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There is more to the knee joint than just the quadriceps:A systematic review with meta-analysis and evidence gap map of hamstring strength,flexibility,and morphology in individuals with gradual-onset knee disorders

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Journal of Sport and Health Science 2024年第4期13卷 521-536页

作者： Helder S.Lopes Marina C.Waiteman Liliam B.priore neal R.Glaviano David M.Bazett-Jones Ronaldo V.Briani Fabio M.Azevedo School of Science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA School of exercise and Rehabilitation Sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

Background:Impairments in hamstring strength,flexibility,and morphology have been associated with altered knee biomechanics,pain,and *** the presence of these impairments in individuals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic review aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in individuals with gradual-onset knee ***:Five databases(MeDLINe,embase,CINAHL,SpORTDiscus,and Web of Science)were searched from inception to September *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between individuals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the Grading of Recommendations Assessment,Development,and evaluation,and evidence gap maps were ***:Seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(pFp),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(SMD)=-0.76,95%confidence interval(95%CI):-1.32 to-0.21)and concentric contractions(SMD=-0.97,95%CI:-1.49 to-0.45).Individuals with pFp presented with reduced hamstring strength compared to painfree controls during isometric(SMD=-0.48,95%CI:-0.82 to-0.14),concentric(SMD=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions(SMD=-0.59,95%CI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with pFp presented with reduced hamstring flexibility when compared to pain-free controls(SMD=-0.76,95%CI:-1.15 to-0.36).evidence gap maps identified insufficient evidence for chondromalacia patel

关键词： Chondromalacia patellae Knee flexors Knee osteoarthritis patellar tendinopathy patellofemoral pain

epitaxially aligned single-crystal gold nanoplates formed in large-area arrays at high yield

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Nano Research 2022年第1期15卷 296-303页

作者： Trevor B.Demille robert D.neal Arin S.preston Zijuan Liang Allen G.Oliver robert A.Hughes Svetlana Neretina College of engineering University of Notre DameNotre DameIndiana 46556USA Department of Chemistry and Biochemistry University of Notre DameNotre DameIndiana 46556USA

Well-tailored nanomaterials with a single-crystal character provide ideal building blocks for on-chip plasmonic *** colloidal methods have demonstrated mastery over the synthesis of such structures,it has proven quite difficult to deploy these same nanomaterials on substrate surfaces in a highly deterministic manner where precise control over position and orientation is ***,we demonstrate a room-temperature two-reagent liquid-phase seed-mediated synthesis of gold nanoplates directly on substrate surfaces in arrays over a square-centimeter *** synthesis is reliant on benchtop lithographic and directed-assembly processes that give rise to single-crystal seeds of gold that express both an epitaxial relationship with the underlying substrate and the internal defect structure required to promote a two-dimensional growth *** resulting structures are highly faceted and,because seed-substrate epitaxy is imposed upon the growing nanoplates,are identically aligned on the substrate *** yields are increased to values as high as 95%using a post-processing sonication procedure that selectively removes a small population of irregularly shaped nanostructures from the substrate surface,and in doing so,gives rise to an uncompromised plasmonic *** work,therefore,advances the techniques needed to integrate single-crystal nanomaterials with wafer-based technologies and provides leading-edge capabilities in terms of defining large-area arrays of plasmonic structures with the nanoplate geometry.

关键词： nanoplates epitaxial array plasmon Brij-700 block copolymer substrate

COVID-19 and low-dose radiation therapy

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Radiation Medicine and protection 2021年第4期2卷 139-145页

作者： neal e.dunlap Victor van Berkel Lu Cai Department of Radiation Oncology University of Louisville School of MedicineLouisvilleKY40202USA Department of Cardiovascular and Thoracic Surgery University of Louisville School of MedicineLouisvilleKY40202USA pediatric Research Institute Departments of PediatricsPharmacology and ToxicologyUniversity of Louisville School of MedicineLouisvilleKY40202USA

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative pathogen of the coronavirus disease 2019(COVID-19),has caused more than 179 million infections and 3.8 million deaths *** health authorities working on the COVID-19 outbreak continue to explore methods to reduce the rate of its transmission to healthy *** protocols thus far have focused on social distancing and masking,treatment with antivirals early in infection,and steroids to reduce the inflammatory *** alternative approach is therapy with low dose radiation(LDR),which has several advantages compared to the current drugs and *** date more than 10 case reports and pilot clinical trial preliminary outcome are available from different *** reports cover a wide range of patient conditions and LDR treatment *** one report showed the failure to observe the improvement of COVID-19 patients after LDR therapy,the majority showed some clinical improvement,and demonstrated the safety of LDR for COVID-19 patients,particularly with 0.5 *** review aims to summarize the potential rationales and mechanisms of LDR therapy for COVID-19 patients,and its current clinical status and potential use.

