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Use of Inhaled PGE1 to Improve Diastolic Dysfunction, LVEDP, Pulmonary Hypertension and Hypoxia in ARDS—A Randomised Clinical Trial

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Open Journal of Anesthesiology 2013年第2期3卷 109-115页

作者： Shahla Siddiqui nawal salahuddin Salwa Zubair Muniza Yousuf Iqbal Azam Anwarul Hassan Gilani Department of Anaesthesiology Critical Care Aga Khan University Karachi Pakistan Department of Biological and Biomedical Sciences Aga Khan University Karachi Pakistan Department of Medicine Pulmonary Criti- cal Care Aga Khan University Karachi Pakistan Pharmacy Services Aga Khan University Karachi Pakistan Section of Cardi- ology Aga Khan University Karachi Pakistan Statistician Community Health sciences Aga Khan University Karachi Pakistan

Introduction: We wished to see the effects of inhaled PGE1 on diastolic dysfunction, left ventricular end diastolic pressure (LVEDP), pulmonary hypertension and hypoxia in ARDS patients. Methods: This is a randomized, prospective, clinical trial conducted in the main adult intensive care unit of a tertiary care University hospital. A total of 67 patients were recruited. Inclusion criteria included all adult patients with a P/F ratio 35 mmHg on Pulmonary artery catheter or suspected on clinical grounds. A transthoracic echo was performed to record the diastolic function, LVEDP and Pa pressures. Subsequently patients were randomized by a block computerized randomization to either cases (n = 34) or controls (n = 33). Cases received nebulised PGE1 over 30 minutes in the ICU and normal saline was administered to controls blindly. Following this the echo and arterial blood gases were repeated. Our primary outcomes were an improvement in diastolic function and P/F ratio of greater than 20% and a decrease in pulmonary pressure and LVEDP of >20%. Results: At baseline, mean diastolic dysfunction was grade II, with a mean LVEDP of >15 and the PaO2/FiO2 ratio was 148.38 ± 60.05 with a mean pulmonary artery pressure of 81.35 ± 16.91. Inhaled PGE1 was followed by an improvement in diastolic dysfunction (grade I, p = 0.001) with a resulting improvement in LVEDP (12 +/? 2, p = 0.001) as well as Pa pressures (97.09 ± 30.06, p = 0.04) and a non significant improvement in PaO2/FiO2 ratio (161.45 ± 77.52, p = 0.21). There were no side effects observed in any patients. Conclusion: Our study shows that there is a significant improvement in diastolic dysfunction, LVEDP and Pa pressures after administration of nebulised PGE1, and an improvement although non-significant in hypoxia in ARDS patients. The trial was registered with *** (NCT00314548) and funded by the Pakistan medical research council.

关键词： ARDS PGE1 Diastolic Dysfunction Nebulised Prostacyclin Hypoxia

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Formation of Natural Melanin/TiO_(2) Nanostructure Hybrids with Enhanced Optical,Thermal and Magnetic Properties as a Soft Material

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 613-620页

作者： Saja Algessair nawal Madkhali Department of Physics College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)P.O.Box 5701Riyadh 11432Saudi Arabia

The natural Melanin/TiO_(2) was synthesized by the use of ultrasonication under UV *** influence of natural melanin on the structural,optical and thermal properties of TiO_(2) nanoparticles was investigated by using Fourier transform infrared spectroscopy,thermogravimetric analysis and UV-Vis *** was observed that incorporating natural melanin on TiO_(2) nanoparticles(TiO_(2)-Mel)occurred at 2.01 eV with a low value of Urbach energy around 100 meV indicating improvement in the crystalline *** measurement at room temperature showed diamagnetic ***,thermal results showed that TiO_(2)-Mel is stable even at temperatures up to 400℃.According to the results obtained by the thermal stability of melanin with titanium dioxide,it can be a good candidate in many applications such as solar cells and optoelectronics.

