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Frailty in People Living with Human Immunodeficiency Virus Aged 50 years and Older: Prevalence and Predictors

World Journal of AIDS 2024年第1期14卷 18-34页

作者： Alassane ndiaye ndèye fatou ngom Kiné ndiaye Assiétou Gaye Elhadji Bara Diop Ahmadou Mboup Houlèye Saou Bessoume Sy Ababacar Niang Betty Fall Mame Awa Faye Outpatient Treatment Clinic (CTA) Dakar Senegal Medicine Department of Health and Sustainable Development/Research and Training Unit (UFRSDD) Alioune Diop University of Bambey Diourbel Senegal Health and Development Institute (ISED) Cheikh Anta Diop University Dakar Senegal Geriatrics and Gerontology Department Fann National Teaching Hospital Center Dakar Senegal

Introduction: Life expectancy improvement for people living with Human Immunodeficiency Virus (HIV) is coming up against the problems associated with aging and chronic diseases. Frailty is a concern affecting a growing number of patients, particularly the elderly in this population. Our study aimed to determine the prevalence of frailty and its predictors on people living with HIV aged 50 years and older followed at the Outpatient Treatment Clinic (CTA) in Dakar. Methodology: We conducted a cross-sectional study of descriptive and analytic purposes ranging from November 2022 to August 2023, in CTA, Dakar (Senegal). We included people living with HIV aged 50 years and older under antiretroviral therapy for at least 6 months (≥6 months). Frailty was considered according to Fried criteria with a score ≥3. To identify the predictors of frailty, we performed a multivariate logistic regression analysis using STATA software version 18. Results: We included 199 patients. The median age at the moment of the study was 58 years old [50 - 91] with a sex ratio (M/F) of 0.58. The most representative age group was that of [50 - 59] years (59.3%). HIV-1 profile was most common in 89.45%. The median duration under antiretroviral therapy was 180 months [6 - 284] and 94% of patients received a Tenofovir Disoproxil Fumarate (TDF)-containing regimen with 43% of them for at least 10 years. Viral load was undetectable (≤40 copies/ml) in 98% of cases. WHO Stage III was more common at inclusion and 55.78% had nadir TCD4+ Lymphocyte counts Conclusion: Our study confirms the high prevalence of frailty among older people living with HIV. Its prevention should consider the management of comorbidities and the implementation of non-pharmacological interventions such as nutrition.

关键词： Frailty HIV Senior Dakar

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Epidemiological, Clinical and Outcome Aspects of Care-Related Tetanus in Dakar, Senegal

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Advances in Infectious Diseases 2022年第2期12卷 230-240页

作者： Viviane Marie Pierre Cisse ndèye fatou ngom Gueye Louise Fortes Imelda Mickelina Thoo Aminata Massaly Khardiata Diallo Mbaye Daye Ka ndèye Aissatou Lakhe Assane Diouf ndèye Maguette Fall Daouda Thioub Aboubakry Sidikh Badiane Latyr Junior Diouf Alassane Sarr Sylvie Audrey Diop Cheikh Tidiane ndour Masserigne Soumaré Moussa Seydi Infectious and Tropical Diseases Department Fann Teaching University Hospital Dakar Senegal Department of Community Health Alioune Diop University Bambey Senegal Department of Health Thies University Thies Senegal

