cancer.scr.ening: Oppor.unities to impr.ve uptake, outcomes, and dispar.ties

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Wor.d Jour.al of Gastr.intestinal Endoscopy 2016年第20期8卷 733-740页

作者： neal Shahidi Winson Y Cheung Division of Gastr.enter.logy Department of Medicine University of British Columbia Vancouver BC V6Z 2K5 Canada Division of Medical Oncology Department of Medicine University of British Columbia Vancouver BC V5Z 4E6 Canada Br.tish Columbia Cancer.Agency VancouverBC V5Z 4E6 Canada

Color.ctal cancer.scr.ening has become a standar. of car. in industr.alized nations for.those 50 to 75 year. of age,along with selected high-r.sk *** color.ctal cancer.scr.ening has been shown to r.duce both the incidence and mor.ality of color.ctal cancer.it is a complex multi-disciplinar. pr.cess with a number.of impor.ant steps that r.quir. optimization befor. tangible impr.vements in outcomes ar. *** both oppor.unistic and pr.gr.mmatic color.ctal cancer.scr.ening,poor.par.icipant uptake r.mains an ongoing ***,cur.ent scr.ening modalities(such as the guaiac based fecal occult blood test,fecal immunochemical test and colonoscopy) may be used or.per.or.ed suboptimally,which can lead to missed neoplastic lesions and unnecessar. endoscopic *** latter.poses the r.sk of adver.e events,such as per.or.tion and post-polypectomy bleeding,as well as financial impacts to the healthcar. ***,ongoing dispar.ties in color.ctal cancer.scr.ening per.ist among mar.inalized populations,including specific ethnic minor.ties(Afr.can Amer.cans,Hispanics,Asians,Indigenous gr.ups),immigr.nts,and those who ar. economically *** this context,we aimed to r.view the cur.ent liter.tur. on these impor.ant ar.as per.aining to color.ctal cancer.scr.ening,par.icular.y focusing on the guaiac based fecal occult blood test,the fecal immunochemical test and colonoscopy.

关键词： Fecal occult blood test Fecal immunochemical test Colonoscopy Neoplasia Polyp

Deter.ination and Quantification of Susceptibility of Her.tance r.sistance to r.ot r.t of Eight Commer.ial Genotypes of Maize (Zea mays L.)

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Agr.cultur.l Sciences 2023年第5期14卷 665-684页

作者： Lazar. José Quintas neal Walker.McLar.n Fr.e State Univer.ity Blofoontein and Crops Research Institute Potchefstroom South Africa Gr.in Cr.ps r.sear.h Institute Potchefstroom South Africa

Maize is susceptible to a number.of diseases that can infect all plant or.ans and ser.e as a constr.int on cer.al pr.duction. The r.duction in cer.al pr.duction caused by disease is estimated at an aver.ge of 9.4%. Cor. r.ot r.t contr.butes gr.atly to the r.duction in gr.in pr.duction and quality. The main objective of this wor. was to r.view the r.sear.h on r.ot r.t in maize to deter.ine the susceptibility of genotypes to r.ot r.t and to quantify the inher.tance of r.sistance to r.ot r.t in maize. The methodology used was a complete 8 × 8 diallel design planted dur.ng the year.1999/2000. r.ot discolor.tion, plant length, r.ot volume, effective volume and yield wer. the evaluated par.meter.. To analyze the data and deter.ine the combinator.al abilities, genetic cor.elations, her.tability and cor.elated r.sponse, diallel analysis was used. Eight par.ntal lines;P28, I137TN, MP706, E739, MO17, B37, B73, and B14 wer. planted. The lines wer. cr.ssed into each other. all combinations accor.ing to the complete diallel model (Model 1). The F1 was har.ested after.matur.tion. For.statistical analysis, the ver.ion of the Agr.base pr.gr.m (2016) was used. r.sults show that F1 hybr.ds showed significant differ.nces in r.ot r.t discolor.tion, plant height, r.ot volume, effective r.ot volume and yield. The P28 line and the B73XE739 cr.ss had, r.spectively, the highest gener.l and specific combinations. r.ot discolor.tion had the highest genetic cor.elation (r.sub>A = 0.47) with plant length. Br.ad and nar.ow her.tability for.r.ot r.t discolor.tion wer., r.spectively, h2 = 0.81 and h2 = 0.51. r.ot r.t discolor.tion showed the highest cor.elated r.sponse (Cr./sub> = 0.14) on plant length.

