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Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier

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Cellular & Molecular Immunology 2019年第2期16卷 178-194页

作者： Aisha nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic McMaster Immunology Research Centre Michael G.DeGroote Center for Learning and DiscoveryMcMaster UniversityHamiltonON L8S 4K1Canada Department of Pathology and Molecular Medicine McMaster UniversityHamiltonON L8S 4K1Canada Department of Medical Biology Laval UniversityQuebec CityQC G1V 0A6Canada

More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual *** cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted *** sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune ***,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and *** this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction *** innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβ***-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell *** induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T *** is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral *** could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis.

关键词： antiviral response genital epithelium HIV-1 IFN-β innate immunity IRF-3 mucosal barrier TLR2

角膜密度测定法及其与角膜前、后仰角的相关性（英文）

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国际眼科杂志 2018年第6期18卷 985-993页

作者： Mohammad Mirzaei nazli Taheri Hossein Akhlaghi Hesam Sadat Hashemi 大不里士大学医学院 Nikookari眼科医院眼科伊朗大不里士***

目的:评估在初治圆锥角膜患者中的角膜密度及其与前和后角膜仰角的相关性。方法:使用Pentacam检测圆锥角膜。角膜密度测量是通过直径12 mm的区域测量,分为环形同心区域和深度,测量更多的角膜前后仰角。根据地形圆锥角膜分类对圆锥角膜... 详细信息

目的:评估在初治圆锥角膜患者中的角膜密度及其与前和后角膜仰角的相关性。方法:使用Pentacam检测圆锥角膜。角膜密度测量是通过直径12 mm的区域测量,分为环形同心区域和深度,测量更多的角膜前后仰角。根据地形圆锥角膜分类对圆锥角膜进行分类。结果:研究包括152例患者[72例圆锥角膜患者(46例男性,26例女性)和80例健康对照受试者(50例男性,30例女性)]。两组间角膜2 mm中心处和角膜环状2～6mm直径处角膜密度测量值差异有统计学意义(K=16.40±2.18 GSU,N=15.31±1.25 GSU,P<0.0001)。当不同深度的密度测量值时,前部层呈现最高值,明显高于中央层和后层的值。当测量不同深度密度值时,前层呈现最高值(KC=23.69±3.71 GSU,N=20.91±2.52 GSU,P<0.0001),显著高于中央层和后层值(KC=14.34±1.70GSU,N=13.61±1.21 GSU,P=0.001;KC=11.40±1.23 GSU,N=12.35±0.88,P=0.002)。各层深度(前、中、后)角膜密度测量值与后角膜高度值的相关性分析显示两者显著相关(分别为r=0.293,r=0.278和r=0.294)。角膜光密度测定每层深度和角膜前角抬高之间没有发现类似的相关性(分别为r=-0.211,r=-0.101,r=0.99)。在对照组受试者中,未发现每层深度角膜前/后角膜高度和角膜后向散射的显著相关性。结论:光密度图显示前圆锥角膜中央区域的光后向散射较高。圆锥角膜患者的角膜光密度值与角膜0～2、6～10、10～12 mm环状区域前、中、后各层角膜高度相关。

关键词：角膜密度测定法光后向散射圆锥角膜 Scheimpflug成像

自体血清滴眼液对屈光性角膜切削术后角膜上皮愈合的影响（英文）

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国际眼科杂志 2019年第4期19卷 527-532页

作者： Ali Mostafaei Behzad Fallahi Motlagh nazli Taheri Siamak Nejatbakhsh 大不里士医科大医学研究中心眼科伊朗*** 大不里士医科大Nikoukari眼科医院伊朗***

目的:研究自体血清滴眼液对屈光性角膜切削术(PRK)后角膜上皮愈合的影响。方法:本研究共纳入20例40眼近视及近视散光患者,其中男性9例,女性11例。每例患者随机选取一眼作为研究组应用20%含自体血清的人工泪液,另一眼为对照组应用常规人... 详细信息

