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Enhancing pharmaceutical potential and oral bioavailability of Allium cepa nanosuspension in male albino rats using response surface methodology

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Asian Pacific Journal of Tropical Biomedicine 2022年第1期12卷 26-38页

作者： Fatiqa Zafar nazish jahan Shaukat Ali Saba Jamil Riaz Hussain Saba Aslam Department of Chemistry University of SahiwalSahiwalPakistan Department of Chemistry University of AgricultureFaisalabadPakistan Department of Chemistry University of OkaraOkaraPakistan Govt.Graduate College for Women Sargodha RoadFaisalabadPakistan

Objective:To enhance the pharmaceutical potential and oral bioavailability of quercetin contents of Allium cepa peel extract by novel nanosuspension ***:Nanoprecipitation approach was successfully used for the formulation of *** obtain pharmaceutical-grade nanosuspension with minimum particle size and polydispersity index,sodium lauryl sulphate was selected as a *** formulation parameters were statistically optimized by the response surface methodology *** optimized nanosuspension was subjected to stability and in vitro dissolution testing and characterized by scanning electron microscopy,atomic force microscopy,Fourier transform infrared spectroscopy,and zeta *** evaluate the preeminence of nanosuspension over coarse suspension,comparative bioavailability studies were carried out in male albino *** pharmaceutical potential of developed nanosuspension was evaluated by antioxidant,antimicrobial,and toxicity ***:The optimized nanosuspension showed an average particle size of 275.5 nm with a polydispersity index and zeta potential value of 0.415 and−48.8 mV,*** force microscopy revealed that the average particle size of nanosuspension was below 100 *** formulated nanosuspension showed better stability under refrigerated *** showed an improved dissolution rate and a 2.14-fold greater plasma concentration of quercetin than coarse ***,the formulated nanosuspension exhibited enhanced antioxidant and antimicrobial potential and was ***:Optimization of nanosuspension effectively improves the pharmaceutical potential and oral bioavailability of Allium cepa extract.

关键词： Allium cepa Nanoprecipitation Pharmaceutical potential Particle size Polydispersity index Stability Toxicity Quercetin

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Nanosuspension enhances dissolution rate and oral bioavailability of Terminalia arjuna bark extract in vivo and in vitro

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Asian Pacific Journal of Tropical Biomedicine 2020年第4期10卷 164-171页

作者： Fatiqa Zafar nazish jahan Khalil-Ur-Rahman Muhammad Rafique Asi Waseeq-Ul-Islam Zafar Department of Chemistry University of OkaraOkaraPakistan Department of Chemistry University of AgricultureFaisalabadPakistan Department of Biochemistry University of AgricultureFaisalabadPakistan Food Toxicology Lab Plant Protection DivisionNuclear Institute for Agriculture and BiologyFaisalabadPakistan Department of Computer Science COMSATS University of Information and TechnologyIslamabadPakistan

Objective:To enhance the dissolution rate and oral bioavailability of Terminalia arjuna bark extract by formulating its ***:Nanoprecipitation approach was used for the formulation of nanosuspension using polysorbate-80 as a *** formulated nanosuspension was assessed for particle size,polydispersity index,zeta potential value and for in vitro dissolution *** bioavailability studies were carried out in Wistar male albino rats by administering a single dose(50 mg/***)of the formulated nanosuspension and coarse *** storage stability of the formulated nanosuspension was determined after three months of storage at room temperature and under the refrigerated *** assay was carried out to evaluate the toxicity of the formulated nanosuspension using two mutant strains(Salmonella typhimurium TA100 and Salmonella typhimurium TA98).Results:The mean particle size of the formulated nanosuspension was 90.53 nm with polydispersity index and zeta potential values of 0.175 and-15.7 m V,*** arjuna nanosuspension showed improved dissolution rate and 1.33-fold higher oral bioavailability than its coarse *** formulated nanosuspension also showed better stability under the refrigerated condition and was non-mutagenic against both ***:Our study demonstrates that nanosuspension technology can effectively enhance the dissolution rate and oral bioavailability of Terminalia arjuna bark extract.

关键词： Terminalia arjuna Nanosuspension Bioavailability Stability Toxicity Polysorbate-80

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