关键词： Maize (Zea mays L.) Discolor.tion Inher.tance Hybr.d Inbr.eds Lines

Intensification of Ethylene Pr.duction fr.m Naphtha via a r.dox Oxy-Cr.cking Scheme： Pr.cess Simulations and Analysis

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Engineer.ng 2018年第5期4卷 714-721页

作者： Vasudev Pr.lhad Har.bal Yun Chen Luke neal Fanxing Li Depar.ment of Chemical and Biomolecular.Engineer.ng North Carolina State University Raleigh NC 27695-7905 USA School of Chemistr. and Chemical Engineer.ng South China University of Technology Guangzhou 510640 China

Ethylene pr.duction by the ther.al cr.cking of naphtha is an ener.y-intensive pr.cess （up to 40 GJ heat per.tonne ethylene）, leading to significant for.ation of coke and nitr.gen oxide （NOx）, along with 1,8- 2 kg of car.on dioxide （CO2） emission per.kilogr.m of ethylene pr.duced, We pr.pose an alter.ative pr.- cess for.the r.dox oxy-cr.cking （r.C） of naphtha, In this two-step pr.cess, hydr.gen （H2） fr.m naphtha cr.cking is selectively comhusted by a r.dox catalyst with its lattice oxygen fir.t, The r.dox catalyst is subsequently r.-oxidized by air.and r.leases heat, which is used to satisfy the heat r.quir.ment for.the cr.cking r.actions, This intensified pr.cess r.duces par.sitic ener.y consumption and CO2 and NOx emissions, Mor.over. the for.ation of ethylene and pr.pylene can he enhanced due to the selective com-bustion of H2, In this study, the r.C pr.cess is simulated with ASPEN Plus^r.based on exper.mental data fr.m r.cently developed r.dox catalysts, Compar.d with tr.ditional naphtha cr.cking, the r.C pr.cess can pr.vide up to 52% r.duction in ener.y consumption and CO2 emissions, The upstr.am section of the pr.cess consumes appr.ximately 67% less ener.y while pr.ducing 28% mor. ethylene and pr.pylene for.ever. kilogr.m of naphtha feedstock,

关键词： Ethylene Naphtha cr.cking Pr.cess intensification Chemical looping Pr.cess simulations

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Evaluation of Tr.nsver.e Mar.ings as a Speed Tr.nsition Zone Counter.easur.s in Small, r.r.l Communities

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Jour.al of Tr.nspor.ation Technologies 2021年第1期11卷 61-77页

作者： Shauna Hallmar. neal Hawkins Skylar.Knicker.ocker Institute for.Tr.nspor.ation at Iowa State Univer.ity Ames USA

Small r.r.l communities located along major.state or.county r.adways typically find most of the tr.ffic along their.main thor.ughfar.s is pass-thr.ugh r.ther.than local tr.ffic. Unfor.unately, dr.ver. passing thr.ugh these communities often enter.at high r.tes of speeds, which ar. often significantly higher.than the speed limit of the local segment. Speed management in r.r.l ar.as r.quir.s differ.nt consider.tions compar.d to ur.an ar.as and, within the US, r.r.l speed management is not as advanced with little exper.ence or.guidance for.agencies to dr.w on. This paper.summar.zes the r.sults of a study that evaluated, in par., sever.l differ.nt types of tr.nsver.e pavement mar.ings within the speed tr.nsition zones in small r.r.l communities. Thr.e differ.nt counter.easur.s wer. evaluated: conver.ing chevr.ns, tr.nsver.e lane mar.ings, and optical speed bar..

