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Chinese Journal of Polymer Science 2001年第1期19卷 1-6页

作者： Chun-qing Liu Yang Liu Ping Xie Rong-ben Zhang Chao-bin He neal Tai-shung Chung PCLCC Center for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China PCLCCCenter for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China PCLCCCenter for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China PCLCCCenter for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China Institute of Materials Research and Engineering National University of Singapore Singapore 119260 Institute of Materials Research and Engineering National University of Singapore Singapore 119260

A novel reactive polyorganosiloxane containing nitro groups was first prepared by acid-catalyzed equilibration polymerization. The monomer, 3-(4-nitrophenoxy)propylmethyldichlorosilane (NPPMS), was synthesized by hydrosilylation reaction with dicyciopentadienylplatinum(II) chloride (Cp2PtCl2) catalyst in high yield. The synthesized polynitroorganosiloxane, which has potential application as a precursor for synthesizing advanced functional polymers, was characterized by FTIR, H-1-NMR, C-13-NMR, Si-29-NMR, vapor pressure osmometry (VPO) and gel permeation chromatography(GPC).

关键词： polyorganosiloxane equilibration polymerization hydrosilylation characterization

Stereotactic radiosurgery in the era of novel systemic therapy for lung cancer brain metastases

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Journal of Cancer Metastasis and Treatment 2019年第4期4卷 17-25页

作者： Sarah Mudra Shruti Bhandari Prashant Tripathi neal Dunlap Goetz Kloecker University of Louisville School of Medicine LouisvilleKY 40202USA Department of Internal Medicine Division of Hematology and Medical OncologyJames Graham Brown Cancer CenterUniversity of Louisville School of MedicineLouisvilleKY 40202USA Division of Infectious Disease University of Louisville School of MedicineLouisvilleKY 40202USA Department of Radiation Oncology James Graham Brown Cancer CenterUniversity of Louisville School of MedicineLouisvilleKY 40202USA

The emergence of novel systemic therapies has spurred a dramatic paradigm shift in lung cancer *** has revealed greater intracranial efficacy in targeted agents and immune checkpoint inhibitors(ICI)compared to conventional ***,advances in stereotactic radiosurgery(SRS)have contributed to the increased use of this highly localized,minimally-invasive treatment modality for local tumor *** this era of precision medicine,the combination of these novel agents and SRS demands further prospective exploration-particularly as questions regarding their sequence of administration and the risk of neurotoxicity remain ***,although data are limited and largely retrospective,literature supports the concurrent administration of ICI and radiation,with no observed increases in immune-related adverse events or acute neurologic *** the case of patients with driver mutations,newer generations of tyrosine kinase inhibitors(TKI)display improved intracranial efficacy and are currently preferred alone upfront in patients with asymptomatic brain metastases(BM)due to lack of *** of combining TKI and SRS is limited with mixed *** this review,we explore the evidence regarding the use of novel systemic agents and SRS for treatment of lung cancer *** practice will continue to be refined as larger,prospective studies yield results.

关键词： Lung cancer stereotactic radiosurgery brain metastasis tyrosine kinase inhibitors immunotherapy

Environmental drivers and genomic architecture of trait differentiation in fire-adapted Banksia attenuata ecotypes

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Journal of Integrative Plant Biology 2019年第4期61卷 417-432页

作者： Tianhua He Byron B.Lamont neal J.Enright Haylee M.D'Agui William Stock School of Molecular and Life Sciences Curtin University School of Veterinary and Life Sciences Murdoch University Centre for Ecosystem Management Edith Cowan University

