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Epidemiological, Clinical and Outcome Aspects of Care-Related Tetanus in Dakar, Senegal

Advances in Infectious Diseases 2022年第2期12卷 230-240页

作者： Viviane Marie Pierre Cisse nd.ye Fatou Ngom Gueye Louise Fortes Imelda Mickelina Thoo Aminata Massaly Khardiata Diallo Mbaye Daye Ka nd.ye Aissatou Lakhe Assane Diouf nd.ye Maguette Fall Daouda Thioub Aboubakry Sidikh Badiane Latyr Junior Diouf Alassane Sarr Sylvie Audrey Diop Cheikh Tidiane ndour Masserigne Soumaré Moussa Seydi Infectious and Tropical Diseases Department Fann Teaching University Hospital Dakar Senegal Department of Community Health Alioune Diop University Bambey Senegal Department of Health Thies University Thies Senegal

Introduction: Tetanus portals of entry are numerous. Amongst these, the carerelated portals of entry are rarely reported. The aim of the study was to describe the epidemiological, clinical and outcome aspects and identify the factors associated with death from care-related tetanus. Patients and Methods: This is a retrospective study of descriptive and analytical purposes. Data were collected from the medical records of patients admitted to the Infectious and Tropical Diseases Department of the National University Hospital Center (CHNU) of Fann in Dakar for care-related tetanus during the period ranging from 1 January 2009 to 31 December 2016. Care-related tetanus was defined as any case of tetanus occurring after a surgical procedure, including circumcisions performed even outside a health facility. Results: In eight years, 50 cases of care-related tetanus were recorded. Care-related tetanus accounted for 6.7% of hospitalized tetanus cases. The mean age of patients was 21 ± 22 years, with a male predominance (sex ratio: 6.14). The procedure had been performed in most cases, either in a health facility in 22 patients (44%) or at home in 16 patients (32%), and occurred after circumcision. In 62% of cases the portal of entry was urological, followed by orthopedic surgery (14%) and visceral surgery (10%). The procedures performed were dominated by circumcision (31 cases), limb amputation (3 cases) and inguinal hernia repair (2 cases). Tetanus was immediately generalized on admission in all patients. Eighty-four percent (84%) of patients were admitted with Mollaret stage II. Cardiovascular (11 cases), infectious (10 cases) and respiratory (9 cases) complications were the most frequent. The hospital case fatality rate was 24%. Factors associated with death were female gender (p = 0.03), age between 15 - 60 years (p = 0.02), incubation time Conclusion: Care-related tetanus remains a concern in poor income countries, particularly in Senegal. The drop of these cases will req

关键词： Tetanus Care Surgery Dakar Senegal

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应用激光多普勒血流仪监测口腔黏膜血流

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北京大学学报（医学版） 2016年第4期48卷 697-701页

作者：王莺 Obada barry Gerhard Wahl 陈波林野北京大学口腔医学院·口腔医院种植科口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081 Rheinische Friedrich-Wilhelms-Universitat Bonn 53111 Bonn German

目的：测量中国汉族人与高加索人的健康成年人口腔黏膜血流参数,比较口腔黏膜血流灌注情况在不同人种间的异同,比较口腔黏膜在上颌与下颌、男性与女性之间的差异性,为口腔种植临床中软组织处理提供参考依据。方法：从德国波恩大学在读... 详细信息

