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1例多发性皮肤神经鞘瘤患者:神经鞘瘤病抑或2型神经纤维瘤?

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 38-38页

作者： Murray A.J. Hughes T.A.T. neal J.W. 王孝文 Institute of Medical Genetics University Hospital of Wales Heath Park Cardiff CF14 4XW United Kingdom Dr.

A 54 year old man presented with numerous cutaneous schwannomas, cranial nerve lesions, and spinal cord lesions, but no evidence of vestibular nerve involvement. There was no family history of neurocutaneous lesions. To help discriminate between the various possible diagnoses in this patient, molecular analysis of two cutaneous schwannomas was undertaken. An identical point mutation in the NF2 gene in the two anatomically distinct tumours was found, confirming this as a case of NF2 mosaicism.

关键词：神经鞘瘤病男性患者神经纤维瘤皮肤多发性脑神经损伤 NF2基因 2型前庭神经损伤脊髓损伤

4种降压药血压反应的异质性:一项随机临床试验

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中华高血压杂志 2023年第7期31卷 604-604页

作者：刘青(译) 练桂丽(审) 不详

高血压是全世界过早死亡的主要危险因素。多种降压疗法可用,但通过个性化靶向药物的最大获益潜力尚不清楚。该研究旨在探讨并量化针对特定个体的特定药物的潜力,以最大限度地提高降压效果。方法:一项随机、双盲、重复交叉试验,在瑞典一... 详细信息

高血压是全世界过早死亡的主要危险因素。多种降压疗法可用,但通过个性化靶向药物的最大获益潜力尚不清楚。该研究旨在探讨并量化针对特定个体的特定药物的潜力,以最大限度地提高降压效果。方法:一项随机、双盲、重复交叉试验,在瑞典一家门诊研究诊所对心血管事件风险较低的1级高血压男性和女性进行研究。混合效应模型用于评估个体对一种治疗的反应比另一种更好的程度.

关键词：随机临床试验混合效应模型交叉试验靶向药物降压药降压效果主要危险因素男性和女性

Identification of new genetic risk factors for prostate cancer

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Asian Journal of Andrology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O＇Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons＇ Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John L. Hopper David E. neal Douglas E Easton Rosalind A. Eeles Section of Cancer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer Epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Genetic Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic Epidemiology Laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Social Medicine University of Bristol Bristol BS8 2PR UK Academic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Royal Marsden NHS Foundation Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingham Medical School Queens Medical Centre Nottingham NG7 2UH UK Institute for Cancer Studies University of Sheffield Sheffield SIO 2RX UK Surgical Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list of authors is provided in the Supplementary Note online Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambridge Research Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence that a substantial part of genetic predisposition to prostate cancer （PCa） may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes： MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

关键词： prostate cancer genetics susceptibility loci SNPs relative risks

术前腋窝超声检查能否排除N_2和N_3期转移性乳腺癌?

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国际医学放射学杂志 2011年第1期34卷 70-页

作者： C.H.neal C.P.Daly A.V.Nees M.A.Helvie 李岳 Department of Radiology University of Michigan Health System1500 E Medical Center

目的确定初诊乳腺癌病人N2和N3期转移的腋窝超声检查假阴性率。材料与方法本研究经机构审查委员会批准并符合HIPAA法案,同时获得病人知情同意。

关键词：腋窝 N2 N3 超声检查术前

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超低剂量四联疗法治疗高血压的成本效益

中华高血压杂志 2023年第11期31卷 1085-1085页

作者： Atkins ER Chye A Lung T Nolde JM Billot L Burke M Chalmers J Figtree GA Hay P Hillis GS Jansen S Marschner S neal B Nelson MR Reid CM Usherwood T Schlaich M Chow CK Rodgers A 刘青 (译) 练桂丽(审校) 不详