关键词： natural melanin/TiO_(2) thermal stability optoelectronic nanostructure UV radiation

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Chemically modified carbon-based electrodes for the determination of paracetamol in drugs and biological samples

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Journal of Pharmaceutical Analysis 2021年第2期11卷 138-154页

作者： Wafaa Boumya nawal Taoufik Mounia Achak Noureddine Barka Sultan Moulay Slimane University of Beni Mellal Research Group in Environmental Sciences and Applied Materials(SEMA)FP KhouribgaB.P.14525000KhouribgaMorocco Chouaib Doukkali University Ecole Nationale des Sciences AppliqueesLaboratoire des Sciences de l’Ingenieur pour l’EnergieEl JadidaMorocco Chemical&Biochemical Sciences Green Process EngineeringCBSMohammed VI Polytechnic UniversityBen GuerirMorocco

Paracetamol is a non-steroidal, anti-inflammatory drug widely used in pharmaceutical applications for its sturdy, antipyretic and analgesic action. However, an overdose of paracetamol can cause fulminant hepatic necrosis and other toxic effects. Thus, the development of advantageous analytical tools to detect and determine paracetamol is required. Due to simplicity, higher sensitivity and selectivity as well as costefficiency, electrochemical sensors were fully investigated in last decades. This review describes the advancements made in the development of electrochemical sensors for the paracetamol detection and quantification in pharmaceutical and biological samples. The progress made in electrochemical sensors for the selective detection of paracetamol in the last 10 years was examined, with a special focus on highly innovative features introduced by nanotechnology. As the literature is rather extensive, we tried to simplify this work by summarizing and grouping electrochemical sensors according to the by which manner their substrates were chemically modified and the analytical performances obtained.

关键词： Paracetamol Electrochemical sensors Modified electrodes Pharmaceutical samples

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Ultrastructural Study of Limb Bud Development in Green Turtles Chelonia mydas

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Asian Herpetological Research 2012年第1期3卷 69-78页

作者： nawal AL-MUKHAINI Taher BA-OMAR Ibrahim MAHMOUD Human and Clinical Anatomy Department College of Medicine and Health SciencesSultan Qaboos University Biology Department College of ScienceSultan Qaboos University

Morphological changes during the embryonic development of limbs of the green turtle,Chelonia mydas,were studied during the entire period of incubation,using transmission and scanning electron microscopy(TEM and SEM). Limb buds were first observed at Stage 2. At that stage,the tip was covered with an apical ectodermal ridge(AER) which began to regress at Stage 6. Associated with AER was the presence of the mesenchymal cells which,consequently,differentiated into muscles,cartilage and bones. The gross features of the skeletal development appeared as a condensation of the cartilaginous structures in the proximal distal region of the limbs. The primordial digits were gradually enclosed by hard keratinized webbed skin. The increase in rate of ossification and skin pigmentation was correlated with the growth of the limbs. The development of the limbs was closely related to the transitional appearance of mucus secretion from the epidermis.

关键词： green turtle Chelonia mydas turtle embryology limb bud development ultrastructure

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Care4U: Integrated healthcare systems based on blockchain

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Blockchain(Research and Applications) 2023年第4期4卷 2-13页

作者： Randa Kamal Ezz El-Din Hemdan nawal El-Fishway Department of Computer Science and Engineering Faculty of Electronic EngineeringMenoufia UniversityEgypt

During the COVID-19 crisis, the need to stay at home has increased dramatically. In addition, the number of sickpeople, especially elderly persons, has increased exponentially. In such a scenario, home monitoring of patientscan ensure remote healthcare at home using advanced technologies such as the Internet of Medical Things (IoMT).The IoMT can monitor and transmit sensitive health data;however, it may be vulnerable to various attacks. In thispaper, an efficient healthcare security system is proposed for IoMT applications. In the proposed system, themedical sensors can transmit sensed encrypted health data via a mobile application to the doctor for ***, three consortium blockchains are constructed for load balancing of transactions and reducing transactionlatency. They store the credentials of system entities, doctors' prescriptions and recommendations according to thedata transmitted via mobile applications, and the medical treatment process. Besides, cancelable biometrics areused for providing authentication and increasing the security of the proposed medical system. The investigationalresults show that the proposed system outperforms existing work where the proposed model consumed lessprocessing time by values of 18%, 22%, and 40%, and less energy for processing a 200 KB file by values of 9%,13%, and 17%. Finally, the proposed model consumed less memory usage by values of 7%, 7%, and 18.75%. Fromthese results, it is clear that the proposed system gives a very reliable and secure performance for efficientlysecuring medical applications.