目的：测量中国汉族人与高加索人的健康成年人口腔黏膜血流参数,比较口腔黏膜血流灌注情况在不同人种间的异同,比较口腔黏膜在上颌与下颌、男性与女性之间的差异性,为口腔种植临床中软组织处理提供参考依据。方法：从德国波恩大学在读学生中招募20名高加索人种学生（男性10例,女性10例,平均年龄25.3岁）和20名中国汉族留学生（男性10例,女性10例,平均年龄28岁）,口腔内设计8个测量点M1~M8,其中于上颌中切牙唇侧黏膜、下颌中切牙唇侧黏膜、上颌腭侧黏膜和颊黏膜各2个点。使用O2C激光多普勒血流仪进行血流参数测量,包括血氧饱和度（saturation oxygen,Sp O2）、平均血红蛋白量（relative amount of hemoglobin,r HB）、单位时间内血流量（flow）、血流速度（velocity）。结果：高加索人种和中国汉族两组之间比较,上颌中切牙血氧饱和度平均值分别为75.6%±8.2%和70.4%±7.6%;颊黏膜血红蛋白量平均值分别为79.9±5.8和83.5±6.6,差异有统计学意义,其余各位点血流参数差异无统计学意义。将测量位点各组之间进行比较：上腭黏膜的血氧饱和度为77.1%±10.9%,平均血红蛋白量为67.8±11.1,单位时间血流量194.1±63.7,相比较其他测量部位差异有统计学意义。男性多个测量位点血氧饱和度普遍低于女性,差异均有统计学意义。结论：口腔中不同解剖部位的黏膜血流灌注情况存在差别,性别之间血红蛋白氧结合能力可能存在差别,并且可能对于软组织愈合能力有一定影响;口腔黏膜血流灌注情况在小样本青年人群中的高加索人种与中国汉族人之间差异无统计学意义。

关键词：口腔黏膜微循环激光多普勒流量测定

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基于GA-BP神经网络和改进粒子群算法的碰撞射流和冷却顶板复合空调系统优化

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东华大学学报（自然科学版） 2024年第1期50卷 110-117页

作者：齐贺闯叶筱高延峰亢燕铭钟珂上海工程技术大学机械与汽车工程学院上海上海市大型构件智能制造机器人技术协同创新中心上海东华大学环境科学与工程学院上海

对碰撞射流和辐射顶板(IJV/RC)复合空调在不同室内负荷条件下运行时的室内热环境进行数值模拟,基于遗传算法-反馈(GA-BP)神经网络建立运行性能(吹风感R_(PD),头足温差Δt,空气交换效率e ACE,工作区平均温度t_(a))与设计变量(送风温度t_... 详细信息

对碰撞射流和辐射顶板(IJV/RC)复合空调在不同室内负荷条件下运行时的室内热环境进行数值模拟,基于遗传算法-反馈(GA-BP)神经网络建立运行性能(吹风感R_(PD),头足温差Δt,空气交换效率e ACE,工作区平均温度t_(a))与设计变量(送风温度t_(s)、送风速度v_(s)、冷却顶板内表面温度t_(c)、房间负荷Q_(c))之间的预测模型,通过相关性分析确定设计变量对运行性能影响的显著性并排序。结果表明,增大v_(s)可使Δt降低,但R_(PD)增大;增大t_(c)有助于降低Δt和R_(PD),但t_(a)升高;为使t_(a)下降,可通过降低t_(s)来实现,但室内空气质量变差。为确保IJV/RC复合空调能在保证室内热舒适的同时提供良好室内空气品质,利用改进粒子群算法对复合空调的运行性能进行多目标同时优化,建立不同房间负荷条件下的设计参量最优匹配关系。研究结果可为IJV/RC复合空调的优化设计和运行控制提供理论指导。

关键词：碰撞射流通风冷却顶板 GA-BP神经网络粒子群优化算法多目标优化

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DEXA Contribution in Bone Densitometry Evaluation on Osteoporosis in Senegal: Results of a Study Realized in African Black Populations

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Open Journal of Rheumatology and Autoimmune Diseases 2016年第4期6卷 85-95页

作者： nd.ye Marième Diagne-Gueye Thierno Oumar Soko Bineta ndiaye Ismaïla Diedhiou Abdou-Rajack ndiaye Service de Médecine Polyvalente Services Médicaux Hopital Principal de Dakar Dakar Sénégal