确定含有厄贝沙坦37.5 mg、氨氯地平1.25 mg、吲达帕胺0.625 mg和比索洛尔2.5 mg的四药联用与厄贝沙坦150 mg相比,对于未经治疗或接受单药治疗的高血压患者的成本效益和成本效用。方法:研究者对四联超低剂量治疗高血压试验进行内部试验... 详细信息

确定含有厄贝沙坦37.5 mg、氨氯地平1.25 mg、吲达帕胺0.625 mg和比索洛尔2.5 mg的四药联用与厄贝沙坦150 mg相比,对于未经治疗或接受单药治疗的高血压患者的成本效益和成本效用。方法:研究者对四联超低剂量治疗高血压试验进行内部试验和建模经济评估。分析是预先计划的,并在试验期间获取药物和卫生服务的使用情况。

关键词：卫生服务成本效用成本效益超低剂量单药治疗厄贝沙坦四联疗法吲达帕胺

脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件

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中华高血压杂志 2016年第10期24卷 905-905页

作者：刘莉叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ

临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法：纳入来自糖尿病治疗和血管保护行动。

关键词： 2型糖尿病心血管事件脂质危险因素患者预测代谢改变心血管病

Smith-Lemli-Opitz综合征的啮齿动物模型中的视网膜退行性病变电生理、生物化学和形态学方面的特性

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美国医学会眼科杂志（中文版） 2005年第2期17卷 124-124页

作者： Steven J. Flicsler neal S. Peachey Michael J. Richards Barbara A. Nagel Dana K. Vaughan 韩亮（译）

目的：评估Smith-Lemli—Opitz综合征（SLOS）动物模型的电生理、组织学和生物化学方面的特性。

关键词： Smith-Lemli-Opitz综合征视网膜退行性病变动物模型生物化学电生理形态学啮齿组织学

A history of high-power laser research and development in the United Kingdom

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High Power Laser Science and Engineering 2021年第2期9卷 41-126页

作者： Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone AWE Aldermaston ReadingUK Oxford Centre for High Energy Density Science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Formerly of Electrox LetchworthUK Formerly of Central Laser Facility Rutherford LaboratoryDidcotUK Formerly of Ferranti Defence Systems LincolnUK Leonardo EdinburghUK Retired AWEReadingUK Formerly of AWE ReadingUK Formerly of Laser Lines Ltd BanburyUK Formerly of Optilas Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK Specialised Imaging Ltd PitstoneUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Magna-Power Electronics Ltd ReadingUK DeBe Lasers Needham Laser TechnologiesWhitchurchUK Blackett Laboratory Imperial College LondonLondonUK SPIE Europe CardiffUK Professor Emeritus(Physics) University of HullKingston upon HullUK Kentech Instruments Ltd WallingfordUK Department of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Emeritus Department of PhysicsUniversity of StrathclydeGlasgowUK Department of Physics Durham UniversityDurhamUK Professor Emeritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Emeritus University of SouthamptonSouthamptonUK Optical Surfaces Ltd KenleyUK JEH Lasers Ltd RugbyUK Scottish Universities Physics Alliance Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Organization Saint-Paul-lez-DuranceFrance Manx Precision Optics Ltd BallasallaUK Laser Lines Ltd BanburyUK Elliot Scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Plasma Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK Heraeus Noblelight Ltd CambridgeUK Mirli Books ChelmsfordUK M Squared Lasers Ltd GlasgowUK University of Hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK Department of Physics University of YorkYorkUK IC Optical Systems Ltd BeckenhamUK Laser Micromachining Ltd St AsaphUK MBDA UK Ltd Brist

The first demonstration of laser action in ruby was made in 1960 by *** of Hughes Research Laboratories,*** laboratories worldwide began the search for lasers using different materials,operating at different *** the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of *** historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years.

关键词： high-power lasers history United Kingdom

2010年类风湿关节炎分类标准——美国风湿病学会和欧洲抗风湿病联盟的联合倡议

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2010年类风湿关节炎分类标准——美国风湿病学会和欧洲抗风湿病联...