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Wave Spectral Patterns during a Historical Cyclone: A Numerical Model for Cyclone Gonu in the Northern Oman Sea

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Open Journal of Fluid Dynamics 2017年第2期7卷 131-151页

作者： Mohammad Nabi Allahdadi nazanin Chaichitehrani Mohammadreza Allahyar Laura McGee North Carolina State University Department of Marine Earth and Atmospheric Sciences Raleigh North Carolina USA Louisiana State University Department of Oceanography and Coastal Sciences Baton Rouge Louisiana USA Iranian Ports and Maritime Organization Tehran Iran

The third generation wind-wave model Mike21-SW was used to study spectral characteristics of waves generated by the historical Cyclone Gonu in June 2007 along and off the Iranian coasts on the northern Oman Sea. The model was forced with the cyclone wind field generated using a Holland (1980) model based on cyclone data obtained from the Joint Typhon Warning Center (JTWC). The wave model was calibrated for the northern Oman Sea using bulk and spectral wave data at a station out of the Chabahar Bay. Evolution of directional-frequency spectra during the cyclone was investigated for two locations near the entrance and off the Chabahar Bay. At the offshore station, energy was contributed to the spectrum over an approximately 180 degree directional span that included different local and remotely generated waves. As the cyclone proceeded northwestward, all spectral directions continuously rotated in the clockwise direction at both locations. Frequency spectra at these locations were investigated for four different times corresponding to different locations of Cyclone’s eye and were justified using the sea growth parameter of the Joint North Sea Wave Project (JONSWAP) experiment. Using the modified JONSWAP parameters for hurricane conditions resulted in a frequency spectrum consistent with simulation results.

关键词： Cyclone Gonu Oman Sea Chabahar Bay Wave Modeling Wave Spectrum JONSWAP

Does perioperative prostaglandin E1 affect survival of patients with esophageal cancer?

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World Journal of Gastrointestinal Surgery 2012年第12期4卷 284-288页

作者： Fahimeh Farrokhnia Jalil Makarem Habibollah Mahmoodzadeh nazanin Andalib Department of Anesthesiology the Cancer Institute Imam Khomeini Medical Center Tehran University of Medical Sciences Tehran 15614 Iran Department of Anesthesiology and Intensive Care Imam Khomeini Medical Center Tehran University of Medical Sciences Tehran 15614 Iran Department of Surgery the Cancer Institute Imam Khomeini Medical Center Tehran University of Medical Sciences Tehran 15614 Iran School of Biology Campus of Science University of Tehran Tehran Iran

AIM: To detect the effect of intraoperative prostaglandin E1 (PGE1) infusion on survival of esophagectomized patients due to cancer. METHODS: In this preliminary study, a double blinded placebo based clinical trial was performed. Thirty patients with esophageal cancer scheduled for esophagectomy via the transthoracic approach were randomized by a block randomization method, in two equal groups: PGE1 group - infusion of PGE1 (20 ng/kg per minute) in the operating room and placebo group - saline 0.9% with the same volume and rate. The infusion began before induction of anesthesia and finished just before transfer to the intensive care unit. The patients, anesthetist, intensive care physicians, nurses and surgeons were blinded to both study groups. All the patients were anesthetized with the same method. For postoperative pain control, a thoracic epidural catheter was placed for all patients before induction of anesthesia. We followed up the patients until October 2010. Basic characteristics, duration of anesthesia, total surgery and thoracotomy time, preoperative hemoglobin, length of tumor, grade of histological differentiation, disease stage, number of lymph nodes in the resected mass, number of readmissions to hospital, total duration of readmission and survival rates were compared between the two groups. Some of the data originates from the historical data reported in our previous study. We report them for better realization of the follow up results. RESULTS: The patients’ characteristics and perioperative variables were compared between the two groups. There were no significant differences in age (P = 0.48), gender (P = 0.27), body mass index (P = 0.77), American Society of Anesthesiologists physical status more than?I?(P = 0.71), and smoking (P = 0.65). The PGE1 and placebo group were comparable in the following variables: duration of anesthesia (277 ± 50 vs 270 ± 67, P = 0.86), duration of thoracotomy (89 ± 35 vs 96 ± 19, P = 0.46), duration of operation (234 ±