Trait divergence between populations is considered an adaptive response to different environments,but to what extent this response is accompanied by genetic differentiation is less clear since it may be phenotypic plasticity. In this study, we analyzed phenotypic variation between two Banksia attenuata growth forms, lignotuberous(shrub) and epicormic resprouting(tree), in fire-prone environments to identify the environmental factors that have driven this phenotypic divergence. We linked genotype with phenotype and traced candidate genes using differential gene expression analysis. Fire intervals determined the phenotypic divergence between growth forms in B. attenuata. A genome-wide association study identified 69 single nucleotide polymorphisms, putatively associated with growth form, whereas no growth form-or phenotype-specific genotypes were eidentified. Genomic differentiation between the two growth forms was low(F_(st)=0.024). Differential gene expression analysis identified 37 genes/transcripts that were differentially expressed in the two growth forms. A small heat-shock protein gene, associated with lignotuber presence, was differentially expressed in the two *** conclude that different fire regimes induce phenotypic polymorphism in B. attenuata, whereas phenotypic trait divergence involves the differential expression of a small fraction of genes that interact strongly with the disturbance regime. Thus, phenotypic plasticity among resprouters is the general strategy for surviving varying fire regimes.

关键词： Environmental drivers genomic architecture trait differentiation

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Understanding pathophysiology / [edited by] Sue E. Huether, Kathryn L. McCance ; section editors, Valentina L. Brashers, neal S. Rote. 4th ed.

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Outcomes of Pringle maneuver in patients undergoing hepatic resection for colorectal liver metastases

2008年

作者： [edited by] Sue E. Huether Kathryn L. McCance section editors Valentina L. Brashers neal S. Rote.

来源：畅想之星图书光盘版（南... 评论

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Hepatobiliary & Pancreatic Diseases International 2021年第6期20卷 588-591页

作者： Li Lian Kuan Christopher P neal Vaux Robertson Michael Jones Ashley R Dennison Giuseppe Garcea Department of Hepatobiliary and Pancreatic Surgery Leicester General HospitalUniversity Hospitals of Leicester NHS TrustLeicester LE54PWUK Discipline of Surgery The Queen Elizabeth HospitalThe University of AdelaideAdelaideSouth AustraliaAustralia

To the Editor:The Pringle maneuver(PM)was initially described more than a century ago to control bleeding associated with hepatic trauma and it remains the most common method to block hepatic inflow and minimize blood... 详细信息

关键词： hepatic Pringle resection

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A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme

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Bioactive Materials 2023年第3期21卷 547-565页

作者： Fei Wei Craig J.neal Tamil Selvan Sakthivel Yifei Fu Mahmoud Omer Amitava Adhikary Samuel Ward Khoa Minh Ta Samuel Moxon Marco Molinari Jackson Asiatico Michael Kinzel Sergey N.Yarmolenko Vee San Cheong Nina Orlovskaya Ranajay Ghosh Sudipta Seal Melanie Coathup Biionix Cluster Department of Internal MedicineCollege of MedicineUniversity of Central FloridaOrlandoFLUSA Advanced Materials Processing and Analysis Centre Nanoscience Technology Center(NSTC)Materials Science and EngineeringCollege of MedicineUniversity of Central FloridaOrlandoFLUSA CMC Materials 870 North CommonsDrAuroraILUSA Department of Chemistry Oakland UniversityRochesterMIMIUSA School of Applied Sciences Department of Chemical SciencesUniversity of HuddersfieldUK Department of Mechanical and Aerospace Engineering University of Central FloridaOrlandoFLUSA Engineering Research Center for Revolutionizing Biomaterials North Carolina A&T UniversityGreensboroNCUSA Department of Automatic Control and Systems Engineering Insigneo Institute for In Silico MedicineUniversity of SheffieldSheffieldS13JDUK

The disability,mortality and costs due to ionizing radiation(IR)-induced osteoporotic bone fractures are sub-stantial and no effective therapy *** radiation increases cellular oxidative damage,causing an imbalance in bone turnover that is primarily driven via heightened activity of the bone-resorbing *** demonstrate that rats exposed to sublethal levels of IR develop fragile,osteoporotic *** reactive surface sites,cerium ions have the ability to easily undergo redox cycling:drastically adjusting their electronic con-figurations and versatile catalytic *** properties make cerium oxide nanomaterials *** show that an engineered artificial nanozyme composed of cerium oxide,and designed to possess a higher fraction of trivalent(Ce^(3+))surface sites,mitigates the IR-induced loss in bone area,bone architecture,and *** investigations also demonstrate that our nanozyme furnishes several mechanistic avenues of protection and selectively targets highly damaging reactive oxygen species,protecting the rats against IR-induced DNA damage,cellular senescence,and elevated osteoclastic activity in vitro and in ***,we reveal that our nanozyme is a previously unreported key regulator of osteoclast formation derived from macrophages while also directly targeting bone progenitor cells,favoring new bone formation despite its exposure to harmful levels of IR in *** findings open a new approach for the specific prevention of IR-induced bone loss using synthesis-mediated designer multifunctional nanomaterials.

