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Innate and adaptive immune responses toward nanomedicines

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Acta Pharmaceutica Sinica B 2021年第4期11卷 852-870页

作者： Iara maíra de Oliveira Viana Sabrina Roussel Joan Defrêne Eliana martins Lima Frédéric Barabé Nicolas Bertrand Laboratory of Pharmaceutical Technology(FarmaTec) Federal University of GoiásGoiás 74605-220Brazil Faculty of Pharmacy UniversitéLaval and CHU de Québec-UniversitéLaval Research CenterQuébec G1V 4G2Canada Department of Medicine Faculty of MedicineUniversitéLaval and CHU de Québec-UniversitéLaval Research CenterQuébec G1V 4G2Canada

Since the commercialization of the frst liposomes used for drug delivery,Doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological *** work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more *** nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond *** parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented *** rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune *** review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions.

关键词： Cancer immunotherapy mRNA vaccine Complement activation macrophage In vivo clearance Anti-PEG antibody Nanoparticle mRNA-1273 BNT162b2 Immunology

Stability of Traveling Waves Solutions for Nonlinear Cellular neural networks with Distributed Delays

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Journal of Systems Science & Complexity 2022年第1期35卷 18-31页

作者： GUO Yingxin GE Shuzhi Sam ARBI adnène School of mathematical Sciences Qufu Normal UniversityQufu 273165China Department of Electrical and Computer Engineering National University of Singapore117576Singapore National School of advanced Sciences and Technologies of Borj Cedria University of CarthageEl Khawarizmi StreetCarthage 2078Tunisia Laboratory of Engineering mathematics(LR01ES13) Tunisia.

This paper investigates the exponential stability of traveling wave solutions for nonlinear delayed cellular neural *** a continuity of the past work(Wu and Niu,2016;Yu,et al.,2011)on the existence and uniqueness of the traveling wave solutions,it is very reasonable and interesting to consider the exponential stability of the traveling wave *** the weighted energy method,comparison principle and the first integral mean value theorem,this paper proves that,for all monotone traveling waves with the wave speed cc2*>0,the solutions converge time-exponentially to the corresponding traveling waves,when the initial perturbations decay at some fields.

关键词： Cellular delayed neural networks comparison principle stability analysis traveling waves solutions

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Impact du traitement carcinologique sur le fonctionnement sexuel et l’image du corps des patientes tunisiennes en rémission d’un cancer du sein localiséImpact of Cancer Treatment on Sexual Functioning and Body Image of Tunisian Patients in remission from Localized Breast Cancer

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Psycho-Oncologie 2024年第3期18卷 241-248页

作者： Nada Charfi Nour regaieg Ines Ayadi Najeh Smaoui Rim Feki Imen Gassara Sana Omri Lobna Zouari Jihène Ben Thabet manel maâlej Bouali Afef Khanfir Mohamed maâlej Service de psychiatrie C CHU Hedi ChakerSfax3000Tunisie Service de carcinologie médicale CHU Habib BourguibaSfax3029Tunisie Facultéde médecine de Sfax Universitéde SfaxSfax3029Tunisie

The diagnosis and the management of breast cancer(BC)affect in a complex way women’s sexual lives and touch the symbol of femininity,which is very important in the constitution of the body *** objectives were to assess the sexual functioning and the body image of patients in remission of localized BC,to determine the links between these two parameters,and to study their relationship with the therapeutic *** conducted a cross-sectional,descriptive,and analytical study in the medical oncology and radiotherapy departments of Habib Bourguiba University Hospital Center in Sfax(Tunisia),between February and August *** were assessed based on a clinical information sheet and two psychometric scales exploring sexual functioning and body image:Female Sexual Function Index(FSFI)and Body Image Scale(BIS).The sample comprised 74 patients with a mean age of 51.55 *** were treated by conservative or radical surgery(44.6%and 55.4%,respectively),chemotherapy(87.8%),hormone therapy(79.7%),targeted therapies(36.5%),and radiotherapy(97.3%).A rate of 51.4%of women had sexual dysfunction(SD),87.8%had hypoactive sexual desire and 36.5%had body image *** body image disorder was significantly associated with DS(p=0.001).The total FSFI score(p=0.001)as well as the subscores of desire(p=0.005),arousal(p=0.003),orgasm(p=0.002),satisfaction(pre significantly lower in patients with body image *** presence of a SD was not associated with any therapeutic *** contrast,the presence of body image disorder was significantly associated with the radical type of surgery(p=0.003)and chemotherapy(p=0.001).Our results showed a relatively high frequency of SD and body image disorder in women in remission from *** two parameters seem to be closely linked,and this link would be maintained by mastectomy and chemotherapy,which appear to be therapeutic modalities incriminated in the disturbance of body *** the importan