关键词： Prostaglandin E1 Esophagectomy Cancer Survival Surgery

An Efficient Reaction Process for the Synthesis of Oxazinanes, and Oxazolidines in the Presence of Air

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International Journal of Organic Chemistry 2012年第4期2卷 362-365页

作者： Mohammad Al-Masum Baillie W. Lott nazanin Ghazialsharif Department of Chemistry Tennessee State University Nashville USA

After purging air through the mixture of aldehydes and amino alcohols and microwaved the reaction mixture at 50°C for minutes gave the corresponding oxazinanes, and oxazolidines in excellent yields.

关键词： Air Oxazinanes Oxazolidines Microwave

Mammalian target of rapamycin;novel insight for management of inflammatory bowel diseases

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World Journal of Pharmacology 2022年第1期11卷 1-5页

作者： Naser-Aldin Lashgari nazanin Momeni Roudsari Saeideh Momtaz Amir Hossein Abdolghaffari Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehran ***Iran Department of Pharmacology Medicinal Plants Research CenterInstitute of Medicinal PlantsACECRKaraj ***Iran Toxicology and Diseases Group(TDG) Pharmaceutical Sciences Research Center(PSRC)The Institute of Pharmaceutical Sciences(TIPS)Tehran University of Medical SciencesTehran ***Iran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran Gastrointestinal Pharmacology Interest Group(GPIG) Universal Scientific Education and Research Network(USERN)Tehran ***Iran

Inflammatory bowel diseases(IBDs),with blurred etiology,show a rising trend and are of global *** various factors involved in IBD pathogenesis and development,inflammation has been shown to play a major *** of the molecular and cellular pathways that induce IBD is an emerging subject to develop targeted *** target of rapamycin(mTOR)is one the most common receptors of many inflammatory pathways,including that of *** this end,we intend to overview the mTOR inhibitors for their possible efficacy in present and future approaches to treatment of IBD.

关键词： Inflammatory bowel diseases Inflammation Mammalian target of rapamycin Mammalian target of rapamycin inhibitors

New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression

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World Journal of Gastroenterology 2015年第21期21卷 6526-6542页

作者： Kathy Saraiva-Pava nazanin Navabi Emma C Skoog Sara K Lindén Mónica Oleastro Mónica Roxo-Rosa Faculdade de Engenharia Universidade Católica PortuguesaCampus de Sintra2635-631 Rio de MouroPortugal Department of Medical Biochemistry and Cell Biology Institute of BiomedicineUniversity of Gothenburg Departamento de Doen?as Infeciosas Instituto Nacional Saúde Dr.Ricardo Jorge1649-016 LisboaPortugal Chronic Diseases Research Center CEDOCNova Medical SchoolCampo Mártires da Pátria1169-056 LisboaPortugal