关键词： Ionizing radiation Osteoporosis Nanozyme Cerium oxide Bone strength Bone resorption

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女王之后,何为英国?

英语文摘 2022年第11期 10-17页

作者： neal Ascherson 李凤芹

当地时间9月8日,英国女王伊丽莎白二世辞世,9月19日,其国葬仪式在伦敦威斯敏斯特教堂举行,随后被安葬于温莎城堡的乔治六世纪念教堂内。96岁的人生,26岁登基,在位70年,对这一本非所愿的命运之择,她终其一生,重诺敬业。在病危的前一天,...

当地时间9月8日,英国女王伊丽莎白二世辞世,9月19日,其国葬仪式在伦敦威斯敏斯特教堂举行,随后被安葬于温莎城堡的乔治六世纪念教堂内。96岁的人生,26岁登基,在位70年,对这一本非所愿的命运之择,她终其一生,重诺敬业。在病危的前一天,她仍在巴尔莫勒尔堡授命特拉斯组建政府。就连她在苏格兰的逝世都被一些人解读为“刻意为之”,对于这块将于2023年10月举行第二次“独立公投”的北境之地,女王或许是防止帝国走向分崩离析的最后纽带。从二战到“脱欧”,她的一生都与英国命运紧密相连。她极识时务,顺时应变,使早已不适应现代文明的君主制度仍能获得支持。她经历了大英帝国的衰落,勉力维系英国在世界的影响力。作为国家元首,她凭一己之力“粘合”英联邦各国的团结与稳定。在自身家族陷入混乱的动荡时代,在为子孙善后的过程中,她更是深刻体验到民意的不可违逆。无论国事、家事,面对危机,她“永不抱怨,永不放弃”,隐忍克己,被视为稳定的象征。但其尸骨未寒,印度便喊话英国归还“光明之山”钻石,南非也加入“讨债”行列,讨要“非洲之星”钻石。而一些英联邦国家,包括加拿大、澳大利亚、新西兰以及印度等,都曾表示过要脱离英联邦的想法。《卫报》专栏作者Afua Hirsch认为,这段时间将成为英国历史的一个分水岭。伴随着女王的离世,被殖民者的声音不用再被边缘化,转而开始成为这种全球性创伤的“高声合唱”。无论如何,历史大势浩荡前行,帝国挽歌曲终人散。“定海神针”倒了,英国何去何从?

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Early testing of insulin resistance: a tale of two lipid ratios in a group of 5th graders screened by the Coronary Artery Risk Detection in Appalachian Communities Project (CARDIAC Project)

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World Journal of Pediatrics 2019年第4期15卷 398-404页

作者： Charles Ituka Mosimah Christa Lilly Awung-Njia Forbin Pamela J.Murray Lee Pyles Elloise Elliot William neal West Virginia University MorgantownUSA University of Yaounde I YaoundeCameroon