关键词： Healthcare Blockchain Cyber security Internet of things Internet of Medical Things Cancelable biometrics

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Fast Texture Segmentation Based on Semi-Local Region Descriptor and Active Contour

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Numerical Mathematics(Theory,Methods and Applications) 2009年第4期2卷 445-468页

作者： nawal Houhou Jean-Philippe Thiran Xavier Bresson Signal Processing Laboratory 5 Ecole Polytechnique Federale de Lausanne （EPFL） Lausanne Switzerland. Department of Mathematics University of California Los Angeles CA 90095-1555 USA.

In this paper, we present an efficient approach for unsupervised segmentation of natural and textural images based on the extraction of image features and a fast active contour segmentation model. We address the problem of textures where neither the gray-level information nor the boundary information is adequate for object extraction. This is often the case of natural images composed of both homogeneous and textured regions. Because these images cannot be in general directly processed by the gray-level information, we propose a new texture descriptor which intrinsically defines the geometry of textures using semi-local image information and tools from differential geometry. Then, we use the popular Kullback-Leibler distance to design an active contour model which distinguishes the background and textures of interest. The existence of a minimizing solution to the proposed segmentation model is proven. Finally, a texture segmentation algorithm based on the Split-Bregrnan method is introduced to extract meaningful objects in a fast way. Promising synthetic and real-world results for gray-scale and color images are presented.

关键词： Semi-local image information Beltrami framework metric tensor active contour Kullback-Leibler distance split-Bregman method.

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A Novel Capability of Object Identification and Recognition Based on Integrated mWMM

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Computers, Materials & Continua 2023年第4期75卷 959-976页

作者： MZeeshan Sarwar Mohammed Hamad Alatiyyah Ahmad Jalal Mohammad Shorfuzzaman nawal Alsufyani Jeongmin Park Department of Computer Science Air UniversityIslamabadPakistan Department of Computer Science College of Sciences and Humanities in AflajPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Computer Engineering Tech University of Korea237 Sangidaehak-roSiheung-siGyeonggi-do15073Korea

In the last decade,there has been remarkable progress in the areas of object detection and recognition due to high-quality color images along with their depth maps provided by RGB-D *** enable artificially intelligent machines to easily detect and recognize objects and make real-time decisions according to the given *** cues can improve the quality of object detection and *** main purpose of this research study to find an optimized way of object detection and identification we propose techniques of object detection using two RGB-D *** proposed methodology extracts image normally from depth maps and then performs clustering using the Modified Watson Mixture Model(mWMM).mWMM is challenging to handle when the quality of the image is not ***,the proposed RGB-D-based system uses depth cues for segmentation with the help of *** it extracts multiple features from the segmented *** selected features are fed to the Artificial Neural Network(ANN)and Convolutional Neural Network(CNN)for detecting *** achieved 92.13%of mean accuracy over NYUv1 dataset and 90.00%of mean accuracy for the Redweb_v1 ***,their results are compared and the proposed model with CNN outperforms other state-of-the-art *** proposed architecture can be used in autonomous cars,traffic monitoring,and sports scenes.

