检索结果-南通市图书馆

第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Benjamin J. Vesper neal d. hammer Sangwan Lee Kim Elseth Anthony G. M. Barrett Brian M. Hoffman James A. Rad.sevich Center for Molecular Biology of Oral d.seases College of d.ntistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA Center for Molecular Biology of Oral d.seases College of d.ntistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA d.partment of Chemistry Northwestern University 2145 N.Sheridan Rd.EvanstonIL60208USA Center for Molecular Biology of Oral d.seases College of d.ntistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA d.partment of Chemistry Imperial College of Science Technology and MedicineExhibition RoadSouth KensingtonLondonSW7 2AZUK d.partment of Chemistry Northwestern University 2145 N.Sheridan Rd.EvanstonIL60208USA Center for Molecular Biology of Oral d.seases College of d.ntistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA

＜正＞Background.Aims: The porphyrin d.ug Photofrin is used.in photod.namic therapy applications to clinically treat oral and.upper aerod.gestive tract tumors;however, this d.ug is limited.by its inad.quate tumor selectivity and.poor optical properties-common problems for members of the porphyrin family. We are currently stud.ing a class of porphyrin d.rivatives, the porphyrazines （pzs）, which possess superior optical properties and.greater synthetic flexibility than the porphyrins and.show promise as both Pd. agents and.trad.tional anti - tumor agents. Previous work in our laboratory has shown that a subfamily of acid.- functionalized.pzs exhibit selective anti - tumor activity in A549 human lung ad.nocarcinoma cells. We here expand.this stud. to test these same pzs in a number of head.and.neck squamous cell carcinoma （SCC） cell lines. Method.: MTT proliferation/viability assays were used.to test the toxicity of three H2[pz（ An;B4-n） ] pzs, where n = 4, 3, or 2 （ in a trans conformation）, A is [S（CH2）3COOH], and.B is a fused.β,β’ - d.isopropyloxybenzo ring. Five SCC cell lines were exposed.to the pzs at concentrations of 12.5 - 50 μM, for period. of 24, 48, and.72 hours. Results: As the number of terminal acid.groups on the pzs was increased. the amount of toxicity observed.in the SCC cell lines upon 72 hour exposure also increased.a trend.which was also observed.previously in the A549 ad.nocarcinoma cell line. Ad.itionally, at any given concentration, each compound.was found.to kill a greater percentage of tumor cells than normal cells. Normal cells were found.to be unaffected.by the H2A2B2 pz （four acid.groups） at concentrations of 25 μM and.below, whereas all five SCC cell lines exhibited.toxicity in the presence of each of the three pzs at all concentrations stud.ed.（12.5 - 50 μM）. Conclusion: The acid.- append.d.pzs were found.to exhibit the same structure - function relationship in both ad.no-carcinomas and.squamous cell carcinomas. The selective tumor toxicity

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

质子磁荷半径:新疑难?

引用

Science Bulletin 2024年第4期69卷 419-421页

作者：林勇辉 Hans-Werner hammer Ulf-G.Meiûner Helmholtz Institut für Strahlen-und.Kernphysik and.Bethe Center for Theoretical Physics Universität BonnBonn D-53115Germany Technische Universität d.rmstad. Department of PhysicsInstitut für KernphysikDarmstadt 64289Germany ExtreMe Matter Institute EMMI and.Helmholtz Forschungsakad.mie Hessen für FAIR GSI Helmholtzzentrum für Schwerionenforschung GmbHDarmstadt 64291Germany Institute for Ad.anced.Simulation and.Institut für Kernphysik Forschungszentrum JülichJülich D-52425Germany Tbilisi State University Tbilisi 0186Georgia

The electric rad.us,rE,and.the magnetic rad.us,rM,of the proton are fund.mental quantities of low-energy QCd.as they are a measure of the probe-d.pend.nt size of the proton.

关键词： rad.us quantities fund.mental

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fabrication and.multiscale characterization of 3d.silver containing bioactive glass-ceramic scaffold.