目的:研究自体血清滴眼液对屈光性角膜切削术(PRK)后角膜上皮愈合的影响。方法:本研究共纳入20例40眼近视及近视散光患者,其中男性9例,女性11例。每例患者随机选取一眼作为研究组应用20%含自体血清的人工泪液,另一眼为对照组应用常规人工泪液。PRK术中,40眼均于角膜表面居中放置直径8 mm的酒精储槽, 20%的酒精作用20s。术后每天观察直到角膜上皮愈合后,分别于1mo,6mo,12mo进行随访。上皮愈合时间为主要观察指标,并记录裸眼视力(UCVA),显然验光和混浊度。结果:两组间术前小瞳检影结果无明显差异。术后1d,2d,3d,研究组平均疼痛评分均显著低于对照组(P<0.05)。术后1d,3d,研究组的平均水平和垂直上皮缺损低于对照组(P<0.05)。研究组上皮完全愈合的平均时间比对照组短约0.7d(3.15±0.366d vs 3.85±0.587d,P=0.00)。结论:研究表明,应用自体血清滴眼液,通过加速角膜上皮愈合和减轻疼痛,从而缩短视力恢复时间,降低屈光性角膜切削术术后不适、混浊度和感染风险。

关键词：角膜自体血清屈光角膜切除术上皮愈合

Differential Cross Section of Electron Scattering From 3He and 3H Nuclei with Considering Pionic Contribution

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World Journal of Nuclear Science and Technology 2012年第4期2卷 150-153页

作者： nazli Hamdolahi Farhad Zolfagharpour Negin Sattary Nikkhoo Department of Physics University of Azad Tehran Markaz Tehran Iran Department of Physics University of Mohaghegh Ardabili Ardabil Iran

The excess pion inside the nucleus could change not only nucleons structure function, but also electron scattering cross section from nuclei. In this paper, we calculate pionic contribution in nuclear structure functions of 3He and 3H nuclei and the differential cross sections of electron scattering from these nuclei. At first, we calculate the Fermi motion and binding energy contribution as an important nuclear medium effect in scattering cross sections and then we add pionic contribution to structure functions and differential cross sections of electron scattering from these nuclei that the Fermi motion and binding energy are considered.

关键词： Pionic Contribution Structure Function Differential Cross Section

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近视人群中角膜生物力学特性的分布(英文)

国际眼科杂志 2014年第3期14卷 390-393页

作者： Mohammad Mirzaei nazli Taheri Hessam Mirzaei Amin Najafi Samira Mirzaei 大不里士医科大学 Nikookari眼科医院伊朗大不里士*** 大不里士大学工业工程系伊朗大不里士***

目的:分析伊朗近视眼及散光人群中角膜生物力学参数的分布特征。方法:对接受激光矫正手术的近视眼及散光患者180眼进行前后节、显然验光等效球镜度、Orbscan II和Zywave全面的术前检查。用眼反应分析仪测量角膜滞后量,角膜阻力因子,模拟... 详细信息

目的:分析伊朗近视眼及散光人群中角膜生物力学参数的分布特征。方法:对接受激光矫正手术的近视眼及散光患者180眼进行前后节、显然验光等效球镜度、Orbscan II和Zywave全面的术前检查。用眼反应分析仪测量角膜滞后量,角膜阻力因子,模拟Goldmann眼压值及角膜补偿后眼压值。分析所有角膜生物力学的分布特性及其与显然验光等效球镜度、性别和年龄的相关性。数据采用SPSS 17软件进行统计学分析,以P<0.05为有显著性差异。结果:平均年龄为28.20±6.78岁。平均显然验光等效球镜为-4.21±1.19D。平均角膜滞后量,角膜阻力因子,模拟Goldmann眼压值和角膜补偿后眼压值分别为10.00±1.28mmHg,10.17±1.45mmHg,15.71±2.67mmHg和16.68±2.41mmHg。近视人群中,28.4%角膜滞后量约为10mmHg,71%从9mmHg增长到11mmHg。25.9%的近视人群的角膜阻力因子为10mmHg,48.7%为9mmHg增长到11mmHg。显然验光等效球镜与角膜滞后量(Rs=0.001,P=0.71)和显然验光等效球镜与角膜阻力因子(Rs=0.01,P=0.18)之间正相关性不明显。结论:研究显示了伊朗近视眼人群中角膜生物力学的分布特征(角膜滞后量,角膜阻力因子,模拟Goldmann眼压值及角膜补偿后眼压值),并证实了角膜生物力学特性参数和显然验光等效球镜,年龄及性别之间没有统计学相关性。

