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Factors associated with mortality in congenital malformations of the gastrointestinal tract in a tertiary center in Senegal

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World Journal of Pediatric Surgery 2023年第1期6卷 24-29页

作者： Tshibwid A Zeng Papa Alassane Mbaye Doudou Gueye ndèye fatou seck Ibrahima Bocar Wellé Rosalie Niang Youssouph Diedhiou Mbaye Fall ndèye Aby ndoye Aloïse Sagna Oumar ndour Gabriel Ngom Department of Pediatric Surgery Albert Royer National Children’s Hospital CenterUniversitéCheikh Anta Diop Facultéde Medecine Pharmacie d'Odonto-StomatologieDakarSenegal Department of Pediatric Surgery Aristide Le Dantec University Teaching HospitalUniversitéCheikh Anta Diop Facultéde Medecine Pharmacie d'Odonto-StomatologieDakarSenegal

Objective Patients with congenital malformations(CMs)of the gastrointestinal tract(GIT)have a very high ***,the literature on the factors associated with mortality in these patients is scarce in sub-Saharan *** aim of this study is to identify independent risk factors for mortality in patients with CMs of the GIT at our pediatric surgical *** We conducted a retrospective analysis of cases with CMs of the GIT managed at a tertiary center from 2018 to *** were subdivided into two groups based on the outcomes,and variables with a significant difference were analyzed by logistic *** Our review included 226 patients,63 of whom died(27.88%).Patient age ranged from 0 to 15 *** into account statistical significance,mortality was more frequent in neonates than in older patients(57.30%vs 6.15%),in patients coming out of the Dakar area than in those from the Dakar area(43.75%vs 19.18%),in patients with abnormal prenatal ultrasound than in those with normal ultrasound(100%vs 26.67%),in premature children than in those born at term(78.57%vs 21.87%),in patients with an additional malformation than in those with an isolated malformation(69.23%vs 25.35%),and in those with intestinal,esophageal,duodenal and colonic atresia than in those with other diagnoses(100%,89%,56.25%and 50%,respectively).Referred patients died more than those who changed hospitals or came from home(55.29%vs 25%and 9.09%,respectively).On multivariable logistic regression,two independent factors of mortality were identified:presence of associated malformation[odds ratio(OR)=13.299;95%Confidence interval(CI)1.370 to 129.137]and diagnosis of esophageal atresia(OR=46.529;95%CI 5.828 to 371.425).Conclusion The presence of an associated malformation or diagnosis of esophageal atresia increases mortality in patients with CMs of the GIT in our environment.

关键词： mortality diagnosis congenital

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Metabolic Emergencies in Newborns in a Subsaharian Neonatology Department: Evaluation of Glucose, Sodium and Potassium Disorders

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Open Journal of Pediatrics 2022年第1期12卷 263-273页

作者： ndèye fatou Sow Amadou Sow Mame Aita seck Yaay Joor Dieng Djeneba Fafa Cissé Papa Moctar Faye ndèye Ramatoulaye Diagne Ousmane ndiaye Department of Pediatrics National Children’s Center Albert Royer Dakar Sénégal

Introduction: Metabolic neonatal adaptation is a complex phenomenon and metabolic disorders can be frequent in immature newborns or in life-threatening situations. In Low and Middle income countries (LMIC) the difficult access to some diagnostic tests makes the management of the metabolic emergencies challenging. The main objectives of this study were to assess the frequency and circumstances of occurrence and to describe the clinical picture associated with glucose, sodium and potassium disorders in neonates. Patients and Methods: Our study was a retrospective and descriptive study conducted in the neonatology unit of National Children Hospital Albert Royer in Dakar (Senegal) from January 1 to December 31, 2014. Results: The prevalence of the studied metabolic disorders was 46.7%. The most common metabolic disorder noted was Hyperglycemia followed by Hyponatremia. Thermoregulation disturbances were found particularly in newborns with serum sodium disorders (hyponatremia 33.5% and hypernatremia 59.7%). Neurological signs were noted in case of blood sugar abnormalities (hypoglycemia 26.1% and hyperglycemia 29.8%). Half of the newborns with hyperglycemia (82 cases/50%) had blood sugar levels greater than or equal to 2 g/l. Hypernatremia was severe (Serum sodium> 180 mmol/l) in 12 neonates (16.7%). The main diagnoses retained were sepsis (159 cases/45.4%), prematurity (96 cases/27.4%), intrauterine growth retardation (66 cases/18.9%), malformations (63 cases/18%), perinatal asphyxia (44 cases/12.6%) and malnutrition (36 cases/10.3%). For most metabolic disorders, the correction was late and was done beyond 48 hours. On average, the correction time varied between 3 hours and 6 days. The most frequent complications were cerebral edema (12 cases), brain death (8 cases) and increased intracranial pressure (3 cases). The most lethal disorders were Hyperkalemia followed by Hyperglycemia. Conclusion: Metabolic disorders especially glucose, sodium and potassium disorders are c

