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Complete separation of the urinary tract from proximal rectum during PSARP surgery: our experience with the novel technique

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World Journal of Pediatric Surgery 2024年第1期7卷 66-69页

作者： Md Samiul hasan Md nazmul Islam Refoyez Mahmud Umama Huq Ashrarur Rahman Pediatric Surgery Bangladesh Shishu Hospital and InstituteDhakaBangladesh

Anorectal malformation(ARM)is a frequently occurring surgical condition in neonates,with a prevalence of 1 in 4000 live births.'In boys with this anomaly,the rectum and urinary tract share a common wall for some distance,often ending up in fistulous *** goals of definite reconstruction are to separate the rectum from the urinary tract without injuring the urethra and mobilizing the rectum to the perineum within the muscle *** the rectum and the urinary tract is the most critical part of this operation and is associated with a significant risk of urinary tract injury.2-5 The original procedure described by Pena and Devries involves multiple stay sutures on the rectal mucosa just above the fistula,lifting the mucosa and continuing a submucosal dissection up to the prostate,where the entire thickness of the intestine can be separated from the urinary tract.

关键词： urinary rectum intestine

Post Thyroidectomy Assessment of Intact Parathyroid Hormone for Early Prediction of Hypocalcaemia

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第2期13卷 71-84页

作者： Md. Masum Billah Ripon Kumar Sarkar Md. Yousuf Ali Saad Zaman Md. nazmul hasan Md. Shehab Uddin Md. Mosleh Uddin Kazi Shameemus Salam Farzana Binte Abedin Leera Department of Otolaryngology-Head & Neck Surgery Universal Medical College Hospital Dhaka Bangladesh Department of Otolaryngology-Head & Neck Surgery National Institute of Ear Nose and Throat Dhaka Bangladesh Shaheed Ahsan Ullah Master General Hospital Gazipur Bangladesh Department of Otolaryngology-Head & Neck Surgery Cumilla Medical College Cumilla Bangladesh Department of ENT Oncology National Institute of Cancer Research & Hospital Dhaka Bangladesh Department of ENT Outdoor Rajshahi Medical College Hospital Rajshahi Bangladesh Department of Otolaryngology-Head & Neck Surgery Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh Department of Biochemistry Delta Medical College Hospital Dhaka Bangladesh

Background: As the half-life of intact parathyroid hormone (iPTH) is very low, it reflects parathyroid insufficiency within minutes to hours after total thyroidectomy. Therefore, iPTH level assessment in the postoperative period can be used to predict the development of hypocalcaemia. The optimal time point to measure serum iPTH is important for the accurate prediction of hypocalcaemia. Aim: This paper aims to evaluate the ability of iPTH as an early predictive marker of hypocalcaemia and determine which time iPTH is more able to predict postoperative hypocalcaemia. Method: This prospective observational study was conducted in the Department of Otolaryngology-Head & Neck Surgery, BSMMU, Dhaka, from July 2020 to December 2021, with 67 patients who underwent total thyroidectomy. iPTH levels were measured on the day before the operation and at 1 hour, 4 hours, and 24 hours after the operation. *** levels were measured on the day before the operation and 1st postoperative day. All the data were compiled and sorted properly and were analyzed statistically. Results: Postoperative hypocalcaemia developed in 18 cases, with an incidence of 26.9%. Pearson correlation showed a significant correlation between postoperative iPTH at 1 hr, 4 h, and 24 hr with 1st postoperative calcium value. The Receiver operating characteristic (ROC) curve was processed for the postoperative iPTH at 1 hr, 4 h, and 24 hr. The sensitivity, specificity, cut-off value, and mean AUC found 93.9%, 94.4%, ≤14.0, 0.988;95.9%, 94.4%, ≤09.5, 0.993 and 91.8%, 94.4%, ≤11.0, 0.993 respectively. Conclusion: iPTH can be used as an early predictor of post-thy-roidectomy hypocalcaemia. 4 hr iPTH showed more sensitivity and specificity for a cut-off value near the laboratory reference range.

关键词： Total Thyroidectomy Hypocalcaemia Serum Intact Parathyroid Hormone Early Predictor of Hypocalcaemia

Systematic mutational analysis of epitope-grafted ED3 immunogenicity reveals a DENV3-DENV4 bi-serospecific ED3 mutant

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Asian Pacific Journal of Tropical Medicine 2022年第2期15卷 63-70,I0001-I0004页

作者： Mamtaz Sultana nazmul hasan Mamunur R.Mahib Mohammad M.Islam Department of Biochemistry and Molecular Biology University of ChittagongChittagong-4331Bangladesh