关键词： Artificial intelligence convolutional neural network depth images interactive-object detection machine learning

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Diabetes onset before or after the age of 65 does it affect the progression of renal and cardiovascular diseases in the elderly patient？

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Journal of Geriatric Cardiology 2016年第3期13卷 267-269页

作者： Yassamine Bentata Haddiya Intissar Karimi Ilham Benabdellah nawal Chemlal Abdeljalil Redouane Abouqal Department of Nephrology Medical Sehool of Oujda University Mohammed the First Oujda Morocco Medical Emergency Department lbn Sina University Hospital Rabat Morocco Laboratory of Biostattics Clinical and Epidemiological Research Medical School University Mohamed V SouissL Rabat Morocco

Type 2 diabetes （T2D） is common in the elderly and more than half of the people with diabetes are over 65 years old. Elderly diabetic patients have a higher frequency of hypertension, coronary artery disease and chronic kidney disease than non-diabetic elderly patients and the risk of these complications increases with patient age, duration of the dia- betes and glycated hemoglobin values. Besides the known classical factors of renal disease progression,

关键词： Cardiovascular disease Diabetes Elderly patients Renal disease

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Folded novel accurate analytical and semi-analytical solutions of a generalized Calogero–Bogoyavlenskii–Schiff equation

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Communications in Theoretical Physics 2021年第9期73卷 26-36页

作者： Mostafa M A Khater S K Elagan M A El-Shorbagy S H Alfalqi J F Alzaidi nawal A Alshehri Department of Mathematics Faculty of ScienceJiangsu University212013ZhenjiangChina Department of Mathematics Obour High Institute For Engineering and Technology11828CairoEgypt Department of Mathematics Faculty of ScienceTaif University P.O.Box 11099Taif 21944Saudi Arabia Department of Mathematics College of Science and Humanities in Al-KharjPrince Sattam bin Abdulaziz UniversityAl-Kharj 11942Saudi Arabia Department of Basic Engineering Science Faculty of EngineeringMenoufia UniversityShebin El-Kom 32511Egypt Department of Mathematics Faculty of Science and ArtsMahayil Asir King Khalid UniversityAbhaSaudi Arabia

This paper studies the analytical and semi-analytic solutions of the generalized Calogero–Bogoyavlenskii–Schiff(CBS)*** model describes the(2+1)–dimensional interaction between Riemann-wave propagation along the y-axis and the x-axis *** extended simplest equation(ESE)method is applied to the model,and a variety of novel solitarywave solutions is *** solitary-wave solutions prove the dynamic behavior of soliton waves in *** accuracy of the obtained solution is verified using a variational iteration(VI)semi-analytical *** analysis and the match between the constructed analytical solution and the semi-analytical solution are sketched using various diagrams to show the accuracy of the solution we *** adopted scheme’s performance shows the effectiveness of the method and its ability to be applied to various nonlinear evolution equations.

关键词： generalized Calogero-Bogoyavlenskii-Schiff equation accurate analytical semianalytical solutions

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Security Analysis for SCKHA Algorithm:Stream Cipher Algorithm Based on Key Hashing Technique

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Chinese Journal of Electronics 2022年 1-16页

作者： Souror Samia El-Fishawy nawal Badawy Mohammed Department of Computer Science and Engineering Faculty of Electronic Engineering Menoufia University

The strength of any cryptographic algorithm is mostly based on the difficulty of its encryption key. However, the larger size of the shared key the more computational operations and processing time for cryptographic algorithms. To avoid increasing the key size and keep its secrecy, we must hide it. The authors proposed a stream cipher algorithm that can hide the symmetric key[1]through hashing and splitting techniques. This paper aims to measure security analysis and performance assessment for this algorithm. This algorithm is compared with three of the commonly used stream cipher algorithms: RC4, Rabbit, and Salsa20 in terms of execution time and throughput. This comparison has been conducted with different data types as audio, image, text,docs, and pdf. Experiments proved the superiority of SCKHA algorithm over both Salsa20 and Rabbit algorithms. Also, results proved the difficulty to recover the secret key for SCKHA algorithm. Although RC4 has a lower encryption time than SCKHA, it is not recommended for use because of its vulnerabilities. Security factors that affect the performance as avalanche effect, correlation analysis, histogram analysis, and Shannon information entropy are highlighted. Also, the ciphertext format of the algorithm gives it the ability to search over encrypted data.

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