Introduction: Tetanus portals of entry are numerous. Amongst these, the carerelated portals of entry are rarely reported. The aim of the study was to describe the epidemiological, clinical and outcome aspects and identify the factors associated with death from care-related tetanus. Patients and Methods: This is a retrospective study of descriptive and analytical purposes. Data were collected from the medical records of patients admitted to the Infectious and Tropical Diseases Department of the National University Hospital Center (CHNU) of Fann in Dakar for care-related tetanus during the period ranging from 1 January 2009 to 31 December 2016. Care-related tetanus was defined as any case of tetanus occurring after a surgical procedure, including circumcisions performed even outside a health facility. Results: In eight years, 50 cases of care-related tetanus were recorded. Care-related tetanus accounted for 6.7% of hospitalized tetanus cases. The mean age of patients was 21 ± 22 years, with a male predominance (sex ratio: 6.14). The procedure had been performed in most cases, either in a health facility in 22 patients (44%) or at home in 16 patients (32%), and occurred after circumcision. In 62% of cases the portal of entry was urological, followed by orthopedic surgery (14%) and visceral surgery (10%). The procedures performed were dominated by circumcision (31 cases), limb amputation (3 cases) and inguinal hernia repair (2 cases). Tetanus was immediately generalized on admission in all patients. Eighty-four percent (84%) of patients were admitted with Mollaret stage II. Cardiovascular (11 cases), infectious (10 cases) and respiratory (9 cases) complications were the most frequent. The hospital case fatality rate was 24%. Factors associated with death were female gender (p = 0.03), age between 15 - 60 years (p = 0.02), incubation time Conclusion: Care-related tetanus remains a concern in poor income countries, particularly in Senegal. The drop of these cases will req

关键词： Tetanus Care Surgery Dakar Senegal

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Hydrogeochemical Characterization of Aquifer Systems and Surface Water/Groundwater Relations in the Lower Senegal River Valley

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Journal of Geoscience and Environment Protection 2024年第6期12卷 232-254页

作者： Abibatou Camara fatou Diop ngom Moctar Diaw Cheikh Tidiane Wade Ibrahima Mall Department of Geology Cheikh Anta Diop University Dakar Senegal Department of Applied Geosciences and Environment Amadou Mahtar Mbow University Dakar Senegal

This study assesses the chemical quality of water resources in the Lower Senegal River valley, based on 35 samples collected in November 2022. Major ion concentrations in surface water and groundwater were analyzed using classical geochemical interpretation diagrams (Piper, GIBBS, etc.) and multivariate geostatistical analyses, including hierarchical cluster analysis (HCA) and principal component analysis (PCA). The results revealed three types of facies: Ca-Mg-HCO3-type facies, characteristic of poorly mineralized waters such as surface waters and groundwater from dune formations and the alluvial plain close to the hydraulic axis;Na-Cl type facies associated with well waters located in the alluvial plain that tap Inchirian or Nouakchottian shallow reservoirs and Maastrichtian deep borehole waters;and mixed Ca-Cl and Na-HCO3 type facies observed in certain floodplain and dune reservoirs. The results showed a strong correlation between sodium, chlorides, bromides, and electrical conductivity, indicating a significant contribution of these ions to groundwater mineralization. The various sources of water mineralization include mixing processes between surface water or rainwater, or calcite or dolomite dissolution processes (for weakly mineralized waters), basic exchanges or inverse basic exchanges between the aquifer and the water table (for moderately mineralized waters), and evaporation processes, halite dissolution, and paleosalinity during periods of marine transgression and regression (for highly mineralized waters). The study also highlighted the high vulnerability of the alluvial aquifer to pollution from intensive irrigated agriculture, as significant quantities of sulfates and nitrates were measured in some samples. These results also highlight the importance of water quality management in the Lower Senegal Valley, particularly as concerns the protection of the alluvial aquifer against pollution from irrigated agriculture.

关键词： Senegal River Valley Groundwater Pollution Agriculture Alluvial Aquifer

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Factors associated with mortality in congenital malformations of the gastrointestinal tract in a tertiary center in Senegal

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World Journal of Pediatric Surgery 2023年第1期6卷 24-29页

作者： Tshibwid A Zeng Papa Alassane Mbaye Doudou Gueye ndèye fatou Seck Ibrahima Bocar Wellé Rosalie Niang Youssouph Diedhiou Mbaye Fall ndèye Aby ndoye Aloïse Sagna Oumar ndour Gabriel ngom Department of Pediatric Surgery Albert Royer National Children’s Hospital CenterUniversitéCheikh Anta Diop Facultéde Medecine Pharmacie d'Odonto-StomatologieDakarSenegal Department of Pediatric Surgery Aristide Le Dantec University Teaching HospitalUniversitéCheikh Anta Diop Facultéde Medecine Pharmacie d'Odonto-StomatologieDakarSenegal