Objective:To identify the residue determinants of the serospecificity and sero-cross-reactivity of dengue virus(DENV)envelope protein domain 3(ED3),which contains two major putative epitopes of ***:We constructed ED3 from DENV3(3ED3)and DENV4(4ED3),and six epitope-grafted variants,where we transferred epitope 1(L304I,K305D,V309M,and S310A)and/or epitope 2(D383N,K384S,K387T,and N389H)of 4ED3 onto 3ED3 and *** albino mice aged 3-4 weeks were immunized against wildtype and epitope-grafted ED3 variants and anti-ED3 IgG antibody responses were determined using ***:Mouse immunization using 3ED3 and 4ED3 generated serotype-specific antisera,as ***,most epitope-grafted ED3s produced antisera serospecific to the template ED3 with little or no cross-recognition of ED3 of the serotype from which the epitopes were *** indicated that a mere grafting of the epitope was not sufficient to transfer serospecificity,contrary to our ***,one epitope-grafted ED3 mutant,where epitope 1 of 3ED3 was grafted onto 4ED3(4ED3^(epi1)),generated antisera that was serospecific to both 4ED3 and ***:The 4ED3^(epi1)is a chimeric ED3 that produces antisera possessing serospecificity to both 3ED3 and 4ED3 onto a common 4ED3 *** 4ED3^(epi1),therefore,provides a unique tool for analyzing serospecificity and sero-cross-reactivity in *** believe that chimeric ED3 may provide a template for future recombinant ED3 possessing serospecificity of multiple DENVs onto a single scaffold and may pave a way developing tri-and/or tetravalent anti-DENV antisera.

关键词： Dengue virus serospecificity Sero-cross-recognition Anti-ED3 antibodies Epitope-grafting Chimeric ED3

Effects of apical sodium-bile acid transporter inhibitor and obeticholic acid co-treatment in experimental non-alcoholic steatohepatitis

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Liver Research 2022年第4期6卷 276-283页

作者： David J.Matye Xuan Qin Mohammad nazmul hasan Lijie Gu Yung Dai Clayton Feng Li Tiangang Li Harold Hamm Diabetes Center Department of PhysiologyUniversity of Oklahoma Health Sciences CenterOklahoma CityOKUSA Department of Pathology and Immunology Baylor College of MedicineHoustonTXUSA NMR and Drug Metabolism Core Baylor College of MedicineHoustonTXUSA

Background and aims:Several bile acids-based monotherapies have been developed for non-alcoholic steatohepatitis(NASH)treatment but clinical trial findings suggest that they do not satisfactorily improve NASH and liver fibrosis in many ***,we have shown that combining a gut-restricted apical sodium-bile acid transporter(ASBT)inhibitor GSK2330672(GSK)with adeno-associated virus(AAV)-mediated liver fibroblast growth factor 15(FGF15)overexpression provides significantly improved efficacy than either single treatment against NASH and liver fibrosis in a high fat,cholesterol,and fructose(HFCFr)diet-induced NASH mouse *** beneficial effects of the com-bined treatment can be attributed to the markedly reduced bile acid pool that reduces liver bile acid burden and intestinal lipid *** aim of this study is to further investigate if combining GSK treatment with the orally bioavailable obeticholic acid(OCA),which induces endogenous FGF15 and inhibits hepatic bile acid synthesis,can achieve similar anti-NASH effect as the GSKþAAV-FGF15 co-treatment in HFCFr-diet-fed *** and methods:Male C57BL/6J mice were fed HFCFr diet to induce NASH and liver *** effect of GSK,OCA,and GSKþOCA treatments on NASH development was compared and contrasted among all ***:Findings from this study showed that the GSKþOCA co-treatment did not cause persistent reduction of obesity over a 12-week treatment *** single treatment nor the GSKþOCA co-treatment reduce hepatic steatosis,but all three treatments reduced hepatic inflammatory cytokines and fibrosis by a similar *** GSKþOCA co-treatment caused a higher degree of total bile acid pool reduction(~55%)than either GSK or OCA treatment ***,such bile acid pool reduction was insufficient to cause increased fecal lipid *** GSKþOCA co-treatment prevented GSK-mediated induction of hepatic cholesterol 7alpha-hydroxylase but failed to induce ileal FGF15 expression.

关键词： Bile acids Farnesoid X receptor(FXR) Fibroblast growth factor 15(FGF15) Apical sodium-bile acid transporter(ASBT) Non-alcoholic steatohepatitis(NASH) Liver fibrosis

Chemically and biologically activated biochars slow down urea hydrolysis and improve nitrogen use efficiency

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Pedosphere 2023年第4期33卷 659-669页

作者： nazmul H.ANTOR Shamim MIA Md.M.hasan Nowrose J.LIPI Keiji JINDO Miguel A.SANCHEZ-MONEDERO Md.H.RASHID Department of Agronomy Patuakhali Science and Technology UniversityDumkiPatuakhali 8602(Bangladesh) Agrosystems Research Groups Wageningen University and ResearchWageningen 6700 AA(The Netherlands) Department of Soil and Water Conservation and Organic Waste Management Spanish National Research Council(CEBAS-CSIC)Murcia 30100(Spain)

