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PNAS:科学家或成功实现利用基因疗法来治疗阿尔兹海默氏症

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现代生物医学进展 2017年第4期17卷 I0001-I0002页

作者： Loukia Katsouri[a] Yau M. Lim[a] Katrin Blondrath[a] Ioanna Eleftheriadou[b] Laura Lombardero[a] Amy M. Birch[a] nazanin mirzaei[a] Elaine E. Irvine[c] Nicholas D. Mazarakis[b], Magdalena Sastre[a], [a]Division of Brain Sciences Imperial College London London W12 0NN United Kingdom [b]Gene Therapy Division of Brain Sciences Imperial College London London W12 0NN United Kingdom [c]Institute for Clinical Sciences Medical Research Council Clinical Sciences Centre London W12 0NN United Kingdom

日前,来自帝国理工学院的研究人员通过利用病毒将特殊的基因片段运输到小鼠大脑中，从而成功抑制小鼠患阿尔兹海默氏症，相关研究刊登于国际杂志PNAS上，该研究或为后期开发治疗诸如阿尔兹海默氏症等神经性疾病的新型疗法提供思路。

关键词：基因疗法治疗利用科学家神经性疾病基因片段研究人员后期开发

A New Formulation of the Scaled Boundary Finite Element Method for Heterogeneous Media:Application to Heat Transfer Problems

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Acta Mechanica Solida Sinica 2024年第2期37卷 285-296页

作者： Nima Noormohammadi nazanin Pirhaji Khouzani Department of Civil Engineering Isfahan University of TechnologyIsfahan84156-83111Iran

The solution to heat transfer problems in two-dimensional heterogeneous media is attended based on the scaled boundary finite element method(SBFEM)coupled with equilibrated basis functions(EqBFs).The SBFEM reduces the model order by scaling the boundary solution onto the inner *** this end,tri-lateral elements are emanated from a scaling center,followed by the development of a semi-analytical solution along the radial direction and a finite element solution along the circumferential/boundary *** discretization is thus limited to the boundaries of the model,and the semi-analytical radial solution is found through the solution of an eigenvalue problem,which restricts the methods’applicability to heterogeneous *** this research,we first extracted the SBFEM formulation considering the heterogeneity of the ***,we replaced the semi-analytical radial solution with the EqBFs and removed the eigenvalue solution step from the *** varying coefficients of the partial differential equation(PDE)resulting from the heterogeneity of the media are replaced by a finite series in the radial and circumferential directions of the element.A weighted residual approach is applied to the radial *** equilibrated radial solution series is used in the new formulation of the SBFEM.

关键词： Scaled boundary finite element method Equilibrated basis functions Heat transfer

Pregnancy complications and outcomes in women with epilepsy

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Open Journal of Obstetrics and Gynecology 2012年第3期2卷 230-234页

作者： mirzaei Fatemeh Ebrahimi B. nazanin Department of Obstetrics and Gynaecology Afzalipour Hospital Kerman University of Medical Sciences Kerman Iran Physiology Research Center Department of Obstetrics and Gynaecology Afzalipour Hospital Kerman University of Medical Sciences Kerman Iran

Epilepsy is the most common serious neurological disorder. This is prospective study to investigate whether women with epilepsy have an increased risk of fetal and maternal complications during pregnancy. In this descriptive cross-sectional study, 50 pregnant women who were presented for delivery at Afzalipour Hospital, Kerman, Iran during 2003 to 2009 were assessed. The groups were compared using the Student’s t-test, and one-way-ANOVA for continuous variables and the chisquare test (or Fisher’s exact test if required) for categorical variables. P values of 0.05 or less were considered statistically significant. All the statistical analyses were performed using SPSS version 13 (SPSS Inc, Chicago, IL, USA) for *** 32 (64%) of cases no fetal complication was found, in 5 cases (10.0%) intrauterine growth retardation (IUGR), in 2 cases (4.0%) post-term labor, in 2 cases (4.0%) fetal distress and in 9 cases (18.0%) preterm labor were found. In 15 patients (30.0%) no maternal complication was found;in 2 cases (4.0%) pregnancy induced hypertension (PIH), in 12 cases (24.0%) preterm labor , in 4 cases (8.0%) bleeding, in 14 cases (28.0%) premature rupture of the membranes (PROM) and in 3 cases (6.0%) other complications were detected. Given these findings and previous studies, it seems that epileptic women required more care during pregnancy and the rate of maternal, fetal and obstetrical complications are relatively high among them.