Objective Patients with congenital malformations(CMs)of the gastrointestinal tract(GIT)have a very high ***,the literature on the factors associated with mortality in these patients is scarce in sub-Saharan *** aim of this study is to identify independent risk factors for mortality in patients with CMs of the GIT at our pediatric surgical *** We conducted a retrospective analysis of cases with CMs of the GIT managed at a tertiary center from 2018 to *** were subdivided into two groups based on the outcomes,and variables with a significant difference were analyzed by logistic *** Our review included 226 patients,63 of whom died(27.88%).Patient age ranged from 0 to 15 *** into account statistical significance,mortality was more frequent in neonates than in older patients(57.30%vs 6.15%),in patients coming out of the Dakar area than in those from the Dakar area(43.75%vs 19.18%),in patients with abnormal prenatal ultrasound than in those with normal ultrasound(100%vs 26.67%),in premature children than in those born at term(78.57%vs 21.87%),in patients with an additional malformation than in those with an isolated malformation(69.23%vs 25.35%),and in those with intestinal,esophageal,duodenal and colonic atresia than in those with other diagnoses(100%,89%,56.25%and 50%,respectively).Referred patients died more than those who changed hospitals or came from home(55.29%vs 25%and 9.09%,respectively).On multivariable logistic regression,two independent factors of mortality were identified:presence of associated malformation[odds ratio(OR)=13.299;95%Confidence interval(CI)1.370 to 129.137]and diagnosis of esophageal atresia(OR=46.529;95%CI 5.828 to 371.425).Conclusion The presence of an associated malformation or diagnosis of esophageal atresia increases mortality in patients with CMs of the GIT in our environment.

关键词： mortality diagnosis congenital

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A Chronic Dysphony Caused by a Bifocal and Pulmonary Laryngeal Tuberculosis

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International Journal of Otolaryngology and Head & Neck Surgery 2023年第2期12卷 55-60页

作者： Aliou Faty Abdou Sy ndeye fatou ngom Djibril Balde Khadim Diouf ndadi Tchiengang Kadielle Junie Heinrich Lübke Regional Hospital Centre of Diourbel Diourbel Senegal Children’s Hospital of Diamniadio Dakar Senegal Departement of Medecine Bambey Alioune Diop University Diourbel Senegal Sociale Hygiene Institute Dakar Senegal Regional Hospital Centre of Sédhiou Sédhiou Senegal

Laryngeal tuberculosis is a rare entity. We consider the case of a woman of 62 who presented a one-year evolving chronic dysphonia chart associated with cough, febricula and general health damage. The nasofibroscopy showed a budding ulcerous lesion of the larynx a priori evoking a granulomatous lesion or cancer. The BAAR spits were strongly positive and the radiographic pictures of the thorax, typically evoked a pulmonary tuberculosis. Seeing the excellent therapeutic response to TB treatment in 4 months period, the bifocal tuberculosis diagnostic was confirmed.

关键词： Tuberculosis Dysphonia Larynx Lungs

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Study on the Perceptions and Social Representations of Husbands on Family Planning in the Health District of Pout/Senegal

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Advances in Reproductive Sciences 2022年第2期10卷 59-72页

作者： Mamadou Saliou Mbengue Abdoul Aziz ndiaye Alioune Badara Tall Rakhmatoulaye Seck Awa Ba ndeye fatou ngom fatou ndiaye Omar Sy Aladji Madior Diop Anta Tal Dia Université Alioune Diop Bambey Bambey Senegal Université Cheikh Anta Diop Dakar Dakar Senegal

Contraception is a set of procedures that aim to achieve temporary infertility in a woman without her ability to conceive being engaged in the future. It plays an essential role in the health of women and children, the psychological well-being of husbands and allows, among other things, savings for the family. The objective was to study the perceptions and social representations of husbands on family planning. A mixed method was used with a qualitative dominance, carried out in the health district of Pout. The result showed that the perceptions and representations of husbands influence this practice family planning. Even if they have positive attitudes and a good level of knowledge about contraceptive methods, their involvement in FP practices remains low with gaps to be filled. Direct or intermediate variables such as the social, cultural, economic and religious aspects are pitfalls. Indeed, the commitment of men and the consideration of their social attributes are variables to be integrated into the process of information and awareness on family planning;this is crucial in achieving Sustainable Development Goal (SDG) 3 (Good Health and Well-being), including its target 7 focused on sexual and proactive health: a second best move towards the demographic dividend.