关键词： Metabolic Disorders Newborn Hypoglycemia Hyperkalaemia Hyperglyce-mia Hypernatremia

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Community Pharmacists’ Knowledge, Practices and Perceptions on Antibiotic Use and Resistance: A Cross-Sectional, Self-Administered Questionnaire Survey, in Guediawaye and Pikine, Senegal

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Open Journal of Epidemiology 2019年第4期9卷 289-308页

作者： Oumar Bassoum Awa Ba-Diallo ndèye Marème Sougou Mamadou Makhtar Mbacke Lèye Mayassine Diongue ndèye fatou Cissé Adama Faye Ibrahima seck Djibril Fall Anta Tal-Dia Department of Public Health and Preventive Medicine Faculty of Medicine Pharmacy and Odontology University Cheikh Anta Diop Dakar Senegal Institute of Health and Development University Cheikh Anta Diop Dakar Senegal Laboratory of Bacteriology and Virology National University Hospital Center Dakar Senegal Laboratory of Therapeutic and Organic Chemistry Faculty of Medicine Pharmacy and Odontology University Cheikh Anta Diop Dakar Senegal

Background: Antibiotic resistance is a threat to global health. Community pharmacists are among the most accessible health professionals. Therefore, their role in improving antibiotic use and subsequently in fighting resistance is crucial. The objective of this study was to evaluate community pharmacists’ knowledge, practices and perceptions on antibiotic use and resistance. Methods: We conducted a cross-sectional study in community pharmacies located in the departments of Guediawaye and Pikine, Senegal. The study took place between November 2017 and February 2018. A total of 121 community pharmacies were located. In each of them, we planned to include one pharmacist. A self-administered questionnaire was used. The data were analyzed using Epi Info 7. The analysis was descriptive. Variables were expressed as number (n) and percentage (%). Results: The response rate was 75.2%. The majority mistakenly thought that antibiotics are always effective against sore throat (64.8%), bronchitis (51.6%), paronychia (72.5%) and dental caries (65.9%). Most respondents knew that self-medication (96.7%), poor treatment compliance (94.5%), inappropriate antibiotic dispensing (79.1%), inappropriate antibiotic prescribing (85.7%) were causes of resistance. Further, causes such as poor hand hygiene and lack of immunization were cited by 9.9% and 6.6% of participants. Moreover, 25.2% knew that third-generation cephalosporins, macrolides and quinolones are critically important antibiotics. In addition, 96.7% and 90.2% said to dispense antibiotics without a prescription and to contact prescribers in case of doubt about the reliability of an antibiotic prescription, respectively. The majority was of the opinion that some antibiotic prescriptions were inadequate (29.7%) and that the consumption of antibiotics was high (92.3%). Conclusion: This study showed a lack of knowledge among community pharmacists practicing in Guediawaye and Pikine towards antibiotic use and resistance. Therefore, it

关键词： Community Pharmacists Knowledge Practices Senegal Antibiotic Resistance

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Study on the Perceptions and Social Representations of Husbands on Family Planning in the Health District of Pout/Senegal

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Advances in Reproductive Sciences 2022年第2期10卷 59-72页

作者： Mamadou Saliou Mbengue Abdoul Aziz ndiaye Alioune Badara Tall Rakhmatoulaye seck Awa Ba ndeye fatou Ngom fatou ndiaye Omar Sy Aladji Madior Diop Anta Tal Dia Université Alioune Diop Bambey Bambey Senegal Université Cheikh Anta Diop Dakar Dakar Senegal