AIM:To establish a cellular model correctly mimicking the gastric epithelium to overcome the limitation in the study of Helicobacter pylori(***) ***:Aiming to overcome this limitation,clones of the heterogenic cancer-derived NCI-N87 cell line were isolated,by stably-transducing it with the human telomerase reverse-transcriptase(h TERT) catalytic subunit *** clones were first characterized regarding their cell growth pattern and *** that we measured the clones' adherence properties,expression of cell-cell junctions' markers(ZO-1 and E-cadherin) and ability to generate a sustained transepithelial electrical *** gastric properties of the clones,concerning expression of mucins,zymogens and glycan contents,were then evaluated by haematoxylin and eosin staining,Periodic acid Schiff(PAS) and PAS/Alcian Blue-staining,immunocytochemistry and Western *** addition,we assessed the usefulness of the h TERT-expressing gastric cell line for *** research,by performing co-culture assays and measuring the IL-8 secretion,by ELISA,upon infection with two *** strains differing in ***:Compared with the parental cell line,themost promising NCI-hT ERT-derived clones(CL5 and CL6) were composed of cells with homogenous phenotype,presented higher relative telomerase activities,better adhesion properties,ability to be maintained in culture for longer periods after confluency,and were more efficient in PAS-reactive mucins *** clones were shown to produce high amounts of MUC1,MUC2 and ***-hT ERT-CL5 mucins were shown to be decorated with blood group H type 2(BG-H),Lewis-x(Lex),Ley and Lea and,in a less extent,with BG-A antigens,but the former two antigens were not detected in the NCI-h *** of the clones exhibited detectable levels of MUC6 nor sialylated Lex and Lea *** good gastric properties,both NCIhT ERT-clones were found to produce pepsinogen-5 and human gastric *** progen

关键词： Helicobacter pylori infection Pathogenesis Human gastric epithelium Cellular model NCI-N87cells

Numerical Modeling of Explosive Loading on Strong Rock Mass with Discontinuity System in Depth 25 m

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Open Journal of Geology 2016年第3期6卷 117-130页

作者： Nabi Nakhaei Mohsen Jami Homan Najafizade Farhad Jahani Adimi Seyed Hossein Mirzeinaly Yazdi Mohsen Pourkermani nazanin Sarhadi Department of Geology Zahedan Branch Islamic Azad University Zahedan Iran

Effect of Explosion on underground structures where drilled on the stony materials can be affected by explosive strength and rock mass properties of tunnel. In this paper, it has been studied on effect of explosion of 10 tons TNT on the round tunnel (diameter: 10 m) in 25 m depth in the mass rocks (RMR > 90) to estimate stability of tunnel to construct underground structure. Regarding to the studied stones, geo-mechanical indices of rock mass have been found to use as strength criteria in UDEC. In the next step, tunnel in real dimensions and founded indices is modeled with UDEC and analyzed stably. Explosion wave indices are found by UFC Instruction and other experimental relations to administer force from explosion wave on the model. Finally, on the base of FISH, indices of explosion wave are administrated in UDEC and tunnel is analyzed dynamically. According to modeling in depth of 25 m, amount of displacement of drilled tunnel in mass rocks (RMR < 90) is very lower than standard criterion and the tunnel is very stable. Development of plastic zone, vertical and horizontal displacement of rock mass around the tunnel, speed variations and stress from explosion wave are modeled and recorded as the graphs and figures.

关键词： Underground Structure Plastic Zone Round Tunnel UDEC Software UFC Instruction

The efficacy of a first aid training course for drivers： an experience from northern Iran

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Chinese Journal of Traumatology 2014年第5期17卷 289-292页

作者： Mohammad Ali Vakili Ali Mohjervatan Seyed Taghi Heydari Armin Akbarzadeh nazanin Sadat Hosini Farideh Alizad Peyman Arasteh Mohammad Javad Moghasemi Health Management and Social Development Research Center Golestan University of Medical Sciences Gorgan Iran Researcher Center for Disaster Management and Emergency Medicine Golestan University of Medical Sciences Gorgan Iran Research Center for Social Determinants of Health Jahrom University of Medical Sciences Jahrom Iran Student Research Committee Shiraz University of Medical Sciences Shiraz Iran

Objective：To evaluate the efficacy of a first aid training course for a group of ***：This study comprised 500 drivers,randomly selected from the road transport *** underwent a course of first aid training and the results were evaluated at 0-3 and 4-6 months after ***：Both quantitative and qualitative improvements were observed in the drivers＇ efficacy in giving first *** the rate of correct interventions was higher at 4-6 months than at 0-3 *** exception was airway management which was not favorably improved after ***：The first aid training course for drivers is beneficial and helpful for prehospital care system in road traffic accidents.