Background In West Virginia (WV),47% of fifth-grade children are either overweight or *** is no clear consensus regarding the definition of insulin resistance in children,and directly measuring insulin on the population level is *** proposed measures examined further in this study include triglyceride (TRIG)/high-density lipoprotein cholesterol (HDL-C) ratio and TRIG/low-density lipoprotein (LDL-C) *** purpose of this study is to examine the relationship between TRIG/HDL-C ratio,TRIG/LDL-C ratio and insulin resistance in fifth-graders with acanthosis nigricans (AN).Methods Between 2007 and 2016,52,545 fifth-grade students in WV were assessed for *** glucose and insulin levels were collected only for a sub-group of students who were AN-positive and was used to determine insulin resistance using the Homeostatic Model for Insulin Resistance (HOMA-IR) *** analysis included t tests and logistic regression with receiver operating characteristic *** Of the students assessed for AN,4.5% (n =2360) tested *** prevalence of insulin resistance was 79% (n =814) among 1030 with AN and complete ***/HDL-C ratio and TRIG/LDL-C ratio were significantly associated with insulin resistance (TRIG/HDL-C:Est.=0.36,P < 0.0001,AUC =0.68;TRIG/LDL-C:Est.=0.87,P < 0.0001,AUC =0.69).Multivariate analysis showed that increased body mass index (Est.=0.05,P < 0.0001),gender (Est.=0.49,p < 0.0001) and TRIG/HDL-C ratio (Est.=0.21,P < 0.0001) were significantly associated with insulin *** TRIG/HDL-C is a better surrogate marker of insulin resistance in AN-positive children compared to TRIG/ LDL-C ratio;so,on a population-level,cholesterol rather than insulin may be obtained for preliminary testing of early insulin resistance in children.

关键词： Acanthosis nigricans CARDIAC Project High-density lipoprotein cholesterol Insulin resistance Low-density lipoprotein cholesterol

Combined U-Pb SHRIMP and Hf isotope study of the Late Paleozoic Yaminue Complex,Rio Negro Province,Argentina:Implications for the origin and evolution of the Patagonia composite terrane

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Geoscience Frontiers 2013年第1期4卷 37-56页

作者： Carlos J.Chernicoff Eduardo O.Zappettini Joao O.S.Santos neal J.McNaughton Elena Belousova National Scientific and Technical Research Council(CONICET) Argentina Argentine Geological-Mining Survey(SEGEMAR) Argentina Argentine Geological-Mining Survey(SEGEMAR).Argentina University of Western Australia PerthWA 6009Australia Redstone Resources.Perth.WA 6849.Australia John de Laeter Centre Curtin UniversityPerthWA 6102Australia ARC National Key Centre for Geochemical Evolution and Metallogeny of Continents(GEMOC) Macquarie UniversitySydneyNSW 2109Australia

We have carried out zircon U-Pb SHRIMP dating and Hf isotope determinations on a biotite paraschist and on a tonalitic orthogneiss of the Yaminué Complex, and re-evaluate this complex in the broader context of the tectonic evolution of the Patagonia composite terrane. In the metasedimentary unit （msuYC）, the youngest detrital zircon dated at 318 ± 5 Ma （Mississippian/Pennsylvanian boundary） indicates a Pennsylvanian （or younger） depositional age. The three main age populations peak at 474, 454 and 374 Ma. Preliminary Hf isotope data for two detrital zircons （447 and 655 Ma） yielded ε（Hf） values of -0.32 and 0.48, indicating that their primary sources contained small amounts of recycled crustal components （of Calymmian age; TDM 1.56 Ga）. Zircons from the orthogneiss （miuYC; intrusive into msuYC） show a crystallization age of 261.3 - 2.7 Ma （Capitanian; late middle Permian） which is broadly coeval with deformation, and Neoarchean-Paleoproterozoic inheritance. Meaningful core-rim relationship between Neoarchean zircon cores and late Permian rims is well defined, indicating the occurrence of Archean crust in this sector of Patagonia. Hf TDM of Permian zircons is mainly Meso-Paleoarchean （2.97-3.35 Ga）, with highly negative e（Hf） values （ca, -33）. Hf TDM of inherited Neoarchean zircon cores is also Meso-Paleoarchean （3.14-3.45 Ga） but more juvenile （ε（Hf） = -0.3）. Hf isotopes reinforce the presence of unexposed ancient crust in this area. Combining geological and isotope data, as well as geophysical models, we identify the Yaminué Complex within the La Esperanza-Yaminué crustal block flanked by two other, distinct crustal blocks： the Eastern block which forms part of the Patagonia terrane sensu stricto, located in the eastern Patagonian region, and the Western block forming part of the Southern Patagonia terrane. Their origins and timing of amalgamation to form the Patagonia composite terrane are also discussed.

关键词： Yaminue Complex U-Pb SHRIMP geochronology Hf isotopes Tectonics North Patagonian Massif Argentina

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