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Development and implementation of spin to stall resin at Anglo Americans Australian underground coal operations

International j.urnal of Mining Science and Technology 2016年第1期26卷 161-168页

作者： Emery j. Canbulat I. Craig P. naylor j. Sykes A. Grasstree Mine Anglo American Coal Middlemount 4746 Australia School of Mining Engineering University of New South Wales Sydney 2075 Australia j.nnmar Australia Smeaton Grange 2567 Australia Rocbolt Resins Sydney 2075 Australia

Longwall mining is by far the most common method of underground coal extraction in Australia. The industry trends and expectations are placing increasing emphasis on the reliability and productivity of these operations. The longwalls are becoming wider and longer while retreat rates are continuously increasing due to significant improvements achieved in longwall equipment reliability and *** increased longwall productivity is placing significant emphasis on the reliability of longwall panel development. Although there have been significant improvements in the reliability of continuous miners and hydraulic drill rigs,the traditional resin encapsulated bolt installation is still the principal method used in all maj.r coal-producing countries around the world. Anglo American realised an opportunity existed to introduce an alternative roof bolt installation technique called ‘‘spin to stall" in *** to stall was first introduced in Anglo American Coal in South Africa where it has been successfully used for over a decade,though implementation of South African spin to stall resin in Australia has proven to be near impossible due to a significant difference in geotechnical conditions,mining method,and,subsequently,roof bolting equipment. Therefore,a new spin to stall development proj.ct was initiated between Anglo American Coal and j.nnmar Australia(SPIN2STALLò). This paper summarises the j.urney of this proj.ct,the results,and the successful implementation of spin to stall achieved at Grasstree Mine.

关键词： Roof boltingRoof bolt installationSpin to stallGeotechnical engineeringStrata control

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Adiponectin signalling in bone homeostasis,with age and in disease

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Bone Research 2021年第1期9卷 15-25页

作者： j.nathan W.Lewis j.mes R.Edwards Amy j.naylor Helen M.McGettrick Rheumatology Research Group Institute of Inflammation and AgeingUniversity of BirminghamBirmingham B152TTUK Ageing&Regeneration Research Group Botnar Research CentreUniversity of OxfordOxford OX37LDUK

Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose metabolism and insulin *** the bone,osteoblasts and osteoclasts express the adiponectin receptors,however,there are conflicting reports on the effects of adiponectin on bone formation and *** studies have shown a pro-osteogenic role for adiponectin in in vivo murine models and in vitro:with increased osteoblast differentiation and activity,alongside lower levels of ***,human studies often demonstrate an inverse relationship between adiponectin concentration and bone ***,the presence of multiple isoforms of adiponectin and multiple receptor subtypes has the potential to lead to more complex signalling and functional *** such,we still do not fully understand the importance of the adiponectin signalling pathway in regulating bone homeostasis and repair in health,with age and in *** this review,we explore our current understanding of adiponectin bioactivity in the bone;the significance of its different isoforms;and how adiponectin biology is altered in ***,furthering our understanding of adiponectin regulation of bone biology is key to developing pharmacological and non-pharmacological(lifestyle)interventions that target adiponectin signalling to boost bone growth and repair in healthy ageing,following inj.ry or in disease.

关键词： homeostasis metabolism consequences

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Model-guided design of a high performance and durability Ni nanofiber/ceria matrix solid oxide fuel cell electrode

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j.urnal of Energy Chemistry 2021年第5期30卷 98-112页

作者： Mengzheng Ouyang Antonio Bertei Samuel j.Cooper Yufei Wu Paul Boldrin Xinhua Liu Masashi Kishimoto Huizhi Wang Max naylor Marlow j.ngyi Chen Xiaolong Chen Yuhua Xia Billy Wu Nigel P.Brandon Department of Earth Science and Engineering Imperial College LondonExhibicion RoadLondon SW72AZUnired Kingdom Department of Civil and Industrial Engineering(D1CI) University of PisaLargo Lucio Lazzarino256J22 PisaItaly Dyson School of Design Engineering Imperial College LondonExhibition RoadLondon SW72AZUnited Kingdom Department of Computing Imperial College LondonExhibition RoadLondon SW72AZUnited Kingdom School of Transportation Science and Engineering Beihang UniversityKejiyuan RdHaidianBeijing 100083China Department of Aeronautics and Astronautics Kyoto UniversityYoshidahonmachiSakyo WardKyotoKyoto Prefecture 606-8501Japang Department of Mechanical Engineering Imperial College LondonExhibition RoadLondon SW72AZUnited Kingdom Department of Chemistry University of CambridgeThe Old SchoolsTrinity LnCambridge CB21TNUnited Kingdom