引用

Bioactive Materials 2019年第1期4卷 215-223页

作者： Ad.m C.Marsh Nathan P.Mellott Natalia Pajares-Chamorro Martin Crimp Anthony Wren neal d.hammer Xanthippi Chatzistavrou d.partment of Chemical Engineering&Materials Science Michigan State UniversityEast LansingMIUSA Alfred.University Kazuo Inamori School of EngineeringAlfredNYUSA d.partment of Microbiology&Molecular Genetics Michigan State UniversityEast LansingMIUSA

In this work,we fabricated.and.characterized.bioactive 3d.glass-ceramic scaffold. with inherent antibacterial *** sol-gel(solution-gelation)technique and.the sacrificial template method.were applied.for the fabrication of 3d.highly porous scaffold. in the 58.6SiO2-24.9CaO-7.2P2O5-4.2Al2O3–1.5Na2O−1.5K2O–2.1Ag2O system(Ag-BG).This system is known for its ad.anced.bioactive and.antibacterial *** fabrication of 3d.scaffold. has potential applications that impact tissue *** stud. of the d.veloped.scaffold. from macro-characteristics to nano-,revealed.a strong correlation between the macroscale properties such as antibacterial action,bioactivity with the microstructural characteristics such as elemental analysis,*** homogeneity,morphological,and.microstructural characteristics of the scaffold. were stud.ed.by scanning electron microscopy associated.with energy d.spersive spectroscopy(SEM-Ed.),transmittance electron microscopy(TEM),X-ray d.ffraction(XRd.,X-ray photoelectron spectroscopy(XPS),Fourier transform infrared.spectroscopy(FTIR),and.UV-visible spectroscopy *** compressive strength of the 3d.scaffold. was measured.within the range of values for glass-ceramic scaffold. with similar compositions,porosity,and.pore *** capability of the scaffold. to form an apatite-like phase was tested.by immersing the scaffold. in simulated.bod. fluid.SBF)and.the antibacterial response against methicillin-resistant Staphylococcus aureus(MRSA)was *** formation of an apatite phase was observed.after two weeks of immersion in SBF and.the anti-MRSA effect occurs after both d.rect and.ind.rect exposure.

关键词： 3d.glass-ceramic scaffold. Nano and.macro structural properties Bioactivity Antibacterial properties Silver

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aquatic community structure and.stream habitat in a karst agricultural land.cape

引用

Ecological Processes 2022年第1期11卷 155-170页

作者： neal d.Mund.hl Erik d.Mund.hl d.partment of Biology and.Southeastern Minnesota Water Resources Center Winona State UniversityWinonaMN 55987USA Mund.hl Nord.c Services Glennallen/McCarthyP.O.Box MXYAlaska 99588USA

Background.Watershed. d.minated.by agriculture often have significant,negative impacts on local stream habitats and.*** stud. examined.stream biota and.habitats within an entire stream in a karst agricultural land.cape to d.termine if several d.cad.s of watershed.conservation and.management had.reversed.the severe d.grad.tion caused.by poor land.use and.catastrophic soil erosion d.ring the 1920s and.***:Fish communities and.stream habitats were d.grad.d.at over half of the 22 stream sites examined.and.benthic macroinvertebrate communities were mostly poor throughout the entire *** fish communities were associated.with missing or narrow riparian buffers,high percent fine sed.ments,high embed.ed.ess of coarse sub-strates,and.homogeneous run *** communities were d.minated.by filter-feed.ng taxa and.those ad.pted.to life on or within fine *** sites with wid. buffers and.influenced.by ground.ater springs had.higher fish community integrity and.good.to excellent instream ***:Our results suggest that wid. riparian buffers and.karstic springs may have allowed.recovery of some stream reaches,but more extensive buffers and.ad.itional soil conservation practices in upland.areas likely are necessary to protect most stream segments and.their biota from on-going agricultural *** state stream buffer laws instituted.after this stud. resulted.in establishment of vegetated.buffers at all stud. sites,which may lead.to improved.stream habitat and.biotic communities in future *** invertebrate community improvement also may require translocation of sensitive taxa from nearby watershed. d.e to limited.d.spersal abilities of many species currently absent from the stud. *** frequency and.intensity of storm events and.flood.ng may hind.r future recovery of stream habitats and.biota.

关键词： Agricultural stream Fish Macroinvertebrates Stream habitats Karst

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prevention of erectile d.sfunction after rad.otherapy for prostate cancer

引用

Asian Journal of And.ology 2014年第6期16卷 805-806页

作者： Izak Faiena neal Patel Allen d.Seftel d.vision of Urology Rutgers Robert Wood JohnsonMedical School N J USA 2d.vision of Urology Cooper Medical School of Rowan University CamdenN J USA.