Osteoporosis, a public health problem is able to occur severe fractures and its prevalence increases in developing countries. Several factors involved in its pathogenesis. These factors are: Heredity, elderly, race, ethnicity, hormones, physical inactivity, sunlight exposure, vitamin D deficiency and certain drugs. In Africa, few data are available and the disease prevalence is maybe underestimated. In Senegal, measure of bone mineral density is recent. In this study, our objective was to determine DEXA patients profile and epidemiological, clinical characteristics of patients for densitometry examination. Thus, 43 cases were collected;lumbar and femoral sites were evaluated. Median lumbar T-score was 0.91 and the femoral T-score was 0.16. Osteopenia was found in 35% of patients and osteoporosis in 26%. Bone Mineral Density was abnormal in 60% of cases. This study is another proof of documented reality of osteoporosis in Senegal. It determines frequency in a population at risk. For the future, it opens way for further larger studies to get better profile of the patients and prevalence osteoporosis in Senegal.

关键词： Osteoporosis Bone DEXA Africa Black Populations

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PDCA循环法结合信息化技术在剖宫产产妇术后镇痛泵管理中的应用

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中国临床护理 2024年第5期16卷 293-296页

作者：孙鹏田野胡佳佳广东省中山市人民医院手术麻醉科广东中山528403

目的探讨PDCA循环法结合信息化技术在剖宫产产妇术后镇痛泵管理中的应用效果。方法选取于笔者所在医院行剖宫产的240例产妇为研究对象。按照入院先后顺序,将2021年7月-12月入院的120例产妇设为对照组,将2022年1月-6月入院的120例产妇设... 详细信息

目的探讨PDCA循环法结合信息化技术在剖宫产产妇术后镇痛泵管理中的应用效果。方法选取于笔者所在医院行剖宫产的240例产妇为研究对象。按照入院先后顺序,将2021年7月-12月入院的120例产妇设为对照组,将2022年1月-6月入院的120例产妇设为观察组,对照组进行剖宫产术后镇痛泵的常规随访管理,观察组运用PDCA循环法结合信息化技术进行术后镇痛泵的随访管理。结果观察组剖宫产术后第1、2天的疼痛评分均低于对照组(t=2.693,P=0.008;t=2.143,P=0.033),疼痛处理时间短于对照组(t=8.370,P<0.001),观察组对疼痛管理的满意度得分高于对照组(t=8.131,P<0.001)。2组镇痛泵相关不良反应发生率比较,差异无统计学意义(χ^(2)=1.677,P=0.195)。结论采用PDCA循环法结合信息化技术对剖宫产产妇术后镇痛泵进行管理,可以有效缩镇痛处理时间,提高镇痛效果与产妇满意度。

关键词：信息化技术 PDCA循环剖宫产产妇镇痛泵疼痛

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先天缺牙相关EDAR基因突变报道及携带双突变位点的HED家系分析

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上海交通大学学报（医学版） 2024年第6期44卷 694-701页

作者：兰嵘代庆刚喻康卞晓玲叶丽娟吴轶群王凤上海交通大学医学院附属第九人民医院口腔第二门诊部上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海市口腔医学研究所上海201999

目的·探索先天缺牙相关的外异蛋白A受体(ectodysplasin A receptor,EDAR)基因突变位点,初步分析EDAR基因突变导致综合征型和非综合征型缺牙的原因。方法·研究对象为就诊于上海交通大学医学院附属第九人民医院口腔第二门诊部的先天缺... 详细信息