关键词： Epilepsy Maternal Complications Fetal Complications

Windcatchers and their applications in contemporary architecture

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Energy and Built Environment 2022年第1期3卷 56-72页

作者： Parham Kheirkhah Sangdeh nazanin Nasrollahi Engineering Faculty Architecture DepartmentIlam UniversityIlamIran

Natural ventilation and cooling have played an essential role in providing comfort *** are passive cooling systems and one of the most familiar elements in Iranian *** can significantly influence on reduce cooling loads and supply the necessary ventilation rate of *** paper aims at providing an in-depth review of the recent developments and applications of windcatchers in modern *** efficiency of windcatcher is also discussed according to the windcatcher’s relevant parameters,i.e.,height,configuration,and *** comprehensive review reveals that these factors have significant impacts on the performance of *** is also shown that a one-sided windcatcher is a better choice in regions with privileged wind ***,other types of it are better in regions with variable wind ***,windcatchers’potential for applying in the contemporary architecture and urban planning shown in the using windcatcher in contemporary buildings,windcatchers in the urban context,new designs,and new technologies of windcatchers sections.

关键词： Windcatcher Wind tower Badgir Natural ventilation Passive cooling CFD

An insight into the role of the association equations of states in gas hydrate modeling:a review

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Petroleum Science 2020年第5期17卷 1432-1450页

作者： Feridun Esmaeilzadeh nazanin Hamedi Dornaz Karimipourfard Ali Rasoolzadeh Department of Chemical Engineering School of Chemical and Petroleum EngineeringShiraz UniversityShiraz 71345Iran

Encouraged by the wide spectrum of novel applications of gas hydrates,e.g.,energy recovery,gas separation,gas storage,gas transportation,water desalination,and hydrogen hydrate as a green energy resource,as well as CO2 capturing,many scientists have focused their attention on investigating this important *** course,from an engineering viewpoint,the mathematical modeling of gas hydrates is of paramount importance,as anticipation of gas hydrate stability conditions is effective in the design and control of industrial ***,the thermodynamic modeling of gas hydrate can be tackled as an equilibration of three phases,i.e.,liquid,gas,and solid *** inseparable component in all hydrate systems,water,is highly polar and non-ideal,necessitating the use of more advanced equation of states(EoSs) that take into account more intermolecular forces for thermodynamic modeling of these *** by the ever-increasing number of publications on this topic,this study aims to review the application of associating EoSs for the thermodynamic modeling of gas *** most important hydrate-based models available in the literature including the van der Waals-Platteeuw(vdW-P) model,Chen-Guo model,and Klauda-Sandler model coupled with and SAFT EoSs were investigated and compared with cubic *** was concluded that the CPA and SAFT EoSs gave very accurate results for hydrate systems as they take into account the association interactions,which are very crucial in gas hydrate systems in which water,methanol,glycols,and other types of associating compounds are ***,it was concluded that the CPA EoS is easier to use than the SAFT-type EoSs and our suggestion for the gas hydrate systems is the CPA EoS.

关键词： Hydrate Mathematical modeling Equation of state SAFT CPA Association EoS

Investigation of a ship resonance through numerical simulation

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Journal of Hydrodynamics 2020年第5期32卷 969-983页

作者： S.S.Kianejad Hossein Enshaei Jonathan Duffy nazanin Ansarifard Australian Maritime College University of TasmaniaLauncestonAustralia

Understanding dynamic stability of a ship on a resonance frequency is important because comparatively smaller external forces and moments generate larger *** roll motion is most susceptible because of smaller restoring *** studies related to the failure modes such as parametric roll and dead ship condition,identified by second generation of intact stability criteria(SGISC)are performed at a resonance ***,the nature of resonance,where the model experiences an incremental roll motion,has not been well *** this study,nonlinear unsteady computational fluid dynamics(CFD)simulations were conducted to investigate the resonance phenomenon using a containership under a sinusoidal roll exciting *** capture the complexity of the phenomenon,simulations were conducted over a range of frequencies to cover the resonance frequency including lower and higher *** addition to the resonance frequency,the phase shift between roll exciting moment and roll angle,as well as the phase difference between acceleration and roll angle,were found to have significant effects on the occurrence of resonance.