关键词： Breast cancer sexual dysfunction body image Female Sexual Function Index Body Image Scale

MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer

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World Journal of Gastroenterology 2014年第32期20卷 11199-11209页

作者： marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle marlène Dufresne.marine Humeau maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier Cancer research Center of Toulouse Team 10 UMR INSERM U1037Université Paul Sabatier P?le Digestif Centre Hospitalier Universitaire Toulouse

Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC.

关键词： MicroRNAs Biomarkers Pancreatic cancer Therapeutic targets Precancerous lesions

Dietary Plant Extracts Combined with Vitamin E Limit the Discoloration in Stored n-3 PUFA Rich Meat

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Agricultural Sciences 2018年第1期9卷 23-36页

作者： Mylène Delosière Emilie Parafita Mihaela Habeanu Dominique Gruffat Denys Durand Université Clermont Auvergne INRA VetAgro Sup UMR1213 Herbivores Clermont-Ferrand France adIV Association pour le Développement de l’Institut des Viandes Clermont-Ferrand France IBNA National Research Development Institute for Animal Biology and Nutrition Balotesti Romania

In finishing cull-cows given n-3 PUFA-rich diets (for 101 ± 3 days preceding slaughter), the ability of vitamin E (2.8 g/animal/day) or vitamin E associated with plant extracts rich in polyphenols (PERP) (126 g/animal/day) to limit discoloration was evaluated on color attributes of Longissimus thoracis (LT) and Semitendinosus (ST) processed meat. Color attributes were determined after muscles ageing and retail display in different packaging systems consisting in 14 d. under vacuum (V), 4 d. aerobic (A) or 7 d. under modified atmosphere (70:30, O2/CO2) (ma). Vit. E associated with PERP were able to limit color deterioration by decreasing metmyoglobin% in ST and LT for all tested packaging systems. The antioxidant association increased the L* coordinate and the oxygenation index as compared with vit. E alone. We show the possibility to limit color deterioration of processed beef by an original dietary antioxidant strategy during the finishing period.

关键词： Color Vitamin E Plant Beef Packaging

research of inverse mathematical model to high-speed trains

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Journal of Central South University 2014年第1期21卷 428-438页

作者：朱涛肖守讷马卫华阳光武 Traction Power National Key Laboratory Southwest Jiaotong University

Operation safety and stability of the train mainly depend on the interaction between the wheel and *** of wheel/rail contact force is important for vehicle control systems that aim to enhance vehicle stability and passenger *** wheel/rail contact forces of high-speed train are very difficult to measure directly,a new estimation process for wheel/rail contact forces was introduced in this *** on the state space equation,dynamic programming methods and the Bellman principle of optimality,the main theoretical derivation of the inversion mathematical model was *** new method overcomes the weakness of large fluctuations which exist in current inverse ***-speed vehicle was chosen as the research object,accelerations of axle box as input conditions,10 degrees of freedom vertical vibration model and 17 degrees of freedom lateral vibration model were established,*** 250 km/h,the vertical and lateral wheel/rail forces were *** the time domain and frequency domain,the comparison of the results between inverse and SIMPACK models were *** results show that the inverse mathematical model has high precision for inversing the wheel/rail contact forces of an operation high-speed vehicle.

关键词： load inversion high-speed vehicle wheel/rail contact force derailment index

revisiting Akaike’s Final Prediction Error and the Generalized Cross Validation Criteria in regression from the Same Perspective: From Least Squares to Ridge regression and Smoothing Splines

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Open Journal of Statistics 2023年第5期13卷 694-716页

作者： Jean Raphael Ndzinga Mvondo Eugène-Patrice Ndong Nguéma Department of mathematics Ecole Polytechnique Yaoundé I Cameroon

In regression, despite being both aimed at estimating the Mean Squared Prediction Error (MSPE), Akaike’s Final Prediction Error (FPE) and the Generalized Cross Validation (GCV) selection criteria are usually derived from two quite different perspectives. Here, settling on the most commonly accepted definition of the MSPE as the expectation of the squared prediction error loss, we provide theoretical expressions for it, valid for any linear model (LM) fitter, be it under random or non random designs. Specializing these MSPE expressions for each of them, we are able to derive closed formulas of the MSPE for some of the most popular LM fitters: Ordinary Least Squares (OLS), with or without a full column rank design matrix;Ordinary and Generalized Ridge regression, the latter embedding smoothing splines fitting. For each of these LM fitters, we then deduce a computable estimate of the MSPE which turns out to coincide with Akaike’s FPE. Using a slight variation, we similarly get a class of MSPE estimates coinciding with the classical GCV formula for those same LM fitters.