关键词： Family Planning Perceptions Social Representations Demographic Dividend

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Low Socio-Economic Level: A Major Obstacle to Therapeutic Observation (Survey of 125 Diabetic Patients)

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Open Journal of Preventive Medicine 2022年第1期12卷 1-9页

作者： Ousseynou Ka Djiby Sow Elhadji Mouhamadou Seck ndeye fatou ngom Guéye Martial Coly Bop Mountaga Elimane Dia Abdoul Aziz ndiaye Papa Gallo Sow Maimouna Mbaye ndour Community Health Department Faculty of Health and Sustainable Development Université Alioune Diop Bambey Senegal Medical Clinic II Centre Hospitalier Abass Ndao Université Cheikh Anta Diop Dakar Senegal Department of Medicine Faculty of Health and Sustainable Development Université Alioune Diop Bambey Senegal

Introduction: Diabetic patients adhering to their treatment are less likely to face complication from their disease. For this reason, we studied the compliance of diabetics with their treatment. Materials and Method: This was a comprehensive cross-sectional study of adherence in diabetic patients. All patients meeting the inclusion criteria were enrolled in the study. This study took place at a private pharmacy called “pharmacy Elhadj Seydou Nourou Tall” located in the city of Pikine during the period from April 1 to September 30, 2019. Results: In total, the study population was composed of 125 diabetics;frequency of 8.47%. The average age was 62.5 years and there were more women (58.4%). Of the patients, 87% had a low socioeconomic level and 72% a low educational level. Only 65.6% of the patients knew their diabetes type. Even though 97.6% of the patients were confident in the treatment but due to financial reasons 20.8% did not adhere to the prescribed treatment and 16.8% to their diets. Moreover, 15.2% of the patients had changed the dosage of the prescribed medication, 44.4% had forgotten to take their medication regularly. 78.4% of them thought they were taking too much medication. No factors were found to be statistically associated with poor adherence, but the proportion of poor adherence patients was higher in patients over 60 years of age, with low socio-economic status and low education. Conclusion: Low socio-economic status is the main barrier to good adherence. Recommendations have been formulated to improve this adherence.

关键词： Adherence Diabetes Socio-Economic Level Barrier Senegal

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Contribution of Electric Tomography, Chemical and Isotopic Tools to the Understanding of the Resilience and Salinization of Wetlands along the Northern Coast of the Cape-Verde Peninsula: The Case of the Retba Lake

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Journal of Geoscience and Environment Protection 2019年第9期7卷 36-57页

作者： Mansour Gueye Abdoul Aziz Gning Mapathé ndiaye fatou Diop ngom Raymond Malou El Hadj Sow Raphael Sarr Département de Géologie Facultédes Sciences et TechniquesUniversité Cheikh Anta DiopDakarSénégal UFR Sciences de l’Ingénierie Université de ThièsThièsSénégal

On the northern coast of the Cape Verde peninsula, Lake Retba is one of the few depressions that have preserved its water body due to the drought that plagued the Sahel in the 1960s. The aim of this article is to understand the resilience of the lake to the drought. For this purpose, a deep knowledge of interactions between the different components of the hydro-system, namely: lake, dune tablecloth, ponds and ocean is necessary. The use of electrical resistivity tomography (ETR) and chemical and isotopic tools yielded conclusive results. Electrical tomography of resistivity (ETR) shows throughout the coastal dune a superposition between fresh and salt water, with even a predominance of salt water at the level of the old canal. The chemistry of the major ions and isotopes confirms this contact between the saltwater bison of the sea and the lake by showing a superposition of the fresh/brackish waters on the salty waters of the bevel, which, in turn, are found in the very salty waters influenced by the lake. This translates a feeding of the lake by the sea through the bevel. At the canal level, this feeding is done, on the surface, by means of ponds whose water characteristics show that they constitute an outcrop of the bevel. The freshwater body of the coastal dune that floats on salt water in the form of a lens also flows into the lake. The feeding of the lake, by the sea through the bevel and the ponds, and by the water table, is therefore effective and attested by all the methods used in this work. It allowed the resilience of the lake against the drought. This inflow of seawater into the lake is at the origin of its salinization and therefore of the salt that settles on the bottom. This study shows that the survival of the lake also depends on safeguarding the ponds located in the north of the lake.