关键词： Low dose radiation Radiation hormesis Radiotherapy COVID-19 SARS-CoV-2

Stereotactic radiosurgery in the era of novel systemic therapy for lung cancer brain metastases

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Journal of Cancer Metastasis and Treatment 2019年第4期4卷 17-25页

作者： Sarah Mudra Shruti Bhandari prashant Tripathi neal dunlap Goetz Kloecker University of Louisville School of Medicine LouisvilleKY 40202USA Department of Internal Medicine Division of Hematology and Medical OncologyJames Graham Brown Cancer CenterUniversity of Louisville School of MedicineLouisvilleKY 40202USA Division of Infectious Disease University of Louisville School of MedicineLouisvilleKY 40202USA Department of Radiation Oncology James Graham Brown Cancer CenterUniversity of Louisville School of MedicineLouisvilleKY 40202USA

The emergence of novel systemic therapies has spurred a dramatic paradigm shift in lung cancer *** has revealed greater intracranial efficacy in targeted agents and immune checkpoint inhibitors(ICI)compared to conventional ***,advances in stereotactic radiosurgery(SRS)have contributed to the increased use of this highly localized,minimally-invasive treatment modality for local tumor *** this era of precision medicine,the combination of these novel agents and SRS demands further prospective exploration-particularly as questions regarding their sequence of administration and the risk of neurotoxicity remain ***,although data are limited and largely retrospective,literature supports the concurrent administration of ICI and radiation,with no observed increases in immune-related adverse events or acute neurologic *** the case of patients with driver mutations,newer generations of tyrosine kinase inhibitors(TKI)display improved intracranial efficacy and are currently preferred alone upfront in patients with asymptomatic brain metastases(BM)due to lack of *** of combining TKI and SRS is limited with mixed *** this review,we explore the evidence regarding the use of novel systemic agents and SRS for treatment of lung cancer *** practice will continue to be refined as larger,prospective studies yield results.

关键词： Lung cancer stereotactic radiosurgery brain metastasis tyrosine kinase inhibitors immunotherapy

Reversible Data Hiding in encrypted Images Based on Adaptive prediction and Labeling

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Computers, Materials & Continua 2022年第11期73卷 3613-3628页

作者： Jiaohua Qin Zhibin He Xuyu Xiang neal N.Xiong College of Computer Science and Information Technology Central South University of Forestry&TechnologyChangsha410004China Department of Mathematics and Computer Science Northeastern State UniversityTahlequah74464OKUSA

Recently,reversible data hiding in encrypted images(RDHeI)based on pixel prediction has been a hot ***,existing schemes still employ a pixel predictor that ignores pixel changes in the diagonal direction during prediction,and the pixel labeling scheme is *** solve these problems,this paper proposes reversible data hiding in encrypted images based on adaptive prediction and ***,we design an adaptive gradient prediction(AGp),which uses eight adjacent pixels and combines four scanning methods(i.e.,horizontal,vertical,diagonal,and diagonal)for *** can adaptively adjust the weight of the linear prediction model according to the weight of the edge attribute of the pixel,which improves the prediction ability of the predictor for complex *** the same time,we adopt an adaptive huffman coding labeling scheme,which can adaptively generate huffman codes for labeling according to different images,effectively improving the scheme’s embedding performance on the *** experimental results show that the algorithm has a higher embedding *** embedding rate on the test image Jetplane is 4.2102 bpp,and the average embedding rate on the image dataset Bossbase is 3.8625 bpp.

关键词： Reversible data hiding adaptive gradient prediction huffman coding embedding capacity

The ALMA-QUARKS Survey.Ⅱ.The ACA 1.3 mm Continuum Source Catalog and the Assembly of Dense Gas in Massive Star-Forming Clumps

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Research in Astronomy and Astrophysics 2024年第6期24卷 119-139页