Biochar is considered a potential technology to enhance chemical fertilizer use efficiency through intensification of the interactions between nutrients and the functional groups on biochar ***,little is known about how the application of activated biochars mixed with urea influences nitrogen(N)mineralization and crop performance in paddy ***,a sawdust-derived fresh biochar(FBC)(ca.400℃)was activated chemically with 15%hydrogen peroxide and biologically with a nutrient solution mixed with a soil inoculum to obtain a chemically activated biochar(CBC)and a biologically activated biochar(BBC),*** chemical and surface properties of FBC,CBC,and BBC were evaluated using spectroscopic methods,i.e.,Fourier transform infrared spectroscopy and 13C nuclear magnetic resonance,and potentiometric charge *** N retention capacity of biochars and their interaction with urea hydrolysis were examined in a laboratory incubation ***,a field experiment was carried out in a paddy field with the biochars unmixed or mixed with urea at a 1:1 *** results showed that negative surface functional groups and negative charges were increased on both activated biochars,especially *** activated biochars contributed to a significant reduction in urea-biochar suspension pH and increased N retention in the incubation *** the enhanced surface properties of the activated biochars,no similar increases in rice biomass and grain yield were observed for these biochars in the field ***,rice biomass,grain yield,apparent N use efficiency,and agronomic N use efficiency were significantly higher with the application of the three biochars compared to no-biochar ***,the results indicate that the application of urea mixed with biochar could enhance crop performance,especially in the case of activated biochar,which would enhance N retention in the soil,reducing N loss.

关键词： chemical property crop yield functionalized biochar nitrogen uptake nutrient use efficiency pyrolysis

Potential probiotic and health fostering effect of host gut-derived Enterococcus faecalis on freshwater prawn,Macrobrachium rosenbergii

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Aquaculture and Fisheries 2022年第1期7卷 59-66页

作者： Sharmin Sultana Khushi Mohammad Saifuddin Sumon Mirja Kaizer Ahmmed Md nazmul hasan Zilani Fatema Ahmmed Stephen G.Giteru Md Golam Sarower Fisheries and Marine Resource Technology Discipline Khulna UniversityKhulna9208Bangladesh Department of Food Science University of OtagoDunedin9016New Zealand Department of Fishing and Post-harvest Technology Faculty of FisheriesChittagong Veterinary and Animal Sciences UniversityKhulshi4225Bangladesh Department of Pharmacy Jashore University of Science and TechnologyJashore7408Bangladesh Department of Chemistry University of OtagoDunedin9016New Zealand Food&Bio-based Products Group AgResearch LimitedPalmerston North4442New Zealand

The present study investigated the potential probiotic effect of Enterococcus faecalis against a pathogenic microorganism,Vibrio harveyi occurring in the giant freshwater prawn(Macrobrachium rosenbergii).*** was isolated from the intestine of *** through biochemical tests and PCR-based molecular *** in-vitro challenge was conducted by mixing isolated probiotic(5.12 log CFU/g)and ***(3.09 log CFU/g).Feeds incorporated with ***(9.02 log CFU/g)were applied to the treatment group during in vivo test in the aquarium and earthen pond(70 m^(2),1 m depth).Pathogenic bacteria were found to be reduced after 8 h(from 5.02 to 3.62 log CFU/g)and 60 days(from 5.44 to 2.15 log CFU/g)of probiotic administration in the in vitro and in vivo test,*** *** mixed feed also showed higher weight gain(WG%,481.22%±17.71%;SGR%,2.93%±0.18%)and digestive enzymes activities(amylase,1.26±0.08 unit/mg;protease,2.78±0.02 unit/mg)compared to control group(WG%,371.31%±13.35%;SGR%,2.30%±0.32%;amylase,0.7±0.03 unit/mg;protease,1.82±0.02 unit/mg).Furthermore,the probiotic also improved the immune response by augmenting NGH(from 73.33%±0.23%to 74.63%±0.11%)and SGH(from 22.24%±0.06%to 23.13%±0.08%)in the treatment ***,*** could be recommended to use against bacterial infections of the ***.