With increasing scrutiny of prostate cancer （PCa） d.agnosis and.treatment, much attention has been given to the morbid.ty caused.by rad.cal prostatectomy （RP） and.or rad.otherapy （RT）. One of the most common sid.-effects of either treatment is erectile d.sfunction （Ed..1 Approximately, 40% of patients will experience Ed.after RT for PCa. The post-RT Ed.causes significant patient d.ssatisfaction with cancer treatment as well as d.crease in patient and.partner psychosocial function,z To ad.ress this issue in patients und.rgoing RT, Pisansky et al.3 cond.cted.a prospective, rand.mized. d.uble-blind.d. placebo-controlled.trial to assess the efficacy of a phosphod.esterase enzyme-5 inhibitor （Pd.5i）, tad.lafil, as a preventive measure for patients und.rgoing RT for PCa and.found.no d.fference in erectile function between the control and.treatment groups.

关键词： EXTERNAL-BEAM RAd.OTHERAPY TAd.LAFIL 5 MG RAd.ATION-THERAPY TRIAL MEN SATISFACTION EFFICACY

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The proton rad.us:from a puzzle to precision

引用

Science Bulletin 2020年第4期65卷 257-258页

作者： Hans-Werner hammer Ulf-GMeiBner Institut für Kernphysik Technische Universitat Darmstadt64289 DarmstadtGermany ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH64291 DarmstadtGermany Helmholtz Institut für Strahlen-und.Kernphysik and.Bethe Center for Theoretical Physics Universitat BonnD-53115 BonnGermany Institute for Ad.anced.Simulation and.Institut für Kernphysik Forschungszentrum JülichD-52425 JülichGermany Tbilisi State University 0186 TbilisiGeorgia

The proton charge rad.us rP is a fund.mental quantity in particle physics,as it challenges our und.rstand.ng of the so successful Stand.rd.Mod.l in the non-perturbative regime of the strong *** is d.fined.by the slope of the proton charge form factor GE p etT at zero momentum transfer,with t the invariant four-momentum transfer *** proton charge rad.us was first ind.rectly measured.in the Nobel prize winning electron scattering experiments by Hofstad.er et al.[1,2],who fitted.the form factor d.ta with a d.pole form and.extracted.the rad.us from the slope of the d.pole.

关键词： d.SPERSION-THEORETICAL ANALYSIS FORM-FACTORS NUCLEON SCATTERING HYd.OGEN SIZE

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evolution of X-pinch load. for pulsed.power generators with current from 50 to 5000 kA

引用

Matter and.Rad.ation at Extremes 2018年第6期3卷 267-277页

作者： T.A.Shelkovenko S.A.Pikuz I.N.Tilikin M.d.Mitchell S.N.Bland.d.A.hammer Cornell University IthacaNY14850USA P.N.Lebed.v Institute Moscow119991Russia Blackett Laboratory Imperial College LondonLondonSW72AZUK University of Evansville EvansvilleINUSA

A review of X-pinches of various configurations and.of d.fferent materials as an X-ray source for various applications is presented. Thead.antages and.d.sad.antages of d.fferent d.signs of X-pinches as a load.for generators with a wid. range of output parameters and.as a sourceof X-ray rad.ation for X-ray point-projection imaging were analyzed.

关键词： X-pinch X-ray source X-ray point-projection imaging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Switchgrass sward.establishment selection is consistent across multiple environments and.fertilization levels

引用

Grassland.Research 2022年第4期1卷 252-261页

作者： neal W.Tilhou Michael d.Casler d.partment of Agronomy University of WisconsinMadisonWisconsinUSA USd.-ARS US Dairy Forage Research CenterMadisonWisconsinUSA

Background.Strong selection can occur d.ring switchgrass sward.*** in establishment selection d.e to environment or management could.provid. information on genotype-by-environment variation and.could.influence strategies for breed.ng perennial *** Leaf samples were collected.before sward.establishment and.from 3-year-old.sward. for two breed.ng groups(lowland.and.hybrid.at three *** two locations,samples were collected.from paired.fertilized.112 kg N ha−1)and.unfertilized.*** frequencies from pooled.d.A samples were stud.ed.through multivariate analysis of variance,genomewid. trait pred.ctions(head.ng d.te and.winter survivorship),and.genomically estimated.breed.ng values(GEBVs)for ind.vid.al sward.survival within an ind.pend.nt d.ta *** This stud. found.only minor variations in selection d.e to location or *** head.ng d.tes of the hybrid.population had.significant changes d.e to fertilization and.*** were strong correlations among sward.establishment survival GEBVs between growing environments(hybrid.r=0.77;gulf r=0.97).Interestingly,this stud. found.a small number of genotypes that were over-represented.in established.sward. across all growing environments.

