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Epidemiological, Clinical, Paraclinical, Etiological and Therapeutic Aspects of Liver Cirrhosis in the Hepato-Gastroenterology Department of the Hospital Aristide Le Dantec in Dakar

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Open Journal of Gastroenterology 2022年第11期12卷 317-323页

作者： Marie Louise Bassène Salamata Diallo Marieme Polele fall Mame Aissé Thioubou Téné Sidibé coumba Cissé Mamadou Ngoné Gueye Department of Gastroenterology and Hepatology Hospital Aristide Le Dantec Dakar Senegal Department of Gastroenterology and Hepatology Peace Hospital Ziguinchor Senegal Department of Gastroenterology and Hepatology Hospital Idrissa Pouye Dakar Senegal

Introduction: Liver cirrhosis is a global public health issue. Our aim was to determine the epidemiological, clinical, paraclinical and therapeutic aspects of liver cirrhosis in the hepato-gastroenterology department of the hospital Aristide Le Dantec in Dakar. Patients and Methods: We conducted a retrospective study with a descriptive focus covering the period from January 1st, 2010 to December 31, 2020. We included the medical records of patients which presented body of clinical and paraclinical arguments which supported the diagnosis of cirrhosis. The data collected were related to age, gender, clinical, paraclinical, therapeutic and prognosis aspects of cirrhosis and were analyzed with the software Sphinx Plus. Results: Prevalence of cirrhosis was 6.2%. Sex ratio was 2.1%. The average age was 38 years. Asthenia (60.9%), altered performance status (60.1%), abdominal pain (37.2%), gastrointestinal bleeding (29.6%) and abdominal swelling (27.8%) were the most common motives of consultation. Physical examination revealed primarily portal hypertension (74.9%), liver failure (2.4%), hepatomegaly (28.2%) and anemia (13.7%). Viral hepatitis B was the most common etiology (81.9%). Abdominal screening (ultrasound/CT scan) showed hepatomegaly (80.6%), liver dysmorphia (87.7%), portal hypertension signs (85.3%) and portal vein thrombosis (18.2%). 55.1% Patients were classified as Child Pugh A, 33.8% were Child Pugh B and 11.1% were Child Pugh C. Tenofovir Disoproxil Fumarate (TDF) was prescribed to all patients affected by hepatitis B virus only. Evolution was characterized by clinical improvement and prognosis reclassification. Conclusion: Liver cirrhosis is a frequent pathology in the hepato-gastroenterology department of the hospital Aristide Le Dantec in Dakar. It affects young male adult. Hepatitis B virus is the leading cause. TDF is an effective treatment.

关键词： Cirrhosis Viral Hepatitis B Portal Hypertension Liver Failure Hepatomegaly

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Response Surface Methodology as an Approach for Optimization of Vinegar Fermentation Conditions Using Three Different Thermotolerant Acetic Acid Bacteria

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Food and Nutrition Sciences 2023年第7期14卷 638-656页

作者： Mariama Ciré Kourouma Malick Mbengue Abdoulaye Thioye coumba Touré Kane Laboratoire de Microbiologie Appliquée et de Génie Industriel (MAGI) Ecole Supérieure Polytechnique (ESP) Université Cheikh-Anta-Diop Dakar Senegal Department of Molecular Biology Institute for Health Research Epidemiological Surveillance and Training (IRESSEF) Dakar Senegal

This study aimed to investigate optimal fermentation conditions of biological acetic acid fermentation for vinegar production. Optimization was performed on 3 acetic acid bacteria strains namely VMA1, VMA7 and VMAO using Response Surface Methodology (RSM). A Box-Behnken-Design (BBD) was achieved with three different independent process parameters involving: fermentation temperature, original alcohol concentration and original acetic acid concentration and one dependent variable (acetic acid yield). The results showed that the mathematical models describe correctly the relationship between responses and factors (F values of the models (p R2 (coefficient of correlation) respectively 0.96, 0.94, 0.98, and adjusted R2 0.95, 0.92, 0.98). The maximum acidity was obtained respectively at fermentation temperatures, original alcohol concentrations and original acetic acid concentrations ranging from [37.5°C - 45°C], [16% - 20% (v/v)], [1.5% - 2% (w/v)] for VMA1, [40°C - 45°C], [14.5% - 20% (v/v)], [1.7% - 2% (w/v)] for VMA7 and [42°C - 45°C], [17% - 20% (v/v)], [1.5% - 2% (w/v)] for VMAO. The use of these acetic strains in the production of vinegar may seriously lead to a decrease or even an ablation of the costs related to the cooling of bioreactors especially in warm and hot countries, in the context of global warming.