关键词：角膜生物力学特性角膜滞后量角膜阻力因子近视

Diffusion-weighted and diffusion-tensor imaging of normal and diseased uterus

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World Journal of Radiology 2015年第7期7卷 149-156页

作者： Duygu Kara Bozkurt Murat Bozkurt Mehmet Ali nazli Ilhan Nahit Mutlu Ozgur Kilickesmez Depatment of Radiology School of Medicine Kafkas University Depatment of Obstetrics and Gynecology School of Medicine Kafkas University Department of Diagnostic and Interventional Radiology Istanbul Training and Research Hospital

Owing to technical advances and improvement of the software, diffusion weighted imaging and diffusion tensor imaging(DWI and DTI) greatly improved the diagnostic value of magnetic resonance imaging(MRI) of the pelvic region. These imaging sequences can exhibit important tissue contrast on the basis of random diffusion(Brownian motion) of water molecules in tissues. Quantitative measurements can be done with DWI and DTI by apparent diffusion coefficient(ADC) and fractional anisotropy(FA) values respectively. ADC and FA values may be changed by various physiological and pathological conditions providing additional information to conventional MRI. The quantitative DWI assists significantly in the differentiation of benign and malignant lesions. It can demonstrate the microstructural architecture and celluler density of the normal and diseased uterine zones. On the other hand, DWI and DTI are useful for monitoring the treatment outcome of the uterine lesions. In this review, we discussed advantages of DWI and DTI of the normal and diseased uterus.

关键词： Magnetic resonance imaging Diffusion weighted imaging Diffusion tensor imaging Uterus

TL Glow Curve Study, Kinetics, PL and XRD Analysis of Mn2+Doped CaAl2O4Phosphors

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Journal of Minerals and Materials Characterization and Engineering 2012年第11期11卷 1081-1084页

作者： Jagjeet Kaur Nemana Subramanyam Suryanarayana Beena Jaykumar Vikas Dubey Ravi Shrivastava Huma nazli Baig Department of Physics Vishwanath Yadav Tamaskar Post Graduate Autonomous College Durg India

The present paper reports Thermoluminescence (TL) Glow curve of Mn2+ doped CaAl2O4 phosphor with different UV exposure time. The Glow peak shows general order kinetics and evaluation of kinetic parameters was done by peak shape method. Calculations of Trap Depth were done with Chen’s different methods and order of kinetics, activation energy and frequency factor are calculated. The recorded glow curve shifts towards higher temperature with increasing intensity as a function of UV exposure time until 30 minutes where it is seen that the peak shifts towards low temperature side and intensity also decreases. The peaks were found at 345?C, 356.83?C, 358?C and 356.73?C respectively using the heating rate 6.7?C/s. The PL (photoluminescence) excitation spectra show peaks at 248 nm and 362 nm whereas emission spectra shows peaks between 364 nm and 551 nm. Sample was characterized by XRD technique.

关键词： Phosphors Photoluminescence Thermoluminescence Kinetic Parameters Trap Depth

Modeling Environmental Susceptibility of Municipal Solid Waste Disposal Sites: A Case Study in São Paulo State, Brazil

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Journal of Geographic Information System 2017年第1期9卷 8-33页

作者： Victor Fernandez Nascimento Anahi Chimini Sobral Pedro R. Andrade Jean Pierre Henry Balbaud Ometto nazli Yesiller Earth System Science Center (CCST) National Institute for Space Research (INPE) Sao José dos Campos Brazil Global Waste Research Institute (GWRI) California Polytechnic State University (Cal Poly) San Luis Obispo USA