关键词： Antagonistic effect Biochemical PCR Digestive enzyme activity Immunity Feed

Position statement of Hepatology Society, Dhaka, Bangladesh, on the management of acute variceal bleeding in a resource-limited setting

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iLIVER 2022年第4期1卷 205-208页

作者： Tanvir Ahmad Shahinul Alam Saiful Islam Golam Azam Mahabubul Alam SKM nazmul hasan Golam Mustafa Motahar Hossain MdAkmat Ali Mobin Khan Kurmitola General Hospital DhakaBangladesh Department of Hepatology BSMMU General SecretaryHepatology SocietyDhakaBangladesh Department of Hepatology BSMMUBangladesh Department of Gastrointestinal-Hepatobiliary and Pancreatic Disorders(GHPD) BIRDEM HospitalBangladesh Department of Hepatology Shahid Syed Nazrul Islam Medical CollegeKishoregonjBangladesh Square Hospital Bangladesh Addin Medical College DhakaBangladesh

Variceal bleeding is one of the important signs of decompensation in patients with cirrhosis of the *** is always a medical emergency and sometimes results in *** year many patients die due to acute bleeding *** outcome depends on bleeding and its complications as well as the severity of the underlying liver *** volume resuscitation,administration of antibiotics and vasoactive drugs,and early endoscopic therapy prevent rebleeding and *** living in rural areas are first referred to a district hospital from the Upazila health complex for any medical ***,commencing the resuscitation process as well as administration of the vasoactive drug(terlipressin)at the first attending hospital before being referred to a higher center will decrease the mortality in patients presenting with acute variceal bleeding.

关键词： Variceal bleeding Resource-limited setting Terlipressin Cirrhosis Primary care physician

Performance Analysis of DEBT Routing Protocols for Pocket Switch Networks

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Computers, Materials & Continua 2021年第3期66卷 3075-3087页

作者： Khairol Amali bin Ahmad Mohammad nazmul hasan Md.Sharif Hossen Khaleel Ahmad Department of Electrical&Electronics Engineering National Defence University of MalaysiaMalaysia Department of Information and Communication Technology Comilla UniversityCumillaBangladesh Department of Computer Science&Information Technology Maulana Azad National Urdu UniversityIndia

Pocket Switched Networks(PSN)represent a particular remittent network for direct communication between the handheld mobile *** to traditional networks,there is no stable topology structure for PSN where the nodes observe the mobility model of human *** is a kind of Delay Tolerant Networks(DTNs)that gives a description to circulate information among the network nodes by the way of taking the benefit of transferring nodes from one area to *** its inception,there are several schemes for message routing in the infrastructure-less environment in which human mobility is only the best manner to exchange *** routing messages,PSN uses different techniques such asDistributed Expectation-Based Spatio-Temporal(DEBT)Epidemic(DEBTE),DEBT Cluster(DEBTC),and DEBT Tree(DEBTT).Understanding on how the network environment is affected for these routing strategies are the main motivation of this *** this paper,we have investigated the impact of network nodes,the message copies per transmission,and the overall carrying out of these routing *** simulator was used to analyze those techniques on the basis of delivery,overhead,and *** result of this task demonstrates that for a particular simulation setting,DEBTE is the best PSN routing technique among all,against DEBTC and DEBTT.

关键词： Pocket switched networks routings distributed cluster detections delay tolerant networks mobility in network

Traditional Use, Phytochemistry, Pharmacological and Toxicological Properties of Acanthus ilicifolius: A Review

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Journal of Biosciences and Medicines 2023年第5期11卷 181-192页

作者： Fatema Tuz Zohora A. H. M. nazmul hasan K. M. Khairul Alam Tania Binte Wahed Department of Pharmacy Faculty of Biological Sciences Jahangirnagar University Savar Dhaka Bangladesh Department of Pharmacy School of Medicine University of Asia Pacific Dhaka Bangladesh

The practice of plants for the deterrence and management of innumerable physiological states and diseases dates back to the history of humankind. Although many of today’s medicinal yields are achieved synthetically, they are often modelled on the chemical composition of medicinal plants. In this accordance, Acanthus genus (Family Acanthaceae) has acknowledged considerable attention due to its wide range of secondary metabolites and its customary usage in Indian and Chinese system of medicine. It is worth to mention that A. ilicifolius is enormously medicinal among all the species of Acanthus genus. This plant is considered to be rich sources of steroids, triterpenoids, saponins, flavonoids, alkaloids, and tannins. Traditionally, the plant has been used for asthma, diabetes, dyspepsia, hepatitis, leprosy, neuralgia, paralysis, ringworm, skin disease, snake bite, leukemia. Toxicological investigation in mice model has showed that, the ethanolic extract of the leaves of this plant have no toxic effect up to dose of 1000 mg/kg BW, 2000 mg/kg BW dose have mild toxicity and 5000 mg/kg BW dose have caused toxic effect in some organ system like liver, heart, pancreas, lung and kidney. Different extract of this plant also exhibited Anti-inflammatory, anti-leishmanial, osteoblastic, hepatoprotective, antioxidant and anticancer activities. This review article is an endeavor to cover current expansion in phytochemical and pharmacological potential of this plant species which will be a good reference tool for investigators who wish to work on natural products.

关键词： Acanthus Acanthaceae Acanthus ilicifolius Anti-Cancer Hepato-Protective Effect