关键词： Vinegar Response Surface Methodology Box-Behnken-Design Optimization

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Northeastern Tropical Atlantic SST and Sahel Rainfall Variability

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Atmospheric and Climate Sciences 2023年第4期13卷 431-454页

作者： Dahirou Wane Abdou Lahat Dieng coumba Niang Amadou T. Gaye Laboratoire de Physique de l’Atmosphère et de l’Océan Siméon Fongang Ecole Supérieure Polytechnique Université Cheikh Anta Diop de Dakar (LPAO-SF/ESP/UCAD) Dakar Senegal

The SST variability during the summer period in the northeastern tropical Atlantic region (NTA) is characterized by an alternation of warming/cooling which represents 87% of the total variability. The aim of this paper is to study the atmospheric responses as well as the precipitation associated with these oceanic conditions. Based on Reynolds’s SST from 1982 to 2019, a normalized Northern Tropical Atlantic index (NTAI) is computed into the region between 15° - 25°W;12° - 16°N and a composite analysis is then performed. It is shown that the NTAI is significantly correlated with the SST’s first principal component mode (PC1) in this region. Moreover, the composite of SST anomalies and atmospheric parameters exhibits a strong local ocean-atmosphere interaction which highly impacts the large-scale atmospheric circulation in West Africa, particularly in the western Sahel. An in-depth analysis shows that the atmospheric response to the warm (cold) SST is a cyclonic (anticyclonic) circulation in the lower layers near the West Africa Coast. This cyclonic (anticyclonic) circulation strengthens/reduces the moisture transport towards the continent in the low levels. In the middle layers of the atmosphere (500 hPa), the warm (cold) composite is associated with a decrease (increase) in the intensity of the African Easterly Jet (AEJ) whereas, in the upper atmosphere (200 hPa), the strengthening (weakening) of the Tropical Easterly Jet (TEJ) is observed. With regard to the composite precipitation field, a positive/negative SST anomaly is associated with significantly enhanced/reduced rainfall in the western Sahelian region. It is found that this relationship (correlation) increases as we are closer to the coasts.

关键词： SST-Rain Sahel Rainfall Senegal Rainfall Ocean-Atmosphere Interaction

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Radio-Anatomical Study of Anterior Variants of the Polygon of Willis

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Open Journal of Radiology 2023年第4期13卷 185-194页

作者： Diop Aboulaye Dione Mar ndeye Bigué Diouf Joseph coumba ndofféne Diop Sokhna Ba Medical Imaging Service Fann Hospital Dakar Senegal Laboratory of Anatomy/UMRED Iba Der Thiam University Thiès Senegal

The anterior system of the polygon of Willis plays an anastomotic role between the carotid territories and communicates with the posterior system. It ensures adequate cerebral blood flow in the event of internal occlusion. Its ability to redistribute blood flow depends on its morphology, the presence and size of the vessels that constitute it and their variants, knowledge of which is essential. The morphology of the carotid system is not constant and a number of variants are well recognized with greater hemodynamic importance. In this context, we undertook this work which aims to seek the anatomical variants of the anterior part of the PW;to determine the diameters of the vessels of the latter and to correlate these results with epidemiological data. We carried out a retrospective, descriptive and analytical study over a period of 4 months at Fann University Hospital, targeting patients who had undergone brain MRI with a 3D TOF sequence whatever the indication. Patients with lesions of cerebrovascular pathologies such as ischemia, hemorrhage, aneurysm, arteriovenous malformations or presenting a limited analysis examination due to the presence of kinetic or other artifact, were not included. Demographic data and anatomical variants were studied as well as the measurements of any continuous arterial segment greater than 0.8 mm in diameter. Those less than 0.8 mm in diameter were considered hypoplastic. The C3 segment of the internal carotid arteries, the A1 segment of the anterior cerebral arteries, the anterior communicating artery, constituted our main measurement sites. The sex ratio was 1.06, the mean age of the patients was 43 years ± 17.9 with extremes of 11 and 85 years. The anterior configuration of the polygon was complete in 57.5% representing 50% of men and 65.5% of women, in 56% of subjects under 40 years old and 58% in subjects over 40 years old. We noted a predominance of type a in 47% of patients followed by type g found in 35% of patients. The morphol

关键词： Polygon of Willis Anamicals Variants Vascular Diseases

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New Procedure to Obtain Specific and High Absorbent Silicon Nanotextures: Inverted Pyramids, Cubic Nano-Microholes, Spiroconical Nano-Microholes and Rhombohedral-Stared Nanosheet Bouquets (Nanobuckets)

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Journal of Modern Physics 2021年第9期12卷 1267-1280页