Mixed ionic electronic conductors(MIECs)have attracted increasing attention as anode materials for solid oxide fuel cells(SOFCs)and they hold great promise for lowering the operation temperature of ***,there has been a lack of understanding of the performance-limiting factors and guidelines for rational design of composite metal-MIEC *** a newly-developed approach based on 3 D-tomography and electrochemical impedance spectroscopy,here for the first time we quantify the contribution of the dual-phase boundary(DPB)relative to the three-phase boundary(TPB)reaction pathway on real MIEC electrodes.A new design strategy is developed for Ni/gadolinium doped ceria(CGO)electrodes(a typical MIEC electrode)based on the quantitative analyses and a novel Ni/CGO fiber-matrix structure is proposed and fabricated by combining electrospinning and tape-casting methods using commercial *** only 11.5 vol%nickel,the designer Ni/CGO fiber-matrix electrode shows 32%and 67%lower polarization resistance than a nano-Ni impregnated CGO scaffold electrode and conventional cermet electrode *** results in this paper demonstrate quantitatively using real electrode structures that enhancing DPB and hydrogen kinetics are more efficient strategies to enhance electrode performance than simply increasing TPB.

关键词： Solid oxide fuel cells Electrospinning Electrochemical impedance spectroscopy Tomography 2-d model Ceria

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Land-walking ***-walking interventions in older adults:Effects on aerobic fitness

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j.urnal of Sport and Health Science 2020年第3期9卷 274-282页

作者： Andrew Haynes Louise H.naylor Howard H.Carter Angela L.Spence Elisa Robey Kay L.Cox Barbara A.Maslen Nicola T.Lautenschlager Nicola D.Ridgers Daniel j.Green School of Human Sciences(Exercise and Sport Science) The University of Western AustraliaPerthWA 6009Australia School of Physiotherapy and Exercise Science Curtin UniversityPerthWA 6102Australia School of Medicine The University of Western AustraliaPerthWA 6009Australia Academic Unit for Psychiatry of Old Age Department of PsychiatryThe University of MelbourneMelbourneVIC 3010Australia North Western Mental Health Melbourne HealthMelbourneVIC 3010Australia Division of Psychiatry WA Centre for Health&AgeingThe University of Western AustraliaPerthWA 6009Australia Institute for Physical Activity and Nutrition(IPAN) School of Exercise and Nutrition SciencesDeakin UniversityGeelongVIC 3125Australia

Background:Low cardiorespiratory fitness is an independent predictor of all-cause and cardiovascular mortality,and interventions that increase fitness reduce ***-walking decreases musculoskeletal impact and risk of falls in older individuals,but it is unclear whether water-walking improves aerobic fitness in the same way as weight-dependent *** randomized controlled trial involved 3 intervention groups—a no-exercise control group(CG),a land-walking(LW)group,and a water-walking(WW)group—to investigate the comparative impacts of LWandWWto CG on ***:Both exercise groups attended individually tailored,center-based,intensity-matched 3×weekly sessions for 24 weeks,which progressed to 150 min of exercise per *** was followed by a 24-week no-intervention *** graded exercise tests were performed on a treadmill at Weeks 0,24,and ***:Maximal oxygen uptake increased from Week 0 to Week 24 in both exercise groups(0.57±0.62 mL/kg/min,0.03±0.04 L/min for LW;0.93±0.75 mL/kg/min,0.06±0.06 L/min for WW,mean±SE)compared to the CG(-1.75±0.78 mL/kg/min,-0.16±0.05 L/min)(group×time,p<0.05).Time to exhaustion increased significantly following LW only(123.4±25.5 s),which was significantly greater(p=0.001)than the CG(24.3±18.5 s).By Week 48,the training-induced adaptations in the exercise groups returned to near baseline ***:Our study supports current physical-activity recommendations that 150 min/week of moderate-intensity exercise produces improvements in fitness in previously sedentary older ***,LW andWW elicit similar improvements in fitness if conducted at the same relative ***-na?ve older individuals can benefit from the lower impact forces and decreased risk of falls associated withWWwithout compromising improvements in cardiorespiratory fitness.