关键词： Linear Model Mean Squared Prediction Error Final Prediction Error Generalized Cross Validation Least Squares Ridge regression

Low Electrical resistance Properties of Acupoints:Roles of NOergic Signaling Molecules and neuropeptides in Skin Electrical Conductance

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Chinese Journal of Integrative Medicine 2021年第8期27卷 563-569页

作者： ma Sheng-xing Lundquist Institute for Biomedical Innovation at Harbor University of California at Los Angeles(UCLA)Medical Center and Department of Obstetrics and Gynecology David Geffen School of Medicine at UCLA and Harbor-UCLA Medical CenterTorranceCA 90502United States

Early studies from several independent laboratories demonstrated that acupoints possess the characteristics of low electrical *** devices are developing to increase the reliability of electrical skin impedance measurements for counteracting the factors including skin dryness,skin thickness,size of the sensing electrode,pressure applied on the electrode,interelectrode distance,room temperature,and *** studies have identified that blood vessels,hair follicles,and nervous components are enhanced in the meridians/acupoints,which represent areas of potentially high neuronal *** evidence shows that nitric oxide(NO)concentrations are enhanced in skin acupoints/meridians.L-arginine-derived NO synthesis modifies skin norepinephrine(ne)synthesis/release in acupoints/meridians,and NO-ne activations play an important role in mediating the skin conductance responses to electrical *** signaling molecules interact with gap junction and transient receptor potential vanilloid *** studies reported that the high conductance at acupoints is a result of the release of the neuropeptides substance P and calcitonin gene-related peptide during neurogenic inflammation in the referred pain *** body conditions caused considerable changes in skin conductance or impedance at *** systematic research with an improved equipment and research design to avoid the influencing factors are requested for a definite answer in this field,the results from anatomical and biochemical studies consistently show that acupoints exist higher levels of nervous components,and NOergic signaling molecules and neuropeptides involved in the skin low resistance at *** increased interest in the acupoints/meridians has led to an open-minded attitude towards understanding this system,which is fundamental important to establish the valid aspects of scientific basis of Chinese medicine mechanisms and therapies.

关键词： acupuncture points skin electric resistance nitric oxide norepinephrine transient receptor potential vanilloid type-1 neuropeptides

Nonparametric Estimation in Linear Mixed Models with Uncorrelated Homoscedastic Errors

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Open Journal of Statistics 2021年第4期11卷 558-605页

作者： Eugène-Patrice Ndong Nguéma Betrand Fesuh Nono Henri Gwét Department of mathematics Ecole Polytechnique Yaoundé Cameroon

Today, Linear Mixed Models (LMMs) are fitted, mostly, by assuming that random effects and errors have Gaussian distributions, therefore using maximum Likelihood (ML) or reML estimation. However, for many data sets, that double assumption is unlikely to hold, particularly for the random effects, a crucial component in which assessment of magnitude is key in such modeling. Alternative fitting methods not relying on that assumption (as ANOVA ones and Rao’s MINQUE) apply, quite often, only to the very constrained class of variance components models. In this paper, a new computationally feasible estimation methodology is designed, first for the widely used class of 2-level (or longitudinal) LMMs with only assumption (beyond the usual basic ones) that residual errors are uncorrelated and homoscedastic, with no distributional assumption imposed on the random effects. A major asset of this new approach is that it yields nonnegative variance estimates and covariance matrices estimates which are symmetric and, at least, positive semi-definite. Furthermore, it is shown that when the LMM is, indeed, Gaussian, this new methodology differs from ML just through a slight variation in the denominator of the residual variance estimate. The new methodology actually generalizes to LMMs a well known nonparametric fitting procedure for standard Linear Models. Finally, the methodology is also extended to ANOVA LMMs, generalizing an old method by Henderson for ML estimation in such models under normali

关键词： Clustered Data Linear Mixed Model Fixed Effect Uncorrelated Homoscedastic Error Random Effects Predictor