目的·探索先天缺牙相关的外异蛋白A受体(ectodysplasin A receptor,EDAR)基因突变位点,初步分析EDAR基因突变导致综合征型和非综合征型缺牙的原因。方法·研究对象为就诊于上海交通大学医学院附属第九人民医院口腔第二门诊部的先天缺牙患者及其家系成员,提取其外周血中的基因组DNA进行全外显子组测序。通过初步筛选后,用PolyPhen-2、Mutation Taster、Provean对潜在突变位点的有害性进行预测,对分析后的突变位点进行Sanger测序验证。进行突变位点的保守性分析,使用在线工具Swiss-Model进行同源建模,分析EDAR蛋白的三维结构变化。对患者及其家系成员的先天缺牙和全身发育情况进行临床检查。结果·在纳入的先天缺牙患者中共发现5名EDAR基因突变患者,1名患者携带移码突变c.368_369insC(p.L123fs),4名患者携带错义突变。在EDAR错义突变患者中,有2名患有非综合征型缺牙(nonsyndromic tooth agenesis,NSTA),分别携带c.77C>A(p.A26E)纯合突变和c.380C>T(p.P127L)杂合突变。另外2名患有少汗型外胚层发育不良(hypohidrotic ectodermal dysplasia,HED),均带有2个基因突变位点:1名为EDAR复合杂合患者,携带来自父亲的EDAR c.77C>T(p.A26V)和来自母亲的EDAR c.1281G>C(p.L427F);另1名为EDAR、外异蛋白A(ectodysplasin A,EDA)双基因突变患者,EDAR c.1138A>C(p.S380R)和EDA c.1013C>T(p.T338M)均来自母亲,这2个位点在此前的报道中仅与NSTA相关。EDAR c.1281G>C(p.L427F)、c.77C>A(p.A26E)为未被报道过的错义突变新位点。错义突变可能通过改变氨基酸残基极性、电荷或体积等,对蛋白空间构象造成影响;移码突变造成了非3整倍数的碱基增加,可能导致蛋白的截短或降解。结论·发现了2个新的EDAR错义突变位点,报道了由EDAR纯合突变导致的NSTA以及由EDA、EDAR双基因突变导致HED的病例,扩展了对于EDAR突变造成HED和NSTA的致病机制的理解。

关键词：外胚层发育不良家族性缺牙外异蛋白A受体外异蛋白A 全外显子组测序

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Complete mitochondrial genome of yellow meal worm （Tenebrio molitor）

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Zoological Research 2014年第6期35卷 537-545页

作者： Li-Na LIU Cheng-ye WANG State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China Key Laboratory of Cultivating and Utilization of Resource Insects of State Forestry Administration Research Institute of Resource lnsects Chinese Academy of Forestry Kunming 650224 China

The yellow meal worm （Tenebrio molitor L.） is an important resource insect typically used as animal feed additive. It is also widely used for biological research. The first complete mitochondrial genome of T. rnolitor was determined for the first time by long PCR and conserved primer walking approaches. The results showed that the entire mitogenome of T. molitor was 15 785 bp long, with 72.35% A＋T content [deposited in GenBank with accession number KF418153]. The gene order and orientation were the same as the most common type suggested as ancestral for insects. Two protein-coding genes used atypical start codons （CTA in nd2 and AAT in COX1）, and the remaining 11 protein-coding genes started with a typical insect initiation codon ATN. All tRNAs showed standard clover-leaf structure, except for tRNASer （AGN）, which lacked a dihydrouridine （DHU） arm. The newly added T. molitor mitogenome could provide information for future studies on yellow meal worm.

关键词： Tenebrionidae Mitogenome Evolution Resource insect yellow meal worm

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Laser Surface Remelting of Fe-based Alloy Coating Deposited by APS

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稀有金属材料与工程 2012年第S1期41卷 407-413页

作者： Fu Teng ye Fuxing Wei Haihong Cui Chong Tianjin Univ Sch Mat Sci & Engn Tianjin 300072 Peoples R China Tianjin Key Lab Adv Joining Technol Tianjin 300072 Peoples R China