关键词： Resonance harmonic excited roll motion natural frequency phase shift phase difference

Smart machine learning or discovering meaningful physical and chemical contributions through dimensional stacking

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npj Computational Materials 2019年第1期5卷 379-386页

作者： Lee A.Griffin Iaroslav Gaponenko Shujun Zhang nazanin Bassiri-Gharb School of Electrical Engineering Georgia Institute of TechnologyAtlantaGAUSA G.W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGAUSA Department of Quantum Matter Physics University of GenevaGenevaSwitzerland ISEM Australian Institute for Innovative MaterialsUniversity of WollongongWollongongAustralia School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGAUSA

Despite remarkable advances in characterization techniques of functional materials yielding an ever growing amount of data,the interplay between the physical and chemical phenomena underpinning materials’functionalities is still often poorly *** reduction techniques have been used to tackle the challenge of understanding materials’behavior,leveraging the very large amount of data ***,we present a method for applying physical and chemical constraints to dimensional reduction analysis,through dimensional *** to traditional,uncorrelated techniques,this approach enables a direct and simultaneous assessment of behaviors across all measurement parameters,through stacking of data along specific dimensions as required by physical or chemical *** proposed method is applied to the nanoscale electromechanical relaxation response in(1−x)PMN-xPT solid solutions,enabling a direct comparison of electric field-and chemical composition-dependent contributors.A poling-like,and a relaxation-like behavior with a domain glass state are identified,and their evolution is tracked across the phase *** proposed dimensional stacking technique,guided by the knowledge of the underlying physics of correlated systems,is valid for the analysis of any multidimensional dataset,opening a spectrum of possibilities for multidisciplinary use.

关键词： stacking chemical relaxation

Viscoelasticity and shear-thinning effects on bio-polymer solution and suspended particle behaviours under oscillatory curve Couette flow conditions

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Biosurface and Biotribology 2018年第1期4卷 1-17页

作者： Alaleh Safari nazanin Emami Michel Jose Cervantes Biotribology Group Division of Machine ElementLulea University of Technology97187 LuleaSweden Division of Fluid and Experimental Mechanics Lulea University of Technology97187 LuleàSweden Water Power Laboratory Norwegian University of Science and Technology7491 TrondheimNorway

Formation of wear particles within total hip replacement is one of the main causes of its *** addition toimproving the lubrication and wear resistance of materials used as bearing surfaces,understanding of wear particledistribution patterns within lubricants inside an implant gap could be used to improve design parameters andimplants'*** this study,the behaviours of biolubricants(with compositions similar to human joint synovialfluid)and suspended particles were investigated by micro-particle image velocimetry in curved mini channels underoscillatory Couette flow *** studied biolubricants had shear-thinning viscoelastic *** found that increasing shear-thinning,elasticity or motion frequency levels did not affect the trend behavioursof biolubricant flows due to the low strain values of the experimental conditions ***,suspended particlesformed strings along flow directions and exhibited cross-stream migration to channel *** frequency,fluidshear thinning and elasticity characteristics and channel dimensions strongly affected particle behaviours.

关键词： particle oscillatory flow

Broadband 1-GHz mid-infrared frequency comb

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Light(Science & Applications) 2022年第10期11卷 2358-2364页

作者： nazanin Hoghooghi Sida Xing Peter Chang Daniel Lesko Alexander Lind Greg Rieker Scott Diddams Precision Laser Diagnostics Laboratory University of ColoradoBoulderCO 80309USA Time and Frequency Division National Institute of Standards and TechnologyBoulderCO 80305USA Department of Physics University of ColoradoBoulderCO 80309USA Department of Chemistry University of ColoradoBoulderCO 80309USA Electrical Computer and Energy Engineering University of ColoradoBoulderCO 80309USA

Mid-infrared(MIR)spectrometers are invaluable tools for molecular fingerprinting and hyper-spectral *** the available spectroscopic approaches,GHz MIR dual-comb absorption spectrometers have the potential to simultaneously combine the high-speed,high spectral resolution,and broad optical bandwidth needed to accurately study complex,transient events in chemistry,combustion,and ***,such a spectrometer has not yet been demonstrated due to the lack of GHz MIR frequency combs with broad and full spectral ***,we introduce the first broadband MIR frequency comb laser platform at 1 GHz repetition rate that achieves spectral coverage from 3 to 13 μ*** frequency comb is based on a commercially available 1.56 μm mode-locked laser,robust all-fiber Er amplifiers and intra-pulse difference frequency generation(IP-DFG)of few-cycle pulses in x(2)nonlinear *** used in a dual comb spectroscopy(DCS)configuration,this source will simultaneously enable measurements with μs time resolution,1 GHz(0.03 cm-1)spectral point spacing and a full bandwidth of>5 THz(>166 cm-1)anywhere within the MIR atmospheric *** represents a unique spectroscopic resource for characterizing fast and non-repetitive events that are currently inaccessible with other sources.

关键词： repetition spacing transient