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Pancreatic islet regeneration and some liver biochemical parameters of leaf extracts of Vitex doniana in normal and streptozotocin-induced diabetic albino rats

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Asian Pacific Journal of Tropical Biomedicine 2014年第2期4卷 124-130页

作者： Okpe Oche Ibrahim Sani Njoku Godwin Chiaka ndidi uche samuel Atabo samuel Department of Biochemistry Ahmadu Bello UnirersityZariaNigeria

Objective:To test two water soluble extracts(aqueous and ethanolic) obtained from the leaves of Vitex doniana in normal and streptozotocin-induced diabetic rats for their effects on pancreatic endocrine tissues and serum marker enzymes for a period of 21 ***:A total of 55 rate divided into 11 groups of 5 rats each were assigned into diabetic and non-diabetic- groups and fallowed by a daily administration of ethanolic and aqueous extracts for21 *** 1 was the normal control while group 7 was treated with standard ***:The histopathological studies of the diabetic rats indicated increase in the volume density of islets,percent of β-cells and size of islet in the groups that received the plant extracts,which suggested regeneration of β-cells along with p-eells repairs,as compared with the non-treated diabetic control which showed complete degeneration of the islet *** was significant reduction(P0.01) in the serum activities of marker enzymes was observed for non-diabetic treated *** of total bilirubin,direct bilirubin and unconjugated bilirubin showed that diabetic control group was significantly higher(P0.01) in total bilirubin and direct bilirubin compared with the normal ***:This herbal therapy appears to bring about repair/regeneration of the endocrine pancreas and hepatic cells protection in the diabetic rat.

关键词： Vitex doniana Pancreatic islet Marker enzymes Diabetes Hepatoprotection

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