关键词： Cardiorespiratory fitness Graded exercise test Physical activity Water exercise

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Effects of acute doxorubicin treatment on hepatic proteome lysine acetylation status and the apoptotic environment

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World j.urnal of Biological Chemistry 2014年第3期5卷 377-386页

作者： Amie j.Dirks-naylor Samir A Kouzi j.seph D Bero Ngan TK Tran Sendra Yang Raean Mabolo School of Pharmacy Wingate University

AIM: To determine if doxorubicin(Dox) alters hepatic proteome acetylation status and if acetylation status was associated with an apoptotic environment. METHODS: Doxorubicin(20 mg/kg; Sigma, Saint Louis, MO; n = 8) or NaCl(0.9%; n = 7) was administered as an intraperitoneal inj.ction to male F344 rats, 6-wk of age. Once animals were treated with Dox or saline, all animals were fasted until sacrifice 24 h later. RESULTS: Dox treatment decreased proteome lysine acetylation likely due to a decrease in histone acetyltransferase activity. Proteome deacetylation may likely not be associated with a proapoptotic environment. Dox did not increase caspase-9,-8, or-3 activation nor poly(adenosine diphosphate-ribose) polymerase-1 cleavage. Dox did stimulate caspase-12 activation, however, it likely did not play a role in apoptosis induction. CONCLUSION: Early effects of Dox involve hepatic proteome lysine deacetylation and caspase-12 activa-tion under these experimental conditions.

关键词： Sirtuin 1 Sirtuin 3 Caspase Apoptosis Acetylation Histone deacetylase Histone acetyltransferase

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营养不良和疾病对马高脂血症的作用

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动物医学进展 1981年第6期 28-30页

作者： j.M.naylor 房胜利

根据脂类的动员规律,研究了健康马禁食120小时,不限制饮水期间脂类动员的情况。目的在于探讨马属家畜发生高脂血症的原因以及血液化学成分的变化。材料和方法 (一)健康马禁食期间脂类动员的研究:

关键词：高脂血症甘油三醋甘油浓度矮马疾病血脂血浆脂类总脂血清游离脂肪酸非酯化脂肪酸甘油三酚氮血症脂肪浸润假性肥大

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半嵌套式PCR检测转几丁质酶基因烟草研究

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中国烟草学报 2002年第2期8卷 11-15页

作者：时焦 M naylor M L Edwards j.I Cooper 韩锦峰青州烟草研究所山东青州262500 英国牛津病毒和环境微生物研究所河南农业大学郑州450002

用含卡那霉素的培养基首先对转几丁质酶基因烟草种子和烟苗进行初步筛选鉴定 ,再用 Western Blot进一步证实抗卡那霉素的转基因烟苗中外源转几丁质酶基因的表达。然后研究半嵌套式 PCR(Semi- nested PCR)检测转几丁质酶基因烟草植株及... 详细信息

用含卡那霉素的培养基首先对转几丁质酶基因烟草种子和烟苗进行初步筛选鉴定 ,再用 Western Blot进一步证实抗卡那霉素的转基因烟苗中外源转几丁质酶基因的表达。然后研究半嵌套式 PCR(Semi- nested PCR)检测转几丁质酶基因烟草植株及其烤后烟叶中的所转目的基因 ;利用限制性内切酶 H ind 对半嵌套式 PCR产物进行酶切 ,从而验证半嵌套式 PCR产物是否为真正的目的基因。研究结果表明 ,半嵌套式 PCR是一种快速。

关键词：半嵌套式PCR 检测转基因烟草几丁质酶基因

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馆藏173年的模式标本的线粒体基因组测序—露齿鲨属(Glyphis)的系统分类学研究

馆藏173年的模式标本的线粒体基因组测序—露齿鲨属(Glyphis)的系...