Contraception is a set of procedures that aim to achieve temporary infertility in a woman without her ability to conceive being engaged in the future. It plays an essential role in the health of women and children, the psychological well-being of husbands and allows, among other things, savings for the family. The objective was to study the perceptions and social representations of husbands on family planning. A mixed method was used with a qualitative dominance, carried out in the health district of Pout. The result showed that the perceptions and representations of husbands influence this practice family planning. Even if they have positive attitudes and a good level of knowledge about contraceptive methods, their involvement in FP practices remains low with gaps to be filled. Direct or intermediate variables such as the social, cultural, economic and religious aspects are pitfalls. Indeed, the commitment of men and the consideration of their social attributes are variables to be integrated into the process of information and awareness on family planning;this is crucial in achieving Sustainable Development Goal (SDG) 3 (Good Health and Well-being), including its target 7 focused on sexual and proactive health: a second best move towards the demographic dividend.

关键词： Family Planning Perceptions Social Representations Demographic Dividend

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Low Socio-Economic Level: A Major Obstacle to Therapeutic Observation (Survey of 125 Diabetic Patients)

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Open Journal of Preventive Medicine 2022年第1期12卷 1-9页

作者： Ousseynou Ka Djiby Sow Elhadji Mouhamadou seck ndeye fatou Ngom Guéye Martial Coly Bop Mountaga Elimane Dia Abdoul Aziz ndiaye Papa Gallo Sow Maimouna Mbaye ndour Community Health Department Faculty of Health and Sustainable Development Université Alioune Diop Bambey Senegal Medical Clinic II Centre Hospitalier Abass Ndao Université Cheikh Anta Diop Dakar Senegal Department of Medicine Faculty of Health and Sustainable Development Université Alioune Diop Bambey Senegal

Introduction: Diabetic patients adhering to their treatment are less likely to face complication from their disease. For this reason, we studied the compliance of diabetics with their treatment. Materials and Method: This was a comprehensive cross-sectional study of adherence in diabetic patients. All patients meeting the inclusion criteria were enrolled in the study. This study took place at a private pharmacy called “pharmacy Elhadj Seydou Nourou Tall” located in the city of Pikine during the period from April 1 to September 30, 2019. Results: In total, the study population was composed of 125 diabetics;frequency of 8.47%. The average age was 62.5 years and there were more women (58.4%). Of the patients, 87% had a low socioeconomic level and 72% a low educational level. Only 65.6% of the patients knew their diabetes type. Even though 97.6% of the patients were confident in the treatment but due to financial reasons 20.8% did not adhere to the prescribed treatment and 16.8% to their diets. Moreover, 15.2% of the patients had changed the dosage of the prescribed medication, 44.4% had forgotten to take their medication regularly. 78.4% of them thought they were taking too much medication. No factors were found to be statistically associated with poor adherence, but the proportion of poor adherence patients was higher in patients over 60 years of age, with low socio-economic status and low education. Conclusion: Low socio-economic status is the main barrier to good adherence. Recommendations have been formulated to improve this adherence.

关键词： Adherence Diabetes Socio-Economic Level Barrier Senegal

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Abdominal Cerebrospinal Fluid Pseudocyst—A Rare Complication of Ventriculoperitoneal Shunt

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Open Journal of Modern Neurosurgery 2023年第3期13卷 105-110页

作者： ndeye fatou seck Ibrahima Bocar Wellé Cheikh Ahmadou Dit ndongo Dieng Florent Tshibwid A. Zeng fatou Sy Doudou Gueye Papa Alassane Mbaye ndeye Aby ndoye Aloïse Sagna Gabriel Ngom Department of Pediatric Surgery Albert Royer National Children’s Hospital Center Université Cheikh Anta Diop Dakar Senegal

An abdominal cerebrospinal fluid pseudocyst is a rare complication of ventriculoperitoneal shunt. Several theories have been suggested to explain its occurrence. The main symptoms are painful abdominal distension and vomiting, abdominal distension on examination, as abdominal ultrasound and computed tomography confirm its diagnosis. The treatment involves drainage associated with drain relocation and resection of the pseudocyst’s wall. We report two patients diagnosed with this condition who underwent surgical treatment. The first patient had an unremarkable 12-month follow-up, while the second died on the seventh postoperative day due to intravascular disseminated coagulation. In these patients, the cause has not been identified;however, an infection cannot be ruled out.