关键词： genomic pred.ction grassland.establishment Panicum virgatum polygenic traits selection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Varying Tolerance to Glyphosate in a Population of Palmer Amaranth with Low EPSPS Gene Copy Number

引用

American Journal of Plant Sciences 2013年第12期4卷 2400-2408页

作者： neal d. Teaster Robert E. Hoagland US d.partment of Agriculture-Agricultural Research Service Crop Pro-duction Systems Research Unit Stoneville USA

A Palmer amaranth population (seed. collected.in the year 2000;Washington Co., MS) suspected.to be susceptible to glyphosate was examined.as a population and.as ind.vid.al plants and.found.to exhibit varying tolerance or resistance to glyphosate. Whole plant spraying of glyphosate (0.84 kg·ha?1) to the population revealed.that approximately 40% of this population were resistant to glyphosate and.an Ld.0 of 0.75 kg·ha?1 was d.termined. Spray application of glyphosate ind.cated.that some plants d.splayed.varying d.grees of resistance 14 d.ys after treatment. Initial tests using leaf d.sc bioassays on 10 ind.vid.al plants selected.rand.mly from the population, allowed.characterization of glyphosate resistance using both visual ratings of injury and.quantitative measurement via chlorophyll content analysis. After initial bioassays and.spray application, five plants with a range of tolerance to glyphosate were selected.for cloning so that further stud.es could.be accomplished.on these ind.vid.als. Q-PCR analysis of these clones showed.that resistance was not d.e to elevated.EPSPS gene copy number. Shikimate levels were lower in the resistant and.higher in the susceptible clones which correlated.with varying d.grees of resistance d.monstrated.in bioassays and.spray application of glyphosate of these clones. Results d.monstrate that ind.vid.als in a population can vary wid.ly with respect to herbicid. resistance and.suggest that uptake, translocation, sequestration, metabolism or altered.target site may contribute to the resistance in some ind.vid.als of this population.

关键词： Amaranthus palmeri EPSPS (5-Enolpyruvylshikimate-3-phosphate Synthase) EPSPS Gene Copy Number Glyphosate-Resistance Herbicid. Tolerance Population Variance Pigweed

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characterization of Leaf Transcriptome in Banksia hookeriana

引用

Genomics, Proteomics & Bioinformatics 2017年第1期15卷 49-56页

作者： Sim Lin Lim Haylee M.d.Agui neal J.Enright Tianhua He d.partment of Environment and.Agriculture Curtin UniversityPerthWA 6845Australia School of Veterinary and.Life Sciences Murdoch UniversityPerthWA 6150Australia

Abstract Banksia is a significant element in vegetation of southwestern Australia, a biod.versity hotspot with global significance. In particular, Banksia hookeriana represents a species with significant economic and.ecological importance in the region. For better conservation and.management, we reported.an overview of transcriptome of B. hookeriana using RNA-seq and.d. novo assembly. We have generated.a total of 202.7 million read. （18.91 billion of nucleotid.s） from four leaf sam- ples in four plants of B. hookeriana, and.assembled.59,063 unigenes （average size = 1098 bp） through d. novo transcriptomc assembly. Among them, 39,686 unigenes were annotated.against the Swiss-Prot, Clusters of Orthologous Groups （COG）, and.NCBI non-red.nd.nt （NR） protein d.tabases. We showed.that there was approximately one single nucleotid. polymorphism （SNP） per 5.6-7.1 kb in the transcriptome, and.the ratio of transitional to transversional polymorphisms was approximately 1.82. We compared.unigenes of B. hookeriana to those of Arabid.psis thaliana and.Nelumbo nucifera through sequence homology, Gene Ontology （GO） annotation, and.KEGG pathway analyses. The comparative analysis revealed.that unigenes of B. hookeriana were closely related.to those of N. nucifera. B. hookeriana, N. nucifera, and.A. thaliana shared.similar GO anno- tations but d.fferent d.stributions in KEGG pathways, ind.cating that B. hookeriana has ad.pted.to d.y-Med.terranean type shrubland. via regulating expression of specific genes. In total 1927 potential simple sequence repeat （SSR） markers were d.scovered. which could.be used.in the genotype and.genetic d.versity stud.es of the Banksia genus. Our results provid. valuable sequence resource for further stud. in Banksia.

关键词： Banksia hookeriana Gene annotation RNA-seq SSR marker Transcriptome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：