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中国海洋湖沼学会鱼类学分会、中国动物学会鱼类学分会2012年学术研讨会

作者：李晨虹 Gavin j.P.naylor Nicolas Straube Shannon Corrigan Michi Holfreiter 上海海洋大学 Hollings Marine Lab 331 Fort JohnsonSouth Carolina 29142USA The University of York Wentworth WayHeslingtonYorkYO105DDUK

露齿鲨,又常被称作河鲨,是一种分布在南亚、东南亚和澳大利亚的稀有物种。目前该属已知至少有五个种:婆罗洲河鲨(Glyphis fowlerae)、恒河鲨(***)、北河鲨(***)、露齿鲨(***)和伊洛瓦底江

关键词：目标基因富集 Illumina测序馆藏标本系统进化分析露齿鲨(GlyphiS)

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新研究确定了与肝病和脂肪代谢有关的肝细胞突变

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中西医结合肝病杂志 2021年第11期31卷 1011-1011页

作者： Stanley W. K. Ng Foad j. Rouhani Simon F. Brunner Natalia Brzozowska Federico Abascal Luiza Moore Lia Chappell Daniel Leongamornlert Aleksandra Ivovic Philip Robinson Timothy Butler Mathij. A. Sanders Nicholas Williams Tim H. H. Coorens j.n Teague Keiran Raine Adam P. Butler Yvette Hooks Beverley Wilson Natalie Birtchnell Michael R. Stratton Iñigo Martincorena Raheleh Rahbari Peter j. Campbell Foad j. Rouhani & Huw naylor Sarah j. Aitken & Matthew Hoare Sarah j. Aitken & Susan E. Davies Sarah j. Aitken Ming Yang Efterpi Nikitopoulou Christian Frezza Matthew Hoare Cancer Genome Proj.ct Wellcome Sanger Institute Hinxton UK Department of Hematology Erasmus University Medical Center Rotterdam The Netherlands Stem Cell Institute University of Cambridge Cambridge UK Department of Surgery Addenbrooke’s Hospital Cambridge UK CRUK Cambridge Institute Cambridge UK Department of Pathology Addenbrooke’s Hospital Cambridge UK MRC Toxicology Unit University of Cambridge Cambridge UK MRC Cancer Unit University of Cambridge Cambridge UK Department of Medicine University of Cambridge Addenbrooke’s Hospital Cambridge UK

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GP... 详细信息

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GPAM 五个基因在肝病患者的肝细胞中发生了突变,过程如图a所示。而其中的FOXO1、CIDEB、GPAM三个基因是对肝细胞如何代谢脂肪和对胰岛素作出反应有直接影响的基因。

关键词： FOXO1 肝病患者细胞突变肝细胞脂肪代谢胰岛素 GPA 剑桥大学

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Can short-term fasting protect against doxorubicin-induced cardiotoxicity?

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World j.urnal of Biological Chemistry 2014年第3期5卷 269-274页

作者： Amie j.Dirks-naylor Samir A Kouzi Sendra Yang Ngan TK Tran j.seph D Bero Raean Mabolo Diep T Phan Stephanie D Whitt Heather N Taylor School of Pharmacy Wingate University

Doxorubicin(Dox) is one of the most effective chemotherapeutic agents used in the treatment of several types of cancer. However the use is limited by cardiotoxicity. Despite extensive investigation into the mechanisms of toxicity and preventative strategies, Dox-induced cardiotoxicity still remains a maj.r cause of morbidity and mortality in cancer survivors. Thus, continued research into preventative strategies is vital. Short-term fasting has proven to be cardioprotective against a variety of insults. Despite the potential, only a few studies have been conducted investigating its ability to prevent Dox-induced cardiotoxicity. However, all show proof-of-principle that short-term fasting is cardioprotective against Dox. Fasting affects a plethora of cellular processes making it difficult to discern the mechanism(s) translating fasting to cardioprotection, but may involve suppression of insulin and insulin-like growth factor-1 signaling with stimulated autophagy. It is likely that additional mechanisms also contribute. Importantly, the literature suggests that fasting may enhance the antitumor activity of Dox. Thus, fasting is a regimen that warrants further investigation as a potential strategy to prevent Dox-induced cardiotoxicity. Future research should aim to determine the optimal regimen of fasting, confirmation that this regimen does not interfere with the antitumor properties of Dox, as well as the underlying mechanisms exerting the cardioprotective effects.

关键词： Fasting Doxorubicin Cardiotoxicity Cardio-protection

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