关键词： Abdominal Pseudocyst Cerebrospinal Fluid Children Complication Ventriculoperitoneal Shunt

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Body Composition in Sickle Cell Disease Patients in the Steady State

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Open Journal of Molecular and Integrative Physiology 2024年第2期14卷 31-38页

作者： Mame Saloum Coly Mouhamadou Mansour Diagne Jean Fidele Nnang Essone Abdou Khadir Sow Salimata Diagne Houndjo Maimouna Toure Aïssatou seck Awa Ba Abdoulaye Ba Abdoulaye Samb Moussa seck Saliou Diop Mor Diaw fatou Bintou Sar Arame Mbengue Laboratory of Physiology and Functional Explorations UFR of Health Sciences Iba Der Thiam University Thies Senegal Laboratory of Physiology and Functional Explorations FMPO Cheikh Anta DIOP University Dakar Senegal Department of Fundamental Sciences FMSS/USS Libreville Gabon Laboratory of Physiology UFR of Health Alioune DIOP University Bambey Senegal National Center of Blood Transfusion Dakar Senegal

Introduction: Previous studies in sickle cell disease (SCD) patients have demonstrated low muscle mass (MM) and high fat mass (FM) percentages compared to individuals with normal hemoglobin. The relationship between the evolutions of body composition (BC) parameters in the active SCD population is not well elucidated. The aim of the present study was to assess the body composition in active adult SCD patients in sub-Saharan Africa during the inter-critical period. Methodology: We conducted a descriptive and analytical cross-sectional study over an 8-month period. Eighteen SCD patients (sex ratio = 1) reported regular physical activity (RPA) corresponding to level 3 (RPA of moderate intensity) of the 4-level Saltin-Grimby physical activity scale were recruited. Anthropometric and BC parameters such as BMI, percentage FM and percentage MM were evaluated using an impedance meter. Results: The study population had a mean age of 26 ± 7 years and a mean BMI of 20.5 ± 1.9 kg/m2. We found a significantly higher percentage of FM in women compared to the men (25.6% ± 10.2% vs 11.1% ± 2.1%;p = 0.001). For the proportion of MM, all the women had a normal percentage. The men mostly had high levels of MM compared with reference norms. Men had significantly greater MM percentages than women (45.4% ± 1.8% vs. 26.5% ± 1.4%;p Conclusion: RPA appears to have positive effects on BC in active population with SCD, and a greater-than-expected effect was observed on MM in male patients. Promoting regular, adapted physical activity would be a promising way of improving BC parameters and quality of life in the SCD population. Further studies with larger cohorts will be needed to better substantiate these results.

关键词： Sickle Cell Disease Body Composition Physical Activity

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Persistent Congenital Paraurethral Cyst, a Rare Cause of Dysuria in a Girl

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Open Journal of Urology 2023年第3期13卷 83-87页

作者： Doudou Gueye ndeye fatou seck Florent Tshibwid A. Zeng Papa Alassane Mbaye Ibrahima Bocar Wellé Lissoune Cissé ndeye Aby ndoye Aloïse Sagna Department of Pediatric Surgery Albert Royer National Children’s Hospital Centre Université Cheikh Anta Diop Dakar Senegal

Congenital paraurethral cyst rarely occurs. Its natural history is spontaneous regression, leading to conservative management adoption. We report an exceptional case of a 13-year-old female with a persistent congenital paraurethral cyst, leading to dysuria. We surgically excised the cyst, and the outcomes were unremarkable 20 months postoperatively.

