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Tributyltin causes generational neurodevelopmental toxicity and the protective effect of folic acid in zebrafish

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Journal of Environmental Sciences 2024年第3期137卷 615-625页

作者： Haoxing Cai naying zheng Chen Tang Yuxuan Zhang zhenghong Zuo Chengyong He State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiang’an Hospital of Xiamen UniversityXiamen UniversityXiamen 361005China

Tributyltin(TBT),a common organotin environmental pollutant,may pose a threat to human development during critical early-life *** aimed to assess the neurodevelopmental intergenerational toxicity of early-life exposure to TBT and the protective effect of DNA methyl donor folic acid(FA).Specifically,after early-life exposure(1–21 days postfertilization,dpf)to TBT(0,1,10 and 100 ng/L),zebrafish(Danio rerio)were cultured in clean medium until sexual *** exposed females were mated with unexposed males to produce embryos(F1).The F1 generation were cultured(4–120 hours post-fertilization,hpf)with and without 1 mmol/L *** neurotoxic effects of early-life TBT exposure for zebrafish and their offspring(F1)were significantly enhanced anxiety and reduced aggression,decreased gene expression of DNA methyltransferase in the brain and increased serotonin levels in the ***,the intergenerational neurodevelopmental toxicity,as manifested in the F1 generation,was attenuated by FA *** summary,early-life TBT exposure led to intergenerational neurodevelopmental deficits in zebrafish,and DNA methyl donors had a protective effect on F1 neurodevelopment,which can inform the prevention and treatment of intergenerational neurotoxicity due to organotin pollutants.

关键词： Tributyltin Neurodevelopment Intergeneration DNA methylation Folic acid Zebrafish

Mepanipyrim induces cardiotoxicity of zebrafish(Danio rerio) larvae via promoting AhR-regulated COX expression pathway

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Journal of Environmental Sciences 2023年第3期125卷 650-661页

作者： Chao Shen Jing He Kongyang Zhu naying zheng Yue Yu Chengyong He Chunyan Yang zhenghong Zuo State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen 361005China State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361005China

The wide use of pesticides has seriously threatened human health and the survival of beneficial organisms. The fungicide mepanipyrim is widely used in viticulture practices. Studies of mepanipyrim-induced toxicity in organisms are still scarce, especially studies on cardiotoxicity. In this study, we aimed to investigate mepanipyrim-induced cardiotoxicity in zebrafish(Danio rerio) larvae. We found that mepanipyrim could induce cardiotoxicity by altering the heart rate and cardiomyocyte diameter of larvae. Meanwhile, RNA sequencing and RT-qPCR data indicated that mepanipyrim exposure could dramatically alter the m RNA expression of calcium signaling pathway-, cardiac muscle contraction-, and oxidative respiratory chain-related genes. Interestingly, by the CALUX cell bioassay, we found that most cytochrome c oxidase(COX) family genes exhibited potential AhR-regulated activity, suggesting that mepanipyrim induced cardiotoxicity via a novel AhR-regulated manner in ***, the AhR antagonist CH_(2)23191 could effectively prevent mepanipyrim-induced cardiotoxicity in zebrafish larvae. In conclusion, the AhR agonist mepanipyrim could induce cardiotoxicity in a novel unreported AhR-regulated manner, which could specifically affect the expression of COX family genes involved in the mitochondrial oxidative respiratory chain. Our data will help explain the toxic effects of mepanipyrim on organisms and provide new insight into the AhR agonistic activity pesticide-induced cardiotoxicity.

关键词： Zebrafish(Danio rerio) Mepanipyrim AhR agonist Cardiotoxicity CH_(2)23191 Cytochrome coxidase

Ferrous Oxide Nanoparticles Induced Abnormal Cardiac Development in Zebrafish Through Hypoxia and Ferroptosis

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Chemical Research in Chinese Universities 2023年第3期39卷 502-507页

作者： zheng naying CHEN Xintan ZHAN Ruyu LIAO Tingting SHI Yiyue SUN Xiaolian CHEN Shuzhen ZUO zhenghong State Key Laboratory of Cellular Stress Biology Xiang’an Hospital of Xiamen UniversitySchool of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen361102China Department of Microbiology and Immunology Fujian Provincial Key Laboratory of Functional and Clinical Translational MedicineXiamen Key Laboratory of Respiratory DiseasesXiamen Medical CollegeXiamen361023China Chest Pain Center Anxi County HospitalQuanzhou362400China State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing210009China

Ferrous oxide nanoparticles(nFeO)have potential applications in biomedicine,industrial processes,and waste water ***,the biocompatibility of nFeO remains *** this study,we synthesized rhombus-shaped nFeO and exposed them to zebrafish embryos to investigate the bio-safety of *** results showed that exposure to nFeO led to pericardial edema,heart bleeding,and enlarged ***,the content of dissolved oxygen ***^(2+)ions,which were released from the core of nFeO,were oxidized into Fe^(3+).This caused the overexpression of tfa and fpn genes,which carried Fe^(3+)into and out of the cell membrane,*** overload of Fe^(3+)caused ferroptosis in zebrafish larvae,which was evidenced by the overexpression of the marker gene ptgs2 and the marker production malondialdehyde(MDA)of ***,neither the ferrostatin-1(Fer-1)inhibitor nor deferoxiamine(DFO)could completely rescue the toxicity caused by *** found that co-treatment of nFeO with CaO_(2),a dissolved oxygen donor,and Fer-1 or DFO could totally rescue pericardial edema and heart *** results provide new knowledge that both hypoxia and ferroptosis play important roles in nFeO-induced zebrafish cardiac developmental toxicity,which is beneficial for the development and safe application of iron-based nanomaterials in the future.