作者： ndeye coumba Y. fall Moussa Touré Remi ndioukane Abdoul Kadri Diallo Diouma Kobor Marcel Pasquinelli Laboratoire de Chimie et de Physique des Matériaux (LCPM) Université Assane Seck de Ziguinchor Ziguinchor Senegal Aix Marseille Université Domaine Universitaire de Saint Jér&ocirc me Marseille France

The present work relates to a process for silicon surface texturing for preparing large-area, silicon nanotextures on silicon substrates at ambient temperature by assisted chemical etching. A novel strategy comprises of two fundamental steps (metal-assisted chemical etching (MACE) and solution post-treatment) of using the silver catalyst to obtain specific nano- or micro-textures. The strategy is based on metal-induced (Ag) local oxidation and dissolution of a silicon substrate in three different concentrations of aqueous fluoride solution with the post-treatment solution. The etching technique is dependent on the etching time and concentration of aqueous fluoride solution. Therefore, detailed scanning electron microscopy observations reveal specifics shapes as inverted pyramids, cubic nano-microholes, spiroconical nano-microholes and rhombohedral-stared nanosheet bouquets (called Nanobukets), obtained for the first time on a (100) silicon surface by this new variant of the MACE method named Double Etching Method (DEM). Silicon nanostructures are used in many nanotechnology applications such as nano-microelectronics, optoelectronics or biomedical applications. UV-Visible spectrometry measurements carried out made it possible to obtain the lowest reflectance and highest absorbance values who are 3% and 97%, respectively for the rhomboedral-stared nanosheet bouquets on (100) crystalline silicon substrates in the UV-visible-NIR wavelength range from 300 to 1200 nm.

关键词： Silicon Nanotextures New Procedure Etching Reflectance Absorption

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Assessment of Total Incapacity for Work or Incapacity in the Criminal Sense in Case of Penetrating Wounds of the Neck

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Forensic Medicine and Anatomy Research 2018年第1期6卷 1-9页

作者： El Hadji Oumar ndoye Bobo Diallo Sidy Ahmed Dia Mouhamed Manibiliot Soumah Mame coumba fall Mor ndiaye Department of Forensic and Labor Medicine University Cheikh Anta Diop (UCAD) Dakar Senegal ENT Department of the University Hospital Center of Fann Dakar Senegal

Penetrating wounds of the neck are often life-threatening. The victims are exposed to vascular and laryngotracheal lesions. The purpose of this work is to report the various aspects of the management of penetrating wounds in our context and to make the medico-legal assessment of incapacity in the criminal sense or total incapacity for work. This is a retrospective study (2002-2014) on thirty-nine (39) cases of penetrating neck wounds, received at the ENT departments of the Aristide Le Dantec and Fann University Hospital Centers. Patients were predominantly male, representing 94% of cases with an average age of 27 years. Seventy (70%) of the accidents occurred in the region of Dakar. In 42% of cases, the circumstance of occurrence was a fight or an assault. The weapon used in most cases by the aggressor was a cutter or a knife. The average waiting time was 37 hours with extremes of 02 and 216 hours. Surgically, all patients had been examined under general anesthesia. In terms of lesions, 37 cases had profound cervical muscle injuries, i.e. 94%. There were 17 vascular lesions (43%). The medico-legal distribution of patients showed that among them, 10% had a total incapacity to work exceeding 21 days. The determination of total incapacity for work is an important medical procedure that requires capability and experience. The doctor must not fall into the trap of the confusion between the TIW on the criminal level and the TIW on the civil level. He must limit medically and should not make judgments.

关键词： Penetrating Neck Wounds Assessment of Total Incapacity for Work Criminal Incapacity Forensic Medicine

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Ipsilateral Simultaneous Shoulder and Elbow Dislocation: A Case Report

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Open Journal of Orthopedics 2022年第5期12卷 236-241页

作者： Abdoulaye Lindor Diop Cheikh Coundoul Papa Amadou Ba Madior Diouf René André Macodou ndiaye coumba Diouf Niang Hô pital Principal de Dakar-Senegal Dakar Senegal

Simultaneous shoulder and elbow dislocation is an uncommon condition, with only about ten cases reported in the literature. It is also called bipolar humeral dislocation or floating humerus. Nerve involvement is sometimes associated but radial nerve impairment is yet to be described. We report a case of bipolar dislocation of the humerus associated with radial nerve impairment occurring on a young 22 years old. Non-surgical treatment was undertaken with a reduction of the elbow followed by a reduction of the shoulder under general anaesthesia. Nerve and functional recovery were achieved at two and ten months respectively.