The large excess of solid waste generated in cities is a result of population growth and economic development. Properly managing this municipal solid waste (MSW) is a challenge, mainly in underdeveloped and developing countries where financial concerns are an added problem. From the environmental point of view, a major issue is properly disposing MSW taking into consideration a wide range of factors, and working with different spatial data. In this study, we used geographic information system (GIS) to perform multi-criteria decision analysis (MCDA) conducted by analytical hierarchy process (AHP). The development of the environmental impact susceptibility model (EISM) for municipal solid waste disposal sites (MSWDS) applied to the state of Sao Paulo, Brazil considered factors such as geology, pedology, geomorphology, water resources, and climate represented by fifteen associated sub-factors. The results indicated that more than 82% of Sao Paulo’s territory is situated in areas with very low, low, and medium environmental impact susceptibility categories. However, in the remaining 18% of the state land area, 85 landfills are located in areas with high and very high environmental impact susceptibility categories. These results are alarming because these 85 landfills receive approximately 17,886 tons of MSW on a daily basis, which corresponds to 46% of all municipal solid waste disposed in Sao Paulo state. Therefore, decision makers, urban planners and policymakers could use the findings of the EISM towards mitigating the environmental impacts caused by MSWDS.

关键词： Modeling Geographic Information System (GIS) Environmental Impact Municipal Solid Waste Landfills Multi-Criteria Decision Analysis (MCDA) Analytic Hierarchy Process (AHP)

角膜胶原蛋白交联疗法对人工晶状体大泡性角膜病变的作用(英文)

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国际眼科杂志 2014年第5期14卷 785-789页

作者： Mohammad Mirzaei nazli Taheri Mohammad Bagher Rahbani Nobar Afshin Lotfi Sedigh Amin Najafi Samira Mirzaei 大不里士医科大学 Nikookari眼科医院眼科伊朗东阿塞拜疆*** 大不里士医科大学 Alavi眼科医院眼科伊朗东阿塞拜疆*** 大不里士医科大学医学院伊朗东阿塞拜疆***

目的:研究核黄素和紫外线(UVA)交联疗法对晚期大泡性角膜病的疗效。方法:15例人工晶状体大泡性角膜病变(PBK)患者参与研究。分别于角膜交联前和干预后1,6mo,对患者行裂隙灯检查、视敏度、异物调查表、角膜透明度分级、眼部疼痛度范围、... 详细信息

目的:研究核黄素和紫外线(UVA)交联疗法对晚期大泡性角膜病的疗效。方法:15例人工晶状体大泡性角膜病变(PBK)患者参与研究。分别于角膜交联前和干预后1,6mo,对患者行裂隙灯检查、视敏度、异物调查表、角膜透明度分级、眼部疼痛度范围、分析仪角膜厚度分析及超声波角膜厚度测量。氯化钠溶液处理1wk后,去除8mm直径范围的中央角膜上皮,在角膜上频繁点滴核黄素30min,后行3min紫外线(UVA)照射交联疗法。结果:15例患者(5男,10女),平均年龄为66±13岁。平均随访时间6.2mo。治疗后1mo全眼角膜透明度统计结果明显优于术前(P<0.05)。6mo时8眼角膜透明度较术前更佳,5眼持平,2眼低于术前(P=0.218)。70%病患异物感减弱。处理后1mo平均中央角膜厚度(CCT)减少(P<0.05)。6mo时,除3眼外均出现渐进性肿胀,但统计显示CCT明显薄于术前(P=0.006)。统计显示术后1mo平均矫正远视力(CDVA)明显优于术前(P=0.010)。6mo后无显著差异(P=0.130)。1mo痛值统计结果明显优于术前(P=0.007)。但6mo平均痛值较1mo高,较术前无明显差异(P=0.070)。结论:术后1mo结果显示角膜胶原交联疗法可显著改善角膜透明度、角膜厚度和眼痛。但是,它对减少PBK患者疼痛和维持角膜透明度方面似乎并无长期持久的效果。这种方法延长了角膜移植的时间间隔,并提高了角膜内皮移植术(DSAEK)过程的可视化。

关键词：大泡性角膜病变角膜胶原交联角膜水肿测厚仪