关键词： Nanoparticle Biocompatibility Heart Zebrafish Iron

基于RBF-BP协作神经网络的公交行程时间预测

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闽江学院学报 2017年第5期38卷 100-107页

作者：黄明芳郑娜英闽江学院经济与管理学院福建福州350108

为利于公交乘客合理化制定日常出行计划,缩减未知的候车时长,进而提升公交出行吸引力.针对公交行程时间动静态影响因素展开综合性分析,以平潭综合实验区3路公交部分路线为例,构建基于RBF-BP协作神经网络的公交行程时间预测模型,应用MAT... 详细信息

为利于公交乘客合理化制定日常出行计划,缩减未知的候车时长,进而提升公交出行吸引力.针对公交行程时间动静态影响因素展开综合性分析,以平潭综合实验区3路公交部分路线为例,构建基于RBF-BP协作神经网络的公交行程时间预测模型,应用MATLAB语言编程进行预测,结果显示在同一状态的公交运行情况下,尤其在样本数据较少时,RBF-BP协作神经网络预测精度更优于BP神经网络、RBF神经网络,具有一定的实际应用价值.

关键词：公交行程时间动静态因素 RBF-BP协作神经网络

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基于同步共轴结构的辐射层析测温仪设计

仪器仪表学报 2023年第9期44卷 237-245页

作者：管今哥卫娜瑛郑永秋陈坤中北大学省部共建动态测试技术国家重点实验室太原030051

光学辐射测温技术因时空分辨率高、测温范围宽等优势在燃烧场温度时空演化特性表征领域具有重要应用价值。固体火箭发动机燃烧室内可测试空间受限,基于多视线投影的三维温度场重构方法因光线遮挡而失效。针对该问题,在傅里叶光学理论基... 详细信息

光学辐射测温技术因时空分辨率高、测温范围宽等优势在燃烧场温度时空演化特性表征领域具有重要应用价值。固体火箭发动机燃烧室内可测试空间受限,基于多视线投影的三维温度场重构方法因光线遮挡而失效。针对该问题,在傅里叶光学理论基础上,建立了燃烧断面与像靶平面之间的物像空间映射关系模型,设计加工了光机电一体化的动态辐射层析测温仪,实现了多个像探测器共光轴且能够同步聚焦于不同空间位置的燃烧断面。试验结果表明,通过对某型号开窗燃烧室内固体推进剂药条燃烧辐射采样数据的卷积与反卷积处理,堆栈的燃烧断面在沿着仪器光轴方向上能够相互分离,在光电信号关系标定基础上利用普朗克辐射定律对已分离的燃烧断面温度分布进行测量过程中,测温的相对误差小于8%。该仪器能够在单向投影光路上以层析方式实现对动态三维燃烧温度场的解析。

关键词：可测试空间受限同步共轴燃烧场三维层析成像温度表征

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基于级联分光成像的动态火焰层析表征方法

光学学报 2023年第9期43卷 85-96页

作者：卫娜瑛管今哥郑永秋张成飞刘喆岳博坤薛晨阳中北大学省部共建动态测试技术国家重点实验室山西太原030051 中国航天科工集团第六研究院六〇一所内蒙古呼和浩特010010 北京大学电子学院北京100084

提出一种多相机共光路层析成像方法,对火焰的时空演化特性进行表征。首先,在成像光路结构中利用级联分光棱镜将光能量分配到不同探测通道,在同步控制器驱动下,成像系统能够对瞬态火焰的不同断面同时进行聚焦。其次,建立光学层析系统的... 详细信息

提出一种多相机共光路层析成像方法,对火焰的时空演化特性进行表征。首先,在成像光路结构中利用级联分光棱镜将光能量分配到不同探测通道,在同步控制器驱动下,成像系统能够对瞬态火焰的不同断面同时进行聚焦。其次,建立光学层析系统的空间物像映射关系,基于反卷积算法实现火焰不同断面位置处自发辐射特性的数值解析。实验结果表明,不同相机能够同步独立地获取火焰辐射信息,可实现对动态火焰的高空间分辨率测试。

关键词：成像系统层析重构分光探测物像映射动态火焰高时空分辨率

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31例盐酸头孢替安药品不良事件分析

北方药学 2018年第7期15卷 177-179页

作者：张玫郑涛王娜颖泰州市人民医院泰州225300 泰州职业技术学院泰州225300

目的:分析院内盐酸头孢替安致不良事件的(ADE)发生原因和特点,为临床安全应用提供药师建议。方法:对我院2010~2016年报告的31例盐酸头孢替安ADE报告进行回顾性归纳分析。结果:31例报告中女性患者明显多于男性,发生年龄段51~60岁最多,不... 详细信息

目的:分析院内盐酸头孢替安致不良事件的(ADE)发生原因和特点,为临床安全应用提供药师建议。方法:对我院2010~2016年报告的31例盐酸头孢替安ADE报告进行回顾性归纳分析。结果:31例报告中女性患者明显多于男性,发生年龄段51~60岁最多,不良事件损害表现以皮肤黏膜损害、循环系统、消化系统损害为主,严重不良事件为过敏性休克、呼吸困难、多型性红斑。结论:盐酸头孢替安临床应用不良事件的发生并不单纯是由于药物本身特性以及患者个体的差异导致,药物的选择、给药剂量、给药频次的不当等也是导致不良事件发生的因素,提示临床合理选择抗菌药物并严格按照药品说明书的给药剂量和给药频次,加强给药后的观察以及发生不良事件的及时干预,可以减少或避免不良事件的发生,提高临床安全用药水平。

关键词：药品不良事件头孢替安合理用药分析