关键词： Bipolar Dislocation Humerus Nerve Involvement

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Modeling and Optimization of Interaction between Small Coastal Pelagic Fish, their Biological Predators and Fishermen

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Open Journal of Optimization 2021年第1期10卷 13-27页

作者： Ibrahima Diedhiou Salimata Gueye Diagne Fambaye Ngom Sow coumba Diallo Diop ndiaga Thiam Gabriel Birame ndiaye Aissatou fall ndoye Gueye Cheikh Anta Diop University of Dakar (UCAD) Dakar Senegal Department of Mathematics and Computer Science (DMI) UCAD Dakar Senegal Oceanographic Research Center Dakar Thiaroye (CRODT) Dakar Senegal Direction of Maritime Fisheries (DPM) Dakar Senegal

Small coastal pelagic fish are one of the fish families most affected by sea fishing. This man-made phenomenon leads to an imbalance in the marine and coastal ecosystem and is one of the main causes of migration north and offshore of the ranges. We used the ordinary differential equations to model the interactions existing between small pelagic resources and fishermen. Modelling follows the same of the Lotka-Volterra equations with a difference in the number of variables. This study confirmed the instability of the marine ecosystem. The objective is first of all to model a system of three interacting individuals composed of two distinct types of predators and two types of prey, and then optimise this interaction with the aim of conserving biodiversity in the ecosystem under study. Determining the Jacobian matrix made it possible to calculate the reproduction rate basic (R0). The study of the strong connectedness has made it possible to reduce the number of variables without losing the objective of the study. A computer program implemented on the language computer python facilitated the visualisation of the results.

关键词： Small Coastal Pelagics Ordinary Differential Equations Modelling Optimisation Basic Reproduction Rate

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Total Hip Prosthesis in Dakar and Forensic Implication

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Forensic Medicine and Anatomy Research 2018年第3期6卷 37-46页

作者： El Hadji Oumar ndoye Serigne Moussa Badiane Mohamadou M. Soumah Sidy Ahmet Dia Mame coumba fall Mor ndiaye Faculty of Medicine Pharmaceutics and Odonto-Stomatology UCAD Service de Médecine Légaleet du Travail Dakar Sénégal Faculty of Health Sciences University Gaston Berger (UGB) Saint-Louis Sénégal

The total hip prosthesis is the ultimate treatment of the hip joint’s wear. It is a delicate surgery and the most common replacements. This study was performed in the Orthopaedic-Traumatology Department of Public Health Establishment of Aristide Le Dantec in Dakar. It aimed to determine the complications of our total hip and highlight their forensic implications. This is a retrospective study from patients collected from January 2000 up to December 2010. The collection of elements records was performed for each patient, based on a file including age, sex, primary-location’s etiology, and types of complications of total hip prostheses. The analysis of these complications has shown that infections, poorly lit information, poor operational planning and technical foul may be the main cause of a forensic implication. This is a retrospective study from patients collected from January 2000 up to December 2010. No lawsuit has been recorded for the complications identified in this work. This is due to the belief in fate, ignorance of the victims and solidarity of the medical profession, the high cost and slow pace of judicial proceedings. The diagnosis of total hip prosthesis complications is mainly based on imaging tests. The absence of scintigraphy in our center remains a limit to the early diagnosis of multiple complications and the proper establishment of the epidemiological profile of these lesions. Taking consciences patients of their rights encourages a legitimate requirement repair the harm inflicted.

关键词： Total Hip Replacement Forensic Implications Bone Scintigraphy Articular and Bone Imaging

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Infectious Pneumonitis Revealing an Anal Imperforation with Recto-Vaginal Fistula: A Case of Late Discovery in a 70-year-Old Woman

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Journal of Biosciences and Medicines 2023年第1期11卷 26-31页

作者： Sall Assane Bâ Massamba Diajhete Rokhaya Adja Awa coumba Sarr Ba Dalahata Degboevi Vahana Toure Elsa Maimouna Coumé Mamadou Geriatrics Department Fann/Dakar University Hospital Dakar Senegal

Introduction: Anorectal malformations concern all anomalies of the terminal part of the digestive tract often diagnosed in the perinatal period. We report a clinical case of anorectal malformation discovered incidentally and very late at 70 years, following complications from the infectious syndrome. Observation: 70-year-old female patient, housewife, uneducated was referred to the hospital for acute febrile, cough, and mental confusion associated with chronic pelvic pain. The genito-anal examination showed an anal imperforation associated with a recto-vaginal fistula complicated by cervico-vaginitis. The evolution during hospitalization was favorable, but the patient died at home, 3 weeks after discharge. Conclusion: The discovery of anorectal malformation in adults is rare and exceptional in an elderly subject. This case demonstrates once again the challenges encountered in developing countries on the socio-economic and health levels.

关键词： Anorectal Malformation Elderly Subject Dakar Senegal

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