作者：许峰玮 Ke Wang Tie Liu Lei Zhu Guido Garay Xunchuan Liu paul Goldsmith Qizhou Zhang patricio Sanhueza Shengli Qin Jinhua He Mika Juvela Anandmayee Tej Hongli Liu Shanghuo Li Kaho Morii Siju Zhang Jianwen Zhou Amelia Stutz neal Jevans Kee-Tae Kim Shengyuan Liu Diego Mardones Guangxing Li Leonardo Bronfman Ken’ichi Tatematsu Chang Won Lee Xing Lu Xiaofeng Mai Sihan Jiao James O.Chibueze Keyun Su Viktor L.Tóth Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Departamento de Astronomía Universidad de ChileLas Condes7591245 SantiagoChile Jet propulsion Laboratory California Institute of Technology4800 Oak Grove DrivePasadena CA 91109USA Center for Astrophysics|Harvard&Smithsonian 60 Garden StreetCambridgeMA 02138USA National Astronomical Observatory of Japan National Institutes of Natural Sciences2-21-1 OsawaMitakaTokyo 181-8588Japan Astronomical Science program The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan School of physics and Astronomy Yunnan UniversityKunming 650091China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Department of physics University of HelsinkiPO Box 64FI-00014 HelsinkiFinland Indian Institute of Space Science and Technology Thiruvananthapuram 695547KeralaIndia Max planck Institute for Astronomy Königstuhl 17D-69117 HeidelbergGermany Department of Astronomy Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Max-planck-Institut für Radioastronomie Auf dem Hügel 6953121 BonnGermany Departamento de AstronomÂıa Universidad de ConcepcionCasilla 160-CConcepci onChile Department of Astronomy The University of Texas at AustinTexas 78712-1205USA Korea Astronomy and Space Science Institute 776 Daedeokdae-roYuseong-guDaejeon 34055Republic of Korea Institute of Astronomy and Astrophysics Academia SinicaRoosevelt RoadTaipei 10617TaiwanChina South-Western Institute for Astronomy Research Yunnan UniversityKunming 650091China Korea Astronomy and Space Science Institute 776 Daedeok-daeroYuseong-guDaejeon 34055Republic of

Leveraging the high resolution,sensitivity,and wide frequency coverage of the Atacama Large Millimeter/submillimeter Array(ALMA),the QUARKS survey,standing for“Querying Underlying mechanisms of massive star formation with ALMA-Resolved gas Kinematics and Structures”,is observing 139 massive starforming clumps at ALMA Band 6(λ~1.3 mm).This paper introduces the Atacama Compact Array(ACA)7 m data of the QUARKS survey,describing the ACA observations and data *** multiwavelength data,we provide the first edition of QUARKS atlas,offering insights into the multiscale and multiphase interstellar medium in high-mass star *** ACA 1.3 mm catalog includes 207 continuum sources that are called ACA *** gas kinetic temperatures are estimated using three formaldehyde transitions with a non-LTe radiation transfer model,and the mass and density are derived from a dust emission *** ACA sources are massive(16–84 percentile values of 6–160 M_(⊙)),gravity-dominated(M∝R^(1.1))fragments within massive clumps,with supersonic turbulence(M>1)and embedded star-forming *** find a linear correlation between the masses of the fragments and the massive clumps,with a ratio of 6%between the *** considering fragments as representative of dense gas,the ratio indicates a dense gas fraction(DGF)of 6%,although with a wide scatter ranging from 1%to 10%.If we consider the QUARKS massive clumps to be what is observed at various scales,then the size-independent DGF indicates a self-similar fragmentation or collapsing mode in protocluster *** the ACA data over four orders of magnitude of luminosity-to-mass ratio(L/M),we find that the DGF increases significantly with L/M,which indicates clump evolutionary *** observed a limited fragmentation at the subclump scale,which can be explained by a dynamic global collapse process.

关键词： stars:formation ISM:kinematics and dynamics ISM:clouds stars:protostars

Varying Tolerance to Glyphosate in a population of palmer Amaranth with Low epSpS Gene Copy Number

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American Journal of plant Sciences 2013年第12期4卷 2400-2408页

作者： neal D. Teaster robert e. Hoagland US Department of Agriculture-Agricultural Research Service Crop Pro-duction Systems Research Unit Stoneville USA

A palmer amaranth population (seeds collected in the year 2000;Washington Co., MS) suspected to be susceptible to glyphosate was examined as a population and as individual plants and found to exhibit varying tolerance or resistance to glyphosate. Whole plant spraying of glyphosate (0.84 kg·ha?1) to the population revealed that approximately 40% of this population were resistant to glyphosate and an LD50 of 0.75 kg·ha?1 was determined. Spray application of glyphosate indicated that some plants displayed varying degrees of resistance 14 days after treatment. Initial tests using leaf disc bioassays on 10 individual plants selected randomly from the population, allowed characterization of glyphosate resistance using both visual ratings of injury and quantitative measurement via chlorophyll content analysis. After initial bioassays and spray application, five plants with a range of tolerance to glyphosate were selected for cloning so that further studies could be accomplished on these individuals. Q-pCR analysis of these clones showed that resistance was not due to elevated epSpS gene copy number. Shikimate levels were lower in the resistant and higher in the susceptible clones which correlated with varying degrees of resistance demonstrated in bioassays and spray application of glyphosate of these clones. Results demonstrate that individuals in a population can vary widely with respect to herbicide resistance and suggest that uptake, translocation, sequestration, metabolism or altered target site may contribute to the resistance in some individuals of this population.