关键词： Tomography Isotope Lake Ponds Aquifer Hydro System Salinization Resilience

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Determinants of the Use of Health Care and Therapeutic Routes of Populations in Rural Senegalese Areas, 2016

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Open Journal of Preventive Medicine 2021年第12期11卷 439-448页

作者： Abdoul Aziz ndiaye Awa Ba-Diop Maimouna Diop Alioune Badara Tall Ousseynou Ka fatou ndiaye Omar Sy Sylla ndeye fatou ngom Aladji Madior Diop Lamine Gueye Anta Tal Dia Université Alioune Diop de Bambey Bambey Senegal Université Cheikh Anta Diop de Dakar Dakar Senegal

In Senegal, access to health care for rural populations and therapeutic choices remain problematic. These problems may be synonymous with insufficient financial resources, long waits, ineffective treatments, or drug shortage in health structures, leading patients to perform various therapeutic behaviours. The aim of this present study was to identify the therapeutic routes of the patients and the determinants of the different uses of health care in the populations of Ferlo. This descriptive and analytical study was carried out as part of the medical consultation days of the 2016 summer at the university in Widou Thiengoly. All patients who met the selection criteria were enrolled. In total, the 150 participants were mainly animal breeders (63.3%) and housewives (26%), also, most were women (90.7%). The analysis of the therapeutic routes showed that the health post was used as first-line and second-line respectively in 85.3% and 59.3% of the study populations. Traditional medicine and self-medication would be used in the third intention. Therapeutic choices were independent of age (p = 0.94), marital status (p = 0.84) and occupation (p = 0.58). On the other hand, social dimensions, such as tradition, appreciation of efficiency, distance, cost, and gender, also determine the use of health care. Women used health post more frequently than men (p = 0.03) (OR: 3.89, CI95% [1.16 - 12.98]) of the order 3.89. The main reasons for self-medication practice were the treatment of headache or fever (46%) and that of fatigue (26%). The prices were more expensive for health facilities (70.9%) than for traditional healers (70% “not expensive at all”) where the waiting time was considered “not long at all” (70%).

关键词： Therapeutic Routes Biomedicine Traditional Medicine Widou Thiengoly

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Abdominal Cerebrospinal Fluid Pseudocyst—A Rare Complication of Ventriculoperitoneal Shunt

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Open Journal of Modern Neurosurgery 2023年第3期13卷 105-110页

作者： ndeye fatou Seck Ibrahima Bocar Wellé Cheikh Ahmadou Dit ndongo Dieng Florent Tshibwid A. Zeng fatou Sy Doudou Gueye Papa Alassane Mbaye ndeye Aby ndoye Aloïse Sagna Gabriel ngom Department of Pediatric Surgery Albert Royer National Children’s Hospital Center Université Cheikh Anta Diop Dakar Senegal

An abdominal cerebrospinal fluid pseudocyst is a rare complication of ventriculoperitoneal shunt. Several theories have been suggested to explain its occurrence. The main symptoms are painful abdominal distension and vomiting, abdominal distension on examination, as abdominal ultrasound and computed tomography confirm its diagnosis. The treatment involves drainage associated with drain relocation and resection of the pseudocyst’s wall. We report two patients diagnosed with this condition who underwent surgical treatment. The first patient had an unremarkable 12-month follow-up, while the second died on the seventh postoperative day due to intravascular disseminated coagulation. In these patients, the cause has not been identified;however, an infection cannot be ruled out.

关键词： Abdominal Pseudocyst Cerebrospinal Fluid Children Complication Ventriculoperitoneal Shunt

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