关键词： Congenital Paraurethral Cyst Persistent Dysuria Girl Surgical Excision

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A Cross-Sectional Survey on Non-Communicable Diseases and Risk Factors in the Senegalese Army

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Health 2016年第14期8卷 1529-1541页

作者： Abdoul Aziz ndiaye Alioune Badara Tall Boubacar Gueye Ibrahima Soce Fall Sidy Mouhamed seck Amady Barro Mbodj ndeye fatou Ngom-Gueye Awa Gaye Anta Tal-Dia Community Health Department University Alioune Diop of Bambey Bambey City Senegal Army Health Service Camp Dial Diop Dakar Senegal WHO Bamako Mali Faculty of Health Sciences Gaston Berger University Saint-Louis Senegal Public Health Department Cheikh Anta Diop University Dakar Senegal

Background: The non-communicable diseases (NCDs) have become a public health priority. The objectives of this study were to measure the prevalence and to assess the risk factors of NCDs among the Senegalese military population to initiate an intervention program. Methods: A cross-sectional survey was conducted in 2014. Two-level stratification was used to sample participants. Data were collected following the protocol recommended by the World Health Organization. Data were managed using Epi-Info 6 software and analyzed using R software. Results: A total of 1224 participants were recruited, of whom 96.9% were men. Their ages ranged from 25 to 60 years with a mean of 39.7 ± 9.2 years. Of participants, 17.2% were active smokers. Average duration of active smoking was 19.9 ± 9 years. The prevalence of current alcohol consumption was 11.5%, with an average of 4 ± 2.7 glasses a day. 97.17% of participants consumed fewer than 5 servings of fruits and vegetables a day. 18.63% had insufficient physical activity. The overall prevalence of high blood pressure was 26.9%. The proportion of those who were overweight was 27.2%;3.3% were obese. 3.0% of participants had diabetes and 44.1% had hypercholesterolemia. After adjusting for waist circumference, the risk of high cholesterol was 2.42 in the 35 - 44 age group and 2.86 in the 45 - 60 age group in comparison with the 25 - 34 age group. 32% were classified as having stage 2 chronic kidney. Conclusions: The findings of this study indicate the importance of risk factors for NCDs in the Senegalese military population. Intervention based on prevention and health promotion is needed.

关键词： Risk Factors NCDs Military

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Spirometric Abnormalities Met among Senegalese Workers Exposed to Chlorine Gas

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Journal of Pharmacy and Pharmacology 2019年第11期7卷 584-592页

作者： Houndjo Salimata Diagne Ouattara Rokia Mbengue Arame Ouedraogo Valentin seck Aissatou Sow Abdou khadre Diaw Mor Toure Maimouna Coly Mame Saloum Ba Awa Sar fatou Bintou Ba Abdoulaye Samb Abdoulaye Laboratoire de Physiologie et d’Explorations Fonctionnelles Faculté de Médecine de Pharmacie et d’Odontologie-Senegal Universite Cheikh Anta Diop de Dakar Dakar BP 5005 Senegal UMI 3189 “Environnement Sante Societies” CNRS CNRST Universite Bamako-UCAD Dakar BP 5005 Senegal UFR des sciences de la sante Thies BP 221 Senegal UFR des sciences de la sante Bambey BP 21400 Senegal

Introduction: Chlorine as a disinfectant has many side effects on respiratory function. This respiratory toxicity may be related to the exposure time. Materials and Methods: Measure the impact of the duration of chlorine gas exposure on the respiratory function of Senegalese workers who work in the national water production factory: Senegalaise Des Eaux (SDE), aged 35-54 years. Twenty-four (24) male subjects exposed to chlorine gas were divided into two groups, one (35-44) and the other (45-54). Clinical examinations were performed on each employee, followed by chest x-rays and spirometry. We included all subjects whose first or last two spirometry results were normal. Results: In the 35-44 years group, 50% of subjects had disturbed spirometry including 41.6% of obstructive syndrome (OS), at the second spirometry and 8.3% had a restrictive syndrome FVC at -25%, at the 3rd spirometry 4/12 had a normal spirometry. The duration of exposure was 10 years. For subjects in 45-54 years, 8/12 had persistent OS or accentuated, then at the 3rd spirometry we had 10 subjects. The duration of exposure was 17.5 years. Conclusion: Compared with (35-44) group, older (45-54) subjects had significant OS, which may be related to duration of exposure.

关键词： Spirometry exposure SDE

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