关键词： Amaranthus palmeri epSpS (5-enolpyruvylshikimate-3-phosphate Synthase) epSpS Gene Copy Number Glyphosate-Resistance Herbicide Tolerance population Variance pigweed

Determination and Quantification of Susceptibility of Heritance Resistance to Root Rot of eight Commercial Genotypes of Maize (Zea mays L.)

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Agricultural Sciences 2023年第5期14卷 665-684页

作者： Lazaro José Quintas neal Walker McLaren Free State University Blofoontein and Crops Research Institute Potchefstroom South Africa Grain Crops Research Institute Potchefstroom South Africa

Maize is susceptible to a number of diseases that can infect all plant organs and serve as a constraint on cereal production. The reduction in cereal production caused by disease is estimated at an average of 9.4%. Corn root rot contributes greatly to the reduction in grain production and quality. The main objective of this work was to review the research on root rot in maize to determine the susceptibility of genotypes to root rot and to quantify the inheritance of resistance to root rot in maize. The methodology used was a complete 8 × 8 diallel design planted during the year 1999/2000. Root discoloration, plant length, root volume, effective volume and yield were the evaluated parameters. To analyze the data and determine the combinatorial abilities, genetic correlations, heritability and correlated response, diallel analysis was used. eight parental lines;p28, I137TN, Mp706, e739, MO17, B37, B73, and B14 were planted. The lines were crossed into each other, all combinations according to the complete diallel model (Model 1). The F1 was harvested after maturation. For statistical analysis, the version of the Agrobase program (2016) was used. Results show that F1 hybrids showed significant differences in root rot discoloration, plant height, root volume, effective root volume and yield. The p28 line and the B73Xe739 cross had, respectively, the highest general and specific combinations. Root discoloration had the highest genetic correlation (rA = 0.47) with plant length. Broad and narrow heritability for root rot discoloration were, respectively, hp>2p> = 0.81 and h2 = 0.51. Root rot discoloration showed the highest correlated response (CR = 0.14) on plant length.

关键词： Maize (Zea mays L.) Discoloration Inheritance Hybrid Inbreeds Lines

Soil carbon sequestration,carbon markets,and conservation agriculture practices:A hypothetical examination in Mozambique

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International Soil and Water Conservation Research 2017年第3期5卷 167-179页

作者： Timoteo e.Simone Dayton M.Lambert Ivan Cuvaca neal S.eash Department of Agricultural&Resource economics 321 Morgan Hall2621 Morgan CircleKnoxvilleTN 37996-4518USA Department Biosystems engineering&Soil Science 2506 EJ Chapman DriveKnoxvilleTN 37996-4531USA

payments for environmental Services(peS)are relatively novel mechanisms whereby the adoption of sustainable management practices by a stakeholder is rewarded by incentives linked to external *** of peS for conservation agricultural practices(CApS)by smallholder farmers may provide opportunities to increase household income or cover the technology costs of adoption if the carbon sequestration benefits of CApS are quantifiable,adoption rates are accelerated and maintained,a mechanism exists whereby carbon sequestration services can be compensated,and carbon offset exchange markets are *** research suggests a methodology to examine a peS market for carbon offsets generated by the adoption of CApS by farmers in *** a cumulative adoption of 60%over a 20-year period,revenue from peS market participation to CA adopters was two times higher than revenue earned when disadoption occurred midway through the *** adoption targets are associated with higher per household returns when fertilizer rates typical to the region are *** and maintaining a sustainable peS system in the study region would require significant investment in time and *** lack of on-the-ground institutions or local support for such a program would also challenge successful ***,the programs where participant success depends on external markets,such as the hypothetical one suggested here,are subject to the ebb and flow of foreign demand for carbon *** these three broad constraints to a peS/CApS program in the region would require grass-roots driven policy initiatives with buy-in at multiple social,economic,and political levels.

关键词： payment for environmental services Conservation agriculture adoption Carbon sequestration