关键词： Drive First aid training Iran

Angioid Streaks in Psuedoxanthoma Elasticum

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Open Journal of Ophthalmology 2017年第1期7卷 57-63页

作者： Mehrdad Mohammadpour nazanin Ebrahimiadib Seyed Ali Tabatabaei Mohammad Soleimani Shima Dehghani Fatemeh Abdi Ghasem Saeedi Anari Amir Hasan Matini Mahyar Noorbakhsh Zahra Ghomi Eye Research Center Farabi Eye Hospital Tehran University of Medical Sciences Tehran Iran Shahid Beheshti Hospital Kashan University of Medical Sciences Kashan Iran

Pseudoxanthoma elasticum (PXE) is a hereditary disorder that affects primarily the elastic tissues of skin, eyes and blood vessels. Its estimated prevalence is thought to be 1:25,000 - 100,000. PXE patients also carry an increased risk for cardiovascular and gastrointestinal diseases. Early diagnosis can play a crucial role in preventing early loss of vision and systemic complications in these patients however despite having characteristic clinical features;it is still to a large extent being under-diagnosed. Here we present two cases of PXE with reduced vision.

关键词： Pseudoxanthoma Elasticum (PXE) Angioid Streaks Drusen

Mortality and Morbidity among COVID-19-Associated Mucormycosis Patients in Iran: A Prospective Cohort Study

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Advances in Infectious Diseases 2023年第3期13卷 407-423页

作者： Somayeh Dolatabadi Mehdi Bakhshaee Masoumeh Hosseinpoor Ali Alizadeh Noghani Mohammadreza Afzalzadeh Imaneh Roshanzamir Bashir Rasoulian Zahra Eslami Mohammadie Alireza Ghodsi nazanin Forghani Parisa Arjmand Zahra Valipour Nima Ameli Department of Biology Hakim Sabzevari University Sabzevar Iran Sinus and Surgical Endoscopic Research Center Mashhad University of Medical Sciences Mashhad Iran Student Research Committee Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Student Research Committee Faculty of Paramedical Sciences Mashhad University of Medical Sciences Mashhad Iran Department of Otolaryngology Mashhad University of Medical Sciences Mashhad Iran

Background: The key contribution of this paper is from investigating the mortality and morbidity rates and related factors associated with COVID-19-associated-mucormycosis among Iranian patients. The existing literature is scarce on this topic, particularly in the context of Iran. The present study investigates mortality and morbidity among 62 confirmed COVID-19-associated-mucormycosis Iranian patients in relation to their demographic characteristics, laboratory test results, predisposing factors, and COVID-related factors. Material and Methods: In this prospective cohort study, the patients were identified in the fifth wave of the disease, between 1st August and 15th October 2021, with data collected at baseline with a three-week follow-up. This was a multicenter investigation with patients admitted to two clinics in Iran. 62 participants were admitted, with the key criteria of them being COVID-19-associated-mucormycosis patients. 53 out of 60 patients underwent corticosteroid therapy and debridement surgery. Intravenous remdesivir (200 mg/ kg/day at day 1, 100 mg/kg/day in following days for up to 5 days) and corticosteroids were administered for 53 out 54 patients. Oxygen therapy was only needed for 30% (n = 19) of the patients. Results: A 40% mortality rate was observed within the three-week follow-up, with deaths concentrated among those with controlled diabetes mellitus (61%) and long-term diabetes mellitus patients (an average of eight versus four years). Higher mortality was also observed in patients with higher leucocytes and those with rhino-orbital-cerebral (59%), followed by nasal (55.6%) mucormycosis. Among survivors, 32% were reinfected, and 56% suffered from loss of vision. Conclusion: The study concludes that mucormycosis is associated with a higher mortality rate among COVID-19 patients with diabetes mellitus, particularly corticosteroid recipients. Thus, urgent attention to this coinfection is warranted in Iran.

关键词： Mucorales COVID-19 Mucormycosis Coinfection Dexamethasone Diabetes Mellitus