关键词： Community Entr.nce Conver.ing Chevr.ns Optical Speed Bar. Pedestr.an Safety Speed Tr.nsitions Tr.ffic Calming Tr.ffic Safety Speed Management

人增生性前列腺间质细胞体外培养及对性激素的反应性

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中华泌尿外科杂志 1998年第10期19卷 616-618页

作者：白志明 COLLINS AT neal DE 海口市人民医院泌尿外科英国纽卡斯尔大学医学院泌尿外科

为了了解前列腺间质细胞对性激素的反应性，用体外细胞培养技术分离培养人增生性前列腺间质细胞，观察了细胞纯度和由性激素诱导的细胞增殖反应。结果显示：间质细胞纯度９７０％，上皮细胞未构成污染；随传代数增加，细胞对性激素的... 详细信息

为了了解前列腺间质细胞对性激素的反应性，用体外细胞培养技术分离培养人增生性前列腺间质细胞，观察了细胞纯度和由性激素诱导的细胞增殖反应。结果显示：间质细胞纯度９７０％，上皮细胞未构成污染；随传代数增加，细胞对性激素的反应性逐渐消失；较之对照组（１００％），雄激素（１７３％±１５％）及雌激素（１６４％±１０％）分别导致了特异性细胞增殖反应（Ｐ＜００５）。体外条件下雄、雌激素联合对间质细胞无协同作用，但使细胞增殖的激素浓度却仅为单纯雄或雌激素组的１％。人增生性前列腺间质细胞体外培养中，雄、雌激素各自对间质细胞的增殖发挥了其生物学作用。体外条件下二者合用敏化了细胞对性激素的反应性，从而导致了间质细胞的增殖，提示了ＢＰＨ发生发展中性激素作用的可能途径。

关键词：前列腺增生症细胞培养间质细胞性激素

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Factor. associated with success of telapr.vir.and bocepr.vir.based tr.ple ther.py for.hepatitis C vir.s infection

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Wor.d Jour.al of Hepatology 2017年第11期9卷 551-561页

作者： Kian Bichoupan Neeta Tandon Valer.e Mar.el-Lafer.ier. neal M patel David Sachs Michel Ng Emily A Schonfeld Alexis Pappas James Cr.smale Alicia Stivala Viktor.ya Khaitova Donald Gar.enier.Michael Linder.an William Olson Ponni V Per.malswami Thomas D Schiano Joseph A Odin Lawr.nce U Liu Douglas T Dieter.ch Andr.a D Br.nch Division of Liver.Diseases Icahn School of Medicine at Mount Sinai Icahn Medical Instititute Janssen Phar.aceuticals Com-panies Division of Janssen Scientific Affairs Inc. Genetics and Genomics Icahn School of Medicine at Mount Sinai

To evaluate new ther.pies for.hepatitis C vir.s (HCV), data about r.al-wor.d outcomes ar. needed. METHODSOutcomes of 223 patients with genotype 1 HCV who star.ed telapr.vir. or.bocepr.vir.based tr.ple ther.py (May 2011-Mar.h 2012) at the Mount Sinai Medical Center.wer. analyzed. Human immunodeficiency vir.s-positive patients and patients who r.ceived a liver.tr.nsplant wer. excluded. Factor. associated with sustained vir.logical r.sponse (SVr.4) and r.lapse wer. analyzed by univar.able and multivar.able logistic r.gr.ssion as well as classification and r.gr.ssion tr.es. Fast vir.logical r.sponse (FVr. was defined as undetectable HCV r.A at week-4 (telapr.vir. or.week-8 (bocepr.vir.. r.SULTSThe median age was 57 year., 18% wer. black, 44% had advanced fibr.sis/cir.hosis (FIB-4 ≥ 3.25). Only 42% (94/223) of patients achieved SVr.4 on an intention-to-tr.at basis. In a model that included platelets, SVr.4 was associated with white r.ce [odds r.tio (Or. = 5.92, 95% confidence inter.al (CI): 2.34-14.96], HCV sub-genotype 1b (Or.= 2.81, 95%CI: 1.45-5.44), platelet count (Or.= 1.10, per.x 104 cells/μL, 95%CI: 1.05-1.16), and IL28B CC genotype (Or.= 3.54, 95%CI: 1.19-10.53). Platelet counts > 135 x 103/μL wer. the str.ngest pr.dictor.of SVr.by classification and r.gr.ssion tr.e. r.lapse occur.ed in 25% (27/104) of patients with an end-of-tr.atment r.sponse and was associated with non-FVr.(Or.= 4.77, 95%CI: 1.68-13.56), HCV sub-genotype 1a (Or.= 5.20; 95%CI: 1.40-18.97), and FIB-4 ≥ 3.25 (Or.= 2.77; 95%CI: 1.07-7.22). CONCLUSIONThe SVr.r.te was 42% with telapr.vir. or.bocepr.vir.based tr.ple ther.py in r.al-wor.d pr.ctice. Low platelets and advanced fibr.sis wer. associated with tr.atment failur. and r.lapse.