The Fe-based amorphous alloy coatings with different porosities were deposited on Q235 steel substrates by means of atmospheric plasma spraying(APS).The as-sprayed coatings were remelted by the facility of a nd:YAG laser to further enhance their compactness and bonding strength via orthogonal experiment *** effects of laser remelting on the microstructure,phase compositions and mechanical properties of the as-sprayed coatings were investigated by optical microscopy,scanning electron microscope,X-ray diffraction and Vickers microhardness *** corrosion performance of the coatings was evaluated by both potential dynamic measurements(PDM)and electrochemical impedance spectroscopy(EIS)in a 10%NaOH *** results indicate that laser power of 700 W,scanning velocity of 4 mm/s,beam size of 3 mm and porosity of 1.19%are the optimized remelting process *** laser-remelted coatings exhibite more homogenous structure as strong metallurgical bonding to *** amorphous phases in the as-sprayed coatings crystallize toα-Fe,Fe2Si,Fe3.5B,and Fe2W phases for the high temperature and rapid solidification in the remelting *** microhardness values of as-sprayed are in the range of 700-800 HV0.1,while the microhardness values of the remelted coatings are enhanced slightly to 750-850 *** PDM and EIS analysis results show that the remelted coatings exhibite relatively excellent corrosion resistance compared with the stainless steel 1Cr18Ni9Ti,however the corrosion resistance of the remelted coatings is inferior to the as-sprayed amorphous coatings.

关键词： Fe-based amorphous alloy coating plasma spraying laser surface remelting corrosion resistance

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Research of warm compaction technology on nylon bonded nd-Fe-B magnets

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Acta Metallurgica Sinica(English Letters) 2009年第3期22卷 174-180页

作者： Xiuhai ZHANG Weihao XIONG Dameng ye Jun QU Zhenhua YAO State Key Laboratory of Material Processing and Die ~z Mould Technoiogy Huazhong University of Scienceand Technology Wuhan 430074 China

Warm compaction and room temperature compaction were applied to prepare bonded nd-Fe-B magnets. The results indicated that the density of magnet was determined by the compaction pressure and warm compaction temperature, whereas, the thermosetting temperature could hardly affect the density of magnet. The mechanical properties of magnets were the best when the thermosetting temperature was 200 ℃. The Br, Hob, and （BH）max of warm compaction magnet were higher than those of room compaction. When the warm compaction temperature and thermosetting temperature were invariable, the density of magnet increased with the increase of compaction pressure, which resulted in the increase of Br, Hcb, and （BH）max of magnet and the decrease of Hcj of magnet. When the warm compaction temperature and compaction pressure were invariable, the magnetic properties of magnets decreased with the increase of thermosetting temperature. The magnetic properties of warm compaction molding magnets were better than those of injection molding magnets.

关键词： Bonded nd-Fe-B magnets Warm compaction molding Magnetic properties Mechanical properties

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A massless scalar field in Robertson-Walker spacetimes:Adiabatic regularization and Green’s function

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Chinese Physics C 2020年第9期44卷 194-209页

作者： Yang Zhang Bo Wang Xuan ye Department of Astronomy CAS Key Laboratory for Researches in Galaxies and CosmologySchool of Astronomy and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China

We study adiabatic regularization of a coupling massless scalar field in general spatially flat Robertson-Walker(RW)*** the conformal coupling,the 2nd-order regularized power spectrum and 4th-order regularized stress tensor are zero,and no trace anomaly exists in general RW *** is a new result that exceeds those found in de Sitter *** the minimal coupling,the regularized spectra are also zero in the radiationdominant and matter-dominant stages,as well as in de Sitter *** vanishing of these adiabatically regularized spectra is further confirmed by direct regularization of the Green's *** a general coupling and general RW spacetimes,the regularized spectra can be negative under the conventional *** a higher order of regularization,the spectra will generally become positive,but will also acquire IR divergence,which is inevitable for a massless *** avoid the IR divergence,the inside-horizon regularization is *** these procedures,nonnegative UV-and IR-convergent power spectrum and spectral energy density will eventually be achieved.

关键词： quantum fields in curved spacetimes inflationary universe mathematical and relativistic aspects of cosmology

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