关键词： Sustained vir.logic r.sponse Hepatitis C vir.s r.lapse Telapr.vir Bocepr.vir Tr.ple-ther.py Classification and r.gr.ssion Adver.e event r.al-wor.d

POLYMEr.SE CHAIN r.ACTION IN DETECTION OF HUMAN PAPILLOMAVIr.S DNA AND TYPES OF CONDYLOMA ACUMINATA

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中华医学杂志(英文版) 1993年第2期106卷 141-144页

作者：朱文元 Cr.ig Leonar.i neal S.Penneys Depar.ment of Der.atology Nanjing Medical CollegeNanjing 210029 Depar.ment of Der.atology and Cutaneotls Sur.er. University of Miami School of MedicineMiamiFlorida 33101USA Depar.ment Of Der.atology and Cutaneous Sur.er. University of Miami School of MedicineMiamiFlorida 33101USA

Sections fr.m 88 par.ffin-embedded tissues identifiedhistopathologically as condyloma acuminata wer. assayed for.he pr.sence of human papillomavir.s (HPV) types 6,11,16,18 and 33 using polymer.se chain r.action followed by *** DNA sequences wer. found in all tissuesof condyloma *** type 6 was pr.sent in 71tissues,type 11 in 16,and type 16 in *** man was doublyinfected with HPV types 6 and *** HPV types 18 and 33wer. *** conclude that condyloma acuminata is mainlypr.duced by HPV types 6 and 11.

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Genomic Stability of Palmer.amar.nth Plants Der.ved by Macr.-Vegetative Pr.pagation

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Amer.can Jour.al of Plant Sciences 2014年第21期5卷 3302-3310页

作者： neal Dwaine Teaster.r.ber. Edwar. Hoagland US Depar.ment of Agr.cultur.-Agr.cultur.l r.sear.h Ser.ice Crop Production Systems Research Unit Stoneville USA

qPCr.(quantitative polymer.se chain r.action) and r.ndom amplified polymor.hic DNA (r.PD) wer. utilized to investigate genetic stability of Palmer.amar.nth cloned plants over.10 gener.tions. DNA fr.m or.ginal par.nt Palmer.amar.nth plants (gr.wn fr.m seeds) was r.-analyzed using qPCr. and confidence levels for.deter.ining ΔΔCt (thr.shold cr.ssing) values wer. established. ANOVA was used to deter.ine var.ation (mar.in of er.or. of these ΔΔCt values. This mar.in of er.or.was applied to qPCr.analysis of DNA fr.m eight individual par.nt plants and their.descendants (10th gener.tion) so that possible differ.nces in EPSPS (5-enolpyr.vylshikimate-3-phosphate synthase) gene copy number.could be ascer.ained. This method (and the associated er.or. indicated a lack of agr.ement in ΔΔCt values of DNA fr.m plants of these two gener.tions. qPCr.analysis showed that in five out of eight clones, EPSPS gene copy number.var.ed mor. than the calculated er.or.(P = 0.05). A second technique to monitor.genetic stability, r.PD was used to deter.ine possible changes in genomic DNA due to extended cloning of these r.gener.ted plants. r.PD analysis showed that four.out of the eight clones differ.d when the pr.files of the two gener.tions wer. compar.d. r.sults show that qPCr.and r.PD analysis point to the fact that sever.l Palmer.amar.nth clones exper.enced changes in genome str.ctur. over.10 gener.tions. Although the glyphosate r.sistance tr.it was r.tained, r.sults suggest that dur.ng cloning studies, the genetic stability of macr.-vegetatively pr.pagated lines should be monitor.d.

关键词： Amar.nthus palmer. EPSPS Gene Copy Number Glyphosate-r.sistant Weeds Palmer amar.nth Pigweed qPCr r.PD